Best Dihydroberberine Supplements (2026)
Dihydroberberine (DHB) is the active metabolite of berberine, offering up to 5x greater bioavailability and longer-lasting effects compared to standard berberine HCl. Because it is absorbed more efficiently, DHB can deliver comparable benefits at much lower doses — typically 100mg to 300mg versus 1000mg+ for regular berberine — with significantly fewer gastrointestinal side effects. Here are the best dihydroberberine supplements on the market.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Double Wood Dihydroberberine 100mg | GlucoVantage DHB 100mg | Capsules | Best Overall | 9.5/10 |
| Peak Performance Super Berberine 200mg | GlucoVantage DHB 200mg | Capsules | Best High-Dose | 9.3/10 |
| Black Forest 5X Berberine | DHB + Ceylon Cinnamon 4000mg | Capsules | Best with Cinnamon | 9.2/10 |
| NatureBell Dihydroberberine + Berberine HCl | DHB 100mg + Berberine HCl 400mg | Capsules | Best Dual-Action | 9.1/10 |
| HealMeal Dihydroberberine | DHB + Ceylon Cinnamon + ALA + Apigenin | Capsules | Best Multi-Ingredient | 9.0/10 |
| Berberine with Dihydroberberine & Ceylon Cinnamon | Berberine HCl + DHB + Ceylon Cinnamon | Capsules | Best Value Combo | 8.9/10 |
| Legendairy Milk Sugar Babe | DHB + Chromium + Cinnamon | Capsules | Best for Craving Control | 8.8/10 |
1. Double Wood Dihydroberberine 100mg – Best Overall
- MORE ABSORBABLE THAN BERBERINE: Studies show that a 100mg dose of Dihydroberberine produced significantly greater plasma concentrations when compared to 500mg of Berberine
- AMPK METABOLIC ACTIVATOR: Like normal Berberine, Dihydroberberine also works as a potent AMPK Metabolic activator meaning it may help with metabolism
- LESS SIDE EFFECTS THAN BERBERINE HLC: Since Dihydroberberine is effective in much lower doses, users are dramatically less likely to experience GI side effects when compared to a berberine supplement
- ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's Dihydroberberine is manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus, it is Vegetarian safe, Non-GMO and gluten-free
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
Double Wood’s GlucoVantage dihydroberberine delivers a precise 100mg dose per capsule with rigorous third-party testing and over 3,000 monthly purchases on Amazon.
Double Wood has built a strong reputation for clean, well-tested supplements, and their dihydroberberine is no exception. Each capsule contains 100mg of patented GlucoVantage dihydroberberine — the most studied and trusted DHB ingredient on the market. The 60-capsule bottle provides a two-month supply at the recommended one capsule per day dosing. Manufactured in the USA in a GMP-certified facility, third-party tested for microbes and heavy metals, and completely vegan, non-GMO, and gluten-free.
- Pros:
- Patented GlucoVantage ingredient with strong research backing
- Third-party tested for purity, heavy metals, and microbes
- Clean label — vegan, non-GMO, gluten-free
- Cons:
- 100mg dose may be insufficient for some users
- No additional support ingredients
Best for: Users who want a pure, well-tested dihydroberberine from a trusted brand
2. Peak Performance Super Berberine 200mg – Best High-Dose
- Why not 5X your berberine absorption? Peak Performance GlucoVantage Super Berberine contains Dihydroberberine (DHB), an active metabolite of berberine. Compared to regular berberine, DHB has shown to be up to 5x more bioavailable/absorbable, and 2x longer-lasting (8 hours vs. 4 hours)
- Super Berberine may help increase plasma BHB ketones.*
- Natural vs Synthetic: Synthetic vitamins and supplements are not as bioavailable, not absorbable / usable and not recognizable to the body as naturally derived supplements. Mounting studies on this natural herb, show increasing adaptogenic benefits. All of our ingredients are carefully chosen and 3rd party tested for purity.
- Vegan & Allergy Free - Free of Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards from trusted suppliers. Easy to swallow pills.
Peak Performance offers 200mg of GlucoVantage dihydroberberine per serving — equivalent to roughly 24,000mg of standard berberine — in a vegan, allergen-free formula.
At 200mg per serving, this is one of the strongest dihydroberberine supplements available. Peak Performance uses the same patented GlucoVantage ingredient as Double Wood but at double the dose. The formula is completely clean: vegan, free from soy, milk, egg, shellfish, corn, wheat, peanuts, gluten, and preservatives. All ingredients are third-party tested for purity. The company also participates in a 1-for-1 donation match with Vitamin Angels.
- Pros:
- 200mg GlucoVantage — one of the highest DHB doses available
- Free from all major allergens
- Third-party tested, GMP manufactured in the USA
- Cons:
- Higher dose means less room for gradual dose adjustment
- Premium price point
Best for: Experienced users who want maximum dihydroberberine potency in a single capsule
3. Black Forest 5X Berberine with Ceylon Cinnamon – Best with Cinnamon
- 5X MORE ABSORTION THAN REGULAR BERBERINE: Black Forest's 5X Berberine contains Dihydroberberine (DHB), an active metabolite of berberine. Compared to regular berberine, DHB has shown to be up to 5x more bioavailable, and 2x longer-lasting (8 hours vs. 4 hours).
- ENHANCED WITH 4000MG OF CEYLON CINNAMON: We added high levels of of ceylon cinnamon for extra support as these herbal supplements work synergistically to support your level goals.
- BERBERINE SUPPLEMENT: This pure Berberine supplement supports overall wellness and metabolic health by influencing key enzymes involved in energy balance and cellular function.
- USA PROUD AND VEGAN SAFE: Black Forest’s Dihydroberberine supplement is manufactured in a GMP Approved Facility and 3rd party tested for safety right here in the USA, Non-GMO, Gluten Free, and Vegan Safe.
Black Forest combines dihydroberberine with 4000mg of Ceylon cinnamon for synergistic metabolic support, earning Amazon’s Choice with over 800 monthly purchases.
The standout feature here is the generous 4000mg Ceylon cinnamon dose paired with dihydroberberine. Ceylon cinnamon (the “true” cinnamon) has its own research supporting blood sugar management, and when combined with DHB, the two work synergistically. Manufactured in a GMP-approved facility, third-party tested, non-GMO, gluten-free, and vegan. The black-sealed bottle protects capsules from moisture, light, and oxygen — a thoughtful detail that maintains product integrity.
- Pros:
- Generous 4000mg Ceylon cinnamon for added metabolic support
- Black-sealed bottle for superior product preservation
- Amazon’s Choice with strong customer ratings
- Cons:
- High cinnamon dose may not suit those already taking cinnamon supplements
- DHB dose not as clearly specified as competitors
Best for: Users who want dihydroberberine enhanced with a clinically meaningful dose of Ceylon cinnamon
4. NatureBell Dihydroberberine + Berberine HCl 500mg – Best Dual-Action
- Dual Action Berberine Support: NatureBell Dihydroberberberine combines 400mg berberine HCl and 100mg dihydroberberine per serving to support balanced sugar levels within normal range and heart health*
- High Absorption GlucoVantage: Features GlucoVantage high absorption bioavailable ingredients designed to deliver 5X absorption and longer-lasting wellness benefits*
- Premium Plant-Based Source: Made with authentic Berberis aristata root extract, offering a dual-action berberine complex for daily wellness support*
- Third-Party Tested: These vegetarian capsules are third-party lab tested for quality and potency; they are also non-GMO and free of gluten, wheat, soy, dairy, eggs, fish, shellfish, and tree nuts
- Pure, High-Quality Ingredients: At NatureBell, we use only the finest ingredients to help support you on your health and wellness journey
NatureBell takes a unique dual-action approach by combining 100mg GlucoVantage dihydroberberine with 400mg standard berberine HCl in every serving.
This formula hedges intelligently: the 100mg DHB provides fast, highly bioavailable support while the 400mg berberine HCl offers sustained-release benefits through standard gut absorption. The 120-capsule bottle delivers 60 servings, making it a two-month supply. Vegan, non-GMO, and sourced from authentic Berberis aristata root. This is an excellent choice for users transitioning from standard berberine who want to experience DHB benefits without fully abandoning their current regimen.
- Pros:
- Dual-action formula combining DHB and standard berberine
- 120 capsules for a full 2-month supply
- Authentic Berberis aristata root source
- Cons:
- The berberine HCl component may still cause GI discomfort
- Two capsules per serving
Best for: Users who want both fast-acting DHB and sustained berberine HCl in one supplement
5. HealMeal Dihydroberberine with Ceylon Cinnamon & ALA – Best Multi-Ingredient
- ENHANCED ABSORPTION WITH DIHYDROBERBERINE – Experience faster and more efficient absorption with Dihydroberberine, a highly bioavailable form of berberine derived from natural sources. Unlike traditional berberine organic, which must convert in the gut, Dihydroberberine is ready for your body to use immediately, potentially minimizing common digestive side effects.*
- POWERFUL RESULTS WITH LOWER DOSES – Achieve the same health benefits with just a third of the dosage compared to regular liposomal berberine. Dihydroberberine with ceylon cinnamon superior bioavailability means fewer capsules, with the same level of effectiveness.*
- EASY-TO-SWALLOW CAPSULES – Our small, size 3 capsules are designed for easy consumption while delivering the researched dose of Dihydroberberine, minimizing unnecessary fillers and ensuring convenience in every serving.*
- MADE IN THE USA FOR QUALITY ASSURANCE – Every batch of our Dihydroberberine is manufactured in the USA, ensuring a stable, bioavailable product with a shelf life of over two years. Check the "best by" date on the bottle for freshness assurance.*
- MORE EFFECTIVE ABSORPTION – Clinical studies reveal that a 100mg dose of Dihydro Berberine delivers plasma levels significantly higher (up to 5X) than a 500mg dose of standard berberine capsules, making it a highly efficient choice for optimal results.*
HealMeal stacks dihydroberberine with Ceylon cinnamon, R-alpha lipoic acid, and apigenin for a comprehensive metabolic support formula.
This is the most feature-rich dihydroberberine supplement on the list. R-alpha lipoic acid (the active form of ALA) provides powerful antioxidant and glucose metabolism support, while apigenin adds anti-inflammatory and calming benefits. Ceylon cinnamon completes the metabolic support stack. The 120-capsule bottle provides a solid supply, and the formula is designed for those who want maximum metabolic support from a single product. Each ingredient is chosen for its synergistic relationship with dihydroberberine.
- Pros:
- Four active ingredients targeting metabolism from multiple pathways
- R-alpha lipoic acid (the bioactive form) included
- 120 capsules for extended supply
- Cons:
- Individual ingredient doses may be compromised in the blend
- Higher price than single-ingredient DHB supplements
Best for: Users who want a comprehensive metabolic stack built around dihydroberberine
6. Berberine with Dihydroberberine & Ceylon Cinnamon Capsules – Best Value Combo
- GlucoVantage Dihydroberberine Supplement - Our advanced berberine and cinnamon supplements contain a proprietary form of berberine shown to be 5x more effective and bioavailable for greater results
- Optimal Berberine Complex - We added high levels of ceylon cinnamon for extra support as these herbal supplements work synergistically to support your goals
- Benefits of Berberine - This super antioxidant formula offer a wide range of health and wellness benefits including heart immune support to help you look and feel your best
- Clean Formula - Vitauthority’s berberine plus cinnamon pills are lab verified vegan and free of gluten soy and artificial colors and made in cGMP American facilities for quality you can trust
- The Vitauthority Difference - We are proud to be a leading authority on science-based vitamins supplements and nutrition with a relentless pursuit of quality and we always stand by our products
A budget-friendly combination of standard berberine and dihydroberberine with Ceylon cinnamon, offering dual-action support at an accessible price point.
This supplement provides a practical combination formula for users who want both berberine forms without paying premium prices. The high-absorption formula pairs dihydroberberine for rapid bioavailability with standard berberine HCl for sustained effects, plus Ceylon cinnamon for additional blood sugar support. The capsule format is straightforward, and the price point makes it one of the most accessible DHB-containing supplements available.
- Pros:
- Affordable dual-berberine formula
- Ceylon cinnamon included for added metabolic support
- Good entry point for trying dihydroberberine
- Cons:
- Less transparency on exact DHB dose compared to branded options
- Non-patented DHB source
Best for: Budget-conscious users who want to try dihydroberberine alongside standard berberine
7. Legendairy Milk Sugar Babe – Best for Craving Control
- SCIENCE-DRIVEN FORMULA: Featuring Reducose Mulberry Leaf Extract and GlucoVantage dihydroberberine to support your wellness goals. Carefully crafted with ingredients known for their potential to promote overall metabolic health.*
- SUPPORT FOR BALANCED LIVING: Helps manage weight, maintain energy balance, and helps encourage feelings of fullness, and supports your healthy lifestyle goals.*
- CLEAN & RELIABLE INGREDIENTS: Gluten-free, dairy-free, soy-free, and Non-GMO Project Verified. Manufactured in the USA in a cGMP-certified facility for the highest quality standards.*
- EASY TO USE: Take one capsule twice daily before meals to help support your wellness routine.*
- SUPPORTS APPETITE MANAGEMENT: Formulated with BHB salts to help maintain satiety and may naturally reduce cravings, making it easier to sustain your healthy daily routine*. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary.
Legendairy Milk’s Sugar Babe uses dihydroberberine with chromium and cinnamon to target sugar cravings and appetite management with a focus on metabolic reset.
Originally designed for postpartum and breastfeeding women, Sugar Babe has found a broader audience among anyone looking to manage sugar cravings naturally. The dihydroberberine works on AMPK activation for metabolic support, chromium enhances insulin sensitivity, and cinnamon provides additional glucose management. Legendairy Milk is a well-respected brand in the women’s health space with strong quality standards. The formula is gentle enough for daily use.
- Pros:
- Specifically formulated for craving and appetite control
- Includes chromium for insulin sensitivity support
- Trusted women’s health brand
- Cons:
- Marketing focused on postpartum may confuse general buyers
- Lower DHB dose than dedicated metabolic supplements
Best for: Women looking for natural craving control and metabolic support with gentle dihydroberberine
8. Toniiq Dihydroberberine 200mg with Ceylon Cinnamon & Milk Thistle – Best Premium
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Toniiq delivers a premium 200mg GlucoVantage dihydroberberine formula enhanced with Ceylon cinnamon and milk thistle for metabolic and liver support.
Toniiq is known for high-potency, rigorously tested supplements, and their DHB offering maintains that standard. At 200mg of GlucoVantage per serving (equivalent to roughly 24,000mg of standard berberine), this is among the most potent options available. The addition of milk thistle supports liver function and detoxification — a smart pairing since berberine metabolism occurs primarily in the liver. Ceylon cinnamon adds metabolic synergy. Every batch is third-party tested with certificates of analysis available.
- Pros:
- Industry-leading 200mg GlucoVantage potency
- Milk thistle for liver support — unique in the category
- Certificates of analysis available for every batch
- Cons:
- Premium price point
- Smaller capsule count per bottle
Best for: Users willing to invest in a premium, potent dihydroberberine with liver support
How to Choose the Best Dihydroberberine Supplement
The single most important factor is whether the supplement uses patented GlucoVantage dihydroberberine. This is the most studied and verified DHB ingredient, and products using it provide confidence in potency and purity. Generic dihydroberberine sources may not deliver the same absorption and effectiveness.
Dosing for dihydroberberine is much lower than standard berberine. Effective doses typically range from 100mg to 300mg daily, compared to 900mg to 1500mg for berberine HCl. A 100mg dose of DHB produces significantly greater plasma concentrations than a 500mg dose of standard berberine, so more is not necessarily better. Start with 100mg and adjust based on results.
Consider whether you want a pure DHB supplement or a combination formula. Standalone products offer precise dosing control, while combination formulas with Ceylon cinnamon, alpha lipoic acid, or milk thistle provide multi-pathway metabolic support. Dual-action products combining DHB with standard berberine HCl offer both immediate and sustained benefits.
Third-party testing, GMP certification, and clean labeling (non-GMO, gluten-free, vegan) are standard quality markers. Look for brands that provide certificates of analysis. Dihydroberberine is generally well-tolerated, but starting with a lower dose helps assess individual response before increasing.
Frequently Asked Questions
What is dihydroberberine and how is it different from berberine?
Dihydroberberine (DHB) is the active metabolite that berberine converts into during digestion. When you take standard berberine, your gut bacteria convert it to DHB before it enters the bloodstream. By taking DHB directly, you bypass this conversion step, resulting in up to 5x greater bioavailability and effects that last approximately 8 hours compared to 4 hours for standard berberine.
How much dihydroberberine should I take daily?
Most supplements recommend 100mg to 200mg per day. Because DHB is so much more bioavailable than standard berberine, a 100mg dose produces plasma concentrations comparable to or exceeding a 500mg dose of berberine HCl. Start with 100mg daily and increase to 200mg if needed, taken 15 to 30 minutes before a meal.
When is the best time to take dihydroberberine?
Take dihydroberberine 15 to 30 minutes before meals for optimal effect on glucose and insulin response during digestion. If taking once daily, before the largest meal of the day is typically recommended. Those taking higher doses may split them between two meals.
Are there any side effects of dihydroberberine?
DHB is generally much better tolerated than standard berberine because the effective dose is so much lower. However, mild digestive discomfort, bloating, or gas can occur, particularly when starting. These side effects are significantly less common and less severe than with standard berberine HCl. As with any supplement, consult a healthcare provider if you’re on medications.
Can I take dihydroberberine with other supplements?
DHB pairs well with Ceylon cinnamon, alpha lipoic acid, chromium, and milk thistle. Avoid combining with standard berberine unless using a specifically formulated dual-action product, as the combined dose may be excessive. Do not take with metformin or other glucose-lowering medications without medical supervision.
How long does it take for dihydroberberine to work?
Many users report noticeable effects on energy and appetite within the first one to two weeks. Measurable improvements in blood sugar markers typically appear within two to four weeks. For lipid panel improvements, allow eight to twelve weeks of consistent use. The enhanced bioavailability of DHB means results often come faster than with standard berberine.
