Best PCOS Supplements (2026)
Polycystic ovary syndrome (PCOS) affects millions of women and is closely linked to hormonal imbalances, insulin resistance, and inflammation. The most effective PCOS supplements target these root causes with ingredients like myo-inositol, D-chiro-inositol, vitex (chasteberry), DIM, and omega-3s to support hormone balance, ovulation, and metabolic health.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Pink Stork Fertility Supplements | Inositol + CoQ10 | Capsules | Best Overall | 9.5/10 |
| Zazzee Myo-Inositol Capsules | Myo-Inositol 2000mg | Capsules | Best Myo-Inositol | 9.4/10 |
| Zazzee D-Chiro-Inositol 50mg | D-Chiro-Inositol 50mg | Capsules | Best D-Chiro-Inositol | 9.3/10 |
| Pink Stork Fertility Gummies | Myo-Inositol + CoQ10 + Folate | Gummies | Best Gummies | 9.2/10 |
| Zazzee PREGNOSITOL Powder | Myo + D-Chiro-Inositol (40:1) | Powder | Best 40:1 Ratio Blend | 9.1/10 |
| Ritual Fertility Support | Inositol + Folate + CoQ10 | Drink Mix | Best Premium Formula | 9.0/10 |
| Pink Stork 2-in-1 Conception Support | Inositol + Folate + CoQ10 | Capsules | Best for Conception | 8.9/10 |
1. Pink Stork Fertility Supplements – Best Overall
- Natural Fertility Support for Women (TTC): Pink Stork Fertility Support is thoughtfully formulated to help nourish your body’s natural fertility process and is more comprehensive than standalone inositol products, blending essential nutrients and supportive herbal ingredients in one 2-in-1 daily female fertility supplement + prenatal vitamin, so no need for a separate prenatal multivitamin. Designed to support hormone balance, reproductive wellness, ovarian health, and cycle regularity - because your journey to conception deserves gentle, consistent care from within. From a women-led brand that prioritizes clarity over hype. Take 2 capsules a day with or without food, 30 servings.
- Science-Backed Nutrients: Our formula includes Myo-Inositol powder and L-5-MTHF (methylated folate) - the active, bioavailable form of folate your body can use, unlike synthetic folic acid that must be converted first - two clinically studied nutrients that play key roles in supporting healthy ovulation, ovarian function, and reproductive health. Thoughtfully included to align with how many TTC shoppers build their plans, with simple directions for consistent use - helping empower you to feel informed and confident as you care for your fertility routine.
- Herbal Support for Cycle Regularity + Hormone Harmony: Features Vitex (Chasteberry), Organic Ashwagandha, Shatavari, and complementary botanicals often chosen during preconception to support healthy hormone balance and a predictable cycle. Our products are realistic - no guarantees, no timelines - just supportive ingredients you can understand and use daily. Clear label, straightforward routine, and easy to take wherever life takes you- at home or on the go - with room to personalize with your provider’s guidance.
- Nutrient-Rich Formula for Preconception Wellness: With CoQ10, iron, zinc, and B vitamins, this formula provides comprehensive nutritional support for reproductive health, along with vitamins important for preconception nutrition. These ingredients help nourish egg quality, support cellular energy, and contribute to hormone regulation - key elements for women TTC. As with any products designed to support hormonal health, Fertility Support may impact your cycle. For best results, we recommend consistent use for at least 3 months; discontinue use once you receive a positive pregnancy test and transition to a prenatal vitamin. Pair with Pink Stork's Fertility Tea and Wild Yam Cream.
- Women-Owned: Pink Stork is women-owned and women-run, founded by a Certified Health Coach committed to clear language and thoughtful formulas. Every bottle is produced with rigorous quality standards and transparent labeling that you can read at a glance. Add it to your TTC routine to support ovulation, cycle balance, and everyday reproductive wellness. Our goal: make the “what should I take?” question feel manageable, with a formula you can stick with over time. Our Fertility Support capsules are vegan, non-GMO, and made without gluten, soy, or artificial ingredients. Third-party tested for purity, UV-protected bottle, crafted with care, & guided by science.
Pink Stork delivers a targeted fertility and PCOS formula with inositol and CoQ10 specifically designed to support ovulation and hormone balance in women.
This doctor-developed formula features myo-inositol alongside CoQ10 for a dual-action approach to PCOS management and fertility support. Inositol is the most extensively studied supplement for PCOS, with clinical research showing it can improve insulin sensitivity, support regular ovulation, and promote healthy hormone levels. CoQ10 adds antioxidant protection for egg quality. Pink Stork formulates all their products specifically for women’s health, with this capsule providing a full 60-count supply.
- Pros:
- Clinically backed inositol + CoQ10 combination for PCOS
- Doctor-developed formula from a women’s health-focused brand
- Supports both hormone balance and egg quality
- Cons:
- Primarily marketed for fertility, though beneficial for general PCOS
- May need to pair with separate D-chiro-inositol for the 40:1 ratio
Best for: Women with PCOS seeking a comprehensive inositol + CoQ10 formula for hormone balance and fertility support
2. Zazzee Myo-Inositol Capsules 2000mg – Best Myo-Inositol
- OUTSTANDING VALUE / 120 CAPSULES / 2000 MG: Our Myo-Inositol Capsules contain 2000 mg per serving AND 120 capsules per bottle – an amazing value! A single bottle contains a full month's supply. Compare this to other leading brands, all of which have less capsules and thus cost more per capsule.
- IDEAL DOSAGE OF 2000 MG / 40:1 RATIO: Studies have shown that a 40:1 ratio of Myo-Inositol to D-Chiro Inositol is the ideal ratio for optimal fertility support. Each dosage provides 2000 mg of Myo-Inositol, providing you with the ideal dosage for fertility and reproductive support.
- FERTILITY, HORMONE AND MENSTRUAL SUPPORT: Specially formulated for women, our Myo-Inositol Capsules support healthy ovarian function, hormonal balance, a healthy menstrual cycle, egg quality, and overall reproductive health.
- 100% VEGETARIAN, NON-GMO & KOSHER: All ingredients, as well as the capsules, are 100% vegetarian - and kosher - and made from the purest sources available. The capsules are made from cellulose, derived from plants.
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our Myo-Inositol Capsules are manufactured in the USA, in a fully compliant facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
Zazzee delivers the gold-standard 2000mg myo-inositol dose per serving in vegan capsules, formulated at the ideal dosage for the research-backed 40:1 ratio.
Myo-inositol at 2000mg per serving is the dosage most frequently used in clinical PCOS research, and Zazzee delivers exactly that in four vegan capsules. The formula is designed to pair with their separate D-chiro-inositol product to achieve the clinically studied 40:1 ratio. Each bottle contains 120 capsules for a full 30-day supply. The product is non-GMO, vegan, and manufactured in an FDA-registered, GMP-certified facility with third-party testing for purity.
- Pros:
- Exact 2000mg clinical dose used in major PCOS studies
- Designed to pair with D-chiro-inositol for the 40:1 ratio
- Vegan, non-GMO, third-party tested
- Cons:
- Requires four capsules per serving for the full 2000mg dose
- D-chiro-inositol sold separately for the complete 40:1 protocol
Best for: Women who want precise, clinical-dose myo-inositol with the flexibility to customize their 40:1 ratio
3. Zazzee D-Chiro-Inositol 50mg – Best D-Chiro-Inositol
- OUTSTANDING VALUE: Our D-Chiro Inositol Capsules contain 50 mg per capsule AND 90 capsules per bottle – an amazing value! A single bottle contains a 3-month supply. Compare this to other leading brands, all of which have less capsules and thus cost more per capsule.
- IDEAL DOSAGE OF 50 MG / 40:1 RATIO: Studies have shown that a 40:1 ratio of Myo-Inositol to D-Chiro Inositol is the ideal ratio for optimal fertility support. Each dosage provides 50 mg of D-Chiro Inositol, providing you with the ideal dosage for fertility and reproductive support.
- FERTILITY, HORMONE AND MENSTRUAL SUPPORT: Specially formulated for women, our D-Chiro Inositol Capsules support healthy ovarian function, hormonal balance, a healthy menstrual cycle, egg quality and overall reproductive health.
- 100% VEGETARIAN: All ingredients, as well as the capsules, are 100% vegetarian, and made from the purest sources available. The capsules are made from cellulose, derived from plants.
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our D-Chiro Inositol Capsules are manufactured in the USA, in a fully compliant facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
Zazzee’s standalone D-chiro-inositol provides the exact 50mg dose needed to complete the research-backed 40:1 ratio when paired with 2000mg myo-inositol.
D-chiro-inositol at 50mg is the precise companion dose to 2000mg myo-inositol, creating the 40:1 ratio shown in clinical research to support ovulation, insulin sensitivity, and androgen reduction in women with PCOS. Zazzee’s standalone product allows for precise dosing and the flexibility to take each inositol form at the optimal time. The 90-capsule bottle provides a full three-month supply at one capsule per day, and the product is vegan, non-GMO, and third-party tested.
- Pros:
- Exact 50mg dose for the clinically studied 40:1 ratio
- 90-capsule bottle provides a 3-month supply
- Simple one-capsule-per-day dosing
- Cons:
- Must be purchased alongside myo-inositol for complete protocol
- Standalone D-chiro has limited benefit without myo-inositol
Best for: Women already taking myo-inositol who need the companion D-chiro-inositol for the optimal 40:1 ratio
4. Pink Stork Premium Fertility Gummies – Best Gummies
- Hormone Balance for Women: Trying to conceive shouldn’t feel like guesswork. Pink Stork Premium Fertility Gummies deliver daily support for your body’s natural reproductive rhythm — with 13 key ingredients recommended by OBGYNs and specialists.
- Expert-Backed Conception for Women: Support your menstrual cycle, ovarian health, hormonal health, egg quality, and luteal phase with two tasty gummies daily. Formulated with Myo-Inositol, CoQ10, and Methylated Folate (the natural, more bioavailable form of folic acid) to help support hormone balance, reproductive health, normal ovulation, cycle regularity, and energy, while CoQ10 and B-Vitamins fuel your cells for the energy your body needs on this journey. Delicious, nutrient-packed, and crafted to support your chances of conception. For best results, take for at least 3 months prior to conception.
- Hormone Harmony + Reproductive Wellness: Balanced hormones are the foundation of fertility. Our blend of vitamins and minerals supports natural hormone balance, ovulation rhythm, and healthy reproductive function. With Vitamin D, Zinc, Selenium, and B12, this clean formula nourishes your body from the inside out, so you can feel more in control of your fertility journey. No more chalky pills or complicated routines. These delicious, mango pineapple-flavored bite-sized gummies make it easy to enjoy fertility-focused nutrients in a convenient daily ritual—perfect for wherever life takes you.
- Clean, Vegan, and Delicious: No mystery ingredients or artificial extras here — just delicious mango pineapple gummies and clean, vegan-friendly nutrition. Third-party tested in GMP-certified facilities, our gummies meet the highest manufacturing standards. Free from GMOs, gluten, soy, and artificial colors and flavors, so you can enjoy them with confidence. Enjoy as part of your ritual with additional Pink Stork Fertility products - including our Fertility Tea (with Vitex and Red Raspberry Leaf) or Myo-Inositol & D-Chiro Inositol supplements. And don't forget Blue Stork Fertility Supplements for men! Once a positive pregnancy test occurs, change to a prenatal like Total Prenatal + DHA.
- Created by Women, For Women: We know the TTC journey isn’t always easy — but we are here to take the guesswork out of your nutrition. Formulated by women’s health experts, crafted with care, made in the USA, and third-party tested for purity, Pink Stork delivers support you can trust. Women-owned, women-run, and backed by experts— we’re here to walk with you every step of the way. As always, we recommend consulting your healthcare provider before using this product alongside medications or other supplements to ensure your personal needs are met. No refrigeration needed.
Pink Stork delivers myo-inositol, CoQ10, and folate in a delicious gummy format that makes daily PCOS supplementation enjoyable and easy to maintain.
For women who struggle with capsule-heavy supplement routines, these gummies provide myo-inositol alongside CoQ10 and prenatal-quality folate in a pleasant-tasting format. The combination targets the three pillars of PCOS management: insulin sensitivity (inositol), antioxidant protection (CoQ10), and fertility readiness (folate). Pink Stork’s gummy format has earned strong reviews for taste and convenience, making daily compliance significantly easier for long-term PCOS protocols.
- Pros:
- Delicious gummy format promotes daily compliance
- Triple-action formula with inositol, CoQ10, and folate
- Doctor-developed by a trusted women’s health brand
- Cons:
- Lower inositol dose per serving compared to capsule options
- Contains added sugar typical of gummy supplements
Best for: Women who prefer gummies over capsules and want a convenient PCOS-supporting formula they’ll actually take daily
5. Zazzee PREGNOSITOL Powder – Best 40:1 Ratio Blend
- 6 MONTH SUPPLY - AND A FREE SCOOP: Each bottle contains a full 6 month supply, with 180 servings per container! For your convenience, each container includes a scoop that is exactly the size of a single serving. With this pre-measured scoop, you can rest assured that you are getting an exact dosage every time! The contents of each scoop can be quickly and easily dissolved in water, and have a neutral to mildly sweet taste.
- IDEAL 40:1 RATIO: Studies have shown that a 40:1 ratio of Myo-Inositol to D-Chiro-Inositol is the ideal ratio for optimal fertility support. Each scoop contains both the ideal dosage AND ideal ratio, formulated to help you on your fertility journey.
- ALL-NATURAL FERTILITY SUPPORT: Designed specifically to provide fertility and reproductive support, PREGNOSITOL Powder contains 2000 mg of Myo-Inositol and 50 mg of D-Chiro Inositol in the ideal 40:1 ratio. Numerous scientified studies have shown that Myo-Inositol and D-Chiro Inositol are effective supplements for enhanced fertility support.
- 100% VEGETARIAN, 100% PURE: All ingredients are 100% vegetarian, and made from the purest sources available. This product does not contain any sweeteners or artificial flavors. In addition, PREGNOSITOL Powder does not contain any wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our PREGNOSITOL Powder is manufactured in the USA, in a fully certified facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
PREGNOSITOL delivers the clinically studied 40:1 myo-inositol to D-chiro-inositol ratio in a convenient powder with a 6-month supply per container.
This unflavored powder provides 2000mg of myo-inositol and 50mg of D-chiro-inositol per serving in the exact 40:1 ratio studied in PCOS and fertility clinical trials. The powder format mixes easily into water or any beverage and eliminates the need to swallow multiple capsules daily. The 6-month supply per container offers exceptional value, and the formula also includes folic acid. Zazzee includes a free measuring scoop for precise dosing and manufactures in an FDA-registered, GMP-certified facility.
- Pros:
- Pre-blended 40:1 ratio eliminates the need for separate products
- 6-month supply per container — outstanding value
- Unflavored powder mixes into any beverage
- Cons:
- Requires mixing — less convenient than capsules for travel
- Unflavored taste may not appeal to all users
Best for: Women who want the complete 40:1 inositol ratio in a single product with maximum long-term value
6. Ritual Fertility Support – Best Premium Formula
- THE FIRST 3-in-1 SUPPLEMENT: formulated to support conception outcomes, and designed in partnership with OB/GYNs and fertility specialists. Features clinically-studied ingredients in doses studied in clinical trials.* Developed with 3 medical doctors on Ritual’s Scientific Advisory Board
- FOLLICULAR HEALTH: 200mg of CoQ10 (Coenzyme Q10)in a bioavailable form, clinically-studied to help support follicular health.*
- OVARIAN HEALTH: NAC (N-acetylcysteine) provides antioxidant support and 1.2 g of NAC is clinically-studied to help support ovarian health.*
- EGG HEALTH: 4g of Myo-Inositol daily is clinically studied to help support normal ovulation cycles and helps support healthy hormone levels and egg health.*
- ANTIOXIDANT: CoQ10 and NAC provide antioxidant properties to support an ideal environment for egg health.*
Ritual brings their science-first approach to fertility and PCOS support with a 3-in-1 drink mix featuring clinically studied doses of inositol, folate, and CoQ10.
Ritual is known for transparency and clinical rigor, and their Fertility Support drink mix delivers on that reputation. The formula features clinically studied doses of myo-inositol alongside methylated folate and CoQ10 in a convenient daily drink mix. Ritual uses third-party testing for every ingredient and publishes their supply chain sources — a level of transparency rare in the supplement industry. The formula is specifically designed to support conception outcomes in women with ovulatory challenges.
- Pros:
- Best-in-class transparency with published ingredient sourcing
- Clinically studied doses of all three key ingredients
- Convenient drink mix format with pleasant taste
- Cons:
- Premium price point reflects Ritual’s quality standards
- Drink mix format requires daily preparation
Best for: Women who prioritize ingredient transparency and clinical-dose formulations from a premium brand
7. Pink Stork 2-in-1 Conception Support – Best for Conception
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This 2-in-1 formula combines inositol with folate and CoQ10 specifically targeting the fertility and conception needs of women with PCOS.
Pink Stork’s 2-in-1 Conception Support pairs myo-inositol with prenatal folate and CoQ10 in a streamlined capsule designed to simplify the supplement routine for women actively trying to conceive with PCOS. The formula addresses insulin sensitivity, egg quality, and prenatal nutrition preparation simultaneously, reducing the need for multiple separate supplements. Doctor-developed and manufactured to Pink Stork’s women’s health standards.
- Pros:
- Streamlines multiple supplements into one conception-focused formula
- Includes prenatal folate for pre-conception nutrition
- Addresses PCOS root causes while preparing for pregnancy
- Cons:
- Primarily designed for women actively trying to conceive
- Inositol dose may be lower than standalone protocols
Best for: Women with PCOS who are actively trying to conceive and want a single, comprehensive support formula
8. Zazzee Myo-Inositol Powder – Best Budget Pick
- 6 MONTH SUPPLY / 183 SERVINGS: Each container contains a full 6 month supply of Myo-Inositol Powder – considerably more than our competitors. Plus, each serving is a research-backed 2000 mg, which equals 183 servings per container.
- FREE SCOOP FOR EXACT DOSAGE: No more wondering exactly how much Myo-Inositol you are actually taking. Each container includes a free, pre-measured scoop that holds exactly 2000 mg of Myo-Inositol Powder. Rest assured that you are getting an exact dosage every time!
- FERTILITY AND REPRODUCTIVE SUPPORT: Specially formulated for women, our Myo-Inositol Powder supports healthy ovarian function, hormonal balance, egg quality and overall reproductive health.
- 100% PURE, VEGAN, KOSHER & NON-GMO: Our Myo-Inositol Powder is 100% pure, plant-derived Myo-Inositol – and nothing else! In addition, this product contains no wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients.
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our Myo-Inositol Powder is manufactured in the USA, in a fully compliant facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you are getting the best value for your money!
Zazzee’s myo-inositol powder delivers a 6-month supply with precise 2000mg dosing via included scoop at one of the lowest per-serving prices available.
For women who want the most cost-effective way to get their daily 2000mg myo-inositol, Zazzee’s unflavored powder is the clear winner. The 6-month supply with included scoop provides 183 servings at the clinical 2000mg dose, delivering months of PCOS support at a fraction of the cost of capsule alternatives. The powder is pure myo-inositol with no fillers, additives, or excipients — just the active ingredient. It dissolves easily in water and has a mildly sweet, pleasant taste.
- Pros:
- Best price per serving for clinical-dose myo-inositol
- 183 servings (6-month supply) per container
- Pure formula with no fillers, additives, or excipients
- Cons:
- Does not include D-chiro-inositol for the 40:1 ratio
- Powder format is less portable than capsules
Best for: Budget-conscious women who want the most affordable way to take clinical-dose myo-inositol daily
9. Pink Stork Fertility + Probiotics – Best with Probiotics
- FERTILITY SUPPLEMENTS FOR WOMEN: Pink Stork Fertility Support Supplement and Fertility Probiotic Supplement for women are a dynamic duo for hormonal support, period support, ovarian health, and reproductive wellness.
- CONCEPTION SUPPORT: OBGYNs recommend starting a prenatal vitamin routine while trying to conceive. Pink Stork Fertility Support supplement offers vitamins to prepare your body for conception, support natural fertility, and aid your menstrual cycle.
- HORMONAL SUPPORT: With added Vitex (Chaste Tree Berry), Myo Inositol, and Zinc, our fertility blend supports a woman’s natural reproductive cycle. It’s recommended to be taken every day leading up to the start of your cycle. Please be mindful as this product may affect your ovulation and/or menstrual cycle; consult with your qualified healthcare provider before use.
- WHY PROBIOTICS? Probiotics are good bacteria that help strengthen your gut barrier and cleanse bacteria from your body; this helps support vaginal pH, immune health, nutrient absorption, feelings of bloat, and more! This is crucial while trying to conceive, to create a healthy environment for ovulation, and support egg quality.
- 6 STRAINS AND ASHWAGANDHA: We've chosen six strains of probiotics, including highly-studied Lactobacillus and Bifidobacterium strains, to specifically target women's fertility health. 200 mg of added Ashwagandha helps support a balanced menstrual cycle - which is vital to support conception for women.
Pink Stork combines their fertility formula with targeted probiotics to support both hormone balance and the gut microbiome connection to PCOS.
Emerging research highlights the gut microbiome’s role in PCOS through its influence on insulin resistance, inflammation, and androgen metabolism. Pink Stork addresses this connection by pairing their fertility-supporting inositol blend with targeted probiotic strains. This dual-action approach supports hormone balance from both the supplemental and microbiome angles, offering a more comprehensive strategy for women who want to address the full spectrum of PCOS factors.
- Pros:
- Addresses the gut-hormone connection increasingly linked to PCOS
- Combines fertility support with digestive and immune health
- Doctor-developed formula from a women’s health specialist brand
- Cons:
- Probiotic potency may be lower than standalone probiotic products
- Premium pricing for the combination formula
Best for: Women who want to address PCOS through both inositol supplementation and gut microbiome support
How to Choose the Best PCOS Supplement
Myo-inositol is the most evidence-backed supplement for PCOS, with dozens of clinical trials demonstrating improvements in insulin sensitivity, ovulation rates, hormone levels, and fertility outcomes. The standard clinical dose is 2000mg per day, ideally combined with 50mg of D-chiro-inositol in the research-backed 40:1 ratio. Products providing this exact ratio in a single formula simplify dosing, while separate myo- and D-chiro-inositol products offer more flexibility.
Consider your primary PCOS concern when selecting a supplement. For fertility and conception, formulas combining inositol with CoQ10 and folate address egg quality and prenatal readiness. For insulin resistance and metabolic symptoms, high-dose myo-inositol (2000-4000mg daily) with chromium may be most effective. For androgen-related symptoms like acne and excess hair growth, DIM, spearmint, and saw palmetto can complement inositol therapy.
Powder, capsule, and gummy formats each have trade-offs. Powders deliver the highest doses at the lowest cost but require mixing. Capsules are convenient and portable but may require swallowing four or more daily to reach clinical doses. Gummies taste best and promote compliance but typically contain lower active ingredient amounts and added sugars. Choose the format that fits your lifestyle and that you’ll actually take consistently.
PCOS supplementation is typically a long-term commitment, so value matters. Powder formats from brands like Zazzee can provide six months of clinical-dose inositol for the price of one month of premium capsules. Third-party testing, GMP certification, and transparent labeling remain essential quality markers regardless of format or price point.
Frequently Asked Questions
What supplements are most effective for PCOS?
Myo-inositol is the most extensively researched and widely recommended supplement for PCOS, with strong evidence supporting its ability to improve insulin sensitivity, promote ovulation, and reduce androgen levels. The optimal approach combines 2000mg myo-inositol with 50mg D-chiro-inositol in a 40:1 ratio. Other beneficial supplements include CoQ10 for egg quality, omega-3 fatty acids for inflammation, vitamin D for metabolic function, chromium for blood sugar regulation, and NAC (N-acetyl cysteine) for ovulation support.
How much inositol should I take for PCOS?
The standard clinical protocol is 2000mg of myo-inositol combined with 50mg of D-chiro-inositol daily, taken in one or two divided doses. Some practitioners recommend up to 4000mg of myo-inositol daily for more severe insulin resistance, but 2000mg is the most commonly studied and recommended dose. The 40:1 myo- to D-chiro-inositol ratio mirrors the body’s natural inositol balance and has shown the best clinical outcomes in PCOS research.
When is the best time to take PCOS supplements?
Myo-inositol is best taken in divided doses — half in the morning and half in the evening — to maintain steady levels throughout the day. Taking inositol with meals can improve absorption and reduce any mild digestive discomfort. CoQ10 is fat-soluble and should be taken with a meal containing healthy fats. Vitamin D is also best absorbed with food. If taking multiple PCOS supplements, spreading them across morning and evening doses prevents potential stomach upset from taking everything at once.
Are there any side effects of PCOS supplements?
Myo-inositol and D-chiro-inositol are generally very well-tolerated, with side effects being rare and typically mild. Some women experience mild nausea, gas, or digestive discomfort when first starting, which usually resolves within a few days. Taking inositol with food helps minimize digestive effects. Doses above 4000mg daily may cause loose stools. Inositol has a strong safety profile and is classified as “generally recognized as safe” (GRAS) by the FDA. However, women with thyroid conditions should be aware that high-dose inositol may affect thyroid medication absorption.
Can I take PCOS supplements with other medications?
Inositol supplements can typically be taken alongside metformin, birth control, and other common PCOS medications, though you should inform your healthcare provider about all supplements you’re taking. Inositol and metformin both target insulin resistance through different mechanisms and may have complementary effects. If you take thyroid medication, separate it from inositol by at least 2-4 hours. Women taking fertility medications like clomiphene or letrozole should work with their reproductive endocrinologist to coordinate supplementation with their treatment protocol.
How long does it take for PCOS supplements to work?
Most women notice initial improvements in 4-8 weeks, with the most significant changes occurring over 3-6 months of consistent use. Insulin sensitivity improvements may begin within 2-4 weeks. Menstrual cycle regularity typically improves over 2-3 cycles (roughly 2-3 months). Ovulation restoration may take 3-6 months. Androgen-related symptoms like acne and excess hair growth are slowest to improve, often requiring 4-6 months due to hair growth cycles. Consistency is key — PCOS supplementation works best as a long-term daily practice rather than intermittent use.
