Best Methyl B12 Supplements (2026)
Methylcobalamin is the active, coenzyme form of vitamin B12 that the body can use immediately without conversion. Unlike cyanocobalamin (the synthetic form found in many cheap supplements), methyl B12 bypasses the liver’s conversion process and goes straight to work supporting nerve function, red blood cell production, DNA synthesis, and energy metabolism. It’s especially important for individuals with MTHFR gene variants, vegans, vegetarians, and older adults with reduced B12 absorption.
Quick Comparison
| Product | Dosage | Form | Best For | Rating |
|---|---|---|---|---|
| Pink Stork B12 Liquid Drops | 5,000 mcg | Liquid Drops | Best Overall | 9.5/10 |
| Luma Nutrition Methyl B12 | 1,000 mcg | Capsules | Best Value | 9.3/10 |
| Methyl-Life L-Methyl Folate + B12 | 15 mg Folate + B12 | Liquid | Best for MTHFR | 9.2/10 |
| BioActive Vitamin B12 | 5,000 mcg | Lozenges | Best Multi-Form B12 | 9.1/10 |
| Thorne Vitamin B12 | 1,000 mcg | Capsules | Best Premium | 9.0/10 |
| Jarrow Formulas Methyl B-12 | 5,000 mcg | Chewable Tablets | Best Chewable | 8.9/10 |
| Vegan B Complex Liquid | 5,000 mcg B12 | Liquid | Best B-Complex Combo | 8.8/10 |
1. Pink Stork Vitamin B12 Liquid Drops – Best Overall
- Fast-Absorbing - Our fast-acting, sublingual liquid B12 is more soluble than capsules, allowing you to get the most nutrients with methylcobalamin b12 out of every serving of our vegan B12 liquid vitamin drops.
- Fuel Your Body and Mind - Our Vitamin B12 liquid supplement contains pure vitamins with 1.7mg of Vitamin B2, 20mgNE of Vitamin B3, 3mg of Vitamin B6, and 5000 mcg of Vitamin B12 to support energy, brain health, and metabolism.
- Be More, Do More - Vitamin B12 sublingual plays a key role in converting carbohydrates into glucose for energy production. Stay alert and energized with sufficient Vitamin B12, including vitamin B12 5000 mcg, alongside other B vitamins in our liquid vitamin B12 drops.
- Speed Up Metabolism - Maximize your gains and get the most out of your diet with a Vitamin B complex that works. Our B12 methylcobalamin with b12 sublingual complex vitamin supplements and b12 liquid support the proper metabolism of macronutrients to help convert food into energy.
- Vegan B Vitamin Drops You Can Trust - All of our liquid Vitamin B Complex supplements are proudly made and bottled in Salt Lake City, Utah in an approved facility that follows strict GMP guidelines. Our sublingual B12 products are Third Party Tested to ensure the highest quality possible and the purity of each batch.
A fast-absorbing liquid methylcobalamin delivering 5,000 mcg per serving for rapid energy and nervous system support.
Pink Stork B12 Liquid Drops provide 5,000 mcg of methylcobalamin in a sublingual liquid format designed for maximum bioavailability. The liquid delivery bypasses the digestive system, allowing B12 to absorb directly through the mucous membranes under the tongue. Each bottle delivers a generous supply with a pleasant flavor, and the formula is vegan-friendly. The product is manufactured in GMP-certified facilities in the USA.
- Pros:
- High-potency 5,000 mcg methylcobalamin per serving
- Sublingual liquid format for superior absorption
- Vegan-friendly and easy to dose
- Cons:
- Higher price point than capsule alternatives
- Liquid form requires careful storage
Best for: Anyone wanting a high-potency, fast-absorbing methylcobalamin supplement in convenient liquid form
2. Luma Nutrition Vitamin B12 Methylcobalamin – Best Value
- High Potency Vitamin B12 1000 mcg: Energy & Metabolism Support: Each serving provides a powerful 1000 mcg of Vitamin B12 (B-12) in easy-to-swallow capsules to help convert food into fuel, support metabolism, and promote all-day energy.
- Supports Nervous System & Brain Health: Vitamin B12 (also known as B 12, B12 vitamin, and Vit B12) plays an essential role in maintaining a healthy nervous system, supporting memory, focus, and overall cognitive function.
- Pure and Effective B12 Support: Unlike many vitamin B12 supplements or B12 complex formulas, Luma Nutrition provides a high-quality B-12 vitamin designed for maximum absorption and reliable support for energy, metabolism, and overall wellness.
- Trusted B12 Vitamin for Daily Wellness: Whether you’re looking for Vitamin B-12, B12 vitamins for energy, or a simple B12 supplement alternative to sublingual B12 or Vitamin B12 gummies, Luma Nutrition delivers premium nutrition you can rely on.
- Made in USA + GMP-Certified Quality: All of Luma Nutrition’s supplements are proudly made in the USA in a GMP-certified facility. Every batch of this B-12 1000 mcg formula is tested for purity and potency, giving you trusted quality in every capsule.
A straightforward, affordable methylcobalamin capsule delivering 1,000 mcg per serving with clean ingredients.
Luma Nutrition delivers pure methylcobalamin at 1,000 mcg per capsule — a solid daily maintenance dose. Each bottle contains 60 vegan capsules, making it a two-month supply at one capsule per day. The formula is free from fillers, artificial colors, and common allergens. Manufactured in the USA in a GMP-certified facility, this is one of the most budget-friendly methylcobalamin options available without sacrificing quality.
- Pros:
- Excellent price-to-value ratio
- Clean, simple formula with no unnecessary additives
- Vegan capsules made in the USA
- Cons:
- Lower dose (1,000 mcg) may not suit those with significant deficiency
- Capsule form absorbs slower than sublingual options
Best for: Budget-conscious buyers looking for a reliable daily methylcobalamin maintenance dose
3. Methyl-Life L-Methyl Folate 15mg Plus Methyl B12 – Best for MTHFR
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
A specialized high-potency liquid combining L-methylfolate with methyl B12 for individuals with MTHFR gene mutations.
This formula pairs 15 mg of L-methylfolate (the active form of folate) with methylcobalamin B12 as a cofactor — specifically designed for people who have difficulty converting synthetic folic acid and cyanocobalamin. The organic berry flavor makes the liquid pleasant to take, and the combination addresses both folate and B12 methylation pathways simultaneously. This is a clinical-grade product trusted by practitioners who work with MTHFR variants.
- Pros:
- Targets both methylfolate and methyl B12 pathways
- High-potency L-methylfolate at 15 mg
- Berry-flavored liquid for easy dosing
- Cons:
- Premium price due to specialized formula
- Overkill for general B12 supplementation needs
Best for: Individuals with MTHFR gene variants who need both methylfolate and methyl B12 support
4. BioActive Vitamin B12 – Best Multi-Form B12
- Full-Spectrum Vitamin B12 - Plus Methyl Folate Cofactor: Methylcobalamin, Adenosylcobalamin & Hydroxocobalamin are the 3 most beneficial forms of Vitamin B12, with each having different functions in the body. They are naturally occurring, biologically active, coenzyme forms of vitamin B12, the forms the body needs for cellular utilization. The formula also provides a full serving of L-Methylfolate, an essential cofactor of B12.
- Maximum Strength (5000 mcg of B12): Each serving contains a maximum strength dose of 5000 mcg of B12. It also delivers 1000 mcg of Methylfolate per serving.
- Methylcobalamin B12 - The Essential Form: Methyl B12 is the form needed to raise overall b12 status levels across the body. It is the most prevalent form within the bloodstream and is needed for carrying out the essential functions of vitamin B12.
- Adenosylcobalamin B12: The "Cellular Energy" Form: This is the form especially needed by the energy factories of the cells, the mitochondria. Adenosylcobalamin helps mitochondria burn food more efficiently for better energy production and metabolism.
- Hydroxocobalamin B12: The "Storage" Form: Shown to be stored and stays in the bloodstream longer and is universally distributed through the body to ensure long-lasting B12 levels. It also plays a role in detoxification processes within the body.
A unique triple-form B12 supplement combining methylcobalamin, adenosylcobalamin, and hydroxocobalamin with methylfolate.
BioActive Vitamin B12 stands out by delivering three bioactive forms of B12 in a single 5,000 mcg serving. The combination of methylcobalamin, adenosylcobalamin, and hydroxocobalamin ensures comprehensive B12 support across multiple metabolic pathways. The formula also includes methylfolate as a cofactor to enhance B12 utilization. This approach means the body can select whichever B12 form it needs most, covering both energy production and neurological support.
- Pros:
- Three bioactive forms of B12 in one supplement
- Includes methylfolate cofactor
- High potency at 5,000 mcg total B12
- Cons:
- Multi-form approach is pricier than single-form products
- Some users may only need methylcobalamin specifically
Best for: Those seeking comprehensive B12 coverage across all active forms rather than methylcobalamin alone
5. Thorne Vitamin B12 (Methylcobalamin) – Best Premium
- Active B12: Each capsule provides 1 mg vitamin B12 as methylcobalamin, which is more efficiently used by the body compared to other forms of vitamin B12, like cyanocobalamin
- Heart & Brain Health: Supports a normal level of homocysteine in the body to benefit healthy cardiac function, blood cell formation, and optimal nerve function*
- Sleep Support: Helps maintain normal circadian rhythms to support restful sleep and supports healthy methylation processes in the body*
- Third-Party Certified: This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)
A pharmaceutical-grade methylcobalamin capsule from one of the most trusted names in professional-grade supplements.
Thorne delivers 1 mg (1,000 mcg) of methylcobalamin per capsule with nothing extra — no artificial flavors, colors, gluten, soy, or dairy. Thorne products are manufactured in NSF Certified for Sport facilities with rigorous third-party testing at every stage of production. Each bottle provides 60 servings, and the capsules are small enough to swallow easily. This is the B12 supplement frequently recommended by functional medicine practitioners and integrative doctors.
- Pros:
- NSF Certified for Sport — highest tier of third-party testing
- Clean formula with zero unnecessary ingredients
- Trusted by healthcare professionals worldwide
- Cons:
- Higher price than store brands for 1,000 mcg dose
- Only available in capsule form from Thorne
Best for: Quality-focused consumers who want a practitioner-grade methylcobalamin supplement with top-tier testing
6. Jarrow Formulas Methyl B-12 5000 mcg – Best Chewable
- Bioactive B12: Jarrow Formulas Methyl B-12 (methylcobalamin) is the biologically active form of vitamin B12; supports brain and nerve health, cellular energy production, healthy cell replication, and red blood cell production (1)
- Homocysteine Metabolism: Methyl B-12 is required for the normal metabolism of homocysteine, supporting its conversion to methionine
- Better Retained With Jarrow B12: Research suggests that methyl B-12 is better retained in the body than cyanocobalamin, and supplementation may be needed by some vegetarians and vegans (1)
- Convenient Chewable Tablet: Each naturally fruit flavored chewable tablet delivers 5000 micrograms (mcg) of methyl B-12; our B12 methylcobalamin formula does not contain wheat, gluten, soybeans, dairy, egg, fish, shellfish, or peanuts, tree nuts or sesame
- Superior Nutrition & Formulation: The goal of Jarrow Formulas is to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary vitamins and supplements; our customers can be assured of purity, value & potency
A high-dose chewable methylcobalamin lozenge with natural cherry flavor that doubles as a sublingual delivery system.
Jarrow Formulas has been a trusted supplement brand since 1977, and their Methyl B-12 lozenges are among the best-selling methylcobalamin products on Amazon. Each cherry-flavored chewable tablet delivers 5,000 mcg of methylcobalamin, and the lozenge format allows for sublingual absorption when dissolved slowly under the tongue. The bottle contains 60 tablets — roughly a two-month supply at one per day. The formula is non-GMO, gluten-free, and suitable for vegetarians.
- Pros:
- Pleasant cherry flavor — no supplement aftertaste
- Can be chewed or dissolved sublingually for faster absorption
- Established brand with decades of supplement expertise
- Cons:
- Contains mannitol and stearic acid as inactive ingredients
- Chewable format not ideal for those who prefer capsules
Best for: People who dislike swallowing capsules and prefer a tasty chewable or sublingual B12 option
7. Vegan Vitamin B Complex Liquid with Methyl B12 – Best B-Complex Combo
- Potent Liquid Vitamin B Complex - B complex vitamins for men and women are essential for maintaining overall health and energy levels and our liquid formula makes it easier than ever to get your Bs
- Fuel your Body - Vit B complex are essential energy vitamins for powering your body but many adults don’t get enough but our vitamin B liquid has you covered simply dilute in a beverage and drink
- What's Inside - Our B complex vitamin supplement contains high levels of 8 B vitamins including folic acid and B12 Methylcobalamin blended into a glycerin and water base so you can ditch the pills
- Carefully Crafted - We make our super B complex with vitamin C for enhanced absorption and we are proud to have No artificial colors flavors gelatin gluten GMOs or unsavory ingredients
- Natures Craft quality - We are proud to be a leading name in tasty liquid vitamins for women men and children because we believe full body wellness should come in many shapes and forms
A comprehensive 9-in-1 liquid B-complex that includes 5,000 mcg methylcobalamin along with all essential B vitamins.
This liquid B-complex delivers methylcobalamin alongside B1, B2, B3, B5, B6, B7 (biotin), B9 (methylfolate), and B12 in a single serving. The liquid format ensures rapid absorption, and the combination approach makes it ideal for people who want to cover all their B vitamin bases rather than supplementing B12 alone. The formula is fully vegan, non-GMO, and provides a two-month supply per bottle.
- Pros:
- Complete B-complex coverage in one liquid serving
- Includes methylated forms of both B12 and folate
- Vegan-friendly with no artificial sweeteners
- Cons:
- B-complex blend means individual B12 dose may be lower than standalone options
- Liquid taste may not appeal to everyone
Best for: Those who want a comprehensive methylated B-vitamin complex rather than standalone B12
8. Nutricost Vitamin B12 Methylcobalamin 2000 mcg – Best Capsule Supply
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A high-count bottle delivering 240 methylcobalamin capsules at an unbeatable per-serving price.
Nutricost is known for delivering straightforward, no-frills supplements at competitive prices, and their methyl B12 is no exception. Each vegetarian capsule provides 2,000 mcg of methylcobalamin — a solid mid-range dose. The 240-capsule bottle translates to an eight-month supply at one capsule per day. The product is non-GMO, gluten-free, and third-party tested for purity. It’s manufactured in a GMP-compliant, FDA-registered facility in the USA.
- Pros:
- 240 capsules per bottle — exceptional long-term value
- 2,000 mcg dose hits a practical sweet spot
- Third-party tested with transparent labeling
- Cons:
- No-frills branding may concern quality-focused buyers
- Standard capsule — no sublingual absorption benefit
Best for: Bulk buyers who want a long-lasting supply of methylcobalamin at the lowest cost per serving
9. Methylated B-Complex by Methyl-Life – Best Full-Spectrum Methylated Formula
- Methylated Vitamin B Complex for Better Absorption: Tired of low-quality formulas that don’t absorb? Our methylated vitamin B complex uses active B12 (methylcobalamin) and methylfolate (L-5-MTHF) to support efficient nutrient absorption, ideal for those with MTHFR or poor methylation issues.
- Vitamin B Complex for Women Supporting Energy & Mood: This vitamin B complex for women and men helps convert food into fuel, supporting natural energy, focus, and a balanced mood. A clean daily supplement that helps reduce fatigue and supports mental clarity without caffeine or sugar crashes.
- Super B Complex with Complete Active B Vitamins: Our super b complex vitamins include all eight essential B-vitamins—B1 through B12—designed to promote metabolism, brain performance, and nervous system function. Each dose delivers bioavailable nutrients your body can readily use.
- Best Methylated B Complex That’s Gentle & Pure: Unlike synthetic blends, this best methylated b complex features vegan, non-GMO ingredients free from artificial fillers or colors. It’s gentle on the stomach and perfect for daily use, supporting sustained energy and stress resilience.
- Trusted 1 Body B Complex You Can Rely On: 1 Body Methylated B Complex is third-party tested and made in the USA in a GMP-certified facility. Our methylated B vitamins formula delivers premium quality, transparency, and peace of mind, backed by science and customer trust.
A premium methylated B-complex providing bioactive forms of every B vitamin for comprehensive methylation support.
This B-complex uses methylated, bioactive forms across the entire B vitamin spectrum — methylcobalamin for B12, methylfolate for B9, pyridoxal-5-phosphate for B6, and so on. The formula is specifically designed for people who need methylation support, including those with MTHFR variants or methylation-related health concerns. Each capsule provides clinically meaningful doses of all eight B vitamins in their most bioavailable forms.
- Pros:
- Every B vitamin in its methylated, bioactive form
- Designed specifically for methylation support
- Suitable for MTHFR and methylation-challenged individuals
- Cons:
- Higher price than basic B12-only supplements
- Full B-complex may be unnecessary if only B12 is needed
Best for: Individuals who need comprehensive methylation support across all B vitamins, not just B12
How to Choose the Best Methyl B12 Supplement
The most important factor when choosing a methyl B12 supplement is ensuring it actually contains methylcobalamin rather than cyanocobalamin. Check the supplement facts panel — it should clearly state “methylcobalamin” as the B12 form. Cyanocobalamin requires liver conversion and may be problematic for individuals with certain genetic variations like MTHFR mutations.
Dosage ranges vary widely, from 500 mcg to 5,000 mcg or higher. For general maintenance, 1,000–2,000 mcg is typically sufficient. If correcting a deficiency, higher doses of 5,000 mcg are common under professional guidance. Vegans, vegetarians, and adults over 50 generally benefit from the higher end of the dosage range since dietary intake and absorption decline in these groups.
Form matters for absorption. Sublingual liquids and lozenges deliver methylcobalamin directly through the mucous membranes, bypassing the digestive system. This can be particularly beneficial for people with digestive issues or low intrinsic factor (the protein needed for B12 absorption in the gut). Standard capsules work fine for most people but may be less efficient for those with absorption challenges.
Look for GMP certification, third-party testing, and clean formulas without unnecessary fillers. Brands like Thorne (NSF Certified for Sport) and Jarrow Formulas have long track records of quality. If you need more than just B12, consider a methylated B-complex that covers the full spectrum of B vitamins in their active forms.
Frequently Asked Questions
What is methyl B12 and how is it different from regular B12?
Methyl B12 (methylcobalamin) is the naturally occurring, active form of vitamin B12 that the body can use immediately. Regular B12 supplements often contain cyanocobalamin, a synthetic form that must be converted in the liver before use. Methylcobalamin skips this conversion step, making it the preferred choice for individuals with MTHFR gene variants or liver function concerns.
How much methyl B12 should I take daily?
For general health maintenance, 1,000–2,000 mcg of methylcobalamin daily is standard. For correcting a deficiency, doses of 5,000 mcg are common. Vegans and adults over 50 often benefit from higher doses since they may have limited dietary intake or reduced absorption capacity. B12 is water-soluble, so excess amounts are typically excreted safely.
When is the best time to take methyl B12?
Methyl B12 is best taken in the morning or early afternoon since it supports energy production and may interfere with sleep if taken too late. Sublingual forms can be taken on an empty stomach for optimal absorption. Capsules are generally well-absorbed with or without food, though taking them with a meal may reduce any mild stomach sensitivity.
Are there any side effects of methyl B12?
Methyl B12 is considered very safe since it’s water-soluble and excess is excreted through urine. Rare side effects may include mild headache, nausea, or a tingling sensation when first starting supplementation. Some individuals with certain genetic profiles may experience overstimulation or anxiety with high-dose methylcobalamin — in these cases, hydroxocobalamin may be a better choice.
Can I take methyl B12 with other supplements?
Methyl B12 pairs well with most supplements and is often combined with methylfolate (5-MTHF) for enhanced methylation support. It works synergistically with iron supplements since B12 is essential for red blood cell production. Avoid taking high-dose vitamin C at the same time as B12, as it may reduce B12 absorption — space them at least two hours apart.
How long does it take for methyl B12 to work?
Many people notice improvements in energy and mental clarity within one to two weeks of consistent supplementation. However, correcting a significant deficiency can take several months of regular use. Sublingual and liquid forms may produce faster noticeable effects since they bypass the digestive system and enter the bloodstream more quickly.
