Best Leaky Gut Supplements (2026)

Leaky gut — or increased intestinal permeability — occurs when the tight junctions between cells in the gut lining become compromised, allowing toxins, undigested food particles, and bacteria to pass into the bloodstream. This can trigger widespread inflammation, digestive issues, and immune responses. The best leaky gut supplements target gut barrier repair through ingredients like L-glutamine, zinc carnosine, collagen peptides, and soothing botanicals such as slippery elm and marshmallow root.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Balance ONE RevivaGut	L-Glutamine + Zinc Carnosine	Powder	Best Overall	9.5/10
Snap Supplements Gut Health	Probiotics + Digestive Enzymes	Capsules	Best Probiotic Bundle	9.3/10
Pink Stork Cortisol Probiotic	Probiotics + Ashwagandha	Capsules	Best for Stress-Related Gut Issues	9.2/10
Organic Inulin Prebiotic Powder	Organic Agave Inulin	Powder	Best Prebiotic Fiber	9.0/10
Lemme Debloat Gummies	Probiotics + Digestive Enzymes	Gummies	Best Gummies	8.9/10
Advanced Acacia Fiber Powder	Organic Acacia Fiber	Powder	Best for Gut Lining Repair	8.8/10
Zinc L-Carnosine Complex 85mg	Zinc Carnosine 85mg	Capsules	Best Targeted Gut Repair	8.7/10

1. Balance ONE RevivaGut — Best Overall

Balance ONE RevivaGut combines the two most clinically studied leaky gut ingredients — L-glutamine and zinc carnosine — with eight additional gut-healing botanicals in a comprehensive repair powder.

This 10-ingredient formula includes therapeutic doses of L-glutamine for enterocyte fuel, clinically studied zinc carnosine that adheres directly to the stomach lining for targeted repair, plus slippery elm, DGL licorice root, marshmallow root, aloe vera, N-acetyl-D-glucosamine, MSM, L-alanyl-L-glutamine, and arabinogalactan prebiotic fiber. The powder format allows for higher therapeutic doses than capsules typically deliver. Non-GMO, gluten-free, dairy-free, and sweetened with monk fruit extract. Made in the USA with third-party testing for purity.

• Pros:
• Comprehensive 10-ingredient formula targeting multiple aspects of gut repair
• Clinically studied zinc carnosine for direct mucosal barrier support
• Powder format allows higher therapeutic doses of L-glutamine

• Cons:
• May contain shellfish allergens (from N-acetyl-D-glucosamine)
• Powder format requires mixing — less convenient than capsules

Best for: Anyone seeking the most comprehensive leaky gut repair formula combining L-glutamine, zinc carnosine, and gut-soothing botanicals

2. Snap Supplements Gut Health — Best Probiotic Bundle

Snap Supplements pairs gut-targeted probiotics with digestive enzymes and organic spirulina-chlorella for a multi-angle approach to digestive healing and microbiome balance.

This bundle addresses leaky gut from the microbiome side, providing beneficial bacteria to crowd out harmful organisms while digestive enzymes help reduce the burden on a compromised gut lining. The organic spirulina and chlorella component adds anti-inflammatory and detoxification support. Manufactured in a GMP-certified facility with quality ingredients. The dual-product approach lets users address both gut flora balance and nutritional support simultaneously.

• Pros:
• Two-product bundle covers probiotics, enzymes, and superfoods
• Spirulina and chlorella add anti-inflammatory support
• GMP-certified manufacturing with quality testing

• Cons:
• Bundle format means tracking two separate supplements
• Does not include L-glutamine or zinc carnosine for direct gut lining repair

Best for: People who want to rebuild their gut microbiome alongside digestive enzyme support as part of a leaky gut protocol

3. Pink Stork Cortisol Probiotic — Best for Stress-Related Gut Issues

Pink Stork combines mood and adrenal support with targeted probiotics, recognizing the gut-brain connection that makes stress a major contributor to intestinal permeability.

This formula includes ashwagandha for cortisol management alongside clinically studied probiotic strains designed to support both mood and gut health. Chronic stress is one of the leading causes of increased intestinal permeability, and this product addresses that root cause while simultaneously supporting the gut microbiome. GMP-certified manufacturing, non-GMO ingredients, and designed specifically for women dealing with the stress-gut connection.

• Pros:
• Addresses the stress-gut connection with ashwagandha + probiotics
• Targets a common root cause of leaky gut (elevated cortisol)
• Clean formulation with GMP-certified manufacturing

• Cons:
• Marketed primarily toward women, though ingredients benefit anyone
• Does not contain gut-lining repair nutrients like L-glutamine

Best for: Anyone whose gut issues are linked to chronic stress, high cortisol, or the gut-brain axis

4. Organic Inulin Prebiotic Powder — Best Prebiotic Fiber

This bulk organic agave inulin powder provides gentle prebiotic fiber that feeds beneficial gut bacteria — a foundational step in restoring the microbiome balance that supports gut barrier integrity.

Inulin is a soluble prebiotic fiber that selectively feeds beneficial Bifidobacterium and Lactobacillus species in the large intestine. These beneficial bacteria produce short-chain fatty acids (SCFAs) like butyrate, which directly nourish colonocytes and strengthen the gut barrier. The 48-ounce (3-pound) bag provides excellent value for long-term supplementation. Organic, gentle on digestion when introduced gradually, and easily mixed into any beverage or food.

• Pros:
• Organic agave inulin supports SCFA production for gut barrier health
• Bulk 3-pound bag offers outstanding value for daily use
• Gentle, well-tolerated prebiotic that dissolves easily

• Cons:
• Can cause gas and bloating if introduced too quickly
• Prebiotic support only — does not directly repair gut lining

Best for: Long-term microbiome support to help rebuild the beneficial bacteria that produce gut-protective short-chain fatty acids

5. Lemme Debloat Gummies — Best Gummies

Lemme Debloat delivers two clinically studied probiotic strains with digestive enzymes in a tasty gummy, making daily gut support simple and enjoyable.

Founded by Kourtney Kardashian Barker, Lemme uses clinically studied probiotic strains selected specifically for digestive comfort and reduced bloating. The addition of digestive enzymes helps break down foods that commonly trigger gut irritation. While not a targeted leaky gut repair supplement, consistent probiotic and enzyme support can reduce the inflammatory burden on a compromised gut lining. Vegan, non-GMO, and free from artificial colors and flavors.

• Pros:
• Two clinically studied probiotic strains for digestive support
• Digestive enzymes reduce gut irritation from food triggers
• Pleasant-tasting gummy format encourages daily compliance

• Cons:
• Lower potency than dedicated leaky gut repair supplements
• Premium pricing for the gummy format

Best for: People who want an easy, palatable daily gut support gummy to complement a broader leaky gut protocol

6. Advanced Acacia Fiber Powder — Best for Gut Lining Support

This organic acacia fiber powder is specifically marketed for leaky gut repair, providing a gentle soluble fiber that supports mucosal lining health without the bloating associated with other fibers.

Acacia fiber (also known as gum arabic) is one of the most gut-friendly prebiotic fibers available. Unlike inulin or psyllium, acacia fiber ferments slowly in the colon, producing less gas and bloating while still feeding beneficial bacteria. Research shows acacia fiber can increase Bifidobacterium and Lactobacillus counts while supporting the mucus layer that protects the intestinal lining. The 16-ounce container provides organic, natural soluble fiber in a pure, unflavored powder that mixes easily into any drink.

• Pros:
• Acacia fiber is one of the best-tolerated prebiotic fibers — minimal gas and bloating
• Supports the protective mucus layer of the gut lining
• Organic, unflavored powder that mixes easily

• Cons:
• Works slowly — requires consistent use over weeks to see benefits
• 16-ounce container may not last long at full therapeutic doses

Best for: People with sensitive digestive systems who need a gentle prebiotic fiber that won’t aggravate existing gut issues

7. Zinc L-Carnosine Complex 85mg — Best Targeted Gut Repair

This 11-in-1 zinc L-carnosine complex delivers the most clinically validated single ingredient for gut lining repair alongside complementary digestive support nutrients.

Zinc carnosine is unique among zinc supplements because the carnosine molecule allows zinc to adhere directly to damaged areas of the stomach and intestinal lining, providing sustained, targeted repair where it’s needed most. Clinical trials have demonstrated zinc carnosine’s ability to reduce markers of intestinal permeability and support mucosal integrity. This formula combines 85mg zinc carnosine with additional gut-supporting ingredients for a comprehensive approach. Non-GMO, manufactured in the USA.

• Pros:
• Zinc carnosine is the most clinically studied ingredient for direct gut lining repair
• Multi-ingredient formula provides comprehensive digestive support
• Capsule format for easy daily dosing

• Cons:
• Zinc supplementation can deplete copper levels over time
• May need to pair with L-glutamine for complete gut repair protocol

Best for: Anyone seeking the most clinically validated ingredient for direct intestinal lining repair and reduced gut permeability

8. Codeage Leaky Gut Supplement — Best Multi-Ingredient Formula

This advanced prebiotic and probiotic formula provides multi-strain beneficial bacteria with prebiotic fiber for comprehensive gut ecosystem restoration.

Addressing leaky gut requires rebuilding the diverse microbiome that supports barrier function, and this supplement delivers advanced prebiotics and probiotics designed to work synergistically. The formula includes multiple probiotic strains shown to support digestive health, immune function, and gut integrity, combined with prebiotic fiber to feed and sustain these beneficial organisms. Suitable for both men and women, manufactured with quality standards.

• Pros:
• Multi-strain probiotic formula for comprehensive microbiome rebuilding
• Includes prebiotic fiber to sustain beneficial bacteria long-term
• Supports both digestive and immune health

• Cons:
• Does not contain L-glutamine or zinc carnosine for direct gut lining repair
• Some users may experience initial adjustment symptoms

Best for: People focusing on microbiome restoration as part of a comprehensive leaky gut healing protocol

9. EZ Melts Kombucha Tablets — Best Dissolvable Option

EZ Melts offers a unique dissolvable tablet format combining kombucha SCOBY culture with apple cider vinegar for gut health support without swallowing pills.

These sugar-free dissolvable tablets provide a novel approach to gut support, delivering fermented kombucha culture (SCOBY) alongside apple cider vinegar in a format that dissolves on the tongue. This is particularly appealing for people who struggle with swallowing capsules or powders. The fermented compounds support healthy gut bacteria and digestive function. Non-GMO, sugar-free, and made without artificial colors or flavors.

• Pros:
• Unique dissolvable format — no swallowing needed
• Fermented kombucha culture provides gut-supportive compounds
• Sugar-free with no artificial ingredients

• Cons:
• Lower potency than dedicated leaky gut repair supplements
• Limited clinical research on tablet-form kombucha for gut permeability

Best for: People who dislike swallowing pills and want convenient, fermented gut support in a dissolvable format

How to Choose the Best Leaky Gut Supplement

The most effective leaky gut supplements contain L-glutamine as a primary ingredient. L-glutamine is the preferred fuel source for enterocytes (intestinal lining cells), and a 2019 clinical trial demonstrated that 15g daily reduced leaky gut markers and improved IBS symptoms by 80%. Look for supplements providing at least 5g of L-glutamine per serving. Powder formats are ideal for achieving therapeutic doses, as capsules typically can’t deliver enough.

Zinc carnosine is the second most important ingredient to look for. Unlike standard zinc supplements, zinc carnosine adheres directly to damaged areas of the gut lining, providing sustained release and targeted healing. Clinical trials show it can reduce intestinal permeability markers within 8 weeks. Effective doses are typically 75-150mg daily.

Beyond these core ingredients, look for supporting botanicals like slippery elm bark, marshmallow root, DGL licorice, and aloe vera — all of which help coat and soothe irritated gut tissue. Prebiotic fibers (inulin, acacia fiber, arabinogalactan) feed the beneficial bacteria that produce butyrate, a short-chain fatty acid that directly nourishes the gut lining. A multi-strain probiotic can help rebuild the diverse microbiome necessary for barrier function.

For the most comprehensive approach, consider combining a dedicated gut-lining repair supplement (L-glutamine + zinc carnosine) with a quality probiotic and prebiotic fiber. Start with lower doses and increase gradually to minimize initial digestive adjustment. Most practitioners recommend a minimum 8-12 week protocol for meaningful gut barrier restoration.

Frequently Asked Questions

What is leaky gut and what causes it?

Leaky gut (increased intestinal permeability) occurs when the tight junctions between intestinal cells become loose, allowing partially digested food, bacteria, and toxins to leak through the gut wall into the bloodstream. Common causes include chronic stress, poor diet high in processed foods and sugar, excessive alcohol, prolonged NSAID use, gut infections, and imbalances in gut bacteria. Symptoms can include bloating, food sensitivities, fatigue, joint pain, skin problems, and autoimmune flare-ups.

How much L-glutamine should I take for leaky gut?

Clinical research suggests 5-15g of L-glutamine daily for gut repair. A landmark 2019 study used 15g per day and showed significant improvement in intestinal permeability and IBS symptoms. Starting with 5g daily and gradually increasing to 10-15g is a common approach. L-glutamine is best taken on an empty stomach for maximum absorption, typically first thing in the morning or between meals.

When is the best time to take leaky gut supplements?

L-glutamine is most effective on an empty stomach, as it’s directly absorbed by intestinal cells without competition from food. Zinc carnosine is best taken with meals, as it can coat the gut lining during digestion. Probiotics are generally taken on an empty stomach or with a light meal. Prebiotic fibers can be taken any time but are often added to morning smoothies or beverages. Splitting doses between morning and evening provides more consistent support throughout the day.

Are there any side effects of leaky gut supplements?

Most leaky gut supplements are well tolerated. L-glutamine is one of the safest amino acids, though very high doses may cause mild headaches or digestive discomfort initially. Zinc supplementation can deplete copper levels over time, so consider a supplement that includes copper or take periodic breaks. Prebiotic fibers can cause temporary gas and bloating if introduced too quickly — start with small amounts and increase gradually. Herbal ingredients like slippery elm and marshmallow root are generally very gentle.

Can I take leaky gut supplements with other supplements?

Leaky gut supplements pair well with omega-3 fatty acids (anti-inflammatory), vitamin D (immune modulation and gut barrier support), collagen peptides (provides glycine and proline for tissue repair), and curcumin (anti-inflammatory). Avoid taking zinc at the same time as iron or calcium, as they compete for absorption. Probiotics should be separated from antibiotics by at least 2-3 hours.

How long does it take for leaky gut supplements to work?

Many people notice reduced bloating and improved digestion within 2-4 weeks of starting a comprehensive leaky gut protocol. However, meaningful repair of the intestinal barrier typically takes 8-12 weeks of consistent supplementation. Full gut ecosystem restoration can take 3-6 months or longer, depending on the severity of gut damage and adherence to dietary and lifestyle changes alongside supplementation. Consistency is far more important than any single ingredient.