Best Phosphatidylserine Supplements (2026)

Phosphatidylserine (PS) is a phospholipid that plays a critical role in brain cell membrane structure and cell-to-cell communication. As the body’s natural production declines with age, supplementation has gained attention for supporting memory, focus, cognitive processing speed, and cortisol management. Clinical research has shown that PS supplementation can benefit healthy adults of all ages, making it one of the most credible nootropic ingredients available.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Double Wood Phosphatidylserine 300mg	Phosphatidylserine 300mg	Capsules	Best Overall	9.5/10
Thorne Phosphatidylserine	PS Isolate 100mg	Capsules	Best Premium	9.4/10
Ginkgo Biloba with Phosphatidylserine	Ginkgo 120mg + PS	Capsules	Best Combo for Memory	9.2/10
Doctor’s Best Phosphatidyl Serine 100mg	PS 100mg (SerinAid)	Capsules	Best Trusted Brand	9.1/10
Alpha GPC with Phosphatidylserine Gummies	Alpha GPC 600mg + PS + Bacopa	Gummies	Best Gummies	9.0/10
Ultra Strength PS 500mg	PS 500mg (Sunflower-Derived)	Capsules	Most Potent	8.9/10
Cognagen Memory Supplement	PS + Clinically Formulated Blend	Capsules	Best Clinically Formulated	8.8/10

1. Double Wood Phosphatidylserine 300mg — Best Overall

Double Wood’s Phosphatidylserine delivers a clinical-strength 300mg per serving in 120 capsules, making it the best-selling and most reviewed PS supplement on Amazon.

With over 5,500 reviews and more than 6,000 units sold monthly, Double Wood has established itself as the market leader in phosphatidylserine supplementation. Each serving provides 300mg of PS complex — well within the 200-400mg range used in clinical studies showing benefits for memory, attention, and processing speed. One study demonstrated that 400mg daily improved processing speed, accuracy, and memory in healthy adults under fatigue. Manufactured in the USA (New York), non-GMO, gluten-free, and third-party tested for purity and potency.

• Pros:
• Clinical-strength 300mg dose backed by cognitive performance research
• Best-selling PS supplement with thousands of verified positive reviews
• Third-party tested, USA-manufactured, with excellent value per capsule

• Cons:
• Contains soy — not suitable for individuals with soy allergies
• Capsules contain gelatin, not vegan-friendly

Best for: Anyone wanting a proven, high-dose phosphatidylserine supplement from the category’s most trusted and reviewed brand

2. Thorne Phosphatidylserine — Best Premium

Thorne’s PS supplement represents the gold standard in practitioner-grade phosphatidylserine, chosen by 100+ professional sports teams and partnered with the Mayo Clinic.

Each capsule delivers 100mg of phosphatidylserine isolate, designed for flexible dosing (1-3 capsules daily). Thorne’s reputation rests on four rounds of third-party testing per product, ensuring label accuracy and freedom from contaminants including heavy metals, pesticides, and microorganisms. The PS isolate form provides pure phosphatidylserine without the variable phospholipid mix found in some complex formulas. Gluten-free, dairy-free, and soy-free. Trusted by professional athletes and frequently recommended by healthcare practitioners.

• Pros:
• Four rounds of third-party testing — the most rigorous quality assurance in the category
• Trusted by 100+ professional sports teams and the Mayo Clinic
• Soy-free PS isolate with flexible dosing options

• Cons:
• Significantly higher price per serving than competitors
• 100mg per capsule requires multiple capsules for full therapeutic dose

Best for: Athletes, professionals, and anyone who demands the highest quality standards and practitioner-grade supplementation

3. Ginkgo Biloba 120mg with Phosphatidylserine — Best Combo for Memory

This nootropic combination pairs ginkgo biloba’s circulation-enhancing effects with phosphatidylserine’s membrane support for a synergistic approach to brain health and memory.

Ginkgo biloba increases cerebral blood flow, delivering more oxygen and nutrients to brain cells, while phosphatidylserine strengthens the cell membranes that facilitate neural communication. Together, they address two complementary pathways for cognitive support. The 120mg ginkgo dose matches the amount used in clinical research. This combination is particularly appealing for older adults who may benefit from both improved circulation and enhanced cell membrane integrity. Non-GMO and manufactured to GMP standards.

• Pros:
• Synergistic combination of ginkgo (circulation) and PS (membrane support)
• Clinically relevant 120mg ginkgo dose
• Cost-effective way to get two brain-health ingredients in one supplement

• Cons:
• PS dose may be lower than standalone PS supplements
• Ginkgo can interact with blood-thinning medications

Best for: Adults seeking combined circulation and cognitive support, especially those concerned about age-related memory decline

4. Doctor’s Best Phosphatidyl Serine 100mg — Best Trusted Brand

Doctor’s Best has been producing science-based supplements for over 35 years, and their PS formula uses SerinAid — a branded, standardized form of phosphatidylserine with an established clinical track record.

Each vegetarian capsule provides 100mg of phosphatidylserine from SerinAid, a branded ingredient with extensive research backing. SerinAid provides PS in a matrix of complementary phospholipids and cofactors that mirror the natural phospholipid environment in the brain. The 120-capsule bottle at a three-per-day dosing schedule provides a 40-day supply at the clinically studied 300mg daily dose. Vegan/vegetarian capsules, gluten-free, and backed by Doctor’s Best’s 35+ year track record in evidence-based supplementation.

• Pros:
• Uses SerinAid branded PS with established clinical research
• Vegetarian capsules suitable for plant-based diets
• 35+ year track record of science-based supplement formulation

• Cons:
• Requires three capsules daily for full 300mg therapeutic dose
• Contains soy-based phosphatidylserine

Best for: Those who prefer a legacy brand with decades of reputation and a clinically standardized PS ingredient

5. Alpha GPC with Phosphatidylserine Gummies — Best Gummies

This 3-in-1 brain support gummy combines Alpha GPC 600mg with phosphatidylserine and Bacopa monnieri for a comprehensive nootropic stack in a delicious chewable format.

For those who prefer gummies over capsules, this product delivers three clinically studied nootropic ingredients in a single chew. Alpha GPC is one of the most bioavailable forms of choline, supporting acetylcholine production for memory and learning. Phosphatidylserine strengthens brain cell membranes, and Bacopa monnieri has been shown in multiple trials to improve memory consolidation and recall. The gummy format makes daily brain health supplementation enjoyable and easy to maintain.

• Pros:
• Three clinically studied nootropic ingredients in one gummy
• Alpha GPC provides highly bioavailable choline for acetylcholine production
• Pleasant-tasting format encourages daily compliance

• Cons:
• Individual ingredient doses may be lower than standalone supplements
• Gummy format limits total active ingredient capacity

Best for: Anyone who wants a multi-ingredient brain health supplement in a convenient, tasty gummy format

6. Ultra Strength Phosphatidylserine 500mg — Most Potent

At 500mg per serving derived from sunflower lecithin, this is the highest-dose phosphatidylserine supplement available, providing soy-free PS for those with allergies or sensitivities.

This ultra-strength formula delivers 500mg of phosphatidylserine per serving, sourced from sunflower lecithin rather than soy — an important distinction for the growing number of consumers avoiding soy. The 240-capsule bottle provides exceptional long-term value. Standardized to 20% active phosphatidylserine content, non-GMO, free from wheat, dairy, gluten, preservatives, eggs, and fish. Third-party lab tested for safety and potency. The sunflower-derived source is also more sustainable and less allergenic than soy-based PS.

• Pros:
• Highest dose available at 500mg per serving
• Soy-free, derived from sunflower lecithin for allergy-friendly supplementation
• 240-capsule bottle provides outstanding value

• Cons:
• Higher dose than most clinical studies used (200-400mg)
• Less well-known brand compared to established competitors

Best for: Anyone seeking the highest-dose PS supplement available, especially those with soy allergies who need a sunflower-derived option

7. Cognagen Memory Supplement — Best Clinically Formulated

No products found.

Cognagen takes a clinically formulated approach to memory support, combining phosphatidylserine with additional brain-targeted nutrients in a synergistic cognitive performance formula.

This supplement goes beyond standalone PS to include a carefully selected blend of ingredients that support different aspects of cognitive function. Phosphatidylserine provides the membrane support foundation, while additional nootropic compounds target neurotransmitter production, blood flow, and neuroprotection. The formula is designed based on clinical research into cognitive decline and memory optimization. Ultra-high potency formulation with ingredients selected for synergistic brain health benefits.

• Pros:
• Multi-ingredient formula designed for synergistic cognitive support
• Clinically formulated based on neuroscience research
• Targets multiple pathways of cognitive function simultaneously

• Cons:
• Multi-ingredient formulas may have lower PS dose than standalone products
• Premium pricing reflects the comprehensive formulation

Best for: People experiencing age-related cognitive changes who want a comprehensive, multi-pathway brain support supplement

8. Vitalitown Phosphatidylserine Complex — Best with B Vitamins

This cortisol supplement combines phosphatidylserine with ashwagandha and L-theanine for a stress-response formula that also supports cognitive function.

Recognizing that elevated cortisol impairs both brain function and overall wellness, this supplement pairs phosphatidylserine’s cortisol-modulating effects with ashwagandha (a clinically studied adaptogen) and L-theanine (which promotes calm focus). Research shows that PS supplementation can blunt the cortisol response to physical and mental stress, making this combination particularly effective for people dealing with stress-related cognitive fog, anxiety, or sleep disruption. The triple-ingredient approach addresses both the cause (stress) and the effect (cognitive impairment).

• Pros:
• Combines PS with ashwagandha and L-theanine for cortisol management
• Addresses the stress-cognition connection from multiple angles
• Suitable for both men and women

• Cons:
• PS dose may be lower due to multi-ingredient formulation
• Ashwagandha may cause drowsiness in some users

Best for: People whose cognitive concerns are linked to chronic stress and elevated cortisol levels

How to Choose the Best Phosphatidylserine Supplement

Clinical research on phosphatidylserine has primarily used doses ranging from 200mg to 400mg daily, often divided into two or three doses taken with meals. A 300mg daily dose is the most common effective target. Higher doses (up to 800mg) have been studied safely but may not provide proportionally greater benefits. For cortisol management, even 100-200mg daily has shown measurable effects in some studies.

Source matters for both quality and allergen concerns. Phosphatidylserine is derived from either soy lecithin or sunflower lecithin. Sunflower-derived PS is preferred by those with soy allergies and is increasingly popular due to sustainability and allergen considerations. Some premium products like Thorne use PS isolate for a purer form without the variable phospholipid mix. The branded ingredient SerinAid (used by Doctor’s Best) has the most clinical research behind it.

Capsules are the most common form and allow for precise dosing. Softgels may offer slightly better absorption due to the lipid delivery system. Gummies are available but typically deliver lower PS doses due to formulation constraints. For maximum absorption, take phosphatidylserine with a meal containing some dietary fat, as PS is a fat-soluble phospholipid.

Quality markers to look for include third-party testing, GMP certification, accurate labeling (ConsumerLab found one brand provided only 10% of its listed PS), and clear identification of the PS source. Established brands with long track records and transparent testing protocols offer the most reliable quality assurance.

Frequently Asked Questions

What is phosphatidylserine and what does it do?

Phosphatidylserine (PS) is a phospholipid — a type of fat molecule that makes up a significant portion of brain cell membranes. It plays essential roles in cell signaling, neurotransmitter release, and cell-to-cell communication in the brain. PS helps maintain the fluidity and integrity of neuronal membranes, which is crucial for memory formation, learning, focus, and cognitive processing speed. The body produces PS naturally, but production declines with age.

How much phosphatidylserine should I take daily?

Most clinical studies use 200-400mg of phosphatidylserine daily, with 300mg being the most common effective dose. This is typically divided into two or three doses taken with meals. For cortisol management, 100-200mg may be sufficient. Some studies have safely tested doses up to 800mg daily. Starting at 100mg and gradually increasing to 300mg over a week or two is a sensible approach for new users.

When is the best time to take phosphatidylserine?

Phosphatidylserine should be taken with meals containing some dietary fat, as it is a fat-soluble compound. Dividing the daily dose across two or three meals helps maintain steady levels. For cognitive support, taking PS with breakfast and lunch aligns with daytime brain demands. For cortisol management or sleep support, an evening dose may be more beneficial. Avoid taking the full daily dose on an empty stomach, as fat content in food enhances absorption.

Are there any side effects of phosphatidylserine?

Phosphatidylserine is generally well tolerated at recommended doses. Occasional side effects include mild digestive discomfort, insomnia (especially at higher doses), or headaches during the initial adjustment period. People taking blood-thinning medications or supplements should use caution, as PS may have mild anticoagulant effects. Soy-derived PS should be avoided by those with soy allergies — choose sunflower-derived products instead.

Can I take phosphatidylserine with other supplements?

Phosphatidylserine pairs excellently with omega-3 fatty acids (DHA and EPA), which complement PS in supporting brain cell membrane health. It also works well with ginkgo biloba for enhanced cerebral blood flow, Alpha GPC or citicoline for acetylcholine support, and Bacopa monnieri for memory consolidation. PS can be safely combined with B vitamins, vitamin D, and magnesium. Those on blood thinners should consult their healthcare provider before combining PS with other anticoagulant supplements like fish oil.

How long does it take for phosphatidylserine to work?

Some users notice improvements in focus and mental clarity within the first 1-2 weeks of supplementation. Measurable improvements in memory, processing speed, and attention typically appear within 4-8 weeks of consistent daily use. Cortisol-modulating effects may be noticeable within 2-4 weeks. As with most nootropic supplements, the benefits tend to accumulate over time, with studies typically running 6-12 weeks to demonstrate significant cognitive improvements.