Best Postbiotic Supplements (2026)
Postbiotics are bioactive compounds produced when probiotic bacteria ferment dietary fibers in the gut. These include short-chain fatty acids like butyrate, enzymes, peptides, and other metabolites that support gut barrier function, immune health, and digestive comfort. Unlike probiotics, postbiotics don’t require live organisms to be effective, making them shelf-stable and less sensitive to storage conditions. The best postbiotic supplements either provide direct postbiotic compounds like tributyrin or combine them with pre- and probiotics for a synbiotic approach.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Peak Performance Synbiotic | CoreBiome Tributyrin + Probiotics | Capsules | Best Overall | 9.5/10 |
| Ritual Synbiotic+ | Tributyrin + LGG + BB-12 | Capsules | Best Premium | 9.4/10 |
| BodyBio Butyrate | Sodium Butyrate | Capsules | Best Pure Postbiotic | 9.3/10 |
| Supernatant Synbiotic | Pre + Pro + Postbiotic Blend | Capsules | Best Comprehensive | 9.1/10 |
| Garden of Life PRE+PRO+POST | 3-in-1 with Postbiotics | Capsules | Best Trusted Brand | 9.2/10 |
| BIOMA Probiotics | Tributyrin + XOS + Bifidobacterium | Capsules | Best for Bloating | 9.0/10 |
| Goli Pre+Pro+Postbiotic Gummies | 3-in-1 Gummy | Gummies | Best Gummy | 8.9/10 |
1. Peak Performance Synbiotic – Best Overall
- Don’t be fooled! Not all prebiotics or probiotic supplements cover all bases. Peak Performance Synbiotic is a Prebiotic + Probiotic + Postbiotic 3-in-1 capsule supplement specifically designed for allround digestive, gut, gastrointestinal health, as well as immune health.* Made with a Prebiotic Complex, Soil-Based Probiotic Blend and clinically tested CoreBiome Tributyrin 55% Extract.
- Prebiotics- Xylooligosaccharides(XOS) (from PreticX) is a new prebiotic XOS (xylooligosaccharide) that has been clinically shown to increase bifidobacteria in the colon and aid in healthy digestion.
- Probiotics - Soil-Based Blend (Bacillus subtilis, Bacillus coagulans, and Bacillus coagulans). Naturally found in the earth and have a longer and more stable shelf-life. Research shows they appear to survive the first part of their journey through the stomach and small intestine.
- Postbiotics - CoreBiome Tributyrin 55% Extract - Backed by clinical studies, supports immune health by promoting a healthy microbiome, supports balanced flora, helps support gut and digestive health and intestinal walls.
- 1-For-1 Donation Match Program! Through our 1-for-1 partnership with the nonprofit Vitamin Angels, every purchase provides a child at risk of malnutrition with vitamins for a full year. To date we have helped over 3 million children through this partnership, so thank you for supporting this mission.
Peak Performance Synbiotic combines clinically tested CoreBiome Tributyrin postbiotic with a soil-based probiotic blend and prebiotic complex in one comprehensive 3-in-1 capsule for complete gut support.
This formula features three functional layers: prebiotics (xylooligosaccharides from PreticX, clinically shown to increase bifidobacteria in the colon), soil-based probiotics (Bacillus subtilis and Bacillus coagulans strains with superior shelf stability), and the clinically tested CoreBiome Tributyrin 55% Extract as the postbiotic component. Tributyrin is a prodrug of butyrate — the primary fuel source for colon cells — and supports gut barrier integrity and immune function. The soil-based probiotic strains are naturally more resilient than traditional strains and survive stomach acid better. Manufactured under GMP regulations with USA quality standards. Vegan capsules.
- Pros:
- Clinically tested CoreBiome Tributyrin postbiotic with published research
- Soil-based probiotics with superior shelf stability and acid survival
- True 3-in-1 formula covering all three biotic categories
- Cons:
- Lower CFU count than dedicated probiotic supplements
- May require consistent use for several weeks to notice benefits
Best for: Users who want a scientifically backed 3-in-1 gut health supplement with clinically tested postbiotic ingredients
2. Ritual Synbiotic+ – Best Premium
- SYNBIOTIC+ 3-IN-1 FORMULA: with prebiotics, probiotics and postbiotics to support a balanced gut microbiome. Our formula is Made Traceable with 11b CFUs with two of the world's most clinically studied probiotic strains. Our visible supply chain tells you what you're putting into your body where it comes from and why. Plus it's designed to thrive with our delayed-release capsule to help reach the colon (not the stomach), an ideal place for probiotics to survive and grow.*
- MADE TRACEABLE: Our world-class scientists scoured the globe for high quality ingredients. Prebiotics PreforPro from Georgia - targets undesirable bacteria and supports growth of beneficial gut bacteria; Probiotics BB-12(Bifidobacterium anamalis ssp. lactis) and LGG (Lactobacillus rhamnosus) from Denmark - provide live microorganisms that contribute to a healthy gut microflora; Postbiotics Butyrate (as Tributyrin) from Spain- for major energy source for the cells that line the colon.*
- SMART CAPSULE: Our innovative nested capsule is designed to thrive with it's delayed-release technology to help the probiotics to reach the colon (not the stomach), an ideal place for probiotics to survive and grow.* Plus we added a minty tab to every bottle so taking your daily gut support can be a more enjoyable experience.* All bottled up in a moisture-controlled technology to protect the probiotic strain. No Refrigeration Needed.
- GUT HEALTH, DIGESTIVE, AND IMMUNITY SUPPORT: Our cutting edge approach to digestive support includes probiotic strains to support healthy regularity and relief of occasional discomforts such as mild and occasional bloating, gas, and diarrhea; postbiotic to supports gut barrier function; prebiotics designed to target undesirable bacteria in the gut and support the growth of beneficial gut bacteria; and probiotics to help support immune health. It’s estimated that 70% of the immune system is located in the gut.*
- THIRD PARTY TESTED: Each batch of Synbiotic+ is tested for identity, purity, strength, and composition, so we can be sure that what’s on the label is what’s in the capsules. We also complete third-party testing to ensure our products are compliant with regulations and guidelines for heavy metals, microbes, and major allergens and to help assure the quality and safety of our products.
Ritual Synbiotic+ features two of the world’s most clinically studied probiotic strains alongside tributyrin postbiotic in an innovative delayed-release nested capsule designed to bypass stomach acid and reach the colon.
The formula includes 11 billion CFUs of Lactobacillus rhamnosus (LGG) and Bifidobacterium animalis ssp. lactis (BB-12) — both among the most researched probiotic strains in existence. The postbiotic component is butyrate delivered as tributyrin sourced from Spain. PreforPro, the prebiotic, targets undesirable bacteria while supporting beneficial gut flora growth. Ritual’s proprietary nested capsule uses delayed-release technology to deliver the contents to the colon rather than the stomach, where probiotics are more likely to survive and colonize. Third-party tested for identity, purity, strength, and composition. No refrigeration needed. 30 capsules per bottle for a one-month supply.
- Pros:
- Two of the world’s most clinically studied probiotic strains (LGG + BB-12)
- Delayed-release nested capsule technology for colon-targeted delivery
- Full supply chain traceability — every ingredient sourced and disclosed
- Cons:
- Premium price point significantly higher than standard gut supplements
- Mint flavor/scent may not appeal to all users
Best for: Users willing to invest in a premium, research-backed synbiotic with advanced delivery technology and full ingredient traceability
3. BodyBio Butyrate – Best Pure Postbiotic
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BodyBio Butyrate is a dedicated postbiotic supplement delivering sodium butyrate in targeted capsules — the most direct way to supplement the short-chain fatty acid that fuels colon cells and supports gut barrier integrity.
Unlike synbiotic formulas that include postbiotics as one component, BodyBio focuses exclusively on butyrate — the short-chain fatty acid that serves as the primary energy source for colonocytes (colon lining cells). Each capsule delivers sodium butyrate in a form designed for gut-level delivery. Butyrate supports gut barrier function, helps regulate inflammation, and promotes a healthy intestinal lining. This is particularly relevant for individuals dealing with leaky gut, gas, bloating, or constipation. The formula contains only butyrate and calcium/magnesium salts — no probiotics, prebiotics, or fillers. 100 capsules per bottle.
- Pros:
- Pure butyrate delivery — the most important postbiotic compound
- Targeted support for gut barrier function and colon cell health
- Clean formula with minimal ingredients and no fillers
- Cons:
- No probiotic or prebiotic components — single-function supplement
- Butyrate has a naturally unpleasant odor that some users notice
Best for: Users specifically seeking direct butyrate supplementation for gut barrier support, leaky gut, or digestive comfort
4. Synbiotic 3-in-1 by Ultra6 – Best Comprehensive
- PROBIOTICS AND PREBIOTICS FOR DIGESTIVE HEALTH: Our daily synbiotic is a 3-in-1 formula that meets the essential gut health needs of both men and women, containing probiotics for men digestive health and probiotics for women digestive health.
- GUT HEALTH SUPPLEMENTS: Featuring probiotics and prebiotics that aid in the production of digestive enzymes, our daily use probiotic blend maintains good gut bacteria diversity, supports digestion and helps provide bloating relief.
- ADVANCED FORMULA FOR GUT HEALTH: Our probiotic prebiotic capsules combine multiple strains of probiotics that fortify the growth and diversity of good gut bacteria. Our formula is an essential blend of men's and women's probiotics for gut health.
- IMMUNE SUPPORT AND BLOATING RELIEF: Our clinically-proven postbiotic not only enhances immune function but also offers bloating relief for men and women, acting as a powerful antioxidant protector. Immune supporting benefits begin to work within 2 hours of taking.
- PURITY AND QUALITY: As a premium gut health supplement, our biome focused formula is non-GMO, third-party tested, and combines both prebiotics and probiotics for women and men, ensuring clean ingredients for your digestive wellness.
This 3-in-1 synbiotic combines prebiotics, probiotics, and postbiotics in a single formula designed for comprehensive digestive health, gut barrier support, and immune function.
The formula features a balanced blend of prebiotic fibers, multiple probiotic strains, and postbiotic metabolites in an all-in-one capsule. The synbiotic approach ensures that prebiotic fibers feed the probiotic bacteria, which in turn produce additional postbiotic compounds in the gut — creating a self-reinforcing cycle of gut health support. This comprehensive approach makes it a good choice for people new to gut health supplements who want one product covering all bases. Manufactured in a GMP-certified facility and designed for daily use. Suitable for both men and women.
- Pros:
- True synbiotic formula with all three biotic categories
- Self-reinforcing prebiotic-probiotic-postbiotic cycle
- Good entry point for gut health supplementation
- Cons:
- Individual component doses may be lower than dedicated products
- Less research-backed strain specificity than premium competitors
Best for: Users new to gut health supplementation who want a comprehensive all-in-one formula
5. Garden of Life Dr. Formulated PRE+PRO+POSTBIOTIC – Best Trusted Brand
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Garden of Life brings its physician-formulated approach to postbiotics with a once-daily 3-in-1 capsule featuring clinically studied probiotic strains alongside prebiotic and postbiotic support.
Formulated by David Perlmutter, MD — a board-certified neurologist and Fellow of the American College of Nutrition — this supplement provides 30 billion CFU probiotics alongside prebiotic fiber and postbiotic compounds. Garden of Life uses specific clinically studied probiotic strains selected for their documented health benefits. The formula supports digestive regularity, immune health, and gut barrier integrity. Shelf-stable (no refrigeration required), Non-GMO Project Verified, and certified gluten-free. 30 vegetarian capsules per bottle for a one-month supply.
- Pros:
- Physician-formulated by board-certified neurologist Dr. Perlmutter
- 30 billion CFU with clinically studied strains
- Non-GMO Project Verified and certified gluten-free
- Cons:
- Higher price than basic synbiotic formulas
- Only 30-day supply per bottle
Best for: Users who value physician-formulated supplements with clinically studied strains and trusted brand credibility
6. Supernatant Synbiotic – Best Multi-Strain
- 𝗧𝗼𝘁𝗮𝗹 𝗚𝘂𝘁 𝗕𝗮𝗹𝗮𝗻𝗰𝗲: Supernatant Synbiotic is a refined 3 in 1 probiotic, prebiotic, postbiotic blend developed to nourish the microbiome and support steady, comfortable digestive function. The formula pairs clinically researched probiotic strains with targeted prebiotic fibers that selectively feed beneficial bacteria. This coordinated approach helps cultivate a well-balanced microbial environment, supports relief from occasional digestive discomfort, encourages smoother digestive processes, and peak colon support. By promoting microbial harmony and consistent nutrient assimilation, it contributes to a lighter, more sustained sense of daily well-being.
- 𝗛𝗲𝗹𝗽𝘀 𝗘𝗮𝘀𝗲 𝗗𝗶𝗴𝗲𝘀𝘁𝗶𝘃𝗲 𝗨𝗽𝘀𝗲𝘁: Formulated to provide supportive relief for occasional intestinal discomfort and periods of microbial imbalance. This carefully designed blend works by encouraging the steady growth of beneficial microbes while helping maintain the gut’s natural ecological resilience. The synergistic ingredients assist in fostering a calm, stable digestive environment, supporting comfortable motility and balanced fermentation. Together, these actions promote a more harmonious microbiome and contribute to consistent digestive well-being over time.
- 𝗖𝗼𝗺𝗳𝗼𝗿𝘁 𝗳𝗼𝗿 𝗦𝗲𝗻𝘀𝗶𝘁𝗶𝘃𝗲 𝗦𝘆𝘀𝘁𝗲𝗺𝘀: Developed to support colon function and provide steady, gentle relief for occasional digestive discomfort and sensitivity. This carefully composed blend helps soothe the intestinal lining and promotes a smooth, regular digestive rhythm while encouraging a calm, balanced microbial environment. Designed for individuals whose digestion is easily unsettled, it supports intestinal resilience, ongoing comfort, and a more stable digestive experience. Together, these actions contribute to a grounded sense of digestive well-being and help the system feel restored over time.
- 𝗜𝗺𝗺𝘂𝗻𝗲 & 𝗪𝗲𝗹𝗹𝗻𝗲𝘀𝘀 𝗦𝘂𝗽𝗽𝗼𝗿𝘁: Formulated with postbiotic supernatants that supply naturally occurring compounds known to help maintain microbial balance and support steady immune function. This thoughtfully designed blend reinforces the body’s everyday protective processes while contributing to overall wellness and year-round resilience. By promoting a stable internal environment and supporting the body’s natural response to periodic stressors or seasonal shifts, it encourages sustained vitality and helps you feel centered, energized, and well supported throughout the day.
- 𝗖𝗹𝗲𝗮𝗻, 𝗦𝗮𝗳𝗲 & 𝗘𝗮𝘀𝘆: Crafted with a focus on purity and transparency, this formula is 100% vegan, non-GM0, and free from gluten, dairy, soy, and artificial additives. Each ingredient is selected with care to ensure quality, consistency, and suitability for daily use. The once-daily capsule format offers a simple way to support your wellness routine, helping the body sustain a natural sense of balance and internal harmony. Designed for long-term use, it contributes to a light, steady feeling of well-being and supports both digestive and immune function in a gentle, sustainable manner.
Supernatant takes a unique approach by including the actual metabolic byproducts of probiotic fermentation alongside live cultures and prebiotics, providing postbiotics in their most natural form.
This synbiotic supplement delivers prebiotics, probiotics, and postbiotics with a focus on including the “supernatant” — the liquid medium containing postbiotic metabolites naturally produced during probiotic fermentation. This approach provides butyrate, enzymes, peptides, and other bioactive compounds in the ratios naturally produced by beneficial bacteria. The formula is designed to ease digestive discomfort, support regularity, and promote overall gut health. It includes multiple probiotic strains for microbiome diversity. Manufactured in a GMP-certified facility.
- Pros:
- Contains natural fermentation metabolites (supernatant) as postbiotics
- Multi-strain probiotic blend for microbiome diversity
- Addresses digestive discomfort, regularity, and gut health simultaneously
- Cons:
- Unique approach may be unfamiliar to mainstream supplement users
- Specific CFU counts and strain details may be less transparent
Best for: Users interested in a natural-fermentation approach to postbiotics with diverse probiotic strains
7. BIOMA Probiotics – Best for Bloating
No products found.
BIOMA combines xylooligosaccharides (XOS) prebiotics, Bifidobacterium probiotics, and tributyrin postbiotic in delayed-release capsules specifically formulated to reduce bloating and support digestive comfort.
BIOMA’s formula targets bloating and digestive discomfort through a strategic combination of XOS prebiotics that selectively feed beneficial bacteria, Bifidobacterium strains that support balanced gut flora, and tributyrin that nourishes colon cells and supports gut barrier integrity. The delayed-release capsule design protects the contents from stomach acid, ensuring delivery to the intestines where they’re most effective. Vegan, gluten-free, and free from common allergens. 60 capsules per bottle for a 30-day supply.
- Pros:
- Specifically formulated for bloating and digestive comfort
- Delayed-release capsules for intestinal-targeted delivery
- Clean, vegan-friendly formula with no common allergens
- Cons:
- Only 30-day supply per bottle
- Newer brand with less long-term track record
Best for: Users primarily seeking relief from bloating and digestive discomfort through a postbiotic-enhanced approach
8. Goli Pre+Pro+Postbiotic Gummies – Best Gummy
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Goli’s 3-in-1 gummy delivers prebiotics, probiotics, and postbiotics in a great-tasting gummy format — the most convenient and enjoyable way to get postbiotic support for people who dislike swallowing capsules.
Goli’s gummy format combines all three biotic categories in a vegan, gluten-free, non-GMO gummy with natural fruit flavors. The formula includes prebiotic fibers, probiotic cultures, and postbiotic compounds in each serving. While gummies inherently can’t match the dosing precision of capsules (particularly for heat-sensitive probiotics), Goli has engineered their formula to maintain viable cultures through the manufacturing process. The brand is well-known for its apple cider vinegar gummies and brings the same commitment to taste and quality to this gut health formula. 60 gummies per bottle.
- Pros:
- Great-tasting gummy format — ideal for capsule-averse users
- World’s first 3-in-1 pre+pro+postbiotic gummy
- Vegan, gluten-free, gelatin-free, and non-GMO
- Cons:
- Gummy format limits dosing compared to capsules
- Added sugars and flavoring agents necessary for taste
Best for: Users who prefer gummies over capsules and want a convenient, tasty way to get daily postbiotic support
How to Choose the Best Postbiotic Supplement
The most important postbiotic ingredient to look for is butyrate, typically delivered as tributyrin or sodium/calcium butyrate. Butyrate is the primary short-chain fatty acid that fuels colonocytes (colon lining cells) and supports gut barrier integrity. CoreBiome Tributyrin is a clinically tested form with published research supporting its benefits. Products that specify their postbiotic source and form are generally more reliable than those that use vague “postbiotic blend” descriptions.
Decide whether you want a pure postbiotic (butyrate only) or a synbiotic formula that includes pre-, pro-, and postbiotics together. Synbiotic formulas offer comprehensive gut support in one product, while pure butyrate supplements allow more targeted dosing for specific gut health concerns like leaky gut or chronic bloating. The synbiotic approach may be more beneficial for general gut health maintenance.
Delivery technology matters for postbiotics. Delayed-release capsules help protect butyrate and probiotic organisms from stomach acid, delivering them to the colon where they’re most effective. Standard capsules may release their contents in the stomach, reducing effectiveness. Look for products that specify enteric-coated, delayed-release, or targeted-delivery capsule technology.
Prioritize products with third-party testing, GMP-certified manufacturing, and clearly disclosed ingredients. For synbiotic formulas, look for specific named probiotic strains (e.g., Lactobacillus rhamnosus GG, Bifidobacterium animalis BB-12) rather than generic “probiotic blend” labels, as named strains have individual research supporting their benefits.
Frequently Asked Questions
What are postbiotics and what do they do?
Postbiotics are bioactive compounds produced when probiotic bacteria ferment dietary fibers in the gut. They include short-chain fatty acids (especially butyrate), enzymes, peptides, cell wall fragments, and other metabolites. Postbiotics support gut barrier function, nourish colon cells, help regulate immune responses, and contribute to overall digestive health. Unlike probiotics, postbiotics don’t require live organisms to be effective.
How are postbiotics different from probiotics and prebiotics?
Prebiotics are dietary fibers that feed beneficial gut bacteria. Probiotics are live microorganisms that contribute to a healthy gut microbiome. Postbiotics are the beneficial byproducts that probiotics produce during fermentation. Think of it as a production chain: prebiotics are the fuel, probiotics are the workers, and postbiotics are the valuable products they create. Synbiotic supplements combine all three for comprehensive gut support.
How much butyrate should I take daily?
Most postbiotic supplements provide 150–600 mg of butyrate (as tributyrin or sodium butyrate) per daily serving. There is no established RDA for butyrate supplementation, but clinical studies typically use doses in this range. Start with the manufacturer’s recommended dose and adjust based on your response. Higher doses may be used under healthcare provider guidance for specific gut health conditions.
When is the best time to take postbiotic supplements?
Most postbiotic supplements can be taken with or without food, though taking them with a meal may improve tolerance and absorption. Synbiotic formulas that include probiotics are often best taken with meals. For pure butyrate supplements, timing is less critical since butyrate doesn’t require food for absorption. Consistency matters more than precise timing.
Are there any side effects of postbiotic supplements?
Postbiotic supplements are generally well-tolerated. Some users may experience mild gas, bloating, or changes in bowel habits during the first 1–2 weeks as the gut adjusts. These effects typically resolve with continued use. Butyrate supplements may have a noticeable odor due to the nature of the compound, but this doesn’t indicate a quality issue. Users with serious gut conditions should consult a healthcare provider before starting postbiotic supplementation.
How long does it take for postbiotics to work?
Some users notice improvements in bloating, gas, and digestive comfort within 1–2 weeks of consistent postbiotic supplementation. Deeper benefits like improved gut barrier function and immune support may take 4–8 weeks to become noticeable. Synbiotic formulas that include probiotics may take slightly longer as the probiotic colonies establish themselves in the gut. Consistent daily use is important for optimal results.
