Best Lithium Orotate Supplements (2026)

Lithium orotate is a low-dose, over-the-counter form of lithium used as a dietary supplement for mood support, cognitive health, and sleep quality. Unlike prescription lithium carbonate (used at much higher doses for bipolar disorder), lithium orotate delivers trace amounts of elemental lithium bound to orotic acid for improved bioavailability. Research suggests that even small amounts of dietary lithium may support emotional balance, brain health, and neuroprotection. These supplements typically provide 1-20mg of lithium orotate per serving, a fraction of prescription doses.

Quick Comparison

Product	Dosage	Form	Best For	Rating
13-in-1 Lithium Orotate 10mg	10mg + Ashwagandha + L-Theanine	Capsules	Best Overall	9.4/10
Double Wood Lithium Orotate	5mg per capsule	Capsules	Best Pure Formula	9.3/10
KAL Lithium Orotate	5mg per VegCap	VegCaps	Best Value	9.1/10
Vital Nutrients Lithium Orotate	5mg + NAC	Capsules	Best Premium	9.0/10
Life Extension Lithium	1000mcg (1mg)	Capsules	Best Microdose	8.9/10
Global Healing Lithium Orotate	10mg per capsule	Capsules	Best High Dose	8.8/10
Swanson Lithium Orotate	5mg elemental	VegCaps	Best Budget Pick	8.7/10

1. 13-in-1 Lithium Orotate 10mg – Best Overall

This comprehensive formula combines 10mg of lithium orotate with 300mg ashwagandha and 100mg L-theanine in a 13-in-1 blend designed for mood, calm, and cognitive support.

Rather than delivering lithium orotate alone, this supplement pairs it with well-researched calming ingredients. Ashwagandha (an adaptogen clinically shown to reduce cortisol and support stress resilience) and L-theanine (an amino acid from green tea that promotes relaxation without drowsiness) work synergistically with lithium orotate to address mood balance from multiple pathways. The comprehensive formula makes it a one-capsule solution for calm, focus, and emotional wellbeing.

• Pros:
• Multi-ingredient approach with ashwagandha and L-theanine
• 10mg lithium orotate — effective moderate dose
• Addresses mood, stress, and calm in one supplement

• Cons:
• Not a pure lithium orotate product
• Combined formula makes individual dose adjustment difficult

Best for: Users seeking a comprehensive mood and calm supplement with lithium orotate as a key ingredient

2. Double Wood Lithium Orotate – Best Pure Formula

Double Wood offers a clean, straightforward 5mg lithium orotate supplement backed by third-party testing and a massive 210-capsule bottle lasting over seven months.

Each capsule delivers exactly 5mg of lithium orotate in a minimal-ingredient formula (lithium orotate, vegetarian capsule, and rice flour). Double Wood manufactures and tests this product in the USA, screening for microbes and heavy metals. The vegan-safe, Non-GMO, gluten-free formula represents one of the best-selling lithium orotate supplements on the market. The 210-capsule count provides exceptional long-term value.

• Pros:
• 210 capsules — 7-month supply
• Third-party tested for purity and heavy metals
• Clean formula with minimal ingredients

• Cons:
• Only available in 5mg dose — need multiple capsules for higher doses
• Rice flour used as filler

Best for: Anyone wanting a pure, well-tested lithium orotate supplement with outstanding long-term value

3. KAL Lithium Orotate 5mg – Best Value

KAL delivers a high-quality 5mg lithium orotate supplement in vegetarian capsules with a base of organic rice extract blend, backed by a 60-day money-back guarantee.

Each VegCap provides 5mg of lithium from both orotate and carbonate forms, combining two lithium sources for a balanced delivery. KAL manufactures this product in their GMP-certified facility in Utah and tests for purity and potency. The 180-capsule bottle provides a full six-month supply. The organic rice extract blend base provides a clean carrier for the active ingredient. KAL stands behind this product with their standard 60-day money-back guarantee.

• Pros:
• 180 capsules for 6-month supply
• Vegan capsules with organic rice extract base
• 60-day money-back guarantee

• Cons:
• Combines orotate with carbonate forms — not pure orotate
• Silica used as additional ingredient

Best for: Value-conscious buyers who want a large supply of quality lithium orotate from a trusted brand

4. Vital Nutrients Lithium Orotate 5mg – Best Premium

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Vital Nutrients pairs 5mg of lithium orotate with N-acetyl-L-cysteine (NAC) for combined brain support, mood balance, and antioxidant protection.

This professional-grade supplement is designed by practitioners and available through healthcare providers. The addition of NAC provides glutathione precursor support, complementing lithium orotate’s neuroprotective properties. The organic bioavailable lithium salt bound to orotic acid supports the phosphoinositol pathway, which plays a role in mood regulation and neuronal signaling. Vital Nutrients maintains strict quality controls including independent third-party testing of every ingredient and finished product. The formula is gluten-free, dairy-free, and soy-free.

• Pros:
• Includes NAC for enhanced brain and antioxidant support
• Practitioner-grade quality with rigorous testing
• Gluten-free, dairy-free, soy-free

• Cons:
• Higher price point than standard supplements
• 90 capsules — smaller count than budget options

Best for: Health professionals and their patients seeking a premium lithium orotate with complementary brain support

5. Life Extension Lithium 1000mcg – Best Microdose

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Life Extension offers the gentlest approach to lithium supplementation with just 1000mcg (1mg) of lithium orotate per capsule, ideal for sensitive individuals or those new to lithium.

This microdose formula provides a fraction of what most lithium orotate supplements deliver, making it an excellent entry point for cautious users. Life Extension is one of the most respected longevity-focused supplement brands, known for evidence-based formulations and rigorous quality testing. The 100-capsule bottle provides over three months of daily use. The low dose is designed to gently support cognitive function and memory without the intensity of higher-dose products.

• Pros:
• Ultra-low 1mg dose for sensitive users
• Trusted Life Extension brand quality
• Non-GMO, gluten-free, vegetarian

• Cons:
• Very low dose may be insufficient for some users
• Only 100 capsules per bottle

Best for: Users new to lithium supplementation or those who prefer ultra-conservative dosing

6. Global Healing Lithium Orotate 10mg – Best High Dose

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Global Healing provides a potent 10mg lithium orotate formula for users seeking a higher dose for more intensive mood, focus, and cognitive clarity support.

Each capsule delivers 10mg of lithium orotate — double the standard 5mg dose — for those who benefit from a stronger supplementation approach. The product is vegan-friendly, Non-GMO, gluten-free, and formulated for superior absorption. Global Healing emphasizes clean, plant-based formulations across their product line. The 60-capsule bottle provides a 2-month supply at one capsule daily.

• Pros:
• Higher 10mg dose in a single capsule
• Vegan, Non-GMO, gluten-free
• Formulated for enhanced absorption

• Cons:
• Higher dose may not be appropriate for all users
• Only 60 capsules per bottle

Best for: Experienced users who have established their tolerance and benefit from a 10mg daily dose

7. Swanson Lithium Orotate 5mg – Best Budget Pick

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Swanson brings their hallmark value pricing to lithium orotate with 60 veggie capsules delivering 5mg of elemental lithium per serving at one of the lowest prices in the category.

Each vegetarian capsule provides 5mg of elemental lithium from lithium orotate. Swanson has been a trusted name in supplements since 1969, manufacturing products in their own GMP-compliant facilities with rigorous purity and potency testing. The 60-capsule bottle provides a two-month supply. While the capsule count is lower than some competitors, the per-bottle price makes it an excellent option for first-time buyers exploring lithium orotate.

• Pros:
• One of the lowest-priced lithium orotate options
• Trusted Swanson quality since 1969
• Vegetarian capsules

• Cons:
• Only 60 capsules per bottle
• Less feature-rich than premium options

Best for: First-time lithium orotate users or budget-conscious buyers who want a trusted brand at a low entry price

8. Elite Life Nutrition Lithium Orotate 5mg – Best Clean Formula

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Elite Life Nutrition differentiates their lithium orotate by stripping out all unnecessary fillers, additives, and heavy metals for one of the purest formulas available.

Each bioavailable capsule contains 5mg of pure lithium orotate with a minimal “Other Ingredients” list that the brand challenges consumers to compare against any competitor. The 120-capsule bottle provides a four-month supply. All Elite Life Nutrition products are manufactured in the USA in a GMP-certified facility and third-party tested for purity and quality. The brand emphasizes premium sourcing and transparency.

• Pros:
• Ultra-clean formula with minimal fillers
• 120 capsules for 4-month supply
• GMP-certified, third-party tested

• Cons:
• Smaller brand with less market presence
• Premium pricing for the clean-formula positioning

Best for: Purity-focused users who want the cleanest possible lithium orotate with no unnecessary additives

How to Choose the Best Lithium Orotate Supplement

Dosage is the primary consideration when selecting a lithium orotate supplement. Products range from ultra-low 1mg (1000mcg) microdoses to 20mg per serving. Most popular products deliver 5mg per capsule, which is the most widely used over-the-counter dose. Start low — especially if you are new to lithium supplementation — and increase gradually only if needed. Read labels carefully, as some products list the total lithium orotate compound weight while others specify the elemental lithium content, which is only about 4% of the orotate compound weight.

Pure lithium orotate products offer the most straightforward supplementation and allow easy dose adjustments. Combination formulas that include ingredients like ashwagandha, L-theanine, or NAC can provide synergistic mood and brain support but limit your ability to adjust individual ingredient amounts. Choose based on whether you prefer simplicity and flexibility or a comprehensive single-product approach.

Quality testing is especially important for lithium supplements. Look for brands that conduct third-party testing for heavy metals, contaminants, and accurate lithium content. GMP certification, Non-GMO verification, and vegetarian capsule options are additional quality markers. Reputable brands like Double Wood, KAL, Vital Nutrients, Life Extension, and Swanson maintain high manufacturing standards.

Lithium orotate is most commonly taken once daily, often in the evening, as some users find it promotes relaxation and improved sleep. Taking it on an empty stomach may improve absorption. Consistency is important — lithium’s mood-supporting benefits develop gradually over days to weeks of regular use.

Frequently Asked Questions

What is lithium orotate and how is it different from prescription lithium?

Lithium orotate is an over-the-counter dietary supplement that delivers trace amounts of the mineral lithium bound to orotic acid. Prescription lithium (typically lithium carbonate or lithium citrate) is used at much higher doses (300-1,800mg daily) to treat bipolar disorder and requires blood monitoring. Lithium orotate supplements provide dramatically lower doses (typically 1-20mg) and are used for general mood support, cognitive health, and sleep quality. The orotate form is believed to be more bioavailable than carbonate, meaning less is needed for dietary supplementation purposes.

How much lithium orotate should I take daily?

Most over-the-counter lithium orotate supplements recommend 5mg per day as a starting dose, which is the most commonly used amount. Some users take 10-20mg daily based on individual needs. Microdose options at 1mg are available for those who prefer a more conservative approach. Do not exceed the manufacturer’s recommended dose, and consult a healthcare provider before starting lithium supplementation — especially if you take medications, have kidney or thyroid conditions, or are pregnant or breastfeeding.

When is the best time to take lithium orotate?

Many users find taking lithium orotate in the evening or before bedtime most beneficial, as it may promote calmness and improved sleep quality. Some people take it on an empty stomach for optimal absorption. However, if you experience stomach sensitivity, taking it with a light meal is fine. The key is consistency — taking it at the same time each day helps maintain steady levels and maximizes the cumulative mood-supporting benefits.

Are there any side effects of lithium orotate?

At standard over-the-counter doses (1-20mg), lithium orotate is generally well tolerated. Some people report mild side effects including slight nausea, increased thirst, or mild drowsiness when starting. Lithium interacts with thyroid function and kidney health, so individuals with thyroid disorders or kidney disease should consult a healthcare provider before use. Lithium can also interact with certain medications including NSAIDs, diuretics, and ACE inhibitors. Long-term use at any dose warrants periodic checkups.

Can lithium orotate help with anxiety and sleep?

Many users report that low-dose lithium orotate helps reduce anxiety and improve sleep quality, though large-scale clinical evidence specifically for these applications is still developing. The mineral lithium plays a role in regulating neurotransmitter systems including serotonin and glutamate, both of which influence mood, anxiety, and sleep. Observational studies have linked higher lithium levels in drinking water with improved mood and emotional stability in populations. Taking lithium orotate before bed may help calm an overactive mind for better rest.

How long does it take for lithium orotate to work?

Some users notice subtle improvements in mood stability and sleep quality within the first few days of taking lithium orotate. However, the most meaningful benefits typically develop over 2-4 weeks of consistent daily use. Cognitive benefits and emotional resilience tend to build gradually, with many users reporting the most significant improvements after one to two months. As with most nutritional supplements, individual responses vary based on factors including diet, stress levels, and overall health.