Best Supplements for Hormonal Acne (2026)
Hormonal acne typically appears along the jawline, chin, and lower cheeks, often flaring before or during menstrual cycles. The most effective supplements for hormonal acne target estrogen metabolism, progesterone balance, and insulin sensitivity using ingredients like DIM, vitex chasteberry, myo-inositol, and zinc.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Zazzee DIM 300 mg | DIM + BioPerine | Capsules | Best Overall | 9.5/10 |
| Myo-Inositol & D-Chiro Inositol | Inositol Blend | Capsules | Best for PCOS-Related Acne | 9.4/10 |
| Vitex Chasteberry 600mg | Vitex Agnus-Castus | Capsules | Best Herbal | 9.2/10 |
| SMNutrition Clear Skin Supplement | Zinc, DIM & Probiotics | Capsules | Best Multi-Action | 9.1/10 |
| DIM Supplement 200 mg | DIM | Capsules | Best Value | 9.0/10 |
| CLEARSTEM MINDBODYSKIN | DIM, B5, Glutathione | Capsules | Best Premium | 8.9/10 |
| DIM Gummies 200 mg | DIM | Gummies | Best Gummies | 8.7/10 |
1. Zazzee DIM 300 mg – Best Overall
- 300 MG DIM PER CAPSULE! Our DIM 300 contains 300 mg of DIM per capsule AND 10 mg of BioPerine per capsule, making it the best value on the market. In addition, each capsule is enhanced with 100 mg of Pure Organic Broccoli, a natural source of DIM that enhances efficacy and absorption. Zazzee DIM 300 is both a great value and a very effective DIM solution!
- 10 MG BIOPERINE PER CAPSULE: Our DIM 300 has been enhanced with 10 mg of BioPerine, an all-natural absorption-enhacing extract derived from black pepper. Numerous studies have shown that the addition of BioPerine increase the body's absorption of other ingredients - including DIM- by 30% or more!
- OUTSTANDING VALUE / 3+ MONTH SUPPLY: Our DIM 300 requires only 1 capsule per serving and contains 300 mg per capsule – an amazing value! A single bottle contains a 3+ month supply. Compare this to other leading brands that require 2 capsules per serving, contain far less than a 100 day supply, and do not provide a 300 mg strength dosage. Our DIM 300 is a bargain not be found elsewhere!
- NATURAL, VEGAN & NON-GMO: All ingredients, including the capsule, are 100% vegan. Our Extra Strength DIM 300 does not contain any sweeteners, artificial flavors, wheat, corn, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Enjoy the amazing benefits of our potent DIM 300 without worrying about what else might be hiding in each capsule!
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our DIM 300 is manufactured in the USA, in a fully compliant facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
Zazzee’s 300 mg DIM with BioPerine is the gold standard for hormonal acne supplementation, delivering the highest clinically relevant dose with enhanced absorption.
Diindolylmethane (DIM) promotes healthy estrogen metabolism by shifting the balance toward less potent estrogen metabolites, directly addressing one of the primary drivers of hormonal acne. At 300 mg per capsule with 10 mg BioPerine for bioavailability, this is one of the most potent DIM supplements available. The 100-count bottle provides over three months of daily supplementation. Vegan, non-GMO, and manufactured in a GMP-certified facility with third-party testing.
- Pros:
- Highest DIM potency at 300 mg per capsule
- BioPerine enhances absorption significantly
- Exceptional 100-count value with third-party testing
- Cons:
- DIM only — no additional skin-supporting nutrients
- May cause temporary hormonal adjustment symptoms in first 1-2 weeks
Best for: Women with confirmed hormonal acne who want maximum DIM potency for estrogen balance
2. Myo-Inositol & D-Chiro Inositol – Best for PCOS-Related Acne
- Many Names Same Great Product - Inositol can go by names like myoinositol vitamin B8 or myo inositol, our product contains 2 forms of this specialized ingredient for health benefits
- Fertility Supplement for Women - Not all female fertility supplements can help achieve hormonal balance for women but this unique blend may help with fertility health and promote cycle balance
- Cycle Support - Anyone looking for a healthy cycle can benefit from our inositol and choline supplement that can also promote healthy and normal ovulation and even help assist in monthly mood support
- Clean Formula - Get the great benefits without the not so great additives with our potent vegan myo and D-chiro inositol and choline supplement made in the USA with globally sourced ingredients
- Natures Craft Quality - We are proud to be a leading name in female hormone balance supplements and prenatal vitamins for women because we believe in family values and want your family to grow
This inositol blend addresses insulin resistance and hormonal imbalance — two key drivers of PCOS-related hormonal acne — with clinically studied ratios.
The supplement combines myo-inositol and D-chiro inositol in the optimal 40:1 ratio recommended by research, along with choline for additional metabolic support. Insulin resistance drives androgen excess, which directly causes hormonal acne in many women with PCOS. By improving insulin sensitivity, inositol helps normalize testosterone and DHEA levels that trigger breakouts. This formula supports menstrual regularity, ovulation, and skin clarity simultaneously. Made in a GMP-certified facility.
- Pros:
- Clinically studied 40:1 myo to D-chiro inositol ratio
- Addresses insulin resistance — a root cause of PCOS acne
- Also supports fertility, menstrual regularity, and mood
- Cons:
- Requires 2-4 capsules daily for full dose
- Most effective for PCOS-related hormonal acne specifically
Best for: Women with PCOS or insulin-resistant hormonal acne looking for comprehensive metabolic and skin support
3. Vitex Chasteberry Supplement 600 mg – Best Herbal
- PMS RELIEF (600mg/3-Month Supply): Premenstrual Syndrome (PMS) can make the monthly menstrual cycle frustrating with mood swings, breast tenderness, and cramping. Vitex berry is often used to support menstrual comfort.*
- HORMONE SUPPORT: Vitex provides support for stable hormone levels in the body.* Hormone balance is associated with multiple aspects of a woman’s cycle, including the buildup of the uterine lining and reliable menstruation.
- REGULARITY SUPPORT: Many factors, like age, hormone imbalances, and years of hormone manipulation by birth control can create complications with the monthly period.* Chasteberry balance supplements are a great way to support healthy menstruation and hormone harmony.*
- DYNAMIC MENOPAUSE SUPPORT: Menstruation can become more complicated and irregular starting in the early stages of perimenopause and menopause. Many women entering menopause turn to Vitex to support their monthly cycle's ease and dependability.*
- THE SMNUTRITION DIFFERENCE: Vitex is formulated Gluten-Free, Non-GMO, Vegetarian, PETA.org Certified, Titanium Dioxide-Free, Silicon Dioxide Free, Third-Party Tested by Intertek Laboratories, and formulated without the top 9 allergens. It is manufactured in a facility that is certified GMP compliant with NSF standards.
Vitex (chasteberry) is one of the most clinically researched herbs for female hormonal balance, acting on the pituitary gland to regulate progesterone and reduce cyclical breakouts.
This supplement provides 600 mg of Vitex agnus-castus per serving with BioPerine for enhanced absorption. Vitex works by modulating prolactin secretion and supporting progesterone production, which helps counterbalance estrogen dominance — a common trigger for jawline and chin acne. Clinical studies demonstrate vitex’s effectiveness for PMS symptoms including cyclical acne, breast tenderness, and mood changes. The formula is clean with no unnecessary binders or fillers.
- Pros:
- 600 mg potent dose backed by clinical research
- Targets progesterone deficiency — a major hormonal acne driver
- BioPerine included for enhanced bioavailability
- Cons:
- Best suited for women specifically (not recommended for men)
- Full benefits require 2-3 menstrual cycles of consistent use
Best for: Women who experience acne flare-ups tied to their menstrual cycle, PMS, or luteal phase
4. SMNutrition Clear Skin Supplement – Best Multi-Action
- TRIPLE ACTION FOR SKIN BALANCE, GLOW & HEALTH: This Clear Skin Supplement is strategically formulated to support the 3 factors that influence your skin the most: hormone balance, the gut microbiome, and skin-essential nutrition.*
- FEATURING DIM FOR BALANCE: Clear-3 is formulated with our #1 DIM supplement. DIM, or diindolylmethane, is a well-studied compound renowned for supporting hormone balance, and in turn, promoting balanced and healthy skin.*
- WITH PROBIOTICS FOR GUT SUPPORT: Your gut microbiome is absolutely foundational to glowing, radiant skin. That’s why Clear-3 includes 18 billion CFU of Lactobacillus and Bifidobacterium probiotic strains, to support overall gut health and skin complexion.*
- CLEAR SKIN VITAMINS WITH ZINC: Zinc is crucial in our formula, along with essential nutrients for clear, glowing, and healthy skin. Each serving supports hydration, collagen production, sebum control, and barrier function, with Hyaluronic Acid, Niacinamide, Selenium, Vitamin B6, and more.*
- UNCOMPROMISING QUALITY: Clear-3 skin supplements for men and women by SMNutrition are manufactured in a facility that adheres to cGMP guidelines. They are Third-Party Tested, and every bottle contains 180 clear skin pills (a 90-day supply).
A triple-action formula combining zinc, DIM, and probiotics to address hormonal balance, gut health, and nutrient-based skin support in a single supplement.
This all-in-one approach targets the three primary pathways that drive hormonal acne: estrogen metabolism (via DIM), gut-skin axis health (via 18 billion CFU probiotics), and mineral-based skin support (via zinc). The formula also includes hyaluronic acid and niacinamide for hydration and pore refinement. Each bottle contains 60 capsules for a one-month supply. Manufactured in the USA under GMP standards with clean, non-GMO ingredients.
- Pros:
- Addresses hormones, gut health, and skin nutrition simultaneously
- Probiotics support the gut-skin axis connection
- Niacinamide helps fade post-acne dark spots
- Cons:
- Multi-ingredient formula means moderate individual doses
- Capsules may be large for some users
Best for: Those who want comprehensive hormonal acne support without taking multiple separate supplements
5. DIM Supplement 200 mg – Best Value
No products found.
A budget-friendly DIM option at 200 mg per capsule that provides effective hormonal acne support at a fraction of premium prices.
This straightforward DIM supplement provides 200 mg of diindolylmethane per capsule for estrogen balance support. Designed for both men and women dealing with hormone-related skin issues, the clean formula avoids artificial fillers and unnecessary additives. Each bottle provides a two-month supply at the standard one-capsule daily dose, making it one of the best values in the DIM category.
- Pros:
- Affordable entry point for DIM supplementation
- Two-month supply per bottle
- Suitable for both men and women
- Cons:
- No BioPerine or absorption enhancers
- Lower dose may require pairing with other supplements for severe acne
Best for: First-time DIM users or budget-conscious shoppers wanting to try hormonal acne supplementation
6. CLEARSTEM MINDBODYSKIN – Best Premium
No products found.
Created by The Acne Guru, this specialist-formulated supplement combines DIM, vitamin B5, glutathione, turmeric, and 5-HTP to target hormonal acne from multiple angles.
MINDBODYSKIN stands apart by addressing the stress-hormone connection that many hormonal acne supplements ignore. 5-HTP helps modulate cortisol and serotonin, both of which influence breakouts. DIM handles estrogen metabolism, glutathione works as a master antioxidant to brighten skin and fade post-acne marks, and turmeric provides anti-inflammatory support. The 90-capsule bottle provides 30 servings at the full 3-capsule daily dose. Backed by a 24-week clinical study showing significant acne reduction.
- Pros:
- Specialist-formulated with clinical study backing
- Unique stress-hormone approach with 5-HTP
- Glutathione helps brighten skin and fade dark spots
- Cons:
- Premium price point (~$58 per bottle)
- 5-HTP contraindicated with SSRI medications
Best for: Adults with stubborn hormonal acne who want a specialist-grade, multi-pathway supplement
7. DIM Gummies 200 mg – Best Gummies
No products found.
These DIM gummies offer 200 mg of hormonal support in a pleasant-tasting, chewable format for those who prefer alternatives to capsules.
Delivering 200 mg of DIM per serving in a flavored gummy form, this product makes hormonal acne supplementation enjoyable and easy to maintain. The pectin-based formula is vegetarian-friendly, and the gummies target hormonal acne, PMS, menopause symptoms, and general estrogen balance. Each bottle provides a one-month supply, and the gummy format tends to improve supplement compliance for those who struggle with pill fatigue.
- Pros:
- Enjoyable gummy format improves daily compliance
- 200 mg DIM per serving for hormonal support
- Vegetarian-friendly pectin base
- Cons:
- Added sugars inherent to gummy format
- Lower potency compared to high-dose capsule options
Best for: Anyone who dislikes swallowing pills but wants daily DIM support for hormonal acne
8. Beam Glow Collagen Powder Bundle – Best Powder
- HORMONE BALANCE FOR WOMEN – Support hormonal harmony with Beam Glow, a daily superpowder made with 18 essential ingredients including chaste tree berry and bromelain. Designed to help regulate hormones, ease PMS symptoms, and promote overall hormonal wellness.*
- HEALTHY SKIN, HAIR & NAILS WITH COLLAGEN PEPTIDES – Beam Collagen Powder is a powerful supplement for skin health, hair growth, and nail strength. Packed with hydrolyzed collagen peptides, it helps improve elasticity and hydration for radiant skin and shiny hair, making it a must-have addition to your beauty routine.
- THYROID SUPPORT FOR WOMEN – Beam Glow includes selenium and vitamin A, two key nutrients shown to support thyroid function and metabolism in women. Add it to your routine to help balance mood, energy, and overall endocrine health.*
- SUPPORT JOINT & BONE HEALTH – Designed for both women and men, this grass-fed collagen supplement promotes joint health, supports bone density, and reduces joint pain and discomfort. It's an ideal choice for active individuals seeking to improve flexibility and mobility with a clean, gluten-free formula.
- NATURAL ENERGY & HYDRATION – Formulated with electrolytes and adaptogens, Glow delivers steady, caffeine-free energy while supporting daily hydration. It’s a clean, refreshing way to power through your day—without crashes or stimulants.*
This comprehensive women’s powder combines collagen, inositol, and ashwagandha for a multi-benefit approach to hormonal balance and skin health.
Beam Glow goes beyond typical acne supplements by combining collagen peptides for skin structure with inositol for hormonal balance and ashwagandha for stress-related hormone management. The powder format allows for customizable dosing and easy mixing into smoothies or beverages. This is ideal for women who want to support both skin appearance and hormonal acne from the inside out. The powder format also avoids the pill fatigue that comes with multi-capsule regimens.
- Pros:
- Combines collagen, inositol, and adaptogenic herbs
- Powder format is easy to mix and customize
- Addresses skin structure and hormonal balance together
- Cons:
- Must be mixed into a beverage (not as convenient as capsules)
- Collagen benefit is more long-term for skin texture than acute acne
Best for: Women who want a comprehensive skin and hormone support powder they can add to daily smoothies
9. Nutriissa ACNEtane – Best High-Potency B5
No products found.
ACNEtane delivers a high-potency pantothenic acid (B5) and L-carnitine formula specifically designed to regulate oil production and reduce hormonal cystic acne.
Pantothenic acid at high doses has been studied for its ability to reduce sebum secretion, which directly contributes to clogged pores and hormonal breakouts. ACNEtane combines B5 with L-carnitine for enhanced lipid metabolism in the skin. The formula is EPEB-certified for purity and potency, providing 120 vegan capsules per bottle. This is a targeted choice for those whose hormonal acne is characterized by excessive oiliness and cystic lesions.
- Pros:
- High-potency B5 specifically targets oil overproduction
- L-carnitine enhances skin lipid metabolism
- EPEB certified for purity and 120-count bottle
- Cons:
- Focused on oil control — may need to pair with DIM for full hormonal support
- Higher daily capsule count required
Best for: Those with oily, cystic hormonal acne who want targeted sebum-reduction support
How to Choose the Best Supplement for Hormonal Acne
Identifying your specific type of hormonal acne is the most important step. Cyclical acne that flares before or during your period points to estrogen dominance or progesterone deficiency — DIM and vitex are the most effective supplements here. Acne linked to PCOS or irregular periods often involves insulin resistance, making myo-inositol the best starting point. Acne paired with excessive oiliness benefits most from pantothenic acid (B5) and zinc.
Look for DIM supplements in the 100-300 mg range with BioPerine or black pepper extract for absorption. Vitex chasteberry works best at 400-600 mg daily and requires 2-3 menstrual cycles for full effect. Myo-inositol is typically dosed at 2,000-4,000 mg daily in the research-backed 40:1 ratio with D-chiro inositol.
Multi-ingredient formulas offer convenience but typically contain lower individual doses. If your hormonal acne is moderate to severe, a targeted single-ingredient supplement (like standalone DIM or vitex) often provides more potent results than an all-in-one formula. You can always stack complementary supplements — for example, DIM for estrogen metabolism plus a probiotic for gut-skin axis support.
Consistency is critical with hormonal acne supplements. Unlike topical treatments that show results in days, hormonal supplements work by gradually shifting metabolic and endocrine pathways. Give any supplement at least 8-12 weeks before evaluating its effectiveness. Quality markers include GMP certification, third-party testing, non-GMO ingredients, and transparent labeling of active ingredient doses.
Frequently Asked Questions
What is the best supplement for hormonal acne?
DIM (diindolylmethane) is widely considered the most effective supplement for hormonal acne. It promotes healthy estrogen metabolism, shifting the balance toward less potent estrogen metabolites that are less likely to trigger breakouts. For women with PCOS-related acne, myo-inositol is equally effective because it addresses insulin resistance, a root driver of androgen excess.
How does DIM help with hormonal acne?
DIM is a natural compound found in cruciferous vegetables like broccoli and kale. It supports Phase I and Phase II estrogen detoxification in the liver, promoting the formation of “good” estrogen metabolites (2-hydroxyestrone) over “bad” ones (16α-hydroxyestrone). This rebalancing reduces estrogen-driven sebum production and inflammation that trigger hormonal breakouts.
How long does it take for hormonal acne supplements to work?
Hormonal acne supplements typically require 8-12 weeks (2-3 menstrual cycles) of consistent use for noticeable results. DIM may show initial improvements within 4-6 weeks. Vitex chasteberry often takes the longest, with full effects apparent after 3 complete menstrual cycles. Inositol for PCOS-related acne may show improvements in 6-8 weeks.
Can men take hormonal acne supplements?
Yes, DIM is effective for both men and women. In men, DIM supports balanced estrogen metabolism and can help reduce estrogen-related skin issues. However, vitex chasteberry is primarily researched for women and is not recommended for men. Zinc, B5, and probiotics are universally effective for acne regardless of gender.
Should I take DIM or vitex for hormonal acne?
DIM is generally the better first choice because it directly supports estrogen metabolism, which is the primary hormonal driver of acne. Vitex is more appropriate if your acne is tied to progesterone deficiency, irregular periods, or specific PMS symptoms. Some women benefit from taking both, but it is best to introduce one at a time to assess individual response.
Are there any side effects of hormonal acne supplements?
DIM may cause temporary changes in menstrual cycle timing, darker urine (harmless), or mild digestive discomfort during the first 1-2 weeks. Vitex can occasionally cause headaches, nausea, or menstrual irregularity as the body adjusts. Inositol is one of the best-tolerated supplements with very few reported side effects. Taking supplements with food and starting at lower doses helps minimize any initial adjustment symptoms.
