Best Supplements for Neuropathy (2026)

Peripheral neuropathy causes tingling, numbness, burning pain, and weakness in the hands and feet due to nerve damage. Research supports several supplements — particularly alpha-lipoic acid, B vitamins, and acetyl-L-carnitine — for supporting nerve health, reducing neuropathic pain, and promoting nerve regeneration. Here are the best supplements backed by clinical evidence for neuropathy support.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Pink Stork Vitamin B12 Liquid	Methylcobalamin B12 5000mcg	Liquid Drops	Best Overall	9.5/10
Advanced Bionutritionals Nerve Support	Benfotiamine, ALA, B12, Acetyl-L-Carnitine	Capsules	Best Comprehensive Formula	9.4/10
L-Methyl Folate 15mg + Methyl B12	L-Methylfolate + Methylcobalamin	Liquid	Best for B-Vitamin Nerve Support	9.2/10
Advanced Nerve Support Formula	R-ALA, Benfotiamine, B12, Acetyl-L-Carnitine	Capsules	Best Premium Nerve Formula	9.1/10
Vitamin B12 Gummies 1000mcg	Vitamin B12	Gummies	Best B12 Gummies	9.0/10
NerveReverse Neuropathy Formula	ALA 600mg, Benfotiamine, B12, D3	Capsules	Best ALA-Based Formula	9.0/10
Nutricost Alpha Lipoic Acid 600mg	Alpha-Lipoic Acid 600mg	Capsules	Best Standalone ALA	8.9/10

1. Pink Stork Vitamin B12 Liquid Drops – Best Overall

Pink Stork delivers 5000mcg of methylcobalamin — the most bioavailable and nerve-active form of B12 — in fast-absorbing liquid drops that bypass digestive absorption issues common in neuropathy patients.

B12 deficiency is a direct cause of peripheral neuropathy, and even patients with normal blood B12 levels may have extremely low B12 levels in their spinal fluid. Methylcobalamin is the preferred form for nerve health because it directly participates in myelin synthesis — the protective sheath surrounding nerve fibers. The liquid sublingual delivery allows B12 to absorb directly through the mouth’s mucous membranes, which is critical for people with gut absorption problems. The vegan formula contains no artificial ingredients and delivers a therapeutic 5000mcg dose per serving.

• Pros:
• Methylcobalamin form specifically supports nerve myelin production
• Liquid sublingual delivery bypasses digestive absorption barriers
• High therapeutic dose of 5000mcg per serving

• Cons:
• B12 alone may not be sufficient for advanced neuropathy
• Liquid form requires refrigeration for optimal potency

Best for: Anyone with neuropathy symptoms who wants the most absorbable form of the most critical B vitamin for nerve health. For more B12 options, see our guide to methyl B12 supplements.

2. Advanced Bionutritionals Nerve Support – Best Comprehensive Formula

No products found.

This dedicated nerve support formula combines the four most clinically studied ingredients for neuropathy — benfotiamine, alpha-lipoic acid, methylcobalamin B12, and acetyl-L-carnitine — in therapeutic doses.

Each ingredient targets a different mechanism of nerve damage: benfotiamine (a fat-soluble form of vitamin B1) protects nerves from glucose-related damage, alpha-lipoic acid acts as a powerful antioxidant that improves nerve blood flow, methylcobalamin supports myelin sheath repair, and acetyl-L-carnitine helps generate new nerve cells and reduces pain. The multi-pathway approach addresses neuropathy more comprehensively than any single ingredient can. Manufactured in a GMP-certified facility with high-quality, bioavailable ingredient forms throughout.

• Pros:
• Four clinically studied neuropathy ingredients in one formula
• Uses bioavailable forms: benfotiamine, methylcobalamin, R-ALA
• Multi-pathway approach targeting different mechanisms of nerve damage

• Cons:
• Premium price point
• Requires multiple capsules per day

Best for: People with moderate to advanced neuropathy who want the most comprehensive single-product approach

3. L-Methyl Folate 15mg + Methyl B12 – Best for B-Vitamin Nerve Support

This high-potency liquid combines L-methylfolate and methylcobalamin B12 — two methylated B vitamins essential for nerve repair and regeneration.

Folate and B12 work synergistically in nerve health. Methylfolate supports DNA synthesis required for nerve cell repair, while methylcobalamin directly participates in myelin production. The methylated forms are critical because up to 40% of the population has MTHFR gene variants that impair conversion of standard folic acid and cyanocobalamin. The 15mg L-methylfolate dose is a high-potency therapeutic amount. The liquid format with organic berry flavor ensures rapid absorption. This combination is particularly beneficial for people with neuropathy related to B-vitamin deficiency or MTHFR mutations.

• Pros:
• Methylated forms bypass MTHFR conversion issues
• High-potency 15mg methylfolate dose
• Liquid format for enhanced absorption

• Cons:
• High folate doses should be monitored by a healthcare provider
• Primarily addresses B-vitamin pathways — doesn’t include ALA or other nerve-specific nutrients

Best for: People with B-vitamin deficiency-related neuropathy or known MTHFR gene variants

4. Advanced Nerve Support Formula – Best Premium Nerve Formula

This premium formula uses R-alpha lipoic acid (the more bioactive form), benfotiamine, methylcobalamin, acetyl-L-carnitine, turmeric, and vitamin D3 for maximum nerve support.

The use of R-alpha lipoic acid rather than standard ALA is a significant advantage — R-ALA is the naturally occurring form and is substantially more bioactive. The formula includes a comprehensive B-vitamin complex with benfotiamine (B1), riboflavin (B2), P5P (active B6), folate, and methylcobalamin (B12), plus vitamin K2 and D3 for additional nerve and immune support. Acetyl-L-carnitine and turmeric curcumin round out the anti-inflammatory and neuroprotective benefits. The 4-capsule daily serving delivers clinical doses across all ingredients.

• Pros:
• Uses R-alpha lipoic acid — the most bioactive form of ALA
• Comprehensive formula with 10+ nerve-supporting ingredients
• Includes turmeric for anti-inflammatory support

• Cons:
• Requires 4 capsules daily
• Higher cost due to premium ingredient forms

Best for: People who want the most comprehensive, premium-ingredient nerve support formula available

5. Vitamin B12 Gummies 1000mcg – Best B12 Gummies

These sugar-free B12 gummies provide 1000mcg of vitamin B12 in a convenient chewable format, ideal for daily nerve maintenance and people who dislike swallowing pills.

A B12 deficiency is one of the most common and treatable causes of peripheral neuropathy, and maintaining adequate B12 levels is essential for ongoing nerve health. These gummies deliver a solid 1000mcg maintenance dose without added sugar, making them suitable for daily use. The chewable format allows some sublingual absorption through the mouth’s mucous membranes, enhancing bioavailability. For people with mild neuropathy symptoms or those looking to prevent B12 deficiency-related nerve issues, this is a pleasant, easy-to-maintain daily supplement.

• Pros:
• Sugar-free formula with no unnecessary additives
• Easy, pleasant gummy format encourages daily compliance
• Good maintenance dose at 1000mcg

• Cons:
• 1000mcg may not be sufficient for severe B12 deficiency
• Gummies generally have lower bioavailability than sublingual liquid

Best for: Daily B12 maintenance for mild neuropathy or neuropathy prevention

6. NerveReverse Neuropathy Formula – Best ALA-Based Formula

NerveReverse centers its formula on 600mg of alpha-lipoic acid — the clinically studied dose shown to improve nerve function and reduce neuropathic pain — alongside benfotiamine, B12, folate, and vitamin D3.

Alpha-lipoic acid at 600mg daily is the most evidence-backed supplement dosage for diabetic neuropathy, with multiple clinical trials showing improvements in nerve conduction, reduced burning and tingling, and improved nerve function scores. The addition of benfotiamine (fat-soluble B1) specifically addresses glucose-related nerve damage, while methylcobalamin B12, L-methylfolate, active B6, and vitamin D3 provide comprehensive nutritional support for nerve repair. The vegan, 60-capsule bottle provides a one-month supply at the recommended 2-capsule daily dose.

• Pros:
• Clinical 600mg ALA dose — the most studied amount for neuropathy
• Combines ALA with benfotiamine for dual neuroprotection
• Includes methylated B vitamins for optimal bioavailability

• Cons:
• ALA may lower blood sugar — diabetics should monitor glucose levels
• 60 capsules per bottle means monthly repurchases

Best for: People with diabetic neuropathy or anyone wanting the clinical dose of ALA in a multi-ingredient nerve formula. Those also interested in vitamin D3 supplementation may want to adjust their D3 intake when using this formula.

7. Nutricost Alpha Lipoic Acid 600mg – Best Standalone ALA

No products found.

Nutricost delivers a straightforward 600mg alpha-lipoic acid per serving in clean, no-nonsense capsules at an unbeatable price point.

Alpha-lipoic acid is the single most-studied supplement for neuropathy, with extensive clinical trial data showing benefits for nerve conduction, pain reduction, and improved symptoms in both diabetic and non-diabetic neuropathy. This standalone ALA supplement provides the clinical 600mg dose per 2-capsule serving with 240 capsules per bottle (120 servings). Nutricost uses no artificial sweeteners, flavors, or colors, and the product is third-party tested for purity. At under $0.10 per serving, it’s one of the most cost-effective ways to add ALA to a neuropathy supplement regimen.

• Pros:
• Clinical 600mg dose at an exceptional value
• 240 capsules — 4-month supply
• Third-party tested, gluten-free, non-GMO

• Cons:
• Racemic ALA (mix of R and S forms) — less bioactive than pure R-ALA
• ALA only — no additional nerve-supporting ingredients

Best for: Budget-conscious buyers who want standalone ALA to add to an existing supplement regimen

8. Acetyl-L-Carnitine 500mg – Best for Nerve Regeneration

No products found.

Acetyl-L-carnitine (ALCAR) is an amino acid that supports nerve cell regeneration and has been shown to reduce neuropathic pain through a unique mechanism — supporting the growth of new nerve fibers.

Unlike antioxidant supplements that protect existing nerves, ALCAR actively supports the creation of new nerve cells and may help regenerate damaged nerve fibers. A systematic review of clinical trials found that acetyl-L-carnitine reduced pain and improved nerve fiber regeneration in patients with neuropathy. The acetylated form crosses the blood-brain barrier more readily than standard L-carnitine, providing both peripheral and central nervous system benefits. The typical therapeutic dose is 500mg twice daily (1000mg total). This clean formula provides 500mg per capsule with no artificial additives.

• Pros:
• Unique mechanism — actively supports nerve fiber regeneration
• Crosses the blood-brain barrier for central and peripheral nerve support
• Well-studied with systematic review evidence in neuropathy

• Cons:
• Requires 2 capsules daily for therapeutic dosing
• May take 2-3 months of consistent use before noticeable improvement

Best for: People looking to actively support nerve regeneration and repair alongside antioxidant supplements like ALA. For complementary B12 supplementation, see our dedicated guide.

How to Choose the Best Supplements for Neuropathy

The most effective neuropathy supplement strategy targets multiple mechanisms: antioxidant protection (alpha-lipoic acid), nerve myelin support (B12, benfotiamine), and nerve regeneration (acetyl-L-carnitine). For the strongest evidence-based approach, combine 600mg alpha-lipoic acid with methylcobalamin B12 and benfotiamine. Comprehensive nerve support formulas that include all three pathways offer the most convenience.

B vitamin forms matter significantly for neuropathy. Look for methylcobalamin (not cyanocobalamin) for B12, benfotiamine (not thiamine HCl) for B1, and pyridoxal-5-phosphate (P5P) for B6. These bioavailable forms are more effective and don’t require conversion by the body. Be cautious with vitamin B6 — doses above 200mg daily can actually cause neuropathy, so avoid high-dose B6 supplements.

For diabetic neuropathy specifically, alpha-lipoic acid at 600mg daily has the strongest clinical evidence. It improves nerve conduction, reduces burning and tingling, and may help stabilize blood sugar. Monitor glucose levels when starting ALA, as it can enhance insulin sensitivity.

Choose GMP-certified products with third-party testing from established brands. Neuropathy supplements require consistent, long-term use — most clinical trials run 3-6 months before measuring significant improvements. Budget for ongoing supplementation and start with one or two key supplements before adding more.

Frequently Asked Questions

What is the best supplement for neuropathy?

Alpha-lipoic acid (600mg daily) has the most clinical evidence for neuropathy, particularly diabetic neuropathy. Methylcobalamin B12 is essential if deficiency is a contributing factor. For the most comprehensive approach, combine ALA with benfotiamine, methylcobalamin, and acetyl-L-carnitine, which target different mechanisms of nerve damage and repair.

How much alpha-lipoic acid should I take for neuropathy?

The clinically studied dose is 600mg per day, taken in one or two doses. Doses up to 1200mg daily have been used in some studies, but 600mg provides the best balance of effectiveness and tolerability. Take ALA on an empty stomach for best absorption, about 30 minutes before meals.

Can supplements reverse neuropathy?

Supplements can slow progression, reduce symptoms, and in some cases support nerve regeneration, particularly if the neuropathy is caused by a nutrient deficiency (such as B12). Acetyl-L-carnitine has shown the most promise for actual nerve fiber regeneration. Results depend on the cause and severity of neuropathy, how early supplementation begins, and whether underlying causes are addressed.

Are there any side effects of neuropathy supplements?

Alpha-lipoic acid may lower blood sugar, so diabetics should monitor glucose levels. High-dose B6 (above 200mg) can worsen neuropathy. 5-HTP and acetyl-L-carnitine may cause mild nausea. Benfotiamine and methylcobalamin are generally well tolerated. Always start with lower doses and increase gradually.

How long does it take for neuropathy supplements to work?

Most people notice initial improvements within 2-4 weeks for B12 supplementation (if deficient) and 4-8 weeks for alpha-lipoic acid. Acetyl-L-carnitine may require 2-3 months for meaningful nerve regeneration. Clinical trials typically run 3-6 months, so consistent, long-term supplementation is key for the best outcomes.

Can I take neuropathy supplements with prescription medications?

Most neuropathy supplements are safe alongside common prescriptions like gabapentin or pregabalin, but there are important interactions to monitor. ALA can enhance blood sugar-lowering effects of diabetes medications. High-dose B vitamins may interact with certain drugs. Always inform your healthcare provider about all supplements you’re taking, especially if you use blood thinners, diabetes medications, or thyroid drugs.

Related Articles

• Best Methyl B12 Supplements
• Best B12 for Energy Supplements
• Best Magnesium Glycinate Supplements