Best Anti-Wrinkle Supplements (2026)
Wrinkles form as collagen and elastin production decline with age, compounded by UV exposure, oxidative stress, and decreasing hyaluronic acid levels. Oral supplements containing hydrolyzed collagen peptides, resveratrol, hyaluronic acid, and vitamin C can support skin structure from the inside out — targeting the root causes of fine lines and wrinkles that topical creams alone cannot reach.
Quick Comparison
| Product | Key Ingredients | Form | Best For | Rating |
|---|---|---|---|---|
| VITASEI Collagen Peptides Powder | Collagen + Resveratrol + Vitamin C | Powder | Best Overall | 9.5/10 |
| 13-in-1 White Tomato Antioxidant Complex | White Tomato + Collagen + Vitamins C & E | Capsules | Best Antioxidant Complex | 9.4/10 |
| BioSchwartz Multi Collagen Peptides | Multi Collagen Types I, II, III, V, X | Capsules | Best Multi-Collagen | 9.3/10 |
| Multi Collagen Peptides Powder Types I-X | 5 Collagen Types + Hyaluronic Acid | Powder | Best Value Collagen | 9.2/10 |
| Multi Collagen Powder with Biotin | Collagen + Biotin + Hyaluronic Acid + Vitamin C | Powder | Best All-in-One | 9.1/10 |
| Collagen Peptides Powder with HA | Organic Collagen + Hyaluronic Acid | Powder | Best Clean Formula | 9.0/10 |
| Collagen Peptides with Biotin & Keratin | Collagen Types I-X + MSM + HA | Capsules | Best Capsule Option | 8.9/10 |
| Sunwarrior Vegan Collagen Peptides | Plant-Based Collagen Builder | Powder | Best Vegan Option | 8.8/10 |
1. VITASEI Hydrolyzed Collagen Peptides Powder – Best Overall
- BOOST YOUR BEAUTY & STRENGTH: Each scoop of Vitasei’s hydrolyzed collagen peptides powder delivers five collagen types (I, II, III, IV, X) with vitamin C, resveratrol, and hyaluronic acid. A powerhouse blend to give your body a daily boost of beauty and strength from within.
- MIX WITH ANY DRINK: Hot or cold, this hydrolyzed collagen blends seamlessly into coffee, tea, smoothies, or shakes. It dissolves easily without clumps, turning your favorite beverage into a nourishing daily ritual you’ll look forward to.
- DELICIOUS COCONUT FLAVOR: Lightly sweetened with stevia, Vitasei’s colágeno hidrolizado features a smooth, natural coconut taste that complements any recipe. Every sip is a refreshing, enjoyable experience that makes consistency simple.
- SUPPORT JOINTS & MOBILITY: Our collagen with resveratrol, vitamin C, and specialized collagen types II & X work together to support flexibility, mobility, and joint comfort – helping you stay active, agile, and ready for everyday movement.
- SUITED FOR WOMEN & MEN: Vitasei’s colágeno hidrolizado for women and men is designed for every lifestyle. With 30 servings per container, this collagen supplement provides daily support for hair, skin, nails, bones, and joints.
A science-backed formula combining hydrolyzed collagen peptides with resveratrol and vitamin C — three ingredients clinically shown to support skin elasticity and reduce wrinkle depth.
VITASEI delivers hydrolyzed collagen peptides alongside resveratrol (a potent polyphenol antioxidant) and vitamin C, which is essential for collagen synthesis. The hydrolyzed form breaks collagen into small peptides that the body can absorb efficiently and use to stimulate new collagen production in the dermis. Resveratrol provides UV protection from the inside and activates sirtuins — longevity genes associated with cellular repair. The powder format allows flexible dosing and mixes easily into coffee, smoothies, or water.
- Pros:
- Triple-action formula: collagen + resveratrol + vitamin C
- Resveratrol activates cellular repair pathways
- Versatile powder mixes into any beverage
- Cons:
- Powder format requires mixing — less convenient than capsules
- Contains bovine collagen — not suitable for vegetarians
Best for: Adults who want a comprehensive anti-wrinkle supplement that combines structural collagen support with antioxidant protection.
2. 13-in-1 White Tomato Antioxidant Complex – Best Antioxidant Complex
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A unique 13-ingredient formula built around white tomato complex — a novel antioxidant clinically shown to protect skin from UV-induced damage and improve skin brightness.
This supplement combines white tomato complex with collagen peptides, vitamins C and E, and 10 additional skin-supporting ingredients. White tomato extract (Solanum lycopersicum) contains colorless carotenoids and phytoene/phytofluene that accumulate in the skin and provide photo-protection from the inside. The formula also delivers collagen peptides for structural support and potent antioxidants to neutralize free radicals that break down collagen and elastin.
- Pros:
- White tomato complex provides unique UV photoprotection
- 13 synergistic ingredients for comprehensive skin support
- Includes both structural (collagen) and protective (antioxidant) components
- Cons:
- Newer ingredient with less long-term clinical data than traditional collagen
- Multiple capsules per serving
Best for: Adults concerned about both wrinkles and sun damage who want cutting-edge antioxidant protection alongside collagen support.
3. BioSchwartz Hydrolyzed Multi Collagen Peptide Capsules – Best Multi-Collagen
- Revitalize your beauty effortlessly: BioSchwartz Hydrolyzed Collagen Peptide Capsules are specially designed to enhance your natural radiance, supporting skin elasticity and vibrancy - packed with types I, II, III, V, and X collagen, these collagen supplements for women nourish your skin from the inside out, reducing visible signs of aging and helping you achieve a supple, youthful complexion that turns heads
- Unleash hair and nail strength: With the power of biotin, keratin, and vitamin C, these collagen capsules for women transform your hair and nails, making them stronger and more resilient - say goodbye to brittle nails and dull hair, and embrace the beauty of luscious locks and immaculate nails, backed by our potent blend that delivers essential nutrients directly where they are needed most
- Support whole body wellness with multi collagen benefits: Combining five crucial collagen types, our collagen peptide capsules offer comprehensive support for your joints, skin, hair, and nails - these collagen pills for women are crafted to improve mobility and flexibility, promoting overall well-being, so you can stay active, feel youthful, and enjoy a lifestyle full of energy and confidence, backed by the nourishing power of collagen
- Enhance your daily routine with convenience: Experience the ease of supporting beauty and health with our collagen capsules - forget complex powders or messy drinks; our capsules deliver the benefits of collagen peptides effortlessly with just one swallow, integrating seamlessly into your daily regimen, offering a hassle-free solution to looking and feeling your best
- Trust in premium quality and science-driven formulation: BioSchwartz stands for excellence with our hydrolyzed collagen peptides capsules, ensuring each capsule is crafted with precision for optimal potency - our dedication to quality means you're choosing a collagen supplement for women that prioritizes ingredient safety and quality
A comprehensive multi-collagen formula providing all five major collagen types (I, II, III, V, X) in convenient capsule form for full-body skin, joint, and connective tissue support.
BioSchwartz delivers hydrolyzed collagen from multiple sources to provide Types I, II, III, V, and X — the collagen types most relevant to skin elasticity, dermal structure, and overall connective tissue health. Type I collagen is the primary structural component of skin, while Types III and V support skin flexibility and the extracellular matrix. The hydrolyzed form ensures rapid absorption and bioavailability. Third-party tested and manufactured in a GMP-certified facility.
- Pros:
- All five major collagen types in one formula
- Convenient capsule format — no mixing required
- Third-party tested for quality assurance
- Cons:
- Does not include vitamin C or hyaluronic acid
- Requires multiple capsules per serving
Best for: Adults who want comprehensive multi-type collagen in an easy capsule format. Pair with a vitamin C supplement for optimal collagen synthesis. For more collagen options, see our guide to collagen for skin.
4. Multi Collagen Peptides Powder Types I, II, III, V, X – Best Value Collagen
- 10g Grass Fed Hydrolyzed Collagen, 4500mcg Biotin, 60mg Vitamin C, 90mg Hyaluronic Acid: Our premium blend of multi collagen not only contains collagen types I, II, III, X, V it also contains collagen boosting ingredients: Biotin, Vitamin C and Hyaluronic Acid for maximum effectiveness.*
- Size: 16 oz, 1lb, measured by weight, not by volume (approximately) Please note that the jar will only be sixty percent full. This is done so that powder does not escape during filling, and is standard for any powder filling.
- Formulated to help Support Hair, Skin, Nails and Joint Health* - Studies have shown that after the age of 25 collagen production naturally decreases. As we age supplementing with collagen can help support healthy skin, hair, nails and joints*. Vitamin C supports the synthesis of collagen, while biotin and hyaluronic acid both support skin health.*
- Better Ingredients, Better Prices: As a direct to consumer company we're able to skip the middle man and pass the savings directly onto the consumer. As a market leader in the Hydrolyzed Collagen space we're able to secure better pricing on higher quality ingredients, that again we're able to pass onto our customers
A budget-friendly multi-collagen powder sourced from grass-fed bovine, chicken, marine, and eggshell membrane for diverse collagen type coverage at an accessible price.
This multi-collagen powder provides all five major collagen types from four different protein sources, ensuring a broad amino acid profile for skin support. The powder is unflavored and dissolves easily in hot or cold beverages. At a lower price point than most premium collagen brands, it delivers competitive collagen dosing per serving with the diversity of sources that single-source collagen products cannot match.
- Pros:
- Four collagen sources for maximum type diversity
- Unflavored — mixes into any food or drink
- Excellent price per serving
- Cons:
- Does not include additional skin-supporting nutrients
- Contains egg and fish — not allergen-free
Best for: Budget-conscious consumers who want a straightforward multi-collagen powder without premium pricing.
5. Multi Collagen Powder with Biotin, Hyaluronic Acid & Vitamin C – Best All-in-One
- PREMIUM GRASS FED, HYDROLYZED MULTI COLLAGEN PROTEIN POWDER + BIOTIN + VITAMIN C AND HYALURONIC ACID: Our premium blend of multi collagen not only contains collagen types I, II, III, X, V it also contains collagen boosting ingredients: Biotin, Vitamin C and Hyaluronic Acid for maximum effectiveness.*
- 2LB / 32 OZ VALUE SIZE: Our 32 OZ jar offers a 3 month supply (90 servings) of our premium multi collagen powder with biotin, vitamin C and hyaluronic acid. At just $0.55 per serving, our value sized jar offers tremendous compared to leading brands that cost nearly $1 per serving. ^Note - 32oz measured by weight, settling will occur and the jar will be approximately 60-65% full.
- COLLAGEN POWDER FOR WOMEN SUPPORTS HAIR, SKIN, NAILS AND JOINT HEALTH - Studies have shown that after the age of 25 collagen production naturally decreases. As we age supplementing with collagen can help support healthy skin, hair, nails and joints. Vitamin C helps regulate the synthesis of collagen, while biotin and hyaluronic acid both support skin health as well.*
- COLAGENO HIDROLIZADO EN POLVO - CONTAINS 5 TYPES OF COLLAGEN to help restore and boost collagen. Types I, II, III, X and V are all present sourced from bovine collagen peptides, beef bone broth collagen powder, chicken collagen peptides and eggshell membrane collagen.
- BUY WITH CONFIDENCE: If you don’t love our Hydrolyzed Multi Collagen with Biotin, Hyaluronic Acid, Vitamin C , Contact us and we will happily provide a full refund. 100% satisfaction guaranteed
A comprehensive 2-pound value size combining multi-type collagen with biotin, hyaluronic acid, and vitamin C — everything needed for wrinkle support in a single scoop.
This all-in-one formula eliminates the need for multiple supplements by combining hydrolyzed multi-collagen peptides with three additional anti-wrinkle powerhouses: biotin for skin cell renewal, hyaluronic acid for moisture retention, and vitamin C for collagen synthesis. The 2-pound container provides exceptional value for daily use, and the unflavored powder mixes seamlessly into morning coffee, smoothies, or oatmeal.
- Pros:
- Collagen + biotin + hyaluronic acid + vitamin C in one product
- 2-pound value size for long-lasting supply
- Eliminates need for multiple separate supplements
- Cons:
- Large container may not be ideal for travel
- Powder can clump if not mixed thoroughly
Best for: Adults who want a single, comprehensive anti-wrinkle powder that covers all the key skin-supporting nutrients without buying multiple products.
6. Collagen Peptides Powder with Hyaluronic Acid – Best Clean Formula
- HIGH-QUALITY CLEAN SOURCES are IMPORTANT for COLLAGEN POWDER ✔ Grass-Fed, Pasture Raised Bovine that is not exposed to hormones or antibiotics ✔ Organic Chicken Bone Broth that simmered for an extended period to extract the collagen protein powder. It ensures that our collagen peptides contain a diverse range of amino acids & essential nutrients ✔ Wild-Caught Fish from their natural environments, free from artificial feed ✔ Eggshell Membrane NEM is the most studied eggs shell membrane available
- MULTI COLLAGEN PROTEIN & SUPER HIGH ABSORPTION ✔ HCL Collagen supplements contain a blend of types I, II, III, V, and X . Each type offers unique benefits for your body, working synergistically. Our hydrolyzed collagen peptide undergoes a meticulous process that breaks down the protein into smaller, bioavailable peptides. It ensures maximum absorption and utilization by your body
- CONTAINS ESSENTIAL COLLAGEN BOOSTER ✔ Natural Vitamin C is the vital nutrient for the body to use collagen ✔ Silica acts as a "building block" for collagen drink, supporting its effective utilization ✔ Hyaluronic Acid creates a moisture-rich environment that allows collagen peptides to stretch without breaking ✔ Zinc as a "guarantee" that the collagen you take will go to the places where it's needed in your body. They work synergistically to enhance the efficacy of our hydrolyzed collagen powder
- EASY TO USE - Herbal Code collagen c is easy to incorporate into your daily routine. Convenient to measured and easily diluted! Simply mix a scoop of the powder into water, juice, or your favorite smoothie to enjoy a liquid collagen nutritious beverage. Without added sweeteners or flavors
- MADE IN USA, THIRD-PARTY TESTED, NON-GMO, NO FILLERS ✔ We are honest with our customers and high quality is our #1 priority! Our Collagen Peptides Powder is carefully sourced, processed, and formulated to ensure maximum potency and purity. HCL all natural supplement do not contain any useless fillers in “Other ingredients” that others use to make manufacturing cheaper. Herbal Code Collagen Peptides protein shake has been manufactured under stringent GMP guidelines
An organic collagen peptides powder paired with hyaluronic acid from the cleanest sourcing available — ideal for consumers who prioritize ingredient purity.
This collagen powder emphasizes clean, organic sourcing with hyaluronic acid for enhanced skin hydration. The formula uses collagen peptides from grass-fed, pasture-raised bovine sources and pairs them with vegan hyaluronic acid for a supplement that supports both skin structure and moisture retention. Free from artificial additives, fillers, and unnecessary ingredients — just clean collagen and HA in every scoop.
- Pros:
- Organic, clean-sourced collagen from pasture-raised cattle
- Added hyaluronic acid for skin hydration
- No artificial additives, fillers, or sweeteners
- Cons:
- Premium pricing for organic sourcing
- Does not include vitamin C for collagen synthesis
Best for: Health-conscious consumers who want the cleanest possible collagen supplement with minimal ingredients. Consider adding a skin supplement with vitamin C for optimal results.
7. Collagen Peptides with Biotin, Keratin & MSM – Best Capsule Option
- Our Parrox Collagen Capsules introduces a powerful 14-in-1 beauty formula featuring Collagen Types I, II, III, V, and X, Biotin, Keratin, and Hyaluronic Acid. Combined with MSM, Grape Seed Extract, Quercetin, and essential vitamins, this all-in-one collagen supplement offers a simplified daily solution for those looking to support their skin, hair, nails, and overall radiance.
- Crafted for both women and men, Parrox Collagen Capsules are formulated with high-absorption peptides and vital nutrients to. Each capsule delivers Collagen, Biotin, Keratin, Vitamins A, C, E, Folic Acid, Zinc, and Magnesium—offering a comprehensive blend to.
- Parrox 14-in-1 Collagen Supplement brings together science-backed ingredients to support daily beauty goals. Combining Collagen Peptides, Hyaluronic Acid, MSM, Grape Seed Extract, and powerful antioxidants, this formula helps simplify your supplement routine and delivers multi-targeted nourishment in just one easy-to-take capsule.
- Say goodbye to scooping powders or chewing sugary gummies. Parrox offers a mess-free, capsule-based beauty solution made for everyday use. With hydrolyzed collagen, keratin, and 11 other nutrients, this formula supports your —all in a clean, compact format.
- Simple, Straightforward Formulation: Parrox’s Collagen Capsules Supplement is made with carefully selected ingredients and contains—offering a clean, balanced formula designed with intention and clarity.
A comprehensive skin capsule combining collagen Types I through X with biotin, keratin, hyaluronic acid, and MSM for wrinkle and elasticity support without any powder mixing.
This capsule formula delivers multi-type collagen peptides along with biotin, keratin (a structural skin protein), MSM (methylsulfonylmethane for sulfur-dependent collagen cross-linking), and hyaluronic acid. The inclusion of keratin alongside collagen provides additional structural protein support that most collagen-only products miss. MSM provides bioavailable sulfur that the body uses to form disulfide bonds in collagen and keratin, strengthening skin structure.
- Pros:
- Convenient capsule format — no mixing or taste concerns
- MSM + keratin provide structural support beyond collagen alone
- Includes hyaluronic acid for moisture retention
- Cons:
- Lower collagen dose per serving than powders
- Multiple capsules needed daily
Best for: Adults who prefer capsules over powders and want a multi-ingredient approach to wrinkle support.
8. Sunwarrior Vegan Collagen Building Peptides Powder – Best Vegan Option
- The Collagen Building Protein Peptides is not a collagen. Collagen Building Protein Peptides means that the product contains the same set of amino acids and nutrients that your body needs to produce its own collagen. Peptides are created when the amino acids undergo a process called hydrolysis to break them down into shorter chains/smaller molecules, which makes them easier for your body to absorb.
- Plant-based amino acids and peptides are collagen precursors, which are nutrients that your body converts efficiently into collagen. Our beauty-enhancing formula also contains strengthening and supporting nutrients such as vitamin C, trace minerals, leafy greens, silica, and biotin. Hydrating compounds such as hyaluronic acid and tremella mushroom extract attract and retain skin moisture.
- Our Silica is sourced from bamboo, silica is a key co-nutrient for collagen and elastin production. It also boosts calcium absorption to strengthen bones, hair, skin, and nails. The source of Vitamin C in the Collagen Building Protein Peptides is from organic amla also known as Indian Gooseberry as well as from organic sea buckthorn berries. These two fantastic sources provide 10 times the potency of vitamin C in oranges.
- This product has a full amino acid profile, BCAAs, MCTs, and is high in vitamin C. It contains biotin, hyaluronic acid, probiotics, and 100% vegan collagen building ingredients, and it tastes amazing. It has no chemicals or artificial ingredients. It has no added sugar, no dairy, no soy and is gluten-free, Non-GMO, and vegan.
- Sunwarrior's Collagen Builder provides all the amino acids and nutrients that a body needs to naturally make that conversion. Collagen is made primarily of three amino acids: proline, hydroxyproline, and glycine, which gives it unique functional properties different from all other proteins. This also makes it the most important structural protein in the body.
A plant-based collagen builder that uses vitamin C, silica, and amino acid precursors to stimulate the body’s own collagen production — the only effective approach for vegans.
Since collagen is an animal protein, vegans cannot take traditional collagen supplements. Sunwarrior solves this by providing the raw materials and cofactors the body needs to manufacture its own collagen: vitamin C, plant-based amino acids (proline, glycine, lysine), silica, and additional botanical extracts. The formula supports the body’s natural collagen synthesis pathway rather than providing pre-formed collagen. Organic, plant-based, and free from common allergens.
- Pros:
- 100% plant-based — suitable for vegans and vegetarians
- Stimulates the body’s own collagen production
- Organic with no artificial ingredients
- Cons:
- Cannot match the direct collagen delivery of animal-sourced supplements
- Results may take longer than hydrolyzed collagen peptides
Best for: Vegans and vegetarians who want to support collagen production and reduce wrinkles using plant-based ingredients. For additional collagen options, see our guide to collagen for anti-aging.
How to Choose the Best Anti-Wrinkle Supplement
Hydrolyzed collagen peptides are the most research-backed ingredient for reducing wrinkle depth and improving skin elasticity. Clinical studies show that daily doses of 2.5-15 grams of hydrolyzed collagen peptides can increase skin hydration, elasticity, and collagen density within 4-12 weeks. Look for “hydrolyzed” collagen, which has been broken into small peptides for optimal absorption. Type I collagen is the most important for skin, though multi-type formulas (I, II, III, V, X) provide broader connective tissue benefits.
Vitamin C is a non-negotiable companion to collagen supplementation. Without adequate vitamin C, the body cannot properly synthesize new collagen — even if you’re supplying collagen peptides. If your collagen supplement doesn’t include vitamin C, take at least 500 mg of vitamin C separately. Hyaluronic acid (HA) is the other critical anti-wrinkle nutrient, as it holds up to 1,000 times its weight in water and maintains the skin moisture that keeps fine lines from appearing. Look for supplements that combine collagen with both vitamin C and HA for the most complete approach.
Antioxidants like resveratrol, astaxanthin, and vitamin E protect existing collagen from degradation by neutralizing free radicals generated by UV exposure and environmental pollution. These ingredients work defensively — preventing collagen breakdown — while collagen peptides work constructively by building new collagen. The combination of both strategies provides the most effective anti-wrinkle approach from supplementation.
Powder formats generally deliver higher collagen doses per serving (10-20 grams) compared to capsules (1-3 grams), making them more effective for wrinkle reduction based on clinical dosing. However, capsules offer convenience and consistent dosing without mixing. For best results, take collagen on an empty stomach or with vitamin C to optimize absorption, and commit to at least 8-12 weeks of daily use before evaluating results.
Frequently Asked Questions
Do anti-wrinkle supplements actually work?
Clinical evidence strongly supports hydrolyzed collagen peptides for skin health. A meta-analysis of multiple randomized controlled trials found that oral collagen supplementation significantly improved skin hydration, elasticity, and wrinkle reduction compared to placebo. Most studies used 2.5-10 grams daily for 8-12 weeks. Results are real but gradual — expect subtle improvements over weeks, not overnight transformation.
How much collagen should I take daily for wrinkles?
Research supports 2.5-15 grams of hydrolyzed collagen peptides daily for skin health benefits. Most studies showing wrinkle reduction used 5-10 grams daily. Powder supplements typically provide 10-20 grams per serving, while capsules deliver 1-3 grams. For capsule users, achieving clinically effective doses may require multiple capsules or combining with dietary collagen sources like bone broth.
How long does it take for collagen supplements to reduce wrinkles?
Most clinical studies report measurable improvements in skin elasticity and wrinkle depth after 4-8 weeks of daily collagen supplementation, with continued improvement through 12 weeks. Hyaluronic acid may improve skin hydration more quickly (within 2-4 weeks), while structural collagen changes take longer. Consistency is essential — sporadic use will not produce meaningful results.
What’s the difference between collagen types I, II, III, V, and X?
Type I is the most abundant collagen in skin and is most directly linked to wrinkle reduction and skin firmness. Type III supports skin flexibility and is often found alongside Type I. Type II is primarily for joint cartilage. Types V and X support the extracellular matrix and cell membranes. For anti-wrinkle purposes, Type I is most important, but multi-type formulas provide broader benefits for skin, joints, and overall connective tissue.
Can vegans get anti-wrinkle benefits from supplements?
Vegans cannot take traditional collagen supplements (which are animal-derived) but can support their body’s collagen production with plant-based collagen builders containing vitamin C, silica, proline, glycine, and lysine. While these don’t deliver pre-formed collagen, they provide the building blocks for the body’s natural collagen synthesis. Supplementing with hyaluronic acid (which can be vegan-sourced) and antioxidants like resveratrol also supports skin health without animal products.
Should I take collagen in the morning or at night?
There is no conclusive evidence that timing significantly affects collagen supplement efficacy. Some experts suggest taking collagen on an empty stomach for optimal peptide absorption, while others recommend taking it with vitamin C to enhance collagen synthesis. The most important factor is consistent daily intake at whatever time fits your routine best. Some people prefer adding collagen powder to morning coffee or an evening smoothie.
