Best Supplements for Chronic Fatigue (2026)

Chronic fatigue goes beyond ordinary tiredness — it’s a deep, persistent exhaustion that doesn’t improve with rest and can make even simple daily tasks feel overwhelming. Whether caused by nutrient deficiencies, mitochondrial dysfunction, or conditions like ME/CFS, targeted supplementation can support the body’s energy production pathways and help restore vitality. The supplements below focus on research-backed ingredients like CoQ10, B vitamins, magnesium, and adaptogens that address the root causes of chronic fatigue.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Lunakai Vegan Energy Gummies	Vitamin B12 3000mcg	Gummies	Best Overall	9.4/10
Lunakai Shilajit Capsules	Shilajit + Ashwagandha + Rhodiola	Capsules	Best Adaptogenic	9.2/10
Double Wood Adaptogen Complex Drops	10 Organic Adaptogens	Liquid Drops	Best Liquid	9.0/10
NATURELO B Complex	B Vitamins + CoQ10 + Folate	Capsules	Best B-Vitamin	9.0/10
EZ Melts Ubiquinol	Ubiquinol CoQ10 100mg	Dissolvable Tablets	Best CoQ10	8.9/10
Cortisol Reducer with Ashwagandha	Ashwagandha + Rhodiola + Magnesium	Capsules	Best for Stress-Related Fatigue	8.8/10
Thorne Adrenal Cortex	Bovine Adrenal Cortex 50mg	Capsules	Best Premium	8.7/10

1. Lunakai Vegan Energy Gummies – Best Overall

These vitamin B12-packed energy gummies deliver 3000mcg of B12 per serving — a critical nutrient for people with chronic fatigue, especially those with absorption issues or plant-based diets.

Vitamin B12 is essential for red blood cell production, neurological function, and cellular energy metabolism. Deficiency is one of the most common and correctable causes of chronic fatigue, and even subclinical low levels can contribute to persistent tiredness and brain fog. These gummies provide 3000mcg of B12 in a bioavailable form, well above the daily minimum, to help replenish depleted stores. They’re vegan, made in the USA, and designed for daily energy support without caffeine or stimulants.

• Pros:
• High-dose B12 addresses one of the most common fatigue causes
• Vegan-friendly — critical for plant-based eaters prone to B12 deficiency
• Caffeine-free energy support with no crash or jitters

• Cons:
• Primarily addresses B12-related fatigue, not all causes
• Gummy format contains added sugars

Best for: Overall energy support, especially for those with B12 deficiency or absorption issues

2. Lunakai Shilajit Capsules – Best Adaptogenic

This extra-strength formula combines shilajit resin with ashwagandha, rhodiola, and cordyceps — four powerhouse adaptogens that support mitochondrial energy production and stress resilience.

Shilajit is a mineral-rich compound that contains fulvic acid, a substance shown to enhance mitochondrial function and improve the body’s ability to produce ATP (cellular energy). Combined with ashwagandha for cortisol management, rhodiola for stamina and mental clarity, and cordyceps for oxygen utilization and physical endurance, this formula addresses chronic fatigue from multiple angles. The adaptogenic blend helps the body normalize its stress response while simultaneously boosting energy production at the cellular level.

• Pros:
• Shilajit’s fulvic acid directly supports mitochondrial ATP production
• Four adaptogens address fatigue from stress, endurance, and cellular angles
• Capsule format for precise dosing without taste concerns

• Cons:
• Takes 2-4 weeks for full effects to develop
• Premium price point for a multi-ingredient formula

Best for: People whose chronic fatigue has an adaptogenic/stress component alongside energy deficiency

3. Double Wood Adaptogen Complex Drops – Best Liquid

This liquid adaptogen complex contains 10 organic herbs specifically chosen for adrenal fatigue recovery, offering superior absorption compared to capsule alternatives.

Liquid supplements bypass the need for capsule dissolution and often absorb faster through sublingual pathways. Double Wood’s formula includes astragalus root, ginkgo leaf, rhodiola, eleuthero root, gotu kola, licorice root, and other adaptogens traditionally used to restore energy in fatigued individuals. The combination targets adrenal recovery, cognitive function, and overall vitality. One month’s supply comes in a convenient dropper bottle that makes dosing flexible and easy to add to water or juice.

• Pros:
• Liquid format for faster absorption and flexible dosing
• 10 organic adaptogens for comprehensive fatigue support
• Third-party tested and manufactured in the USA

• Cons:
• Herbal taste may be unpleasant for some users
• Proprietary blend doesn’t specify individual herb amounts

Best for: People who prefer liquid supplements or have difficulty absorbing capsules. For targeted CoQ10 energy support, consider adding a dedicated CoQ10 supplement.

4. NATURELO B Complex – Best B-Vitamin

NATURELO delivers all eight essential B vitamins from whole food sources alongside CoQ10, making it one of the most comprehensive B-complex options for chronic fatigue.

B vitamins are collectively essential for energy metabolism — they help convert food into ATP, support red blood cell production, and maintain nervous system function. Chronic fatigue patients frequently show suboptimal levels of B12, B6, and folate. NATURELO uses methylated forms (methylfolate, methylcobalamin) for superior bioavailability, plus the inclusion of CoQ10 provides additional mitochondrial support. The whole food fruit and vegetable blend adds naturally occurring cofactors that enhance absorption.

• Pros:
• All eight B vitamins in methylated, bioavailable forms
• Includes CoQ10 for added mitochondrial energy support
• Whole food sourced with natural cofactors for better absorption

• Cons:
• 120-capsule bottle requires daily consistency
• May cause mild nausea if taken on an empty stomach

Best for: Addressing B-vitamin deficiencies that contribute to chronic fatigue and low energy

5. EZ Melts Ubiquinol – Best CoQ10

Ubiquinol is the active, reduced form of CoQ10 that the body can use immediately for mitochondrial energy production — making it particularly valuable for chronic fatigue sufferers.

CoQ10 plays a direct role in producing ATP within mitochondria, and research shows that people with chronic fatigue syndrome often have lower CoQ10 levels. Ubiquinol (the reduced form) is significantly more bioavailable than ubiquinone, meaning more of the supplement reaches cells where it’s needed. EZ Melts delivers 100mg of ubiquinol in a pleasant dissolvable tablet format, so it absorbs through the mouth for faster uptake. Studies suggest it takes approximately 3 months of consistent CoQ10 supplementation to see meaningful improvements in chronic fatigue.

• Pros:
• Ubiquinol form is 3-6x more bioavailable than standard CoQ10
• Dissolvable tablet format enhances absorption
• Directly supports mitochondrial ATP production

• Cons:
• Takes up to 3 months to see full effects on chronic fatigue
• Higher cost than standard ubiquinone CoQ10 supplements

Best for: People with chronic fatigue who want targeted mitochondrial energy support

6. Cortisol Reducer with Ashwagandha – Best for Stress-Related Fatigue

Chronic stress burns through the body’s energy reserves and elevates cortisol, creating a fatigue cycle. This formula combines ashwagandha with rhodiola and magnesium to break that cycle.

Many cases of chronic fatigue are driven by prolonged stress that has depleted adrenal reserves and left cortisol levels chronically elevated. This 120-capsule formula provides a two-month supply of ashwagandha for cortisol modulation, rhodiola for stamina and mental resilience, and magnesium for nervous system support and muscle recovery. The combination works to normalize the stress response rather than simply stimulating energy, addressing the underlying cause of stress-induced fatigue.

• Pros:
• Targets the stress-fatigue connection directly through cortisol modulation
• Two-month supply provides good value
• Ashwagandha and rhodiola work synergistically for stress resilience

• Cons:
• Requires 2-4 weeks for effects to become noticeable
• May not be sufficient for fatigue caused by nutrient deficiencies

Best for: People whose chronic fatigue is primarily driven by prolonged stress and cortisol dysregulation

7. Thorne Adrenal Cortex – Best Premium

Thorne’s bovine adrenal cortex extract directly nourishes depleted adrenal glands, making it a targeted premium option for fatigue associated with adrenal exhaustion.

Thorne is one of the most trusted names in professional-grade supplementation, and their Adrenal Cortex provides 50mg of bovine adrenal cortex extract per capsule. This glandular approach provides the raw materials needed to support adrenal function when the glands have been depleted by chronic stress, illness, or overexertion. Many integrative practitioners specifically recommend adrenal cortex supplementation for patients with chronic fatigue who show signs of adrenal insufficiency. The clean, minimal formula contains no unnecessary fillers.

• Pros:
• Professional-grade quality from one of the most trusted supplement brands
• Targeted glandular support for adrenal exhaustion
• Minimal, clean formula with no unnecessary additives

• Cons:
• Not suitable for vegetarians or vegans (bovine-derived)
• Premium price point

Best for: People with chronic fatigue linked to adrenal exhaustion who want professional-grade support. For broader energy support, pair with a methylated B12 supplement.

8. Rhodiola Rosea by NutraChamps – Best Standalone Adaptogen

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Rhodiola rosea is the premier adaptogen for fatigue — research shows it significantly reduces mental and physical exhaustion while improving cognitive function under stress.

Among all adaptogens, rhodiola has the strongest evidence base specifically for fatigue reduction. Clinical trials show it reduces mental fatigue, improves exercise performance, and enhances cognitive function in stressed and fatigued individuals. This supplement standardizes to 3% rosavins and 1% salidroside — the exact ratios used in most clinical research. Effects often appear within the first week of use, making rhodiola one of the faster-acting adaptogens. It’s also energizing without being stimulating, so it won’t disrupt sleep.

• Pros:
• Strongest evidence base among adaptogens specifically for fatigue
• Standardized to research-backed rosavin and salidroside ratios
• Many users notice improvement within the first week

• Cons:
• May be too stimulating if taken late in the day
• Works best for stress-related fatigue rather than nutrient deficiency

Best for: People with chronic mental and physical fatigue who want a single, well-researched adaptogen

9. Acetyl L-Carnitine by NOW Foods – Best for Mitochondrial Support

Acetyl L-carnitine transports fatty acids into mitochondria for energy production and crosses the blood-brain barrier to support cognitive energy — addressing two hallmarks of chronic fatigue.

Research shows that people with chronic fatigue syndrome frequently have low carnitine levels, and supplementation can improve both physical energy and mental clarity. Acetyl L-carnitine (ALCAR) is the preferred form because it crosses the blood-brain barrier, providing cognitive support alongside physical energy. NOW Foods delivers 500mg per capsule of pure ALCAR, and the brand is known for rigorous third-party testing and GMP manufacturing. Taking 1-2 capsules daily supports fatty acid metabolism and mitochondrial function.

• Pros:
• Addresses documented carnitine deficiency common in ME/CFS
• Acetyl form crosses the blood-brain barrier for cognitive energy
• Well-established brand with rigorous quality testing

• Cons:
• Should be avoided by people with hypothyroidism or Hashimoto’s
• May cause mild GI discomfort in some users

Best for: Chronic fatigue sufferers who experience both physical exhaustion and brain fog

10. Nutricost Magnesium Glycinate – Best Mineral Support

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Magnesium glycinate addresses the mineral deficiency that contributes to fatigue, muscle weakness, poor sleep, and impaired energy production in chronic fatigue patients.

Magnesium is involved in over 300 enzymatic reactions in the body, including ATP production, muscle function, and sleep regulation — all areas impacted by chronic fatigue. Glycinate is the preferred form for fatigue because it’s gentle on digestion, highly absorbable, and the glycine component supports sleep quality. Nutricost offers 120mg of elemental magnesium per capsule at an excellent price point, with 240 capsules per bottle for a long-lasting supply. Many chronic fatigue patients notice improvements in sleep quality and energy within 1-2 weeks of starting magnesium supplementation.

• Pros:
• Addresses widespread magnesium deficiency linked to fatigue
• Glycinate form is gentle on digestion with calming glycine
• Excellent value — 240 capsules per bottle

• Cons:
• May need multiple capsules daily to reach therapeutic doses
• Magnesium alone may not resolve multi-factorial fatigue

Best for: Foundational mineral support for chronic fatigue, especially those with poor sleep and muscle weakness

How to Choose the Best Supplement for Chronic Fatigue

The first step in choosing a chronic fatigue supplement is identifying the likely root cause of your fatigue. If you suspect nutrient deficiency (common in vegetarians, those with GI issues, or people on restricted diets), start with B12, iron, magnesium, and vitamin D testing. Correcting a deficiency can produce dramatic improvement. If deficiency isn’t the issue, mitochondrial support with CoQ10 and acetyl L-carnitine targets cellular energy production directly.

For stress-driven fatigue, adaptogens are the most appropriate choice. Rhodiola rosea has the strongest evidence for fatigue reduction and works relatively quickly. Ashwagandha is better for chronic stress and cortisol dysregulation. Shilajit combines mineral replenishment with mitochondrial support. Many people benefit from stacking an adaptogen with a nutrient-based supplement for a dual-pronged approach.

Form matters for absorption. Methylated B vitamins (methylcobalamin, methylfolate) are more bioavailable than standard forms. Ubiquinol is far more absorbable than ubiquinone (standard CoQ10). Magnesium glycinate absorbs better than oxide or citrate. Liquid supplements may absorb faster than capsules, particularly for people with compromised digestion — a common issue in chronic fatigue patients.

Be patient with timelines. While some supplements like rhodiola and B12 may produce noticeable effects within days to a week, others like CoQ10 and ashwagandha typically require 4-12 weeks of consistent use. Start with one supplement at a time, give it adequate time to work, and then add others as needed to build a personalized fatigue-fighting stack.

Frequently Asked Questions

What is the best supplement for chronic fatigue syndrome?

There is no single best supplement for everyone with chronic fatigue, as the condition has multiple contributing factors. However, CoQ10 (ubiquinol form) is one of the most frequently recommended because it directly supports mitochondrial energy production, and research shows many ME/CFS patients have low CoQ10 levels. Other strong candidates include vitamin B12 (methylcobalamin), magnesium glycinate, acetyl L-carnitine, rhodiola rosea, and vitamin D. A combination approach typically produces better results than any single supplement.

How long do chronic fatigue supplements take to work?

Timelines vary considerably by ingredient. Vitamin B12 can produce noticeable effects within 48 hours if deficiency is the cause. Rhodiola rosea often shows effects within the first week. Magnesium glycinate typically takes 1-2 weeks for sleep and energy improvements. CoQ10 requires approximately 2-3 months of consistent use. Ashwagandha needs 4-8 weeks for full cortisol-modulating effects. Start with the faster-acting supplements and layer in slower ones over time.

Can I take multiple chronic fatigue supplements together?

Yes, and in fact a multi-supplement approach often works best because chronic fatigue usually involves multiple contributing factors. A common effective stack includes: B12 + rhodiola in the morning for energy and mental clarity, and magnesium glycinate + CoQ10 in the evening for mitochondrial support and sleep quality. However, start with one supplement at a time (spaced 2-4 weeks apart) so you can identify which ones are providing benefit and watch for any interactions.

Is CoQ10 effective for chronic fatigue?

Research supports CoQ10 for chronic fatigue, particularly the ubiquinol form. CoQ10 is essential for mitochondrial ATP production, and multiple studies have found that people with chronic fatigue syndrome have lower CoQ10 levels than healthy controls. Supplementation studies show improvements in fatigue symptoms, though effects typically take about 3 months to become noticeable. A dose of 100-200mg daily of ubiquinol is the typical recommendation. CoQ10 also acts as a powerful antioxidant, potentially reducing the oxidative stress associated with chronic fatigue.

What vitamins am I likely deficient in if I have chronic fatigue?

The most common deficiencies associated with chronic fatigue include vitamin B12 (especially in vegetarians and those with absorption issues), vitamin D (widespread in the general population), iron (particularly in menstruating women), magnesium (estimated to affect up to 50% of adults), and folate. Getting blood work to test these levels is highly recommended before starting supplementation, as correcting an actual deficiency can produce dramatic improvement in energy levels.

Are adaptogens effective for chronic fatigue?

Adaptogens show promising results for chronic fatigue, particularly when stress is a contributing factor. Rhodiola rosea has the strongest evidence, with clinical trials showing significant reductions in mental and physical fatigue. Ashwagandha helps by modulating cortisol and supporting the body’s stress response. Cordyceps may improve oxygen utilization and exercise tolerance. Adaptogens work best when fatigue is driven by prolonged stress, burnout, or adrenal depletion rather than pure nutrient deficiency. They complement (but don’t replace) nutrient-based supplementation.

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