Best PEA (Palmitoylethanolamide) Supplements (2026)

Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide produced by the body in response to inflammation and pain. As a supplement, PEA has gained traction for its ability to support nerve comfort, joint health, and the body’s natural inflammatory response — all without the side effects associated with traditional pain relievers. Micronized and liposomal forms have improved bioavailability, making PEA supplements more effective than ever.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Neurogan Ultra Micronized PEA	Micronized PEA 1,500mg	Capsules	Best Overall	9.5/10
X Gold Health Micronized PEA	Micronized PEA 600mg	Capsules	Best Clinically Studied Dose	9.3/10
Natgrown PEA 600mg	PEA 600mg	Capsules	Best Value	9.1/10
Everyday Nutrition PEA + Luteolin	PEA 400mg + Luteolin	Capsules	Best Synergy Formula	9.0/10
Gade Nutrition PEA + Quercetin	PEA 800mg + Quercetin 200mg	Capsules	Best for Immune Support	8.9/10

1. Neurogan Ultra Micronized PEA – Best Overall

Neurogan delivers a potent 1,500mg per serving of ultra-micronized PEA, making it the highest-dose single-ingredient option on this list.

Each bottle contains 90 capsules for a 30-day supply at the full serving size. The micronization process reduces particle size for significantly better absorption compared to standard PEA powder. Neurogan is a family-owned brand based in California that manufactures in a GMP-certified facility with third-party lab testing for purity and potency. The formula is free from fillers, gluten, soy, and artificial additives.

• Pros:
• Highest dose available at 1,500mg per serving
• Ultra-micronized for superior bioavailability
• Third-party tested, GMP-certified, made in the USA

• Cons:
• Premium price point
• Three capsules per serving may be inconvenient

Best for: Anyone seeking maximum-strength PEA for chronic discomfort and nerve support.

2. X Gold Health Micronized PEA 600mg – Best Clinically Studied Dose

X Gold Health delivers 600mg of 99% pure micronized PEA per serving — the exact dose used in clinical studies showing significant comfort improvements after just a few weeks.

The bottle provides 120 capsules (60 servings), offering solid value for a two-month supply. The micronized formulation ensures enhanced absorption over standard PEA. This supplement is manufactured in the USA, non-GMO, vegetarian, and free from gluten, soy, dairy, nuts, and artificial preservatives. It matches the clinical study dosage that demonstrated meaningful improvements in comfort levels.

• Pros:
• Clinically studied 600mg dosage
• 99% pure micronized PEA for high bioavailability
• 120 capsules provide a 2-month supply

• Cons:
• No complementary ingredients like luteolin
• Two capsules per serving needed

Best for: Those who want the exact dose backed by clinical research for natural discomfort relief.

3. Natgrown PEA 600mg – Best Value

Natgrown offers a straightforward 600mg PEA formula at one of the most competitive price points in the category.

Each bottle contains 120 capsules for a full 60-day supply. The formula mirrors clinical study dosages and uses pure palmitoylethanolamide without unnecessary fillers. Natgrown products are made in the USA and are free from gluten, milk, soy, tree nuts, peanuts, and wheat. The no-frills approach keeps the price accessible without compromising on the active ingredient quality.

• Pros:
• Excellent price per serving
• Clean, simple formula with no fillers
• 120-capsule bottle lasts two months

• Cons:
• Not micronized, so absorption may be lower
• Less established brand compared to premium options

Best for: Budget-conscious buyers who want a reliable PEA supplement without paying a premium.

4. Everyday Nutrition PEA + Luteolin – Best Synergy Formula

This advanced formula combines 400mg of PEA with luteolin, polydatin, and magnesium glycinate for a multi-pathway approach to discomfort relief.

The addition of luteolin — a flavonoid with its own anti-inflammatory properties — creates a synergistic effect that enhances PEA’s natural benefits. Polydatin adds antioxidant support while magnesium glycinate contributes to nerve and muscle relaxation. The supplement is manufactured in the USA under GMP standards and is non-GMO with high-absorption formulation. Each bottle contains 90 capsules.

• Pros:
• Synergistic multi-ingredient formula
• Luteolin enhances PEA’s effectiveness
• Added magnesium glycinate for nerve support

• Cons:
• Lower PEA dose at 400mg per serving
• More complex formula may not suit purists

Best for: Those who want a comprehensive formula targeting multiple pathways of discomfort relief.

5. Gade Nutrition PEA 800mg + Quercetin – Best for Immune Support

Gade Nutrition pairs 800mg of micronized PEA (99% pure) with 200mg of quercetin phytosome for dual-action comfort and immune support.

The quercetin phytosome technology binds quercetin to phospholipids for dramatically improved absorption compared to standard quercetin. This pairing supports both the body’s inflammatory response and antioxidant defenses. The formula is free from GMOs, gluten, soy, and artificial additives, and is manufactured in the USA. Each capsule delivers a potent combination for nerve comfort, joint health, and cellular protection.

• Pros:
• High 800mg PEA dose with quercetin phytosome
• Dual-action comfort and immune support
• Clean formula with no artificial additives

• Cons:
• Newer product with fewer reviews
• Higher price than single-ingredient options

Best for: Anyone seeking PEA combined with powerful antioxidant and immune support.

6. Ulmubra Liposomal PEA 1,300mg + Luteolin – Best Absorption

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Ulmubra uses liposomal delivery technology to protect PEA from stomach acid degradation, ensuring superior absorption and maximum bioavailability.

Each serving provides 1,300mg of PEA combined with 100mg of luteolin in easy-to-swallow softgels. The liposomal encapsulation mimics cell membrane structure, allowing PEA to be more efficiently absorbed at the cellular level. The micronized PEA formula reduces particle size for additional bioavailability gains. This combination of liposomal delivery and micronization makes it one of the most bioavailable PEA supplements available.

• Pros:
• Liposomal delivery for maximum absorption
• High 1,300mg dose with luteolin synergy
• Convenient softgel format

• Cons:
• Softgels may be large for some users
• Premium pricing reflects advanced delivery technology

Best for: Those prioritizing maximum absorption and bioavailability from their PEA supplement.

7. Rosmolo PEA 1,500mg + Luteolin + Turmeric – Most Potent

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Rosmolo packs 1,500mg of micronized PEA with 98% standardized luteolin and turmeric into a high-absorption tablet for comprehensive discomfort management.

The 3-in-1 formula combines PEA’s endocannabinoid support with luteolin’s anti-inflammatory properties and turmeric’s bioavailability-enhancing curcuminoids. Each tablet is designed for high absorption and the micronized PEA is standardized to 99% purity. The product is made in the USA and designed for those who want maximum potency in a single product. Each bottle contains 60 tablets for a 30-day supply.

• Pros:
• Triple-action formula with PEA, luteolin, and turmeric
• High 1,500mg PEA dose per serving
• 98% standardized luteolin for consistent potency

• Cons:
• Tablets may be large
• Effects may take several weeks to become noticeable

Best for: Those seeking the most potent multi-ingredient PEA formula for chronic discomfort.

8. XpandAge Life Sciences PEA Complex – Best Multi-Nutrient

XpandAge combines micronized PEA with luteolin, NADH, rutin, and lysine for a unique multi-nutrient approach to nerve and immune health.

The addition of NADH supports cellular energy production while rutin provides vascular and antioxidant support. Lysine contributes to immune function and tissue repair. This comprehensive formula targets multiple wellness pathways beyond simple discomfort relief. Each bottle contains 60 vegetable capsules and is made in the USA from premium natural ingredients. The formula is suitable for vegans.

• Pros:
• Unique 5-ingredient formula for comprehensive support
• NADH adds cellular energy benefits
• Vegan-friendly vegetable capsules

• Cons:
• Individual ingredient doses may be lower due to multi-ingredient formula
• From a smaller, less established brand

Best for: Those who want a multi-nutrient PEA supplement for overall nerve, immune, and energy support.

How to Choose the Best PEA Supplement

The most important factor when selecting a PEA supplement is the form of PEA used. Micronized PEA has a smaller particle size that significantly improves absorption compared to standard PEA powder. Liposomal delivery takes this further by encapsulating PEA in phospholipid layers that protect it through digestion. Either option is preferable to non-micronized forms.

Clinical studies have used dosages of 300-600mg daily for several weeks to demonstrate meaningful comfort improvements. Higher doses of 1,000-1,500mg are common in supplements targeting more significant discomfort. Starting at the clinical dose of 600mg and adjusting based on individual response is a sensible approach. PEA can also pair well with other joint support supplements for comprehensive comfort.

Complementary ingredients like luteolin and quercetin can enhance PEA’s effects through synergistic anti-inflammatory pathways. Look for products manufactured in GMP-certified facilities with third-party testing for purity and potency. PEA is generally well-tolerated with minimal side effects, making it suitable for long-term use.

Capsules are the most common form and offer convenient dosing. Softgels with liposomal delivery may provide better absorption but can be larger. For those also managing stress or nerve discomfort, consider combining PEA with magnesium glycinate for additional nerve and muscle support.

Frequently Asked Questions

What is PEA (palmitoylethanolamide) and what does it do?

PEA is a fatty acid amide naturally produced by the body as part of its endocannabinoid system. It works by interacting with PPAR-alpha receptors to help modulate pain signals and inflammatory responses. As a supplement, PEA supports nerve comfort, joint health, and the body’s natural ability to manage discomfort without the side effects of traditional anti-inflammatory medications.

How much PEA should I take daily?

Clinical studies have used 300-600mg daily, with most supplements recommending 600-1,500mg per day depending on severity of discomfort. Starting at 600mg — the most commonly studied dose — and increasing as needed is a practical approach. PEA can be taken as a single dose or split between morning and evening.

When is the best time to take PEA?

PEA can be taken with or without food, though taking it with a meal containing fats may improve absorption. Most users take it in the morning or split their dose between morning and evening for sustained support throughout the day. Consistency is key — benefits typically build over 2-4 weeks of daily use.

Are there any side effects of PEA?

PEA is generally very well tolerated with a strong safety profile in clinical studies. Side effects are rare but may include mild digestive discomfort in some individuals. Because PEA is a naturally occurring compound in the body, it does not carry the risks associated with NSAIDs or other traditional pain management options.

Can I take PEA with other supplements?

PEA pairs well with many supplements. Luteolin and quercetin can enhance its anti-inflammatory effects. It can also be combined with curcumin, omega-3 fatty acids, and magnesium for comprehensive pain and inflammation support. There are no well-documented negative interactions with common supplements or medications, but consult a healthcare provider if taking prescription medications.

How long does it take for PEA to work?

Most clinical studies show meaningful improvements after 2-4 weeks of consistent daily use. Some users report initial benefits within the first week, particularly at higher doses. PEA’s effects are cumulative, so consistent use over several weeks provides the best results. It is not designed for immediate acute pain relief.

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