Best Lumbrokinase Supplements (2026)
Lumbrokinase is a potent fibrinolytic enzyme complex extracted from earthworms, used for centuries in Traditional Chinese Medicine. It supports healthy circulation by breaking down fibrin — a protein that can accumulate in blood vessels and impair blood flow. Lumbrokinase is considered more targeted than nattokinase because it acts selectively in the presence of existing fibrin, making it a popular choice for cardiovascular and circulatory support.
Quick Comparison
| Product | Potency | Form | Best For | Rating |
|---|---|---|---|---|
| Doctor’s Best Lumbrokinase | 720,000 IU per serving | Veggie Capsules | Best Overall | 9.5/10 |
| Researched Nutritionals Lumbrokinase | 880,000 IU per serving | Delayed-Release Capsules | Best Premium | 9.4/10 |
| Double Wood Lumbrokinase | 10,000 FU/gram (150mg) | Veggie Capsules | Best Value | 9.3/10 |
| Dr. Mercola Lumbrokinase Enzymes | 2,000 FU per capsule | Delayed-Release Capsules | Best Delayed Release | 9.2/10 |
| Canada RNA Boluoke | 20mg per capsule | Enteric-Coated Capsules | Most Researched | 9.2/10 |
| LongLifeNutri Lumbrokinase | 2,000,000 Units per serving | Vegetarian Capsules | Most Potent | 9.1/10 |
| Puregen Labs Lumbrokinase | 40mg (800,000 units) | Vegetarian Capsules | Best Budget Pick | 9.0/10 |
1. Doctor’s Best Lumbrokinase – Best Overall
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Doctor’s Best delivers a trusted, well-dosed lumbrokinase formula that has been a category leader for years.
Each serving provides 40mg of lumbrokinase standardized to 720,000 Lumbrokinase Units. The formula uses veggie capsules with minimal excipients — just maltodextrin and medium chain triglycerides alongside the enzyme. Doctor’s Best is a well-established supplement brand known for science-backed formulations and rigorous quality testing. The 60-capsule bottle provides a full two-month supply at the standard one-capsule-per-day dosage.
- Pros:
- Trusted brand with long track record in the lumbrokinase category
- Clean formula with minimal inactive ingredients
- Standardized potency at 720,000 IU per serving
- Cons:
- Not enteric-coated or delayed-release
- Single-capsule serving may be lower potency for some protocols
Best for: Anyone seeking a reliable, well-established lumbrokinase supplement from a trusted brand
2. Researched Nutritionals Lumbrokinase – Best Premium
- Circulatory Health Support - Lumbrokinase helps promote healthy circulation, balanced coagulation and fibrinolysis.*
- High-Potency Formula - Delivers 880,000 IU per serving of lumbrokinase enzymes to support circulatory health and optimal fibrin metabolism.*
- Mechanisms of Action - Supports healthy fibrin metabolism through natural enzymatic pathways, promotes normal fibrin breakdown, and encourages the body’s natural fibrinolytic processes.*
- Enteric-Coated Capsules - This lumbrokinase supplement features delayed-release ASE enzymes that bypass stomach acid and are released in the intestines for maximum efficacy.
- Non-GMO & Dairy-Free - These nutritional supplements are manufactured without milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame, soy, corn, and gluten. Produced in a facility that may process other ingredients containing these allergens.
The highest-potency option on the market with enteric-coated delayed-release capsules for maximum absorption.
Researched Nutritionals delivers 880,000 IU per two-capsule serving in delayed-release capsules designed to bypass stomach acid and dissolve in the small intestines. This is critical because lumbrokinase can be inactivated by stomach acid. The formula is free from all major allergens including milk, eggs, fish, soy, wheat, corn, and gluten. This is a practitioner-grade supplement often recommended by integrative medicine professionals for serious circulatory support protocols.
- Pros:
- Highest IU count per serving (880,000 IU)
- Enteric-coated delayed-release capsules protect the enzyme from stomach acid
- Practitioner-grade quality and purity standards
- Cons:
- Premium price point
- Requires two capsules per serving
Best for: Those seeking a practitioner-grade, high-potency lumbrokinase with optimal absorption. For additional circulatory support, see our guide to nattokinase supplements.
3. Double Wood Lumbrokinase – Best Value
- PROTEOLYTIC ENZYMES: Lumbrokinase may help support and maintain healthy overall function
- SUPPORTS HEALTHY CIRCULATION: Lumbrokinase may help support and maintain healthy circulatory
- TWO MONTH SUPPLY: Our Lumbrokinase supplement contains 60 servings of 150mg (10,000FU / gram high activity lumbrokinase)
- NO FILLERS: Double Wood includes no fillers to ensure you are getting nothing but high activity Lumbrokinase enzymes
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
A generous 120-capsule supply with no fillers and high activity lumbrokinase at an accessible price.
Double Wood provides 150mg of lumbrokinase per two-capsule serving, standardized to 10,000 FU per gram. The formula contains zero fillers — just lumbrokinase and hypromellose veggie capsules. With 120 capsules per bottle providing a two-month supply, this is one of the best value options in the lumbrokinase category. Double Wood is known for third-party testing and clean, no-frills formulations across their supplement line.
- Pros:
- 120-capsule bottle offers excellent value
- Zero fillers — only lumbrokinase and capsule material
- Third-party tested for purity and potency
- Cons:
- Not delayed-release capsules
- Potency measured in FU rather than IU, making direct comparisons difficult
Best for: Budget-conscious buyers who want a clean, high-quality lumbrokinase without paying premium prices
4. Dr. Mercola Lumbrokinase Enzymes – Best Delayed Release
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A delayed-release formula combining lumbrokinase with protease for comprehensive fibrinolytic support.
Dr. Mercola’s formula is described as nearly 30x stronger than typical proteolytic enzymes. Each capsule delivers a fibrinolytic enzyme blend including both lumbrokinase and protease in a delayed-release capsule designed to reach the intestines for proper absorption. The formula is non-GMO, gluten-free, and soy-free. With 30 capsules per bottle at a one-capsule-per-day serving, this is a month’s supply per bottle.
- Pros:
- Delayed-release capsules for optimal absorption
- Combined lumbrokinase + protease blend for broader enzymatic support
- Clean formula free from GMOs, gluten, and soy
- Cons:
- Only 30 capsules per bottle
- Higher cost per serving compared to some competitors
Best for: Those who want a delayed-release formula with complementary proteolytic enzymes
5. Canada RNA Boluoke – Most Researched
- Boluoke may support a healthier blood state by aiding coagulation & fibrinolysis balance in the body*
- Derived from earthworms, Boluoke contains the lumbrokinase enzyme & aids fibrin breakdown*
- Free of common allergens like wheat/gluten, dairy, egg, soy, corn, and nuts*
- Supports and maintains healthy coagulation activity of the body
The most clinically studied lumbrokinase product on the market, backed by extensive research in China and globally.
Boluoke is a proprietary lumbrokinase extract that has been used in the largest clinical trials involving lumbrokinase, including a study with 16 hospitals and 1,560 patients. The enteric-coated capsules are allergen-free (no wheat, gluten, dairy, egg, soy, corn, or nuts). The recommended dosage ranges from 1 capsule one to three times daily for chronic conditions, with higher dosing protocols available under physician guidance. This is the gold standard lumbrokinase product in the integrative medicine community.
- Pros:
- Most extensively researched lumbrokinase product available
- Enteric-coated for acid resistance and intestinal release
- Free from all common allergens
- Cons:
- Premium pricing reflects clinical pedigree
- Best used under practitioner guidance
Best for: Individuals working with a healthcare practitioner who want the most clinically validated lumbrokinase available
6. LongLifeNutri Lumbrokinase – Most Potent
- MAINTAIN DAILY WELLNESS: Feel empowered every day with LongLifeNutri Lumbrokinase 100mg supplement, designed to complement your active, vibrant lifestyle. Each capsule is crafted to work naturally with your body for a smooth, seamless addition to your wellness routine.
- NATURALLY SOURCED: Benefit from each dose of 100mg, equivalent to 2,000,000 lumbrokinase units, promoting long-lasting vitality. Sourced from Eisenia Foetida, where the natural enzyme is extracted. This supplement fits seamlessly into a proactive approach to maintaining your circulatory health.
- CONVENIENT 2-MONTH SUPPLY: With 120 easy-to-swallow vegetarian capsules, LongLifeNutri lumbrokinase supplement offers a convenient two-month supply. Enjoy daily support without the need for constant refills, helping you stay consistent with your wellness goals.
- MADE IN THE USA & LAB TESTED: Made with integrity, LongLifeNutri Lumbrokinase capsules are manufactured in the USA under strict quality control and are third-party tested for purity, ensuring a clean and effective supplement you can rely on.
- SATISFACTION GUARANTEED: Enjoy the peace of mind of a 365-day health harmony guarantee, plus a complimentary pill organizer to help you stay on track with your wellness routine.
An ultra-high-potency formula delivering 2,000,000 lumbrokinase units per serving in a convenient two-month supply.
LongLifeNutri offers 100mg of lumbrokinase per capsule with a maximum activity of 2,000,000 units per serving — making it one of the most potent options available. The 120-capsule bottle provides a two-month supply at the recommended two-capsule daily dosage. The formula is vegetarian, non-GMO, gluten-free, and manufactured in the USA with third-party lab testing. Most users report experiencing benefits within 4-6 weeks of consistent use.
- Pros:
- Extremely high potency at 2,000,000 units per serving
- 120 capsules for a full two-month supply
- Lab-tested and manufactured in the USA
- Cons:
- Newer brand with less market history
- LKU units vary by manufacturer, making cross-brand comparisons challenging
Best for: Those seeking the highest possible potency lumbrokinase at a competitive price point
7. Puregen Labs Lumbrokinase – Best Budget Pick
- ✔️ POWERFUL FORMULA: Our Highly Potent Lumbrokinase enzyme contains 40 mg per capsule and not per each serving like most other brands.
- ✔️ Clean Formula: Our product is free from stearates and other harmful inactive ingredients. Just look at our formula. Everything you need and nothing you dont.
- ✔️ SUGGESTED DOSAGE: As a dietary supplements, take 1 vegetarian capsules daily or as directed by your healthcare professional.
- ✔️ QUALITY YOU CAN TRUST: Our formula is Vegetarian Friendly, ALLERGEN-FREE, GLUTEN-FREE, and made in a facility following strict GMP guidelines to ensure safety and quality. Our product is made in a facility following strict GMP guidelines to ensure safety. This product is made and quality tested in the United States with globally sourced ingredients.
A straightforward, affordable lumbrokinase option with solid potency and clean ingredients.
Puregen Labs delivers 40mg of high-activity lumbrokinase per capsule with no harmful additives. The formula is non-GMO, gluten-free, and made in the USA in a GMP-certified facility. With 60 vegetarian capsules per bottle, this provides a two-month supply at one capsule daily. It’s an accessible entry point for anyone exploring lumbrokinase supplementation without committing to premium-priced options.
- Pros:
- Affordable price makes it accessible for first-time users
- Clean formula with no harmful additives
- Made in the USA in a GMP-certified facility
- Cons:
- Lower potency than premium options
- Not delayed-release capsules
Best for: First-time lumbrokinase users or anyone on a budget who wants a quality product
8. Allergy Research Group Lumbrokinase – Best for Sensitive Individuals
- Circulatory System Support: Potent Lumbrokinase Circulatory System Support aids healthy fibrinolytic activity and supports blood circulation within the normal range for cardiovascular health*
- Enzyme Power: Each delayed-release capsule delivers 32 mg (600,000 IU) of lumbrokinase, formulated to support cardiovascular health and healthy blood flow*
- Optimized Use: For circulatory and cardiovascular support, take two capsules twice daily with 8–10 oz of water, or as directed by a healthcare practitioner*
- Highest Purity Standards: Our supplements are free from gluten, dairy, soy, corn, nuts, egg, shellfish, fish, sesame and yeast
- Solutions Backed by Science: For more than 45 years, Allergy Research Group has delivered trusted supplements through our relentless focus on quality, consistency and innovation
A hypoallergenic, delayed-release formula from a brand with over 45 years of experience in clean supplementation.
Allergy Research Group delivers 32mg (600,000 IU) of lumbrokinase per delayed-release capsule. The formula is free from gluten, dairy, soy, corn, nuts, egg, shellfish, fish, sesame, and yeast — making it one of the cleanest options for those with multiple sensitivities. ARG has over 45 years of experience creating supplements for sensitive individuals. The recommended dosage is 1-2 capsules in the morning, 1-2 in the afternoon, and 2 at bedtime for full circulatory support.
- Pros:
- Free from all major allergens — ideal for sensitive individuals
- Delayed-release capsules for protected delivery
- Over 45 years of brand expertise in hypoallergenic formulations
- Cons:
- Only 30 capsules per bottle at the higher dosing protocol
- More complex dosing schedule
Best for: Individuals with multiple food sensitivities or allergies who need a clean, delayed-release lumbrokinase. Those interested in broader circulatory support may also want to explore circulation supplements.
How to Choose the Best Lumbrokinase Supplement
When selecting a lumbrokinase supplement, the most important factor is delivery format. Since lumbrokinase can be inactivated by stomach acid, delayed-release or enteric-coated capsules offer a significant advantage for absorption. Products from Researched Nutritionals, Dr. Mercola, and Allergy Research Group all feature this protective technology.
Potency comparisons can be confusing because manufacturers use different measurement units — International Units (IU), Fibrinolytic Units (FU), and Lumbrokinase Units (LKU). These are not directly interchangeable, so comparing products across different measurement systems requires caution. Focus on brands that clearly disclose their standardization method and activity levels.
For general circulatory maintenance, a standard dose of 20-40mg per day is typical. For more intensive protocols, higher doses of up to 60-80mg daily may be used under practitioner supervision. Lumbrokinase should be taken on an empty stomach for optimal absorption, and it’s best to avoid taking it simultaneously with other proteolytic enzymes that could break it down.
Look for products manufactured in GMP-certified facilities with third-party testing. Reputable brands like Doctor’s Best, Researched Nutritionals, and Allergy Research Group all meet these quality standards. If you’re on blood thinners or anticoagulant medications, consult with a healthcare provider before starting lumbrokinase.
Frequently Asked Questions
What is lumbrokinase and what does it do?
Lumbrokinase is a group of fibrinolytic enzymes extracted from earthworms. It supports healthy circulation by breaking down fibrin, a protein that can accumulate in blood vessels. Unlike broader-acting enzymes, lumbrokinase acts selectively in the presence of existing fibrin, making it a targeted option for circulatory support. It also has antithrombotic properties that help prevent blood cells from sticking together.
How much lumbrokinase should I take daily?
Standard maintenance dosing is typically 20-40mg per day (one capsule of most products), taken on an empty stomach. For more intensive support, practitioners may recommend 2 capsules two to three times daily. Always follow the specific product’s label instructions and consult a healthcare provider for personalized dosing.
When is the best time to take lumbrokinase?
Lumbrokinase is best taken on an empty stomach, at least 30 minutes before meals. Many protocols recommend splitting doses between morning and evening for sustained enzymatic activity throughout the day. Taking it away from food helps prevent the enzyme from being used on dietary proteins instead of fibrin.
How does lumbrokinase compare to nattokinase?
Lumbrokinase is considered more targeted than nattokinase because it acts selectively on existing fibrin without disrupting normal clotting processes. Nattokinase has broader activity and may also degrade thrombin, which could potentially increase bleeding risk. Lumbrokinase is often preferred for long-term use or for individuals who need more precise fibrinolytic support.
Are there any side effects of lumbrokinase?
Lumbrokinase has a long safety history in Traditional Chinese Medicine. In clinical trials, the overall adverse reaction rate was under 2%, with mild symptoms like skin itching (0.58%), skin rash (0.19%), and occasional nausea or diarrhea (1.15%). No major hemorrhagic side effects have been reported. However, it should not be taken by those with active bleeding, recent surgery, or known allergy to earthworms.
Can I take lumbrokinase with blood thinners?
While lumbrokinase has been used alongside blood thinning agents in clinical studies without reported adverse interactions, you should always consult your physician before combining lumbrokinase with anticoagulants like warfarin, heparin, or antiplatelet drugs like Plavix. Lumbrokinase should be stopped at least one week before any scheduled surgery.
