Best Acne Supplements (2026)
Acne supplements target breakouts from the inside out by addressing root causes like excess sebum production, hormonal imbalance, gut health, and nutrient deficiencies. The most effective formulas combine ingredients like zinc, DIM, vitamin A, pantothenic acid (B5), and probiotics to reduce inflammation and support clearer skin over time.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Zazzee DIM 300 mg | DIM + BioPerine | Capsules | Best Overall | 9.5/10 |
| SMNutrition Clear Skin Supplement | Zinc, DIM & Probiotics | Capsules | Best Multi-Action | 9.3/10 |
| Acnetame Acne Pills | Vitamin A, B5 & NAC | Tablets | Best for Oily Skin | 9.1/10 |
| Perfect Skin Acne Pills | Niacinamide, Zinc & Probiotics | Capsules | Best for Teens | 9.0/10 |
| Vitex Chasteberry 600mg | Vitex Agnus-Castus | Capsules | Best for Hormonal Acne | 8.9/10 |
| CLEARSTEM MINDBODYSKIN | DIM, B5, Glutathione | Capsules | Best Premium | 8.8/10 |
| Himalaya Organic Neem | Neem Extract | Caplets | Best Herbal | 8.7/10 |
1. Zazzee DIM 300 mg – Best Overall
- 300 MG DIM PER CAPSULE! Our DIM 300 contains 300 mg of DIM per capsule AND 10 mg of BioPerine per capsule, making it the best value on the market. In addition, each capsule is enhanced with 100 mg of Pure Organic Broccoli, a natural source of DIM that enhances efficacy and absorption. Zazzee DIM 300 is both a great value and a very effective DIM solution!
- 10 MG BIOPERINE PER CAPSULE: Our DIM 300 has been enhanced with 10 mg of BioPerine, an all-natural absorption-enhacing extract derived from black pepper. Numerous studies have shown that the addition of BioPerine increase the body's absorption of other ingredients - including DIM- by 30% or more!
- OUTSTANDING VALUE / 3+ MONTH SUPPLY: Our DIM 300 requires only 1 capsule per serving and contains 300 mg per capsule – an amazing value! A single bottle contains a 3+ month supply. Compare this to other leading brands that require 2 capsules per serving, contain far less than a 100 day supply, and do not provide a 300 mg strength dosage. Our DIM 300 is a bargain not be found elsewhere!
- NATURAL, VEGAN & NON-GMO: All ingredients, including the capsule, are 100% vegan. Our Extra Strength DIM 300 does not contain any sweeteners, artificial flavors, wheat, corn, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Enjoy the amazing benefits of our potent DIM 300 without worrying about what else might be hiding in each capsule!
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our DIM 300 is manufactured in the USA, in a fully compliant facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
Zazzee delivers one of the highest-potency DIM supplements on the market at 300 mg per capsule, enhanced with BioPerine for superior absorption.
Diindolylmethane (DIM) is a compound derived from cruciferous vegetables that supports estrogen metabolism, making it one of the most effective ingredients for hormonal acne. Each bottle provides 100 capsules for over a three-month supply. The formula is vegan, non-GMO, and manufactured in a GMP-certified facility. BioPerine (black pepper extract) at 10 mg per capsule significantly boosts bioavailability compared to standalone DIM products.
- Pros:
- High 300 mg DIM dose with BioPerine for enhanced absorption
- 100-count bottle offers excellent long-term value
- Vegan, non-GMO, and third-party tested
- Cons:
- Single-ingredient focus (no zinc, probiotics, or vitamins)
- May take 4-6 weeks to see noticeable skin changes
Best for: Anyone dealing with hormonal acne who wants a targeted, high-potency DIM supplement
2. SMNutrition Clear Skin Supplement – Best Multi-Action
- TRIPLE ACTION FOR SKIN BALANCE, GLOW & HEALTH: This Clear Skin Supplement is strategically formulated to support the 3 factors that influence your skin the most: hormone balance, the gut microbiome, and skin-essential nutrition.*
- FEATURING DIM FOR BALANCE: Clear-3 is formulated with our #1 DIM supplement. DIM, or diindolylmethane, is a well-studied compound renowned for supporting hormone balance, and in turn, promoting balanced and healthy skin.*
- WITH PROBIOTICS FOR GUT SUPPORT: Your gut microbiome is absolutely foundational to glowing, radiant skin. That’s why Clear-3 includes 18 billion CFU of Lactobacillus and Bifidobacterium probiotic strains, to support overall gut health and skin complexion.*
- CLEAR SKIN VITAMINS WITH ZINC: Zinc is crucial in our formula, along with essential nutrients for clear, glowing, and healthy skin. Each serving supports hydration, collagen production, sebum control, and barrier function, with Hyaluronic Acid, Niacinamide, Selenium, Vitamin B6, and more.*
- UNCOMPROMISING QUALITY: Clear-3 skin supplements for men and women by SMNutrition are manufactured in a facility that adheres to cGMP guidelines. They are Third-Party Tested, and every bottle contains 180 clear skin pills (a 90-day supply).
This triple-action formula combines zinc, DIM, and probiotics in a single supplement to address hormonal balance, gut health, and skin nutrition simultaneously.
The Clear Skin Supplement includes DIM for hormone balance, 18 billion CFU of Lactobacillus and Bifidobacterium probiotic strains for gut-skin axis support, and zinc for sebum regulation. Each bottle contains 60 capsules for a one-month supply. The formula also includes hyaluronic acid and niacinamide for additional skin hydration and complexion support. Manufactured in the USA under GMP standards.
- Pros:
- Three-pronged approach targeting hormones, gut health, and skin nutrients
- Includes probiotics clinically linked to clearer skin
- Contains niacinamide for pore refinement and brightness
- Cons:
- Capsules are relatively large
- Higher selenium content may not suit everyone
Best for: Those who want an all-in-one acne supplement covering multiple root causes
3. Acnetame Acne Pills – Best for Oily Skin
- Best acne pills for women, men, teens, and adults with oily skin. May help clear your skin by decreasing facial and body oil, helps skin healing time, and its ability to regulate cystic acne breakouts. These are the top supplements for acne on Amazon because it actually works.
- Best results may be achieved by using this acne supplement for an extended period of time. You may want to speak to your physician or dermatologist if you want to exceed 1 pill per day. Do not take these acne vitamins if you have dry skin.
- Effective acne pills ingredients such as Vitamin A, Pantothenic Acid, and NAC from a GMP certified manufacturer to give you the clear skin you deserve from the top ingredients on the market to help fight cystic acne. These pills for acne and pimples may clear your complexion because they have years of success showing it has an effect from inside out.
- Boost your confidence naturally with this acne vitamin supplement which can also be taken along with Estrohalt. Drug and antibiotic free is why we think it is the pill you need to take.
- There simply isn’t any other OTC acne pill with more in-depth videos and testimonials. You can either look the same or you can try Acnetame!
Acnetame is one of the most established acne supplements on Amazon, specifically formulated to reduce excess oil production and clear cystic breakouts.
The formula centers on pantothenic acid (vitamin B5) and N-acetyl cysteine (NAC), both shown to regulate sebum output. Additional ingredients include vitamin A, selenium, chromium, CoQ10, and BioPerine for absorption. Each tablet is potent enough for once-daily dosing, and one bottle lasts at least 30 days. GMP-certified manufacturing and an extensive library of customer testimonials back this product’s track record.
- Pros:
- Specifically targets excess oil and sebum production
- Includes NAC, a powerful antioxidant for skin repair
- One of the most reviewed acne supplements on Amazon
- Cons:
- Not recommended for those with dry skin
- Tablets are large and may be hard to swallow
Best for: People with oily, acne-prone skin looking to control sebum production
4. DIM Supplement 200 mg – Best Value
No products found.
An affordable DIM option at 200 mg per capsule that delivers solid hormonal acne support without breaking the bank.
This straightforward DIM supplement provides 200 mg of diindolylmethane per capsule for estrogen balance and hormonal acne support. The formula is designed for both men and women, making it versatile for anyone experiencing hormone-related breakouts. Clean ingredient profile with no artificial fillers, and each bottle provides a full two-month supply at the recommended dosage.
- Pros:
- Budget-friendly price point for quality DIM
- Suitable for both men and women
- Two-month supply per bottle
- Cons:
- Lower DIM dose than premium options
- No added absorption enhancers like BioPerine
Best for: Budget-conscious shoppers who want a straightforward DIM supplement for hormonal acne
5. Vitex Chasteberry Supplement 600 mg – Best for Hormonal Acne
- PMS RELIEF (600mg/3-Month Supply): Premenstrual Syndrome (PMS) can make the monthly menstrual cycle frustrating with mood swings, breast tenderness, and cramping. Vitex berry is often used to support menstrual comfort.*
- HORMONE SUPPORT: Vitex provides support for stable hormone levels in the body.* Hormone balance is associated with multiple aspects of a woman’s cycle, including the buildup of the uterine lining and reliable menstruation.
- REGULARITY SUPPORT: Many factors, like age, hormone imbalances, and years of hormone manipulation by birth control can create complications with the monthly period.* Chasteberry balance supplements are a great way to support healthy menstruation and hormone harmony.*
- DYNAMIC MENOPAUSE SUPPORT: Menstruation can become more complicated and irregular starting in the early stages of perimenopause and menopause. Many women entering menopause turn to Vitex to support their monthly cycle's ease and dependability.*
- THE SMNUTRITION DIFFERENCE: Vitex is formulated Gluten-Free, Non-GMO, Vegetarian, PETA.org Certified, Titanium Dioxide-Free, Silicon Dioxide Free, Third-Party Tested by Intertek Laboratories, and formulated without the top 9 allergens. It is manufactured in a facility that is certified GMP compliant with NSF standards.
Vitex agnus-castus (chasteberry) is one of the most researched herbs for hormonal balance, particularly for women dealing with cyclical breakouts tied to their menstrual cycle.
This supplement provides 600 mg of vitex chasteberry per serving, targeting the pituitary gland to help regulate progesterone and prolactin levels. Clinical research supports vitex for reducing PMS-related acne flare-ups and improving overall hormonal equilibrium. The formula is clean with no unnecessary additives, and each bottle provides a generous supply. BioPerine is included for enhanced absorption.
- Pros:
- Clinically researched herb for female hormonal balance
- 600 mg potent dose with BioPerine
- Addresses root cause of cyclical hormonal breakouts
- Cons:
- Primarily beneficial for women with hormonal acne
- Results may take 2-3 menstrual cycles to fully manifest
Best for: Women experiencing acne flare-ups tied to their menstrual cycle or hormonal fluctuations
6. Perfect Skin Acne Pills – Best for Teens
- High-Potency Clear Skin Pills: Harness the nutritional support power of acne supplements for teens and adults. Perfect Skin acne pills contain 13 concentrated ingredients — including Niacinamide, Vitamin A, Probiotic, Biotin and Zinc — to help visibly shrink blemishes, balance sebum production, and maintain a radiant complexion.
- Clear Skin Vitamins for Blemishes & Breakouts: Specifically formulated to ease pimples and acne flare-ups on the face, chin, back and body. Skin clearing supplements, like Niacinamide and Pantothenic Acid, work together to refine pores, while antioxidants help protect against further irritation.
- Anti Acne Blend: Zinc, Vitamins B, Vitex, Saw Palmetto, and Lactobacillus Acidophilus combine to address multiple factors that contribute to acne. This synergistic approach of herbals, vitamins and minerals for acne in Perfect Skin supplement helps supports skin health from within.
- Minimizes Scarring & Dark Spots: By nurturing healthy skin renewal, our Acne Supplement for teens, women & men help reduce the appearance of acne scars and discoloration. Acne Pills (pastillas para el acne en la cara in Spanish) also soothe irritation, supporting a smoother, more even-toned complexion. The Perfect Skin niacinamide probiotics vitex combination promotes inside-out clarity and helps maintain a balanced complexion.
- Quality You Can Trust: Proudly made in the USA under strict manufacturing standards. These vegan, non-GMO skin cleanse capsules are designed for both teens and adults seeking an all-in-one supplement for healthy, confident skin. A premium choice for anyone seeking acne natural supplements with clean ingredients and reliable results.
A comprehensive 13-ingredient formula combining niacinamide, zinc, vitamin A, probiotics, and herbal extracts specifically designed for teen and adult acne.
Perfect Skin includes niacinamide and pantothenic acid for pore refinement, zinc for inflammation control, vitamin A for cell turnover, vitex and saw palmetto for hormonal support, and Lactobacillus acidophilus for gut-skin health. The broad-spectrum approach addresses face, chin, back, and body acne. Made in the USA under strict manufacturing standards with vegan, non-GMO capsules. Each bottle provides 60 capsules.
- Pros:
- 13 targeted ingredients for comprehensive acne support
- Includes probiotics for gut-skin axis support
- Vegan, non-GMO, and USA-manufactured
- Cons:
- Large capsules may be difficult for younger teens to swallow
- Multi-ingredient formula means lower individual doses
Best for: Teens and young adults looking for an all-around acne vitamin with multiple active ingredients
7. CLEARSTEM MINDBODYSKIN – Best Premium
No products found.
Developed by a licensed acne specialist, MINDBODYSKIN is a premium supplement targeting hormonal acne through DIM, vitamin B5, glutathione, and 5-HTP.
This formula takes a unique approach by incorporating 5-HTP for stress hormone management alongside DIM for estrogen metabolism, glutathione as a master antioxidant for skin brightening, and turmeric for anti-inflammatory support. The 90-capsule bottle provides a 30-day supply at the full 3-capsule daily dose. Many users report visible improvements in 7-10 days, though the brand recommends a minimum 3-month commitment for progressive results. Gluten-free and cruelty-free.
- Pros:
- Developed by a licensed acne specialist (The Acne Guru)
- Addresses stress, hormones, and liver detoxification simultaneously
- Glutathione helps fade post-acne dark spots
- Cons:
- Premium price point
- Contains 5-HTP, which may interact with SSRI medications
Best for: Adults with persistent hormonal acne willing to invest in a premium, specialist-formulated supplement
8. DIM Gummies 200 mg – Best Gummies
No products found.
For those who dislike swallowing capsules, these DIM gummies deliver 200 mg of hormone-balancing support in a tasty, chewable format.
These gummies provide 200 mg of DIM per serving in a flavored, easy-to-take gummy form. They target hormonal acne, PMS symptoms, and overall estrogen balance without any pills or capsules. The formula is pectin-based (not gelatin), making it suitable for vegetarians. Each bottle provides a full month’s supply. This is an excellent entry point for people new to DIM supplementation who want a more enjoyable daily routine.
- Pros:
- Pleasant-tasting gummy format — no pills to swallow
- 200 mg DIM per serving for hormonal balance
- Vegetarian-friendly pectin-based formula
- Cons:
- Contains added sugars typical of gummy supplements
- Lower potency than capsule-based DIM options
Best for: Anyone who struggles with swallowing pills but wants DIM support for hormonal acne
9. Seraph Acne Supplement – Best Clean Formula
- HORMONAL ACNE SUPPORT - Target stubborn breakouts at the source with a skin supplement designed to address hormonal imbalances. This natural acne treatment combines zinc, probiotics, and skin-clearing vitamins to help calm active flare-ups and reduce future breakouts—without harsh medication.
- CLEAN INGREDIENTS THAT WORK - Packed with acne-fighting essentials like zinc for acne, vitamin A, and targeted probiotics, this supplement is free from fillers, artificial dyes, and common allergens. A pure approach to clear skin, backed by science and transparency.
- DAILY SKIN VITAMINS - More than just acne pills—this is a full-spectrum skin vitamin designed to nourish from within. Supports hydration, helps reduce clogged pores, and promotes a visibly healthier complexion over time.
- ZINC FOR ACNE AND OIL CONTROL - Formulated with zinc and vitamin A—two dermatologist-recommended nutrients known to help reduce breakouts and regulate sebum. A powerful yet gentle option for women struggling with hormonal or cystic acne.
- BACKED BY SCIENCE, LOVED FOR RESULTS - Developed with clinical insight and clean ingredients, this supplement bridges the gap between skin care and self care. Designed to support clear skin from the inside out—without harsh prescriptions or synthetic fillers.
Seraph is a newer entrant focused on clean, clinically studied ingredients including zinc, vitamin A, and targeted probiotics for inside-out skin clarity.
This supplement combines zinc for acne and oil control, vitamin A for cell turnover, and probiotics for gut-skin axis support in a clean formula free from fillers, artificial dyes, and common allergens. Designed as a daily skin vitamin that goes beyond acne pills to nourish hydration and overall complexion health. Made in the USA with transparent ingredient sourcing. Each bottle contains 60 tablets for a 30-day supply.
- Pros:
- Ultra-clean ingredient profile with no fillers or artificial dyes
- Dermatologist-recommended nutrients (zinc + vitamin A)
- Suitable for both women and men
- Cons:
- Newer brand with fewer long-term reviews
- No DIM for those specifically seeking hormonal support
Best for: Anyone wanting a clean, no-nonsense acne supplement focused on zinc and vitamin A
10. Himalaya Organic Neem – Best Herbal
No products found.
Neem has been used for centuries in Ayurvedic medicine for skin purification, and Himalaya’s USDA Organic formula delivers a potent, single-herb approach to acne support.
Himalaya’s Organic Neem provides 600 mg of USDA-certified organic neem leaf per caplet. Neem is traditionally used for blood purification and skin detoxification, helping to clear impurities that contribute to breakouts. The formula is vegan, non-GMO, gluten-free, and contains no artificial ingredients. Each bottle provides 60 caplets for a one-month supply. This is a standout choice for those who prefer herbal, single-ingredient supplements over complex multi-nutrient formulas.
- Pros:
- USDA Organic certified neem from a trusted Ayurvedic brand
- Single-herb approach — easy to stack with other supplements
- Vegan, non-GMO, and free from artificial additives
- Cons:
- Does not directly address hormonal or nutritional acne causes
- Bitter taste if caplet is chewed or broken
Best for: Those who prefer an herbal, Ayurvedic approach to skin purification and acne support
How to Choose the Best Acne Supplement
The right acne supplement depends on the root cause of your breakouts. Hormonal acne, which typically appears along the jawline, chin, and lower cheeks and often flares with menstrual cycles, responds best to DIM (diindolylmethane) and vitex chasteberry. These ingredients support healthy estrogen metabolism and progesterone balance. Look for DIM doses between 100-300 mg, ideally paired with BioPerine for absorption.
For acne driven by excess oil production, supplements featuring pantothenic acid (vitamin B5), zinc, and NAC (N-acetyl cysteine) are most effective. Zinc at 15-30 mg daily helps regulate sebum and reduce inflammation, while B5 at 500+ mg supports lipid metabolism in the skin. Vitamin A also plays a key role in cell turnover and pore health, though doses should stay within recommended daily limits.
Gut health is increasingly recognized as a factor in skin clarity. Supplements with probiotics (particularly Lactobacillus and Bifidobacterium strains) support the gut-skin axis and may reduce inflammatory acne. Multi-action formulas that combine DIM, zinc, probiotics, and vitamins offer the most comprehensive approach but may contain lower individual doses of each ingredient.
Quality markers to look for include GMP-certified manufacturing, third-party testing, non-GMO and allergen-free formulations, and transparent ingredient labels. Most acne supplements require 4-8 weeks of consistent use before visible results appear, so patience and consistency are essential.
Frequently Asked Questions
What supplements are best for acne?
The most effective supplements for acne include zinc (15-30 mg daily), DIM (100-300 mg) for hormonal balance, vitamin A for cell turnover, pantothenic acid (B5) for oil control, and probiotics for gut-skin health. The best choice depends on your acne type — hormonal acne responds better to DIM and vitex, while oily-skin acne benefits more from zinc and B5.
How long do acne supplements take to work?
Most acne supplements require 4-8 weeks of consistent daily use before noticeable improvements appear. Hormonal supplements like DIM and vitex may take 2-3 menstrual cycles (8-12 weeks) for full effect, as they work by gradually shifting hormone metabolism. Some users report initial improvements within 2-3 weeks, particularly with zinc-based formulas.
Can I take acne supplements with prescription acne medication?
Many acne supplements can be taken alongside topical prescriptions like retinoids or benzoyl peroxide. However, supplements containing vitamin A should be used cautiously if you are taking oral isotretinoin (Accutane), as both increase vitamin A levels. Supplements with 5-HTP should not be combined with SSRI antidepressants. Always consult a dermatologist before combining supplements with prescription treatments.
Do DIM supplements really help with acne?
DIM (diindolylmethane) supports healthy estrogen metabolism by promoting the conversion of estrogen into less potent forms. This is particularly beneficial for hormonal acne that flares with menstrual cycles or hormonal shifts. Research on DIM for acne is promising, and it is one of the most frequently recommended natural supplements by dermatologists and hormone specialists for hormone-related breakouts.
What is the best vitamin for acne-prone skin?
Zinc is widely considered the single most effective vitamin/mineral for acne-prone skin, supported by multiple clinical studies showing reduced inflammatory lesions with zinc supplementation. Vitamin A (retinol) supports skin cell turnover and pore health, niacinamide (B3) reduces inflammation and redness, and pantothenic acid (B5) helps regulate oil production. A combination of these nutrients often yields the best results.
Are there side effects of taking acne supplements?
Most acne supplements are well-tolerated when taken at recommended doses. Zinc can cause nausea if taken on an empty stomach. High-dose vitamin A may cause dryness or headaches. DIM may temporarily shift hormonal patterns during the first few weeks. Niacin-containing supplements can cause flushing (a warm, tingling sensation). Starting with lower doses and taking supplements with food minimizes most side effects.
