Best Apigenin Supplements (2026)

Apigenin is a natural flavonoid found abundantly in chamomile, parsley, celery, and other plants. It has gained significant attention in the biohacking and longevity community, particularly after being highlighted by neuroscientist Andrew Huberman for its potential to support relaxation, sleep quality, and cognitive function. Apigenin works by interacting with GABA receptors in the brain, promoting a sense of calm without the grogginess associated with melatonin. The best apigenin supplements deliver effective doses of this potent bioflavonoid in pure, well-tested formulations.

Quick Comparison

Product	Dose	Form	Best For	Rating
Double Wood Apigenin	50mg	Capsules	Best Overall	9.5/10
Nutricost Apigenin	50mg	Capsules	Best Value	9.3/10
Codeage Liposomal Apigenin	50mg	Capsules	Best Liposomal	9.2/10
Apigenin with L-Theanine	Apigenin + L-Theanine	Capsules	Best Sleep Combo	9.1/10
Swanson Apigenin	50mg	Capsules	Best Trusted Brand	9.0/10
Force Factor Apigenin	50mg	Capsules	Best for Prostate Health	8.9/10
Deal Supplement Apigenin	100mg	Capsules	Best High Dose	8.8/10

1. Double Wood Apigenin – Best Overall

Double Wood’s Apigenin supplement has become the go-to choice for biohackers and sleep optimizers, offering a clean 50mg dose in a well-tested, affordable formula.

Each bottle contains 120 capsules at 50mg per capsule, providing a full two-month supply. Double Wood sources their apigenin from chamomile and manufactures in the USA. Every batch undergoes third-party testing for purity and potency. The formula is soy-free, gluten-free, non-GMO, and vegan. At the recommended dose of 50mg (1 capsule) before bedtime, this is one of the most cost-effective apigenin supplements available.

• Pros:
• Clean, single-ingredient formula with verified 50mg per capsule
• Third-party tested for purity and potency
• 120-capsule count provides excellent value (2-month supply)
• Vegan, soy-free, gluten-free, and non-GMO

• Cons:
• Single-ingredient formula (no synergistic compounds)
• Can sell out frequently due to high demand

Best for: Anyone looking for a pure, well-tested apigenin supplement at the Huberman-recommended 50mg dose

2. Nutricost Apigenin – Best Value

Nutricost delivers the lowest per-serving cost in the apigenin category with 180 capsules per bottle, making this an outstanding value for daily supplementation.

Each capsule provides 50mg of apigenin, and at 180 capsules per bottle, this is a six-month supply at one capsule daily. Nutricost manufactures in GMP-compliant, FDA-registered facilities, and every batch is tested by independent, ISO-accredited laboratories. The formula is vegan, non-GMO, and gluten-free with no unnecessary fillers or additives.

• Pros:
• 180 capsules per bottle for exceptional long-term value
• ISO-accredited third-party lab testing
• Clean, simple ingredient list
• GMP-compliant and FDA-registered manufacturing

• Cons:
• No liposomal or enhanced absorption technology
• Less brand recognition in the biohacking community compared to Double Wood

Best for: Budget-conscious users who want a pure 50mg apigenin supplement with verified quality at the lowest per-serving price

3. Codeage Liposomal Apigenin – Best Liposomal

Codeage uses liposomal delivery technology with non-GMO sunflower phospholipids to enhance apigenin’s naturally low bioavailability, making this the premium absorption choice.

Each capsule delivers 50mg of apigenin from chamomile extract encapsulated in a liposomal phospholipid complex using phosphatidylcholine from non-GMO sunflower oil. The liposomal delivery system protects apigenin through the digestive process, potentially increasing the amount that reaches the bloodstream. Each bottle contains 90 capsules for a three-month supply. The formula is vegan, gluten-free, and non-GMO.

• Pros:
• Liposomal technology for enhanced absorption
• Uses non-GMO sunflower phospholipids (not soy-based)
• Three-month supply per bottle
• Established brand with strong reputation in supplement industry

• Cons:
• Higher price point compared to standard apigenin capsules
• Liposomal benefits for apigenin specifically are not yet proven in human trials

Best for: Users willing to pay a premium for enhanced absorption technology and maximum bioavailability

4. Apigenin with L-Theanine – Best Sleep Combo

This synergistic formula combines apigenin with L-theanine for a powerful one-two punch targeting sleep quality and relaxation without melatonin.

By pairing apigenin’s GABA receptor activity with L-theanine’s ability to promote alpha brain waves and reduce stress, this combination addresses sleep from multiple angles. L-theanine, an amino acid found naturally in green tea, has been shown in clinical studies to promote relaxation without sedation. Together, these two compounds create a calming effect that supports both falling asleep and maintaining deep sleep. This makes it an excellent melatonin-free sleep aid for those who want to improve sleep quality naturally. For more L-theanine options, check out our dedicated guide.

• Pros:
• Synergistic combination targeting multiple sleep pathways
• Melatonin-free formula avoids dependency concerns
• L-theanine adds daytime relaxation benefits when taken separately
• Single-capsule serving for convenience

• Cons:
• Combined formula means less flexibility in individual dosing
• May be more expensive than buying separate supplements

Best for: Users seeking a melatonin-free sleep support formula that combines apigenin with synergistic relaxation compounds

5. Swanson Apigenin – Best Trusted Brand

Swanson has been a household name in supplements since 1969, and their apigenin delivers reliable quality from a brand with over 50 years of manufacturing experience.

Each capsule provides 50mg of apigenin sourced from celery seed extract, differentiating it from chamomile-derived options. The bottle contains 90 capsules for a three-month supply at one capsule daily. Swanson’s long track record and established quality control processes give confidence in consistency batch after batch. The formula supports sleep, relaxation, prostate health, and cellular antioxidant activity.

• Pros:
• Over 50 years of brand heritage and manufacturing expertise
• Celery-derived apigenin (alternative source for chamomile-sensitive users)
• 90-capsule count at an affordable price
• Widely available through multiple retailers

• Cons:
• Contains gelatin capsules (not vegan-friendly)
• May contain magnesium stearate

Best for: Users who value brand heritage and want apigenin from a non-chamomile source

6. Force Factor Apigenin – Best for Prostate Health

Force Factor positions their apigenin specifically for prostate health alongside relaxation support, backed by clinical research on apigenin’s role in prostate wellness.

Each bottle provides 60 vegan capsules with 50mg of apigenin per capsule. Force Factor is known for their science-backed approach to supplement formulation, with all ingredients validated for identity, potency, purity, and safety. The formula is free from artificial colors, preservatives, and gelatin. This is a solid option for men seeking both the sleep and prostate health benefits of apigenin in one supplement.

• Pros:
• Specifically researched for prostate health benefits
• Vegan formula with no artificial colors or preservatives
• Rigorous ingredient validation and quality testing
• Well-known brand in the sports nutrition and health supplement space

• Cons:
• Smaller 60-capsule count (two-month supply)
• Higher per-capsule cost than some competitors

Best for: Men interested in apigenin’s dual benefits for sleep quality and prostate health

7. Deal Supplement Apigenin – Best High Dose

Deal Supplement offers the highest dose per serving at 100mg from chamomile flower extract, with a massive 240-capsule count providing up to a four-month supply.

Each capsule contains 50mg, with a two-capsule serving providing 100mg of apigenin extracted from raw chamomile plant. The 240-capsule bottle is one of the largest on the market, offering outstanding long-term value. The formula retains the active bioflavonoid phytonutrients naturally found in chamomile. Third-party lab tested, non-GMO, and free from gluten, dairy, eggs, peanuts, soy, wheat, and tree nuts.

• Pros:
• 240 capsules per bottle for exceptional value
• 100mg per serving for those needing a higher dose
• Raw chamomile extract retains natural phytonutrients
• Free from all major allergens

• Cons:
• 100mg may be too high for first-time users
• Two capsules per serving for the full 100mg dose

Best for: Experienced users who want a higher-dose apigenin supplement with outstanding long-term value

8. Beam Dream Sleep Powder – Best Sleep Blend with Apigenin

Beam Dream combines apigenin with L-theanine, reishi mushroom, magnesium, and nano hemp in a delicious hot cocoa-style powder for a comprehensive nighttime ritual.

Rather than a standalone apigenin supplement, Beam Dream is a multi-ingredient sleep support formula that includes apigenin alongside other clinically studied sleep compounds. The cinnamon cocoa flavor makes it an enjoyable bedtime routine, and the powder format allows for faster absorption than capsules. Each serving delivers a blend of five sleep-promoting ingredients that work synergistically. Third-party tested for quality and purity.

• Pros:
• Multi-ingredient sleep formula with apigenin as one component
• Delicious hot cocoa flavor makes supplementation enjoyable
• Includes magnesium, L-theanine, and reishi for comprehensive sleep support
• Third-party tested

• Cons:
• Apigenin dose per serving is not standardized to a specific milligram amount
• Premium pricing compared to standalone apigenin capsules

Best for: Users who want apigenin as part of a comprehensive, great-tasting nightly sleep routine

How to Choose the Best Apigenin Supplement

The standard recommended dose for apigenin is 50mg, which is what neuroscientist Andrew Huberman suggests as part of his sleep support protocol. Most standalone apigenin supplements offer this dose per capsule. If you are new to apigenin, start with 50mg and assess your response before increasing. Some users find that 100mg works better for them, while others do well at the lower dose. Take apigenin approximately 30 to 60 minutes before bedtime with a source of dietary fat for optimal absorption.

Apigenin has naturally low oral bioavailability, meaning much of it may be degraded before reaching the bloodstream. Liposomal formulations (like Codeage) use phospholipid technology to protect the compound through digestion, potentially increasing absorption. Another approach is pairing apigenin with resveratrol, which research suggests may increase apigenin’s bioavailability by over 200%. Standard capsule formulations still deliver benefits, but those seeking maximum effect may want to consider enhanced delivery formats.

Apigenin is sourced primarily from chamomile flowers, though some brands derive it from celery seed, grapefruit, or parsley. For those with chamomile allergies, celery-derived options like Swanson provide an alternative. Look for supplements that list the specific apigenin content on their supplement facts panel rather than just “chamomile extract,” which may contain varying amounts of the active compound. Purity levels of 98% or higher indicate a well-refined product.

Quality markers to look for include third-party testing by independent laboratories, GMP-certified manufacturing facilities, and clean labels free from unnecessary fillers, artificial colors, and common allergens. If you’re using apigenin primarily for sleep, consider combination formulas that include synergistic ingredients like L-theanine and magnesium for sleep, which can amplify the relaxation effects.

Frequently Asked Questions

What is apigenin and what does it do?

Apigenin is a natural flavonoid compound found in chamomile, parsley, celery, and other plants. It acts on GABA receptors in the brain to promote relaxation and support sleep quality without causing grogginess. Research also suggests it has antioxidant properties, may support healthy cortisol levels, and could play a role in cellular health and healthy aging. It gained widespread attention after neuroscientist Andrew Huberman recommended it as part of his sleep optimization protocol.

How much apigenin should I take daily?

The most commonly recommended dose is 50mg taken once daily, typically 30 to 60 minutes before bedtime. Some users increase to 100mg if they don’t notice effects at the lower dose. Research studies have used doses ranging from 50mg to 500mg, but higher doses are generally unnecessary for sleep support. Always start with the lowest effective dose and consult a healthcare provider if you’re taking medications.

When is the best time to take apigenin?

For sleep support, take apigenin 30 to 60 minutes before bedtime with a small amount of dietary fat to enhance absorption. For general antioxidant or cellular health benefits, it can be taken in the morning with breakfast. Taking it too early in the evening may not provide optimal sleep effects, while taking it right at bedtime may not allow enough time for absorption.

Are there any side effects of apigenin?

Apigenin is generally well-tolerated with a low side effect profile. Some users report mild drowsiness (which is often the intended effect), and occasional stomach upset at higher doses. Because apigenin interacts with GABA receptors, it may enhance the sedative effects of other sleep aids, alcohol, or benzodiazepines. Those sourced from grapefruit may interact with medications metabolized by CYP enzymes, similar to grapefruit juice interactions.

Can I take apigenin with other supplements?

Apigenin pairs well with several other sleep and relaxation supplements. The most popular combination is apigenin with L-theanine and magnesium glycinate or magnesium threonate, which is the core of the Huberman sleep stack. Apigenin can also be combined with glycine, tart cherry extract, or lemon balm for enhanced sleep support. Avoid combining with sedating supplements like valerian root or kava at high doses unless you’ve assessed your individual response.

How long does it take for apigenin to work?

Many users report feeling calming effects within 30 to 60 minutes of taking apigenin, which is why pre-bedtime timing is recommended. For sleep quality improvements, consistent daily use over one to two weeks tends to produce the most noticeable results. The antioxidant and cellular health benefits of apigenin are longer-term effects that develop with sustained supplementation over weeks to months.

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