Best Berberine HCl Supplements (2026)
Berberine HCl is one of the most researched plant-based compounds for metabolic health, blood sugar management, and cardiovascular support. Extracted primarily from plants like barberry, goldenseal, and Chinese goldthread, berberine activates AMPK — an enzyme that plays a central role in regulating metabolism. These are the best berberine HCl supplements available right now.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Effective Nutra Berberine Gummies | Berberine 1200mg + Ceylon Cinnamon | Gummies | Best Overall | 9.5/10 |
| Ceylon Cinnamon Berberine Gummies | Berberine HCl 2000mg + Ceylon Cinnamon | Gummies | Best High-Dose Gummy | 9.3/10 |
| Serene Herbs GLP-1 with Berberine | Berberine + Innoslim + Chromium | Capsules | Best for Metabolic Reset | 9.2/10 |
| Sunergetic Berberine 500mg | Berberine HCl 500mg | Capsules | Best Pure Formula | 9.1/10 |
| Extreme Berberine Plus | Berberine + ALA + CoQ10 + Cinnamon | Capsules | Best Multi-Ingredient | 9.0/10 |
| Toplux Berberine 1800mg | Berberine HCl 1800mg | Capsules | Most Potent | 8.9/10 |
| Berberine with Ceylon Cinnamon & Bitter Melon | Berberine 1500mg + Bitter Melon + Gymnema | Capsules | Best Blood Sugar Blend | 8.8/10 |
1. Effective Nutra Berberine Gummies – Best Overall
- Premium Berberine with Ceylon Cinnamon: Crafted with high-quality berberine and premium Ceylon cinnamon, our gummies deliver a potent blend to help you feel your best every day. These ingredients are thoughtfully combined to support energy balance, overall wellness, and a healthy lifestyle. Perfect for both men and women seeking a convenient health solution.*
- Metabolism & Heart Wellness Support: Formulated to help maintain healthy metabolic function and promote heart wellness, these gummies offer a clean, effective, and convenient way to support your overall health. Enjoy the benefits of berberine and Ceylon cinnamon in a naturally delicious format.*
- Natural Energy & Vitality in Every Bite: Experience the natural benefits of berberine in a delicious and sugar-free gummy form. Designed to support an active, vibrant lifestyle, these gummies make it simple to incorporate essential wellness support into your daily routine.*
- Convenient & Easy-to-Take Gummies: No more dealing with messy powders or hard-to-swallow capsules! Our naturally flavored, sugar-free gummies are designed for convenience and taste, making it easier than ever to enjoy the benefits of berberine. Simply take 2 gummies daily or as recommended by your healthcare professional. Each bottle includes 90 gummies, providing a 45-day supply.*
- For Every Lifestyle: Vegan, Non-GMO, Gluten-Free, Dairy-Free, Soy-Free, Gelatin-Free, and Pectin-Based. Produced in a GMP-certified facility and rigorously third-party tested, these gummies are crafted with clean ingredients to fit into any wellness routine.*
Effective Nutra delivers a potent 1200mg berberine dose in a sugar-free gummy format that makes daily supplementation easy and enjoyable.
Each serving combines berberine HCl with Ceylon cinnamon for synergistic blood sugar support. The sugar-free formula uses natural sweeteners, making it suitable for those monitoring glucose levels. Produced in a GMP-certified facility with third-party testing for purity and potency. The gummy format offers superior compliance compared to large capsules that some users find difficult to swallow.
- Pros:
- Sugar-free gummy format with great taste
- 1200mg berberine per serving with Ceylon cinnamon
- Third-party tested, GMP-certified manufacturing
- Cons:
- Higher cost per serving than capsule alternatives
- Gummies may not suit those who prefer traditional capsules
Best for: Anyone who wants a convenient, sugar-free berberine supplement with added cinnamon for metabolic support
2. Ceylon Cinnamon Berberine Gummies 2000mg – Best High-Dose Gummy
- Berberine Ceylon Cinnamon Supplement - Berberine HCl, a natural compound with numerous benefits, is paired with Ceylon cinnamon, a cleaner, gentler option that's neither spicy nor bitter. Their 1:1 ratio (2000 mg blend per serving) is designed to support healthy eating habits, digestion & immunity, helping you achieve a balanced lifestyle. *A healthier and tastier choice, sugar-free orange flavored vegan gummies
- Premium 9-in-1 Upgraded Formula - Our cinnamon berberine supplement contains bitter melon, green tea, black pepper and added chromium, magnesium glycinate, vitamins B6 & B12 to better support your wellness goals. Helps break down the burden of daily intake and improve fatigue caused
- Organic Ceylon Cinnamon - Experience the natural power of "Real Cinnamon", sourced directly from the Cinnamon Tree in Sri Lanka, making it a safer, gentler option for long-term use than common cassia cinnamon. It works better with berberine to effectively activate energy switch for an ideal curve
- Vegan, Natural, Sugar Free - Delicious orange flavor, contains no animal gelatin, sweetened with natural stevia and monk fruit, it's a healthier choice with low calories and no aftertaste. Free of GMOs, gluten, dairy, soy, sugar, binders, yeast and artificial ingredients and flavors
- Quality First - All of our berberine ceylon cinnamon gummies are manufactured, tested and bottled for the superior quality and consistency. Get rid of the frustrating berberine capsules, pills or cinnamon powder, have a go at this wonderful yummy berberine with ceylon cinnamon gummy alternative, it will give you a new and wonderful experience!
This high-potency formula packs 2000mg of berberine HCl per serving alongside organic Ceylon cinnamon in a sugar-free chewable gummy.
The 2000mg dose is one of the strongest available in gummy form, making it a solid choice for those who need higher berberine intake. Ceylon cinnamon (not cassia) adds metabolic benefits without the coumarin concerns associated with cheaper cinnamon varieties. Each batch is manufactured in the USA under strict GMP protocols.
- Pros:
- One of the highest-dose berberine gummies at 2000mg
- Organic Ceylon cinnamon included
- Sugar-free formula suitable for blood sugar management
- Cons:
- High dose may cause GI discomfort in some users
- Two-gummy serving size
Best for: Users who need a high-potency berberine gummy without compromising on cinnamon quality
3. Serene Herbs GLP-1 Supplement with Berberine – Best for Metabolic Reset
- APPETITE CONTROL: Support your wellness journey with our all natural non-stimulant GLP-1 supplement designed to help balance cravings, support healthy digestion, and promote steady energy levels throughout your day without jitters or crashes.
- RESEARCH-BACKED INGREDIENTS: Features premium Berberine HCl, InnoSlim, Actiponin, African Mango extract, Apple Cider Vinegar, White Kidney Bean extract, Green Tea Extract, Banaba Leaf, Bitter Melon, and BioPerine for enhanced absorption and metabolic support.
- EASY DAILY ROUTINE: Take 2 capsules with your first meal to kickstart your wellness routine - supports healthy digestive balance in week 1, helps reduce food cravings by weeks 2-3, and promotes balanced metabolic rhythm by months 3-4.
- USA MADE & TESTED: Crafted in FDA-registered cGMP-certified facility using globally sourced premium ingredients, our vegan, non-GMO, stimulant-free formula undergoes rigorous third-party lab testing for purity, potency and quality assurance.
- WELLNESS RESET: We are focused on helping you create sustainable healthy habits and balanced food choices rather than restrictive crash dieting - experience a gentle metabolic reset approach rooted in traditional herbal wellness science and modern research.
Serene Herbs combines berberine with Innoslim and chromium for comprehensive metabolic and appetite support targeting GLP-1 pathways.
This formula goes beyond standard berberine by including Innoslim (a patented Astragalus and Panax notoginseng blend) that research suggests may support GLP-1 production. Chromium picolinate rounds out the formula for additional insulin sensitivity support. Capsule form with clear dosing instructions. Manufactured in the USA in a GMP-registered facility.
- Pros:
- Multi-pathway metabolic support with berberine + Innoslim
- Includes chromium for added blood sugar support
- Targets GLP-1 pathways naturally
- Cons:
- Premium price point for the multi-ingredient formula
- May be more than needed for those seeking pure berberine
Best for: Users looking for a comprehensive metabolic support formula built around berberine
4. Sunergetic Berberine 500mg – Best Pure Formula
- CARDIOVASCULAR SUPPORT: Berberine may support cardiovascular function
- AMPK ACTIVATOR: Berberine is a powerful AMPK Activator that supports antioxidant activity and metabolic function
- TWO MONTH SUPPLY: Double Wood's Berberine contains 60 convenient single dose capsules, each with 500mg. Unlike competitors, we offer a convenient single capsule serving
- ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's Berberine is manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus, it is Vegetarian safe, Non-GMO and gluten-free
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
A straightforward, no-nonsense berberine HCl supplement delivering 500mg per capsule with third-party testing and clean ingredients.
Sunergetic keeps it simple with 500mg of berberine HCl per capsule and nothing else unnecessary. The 60-capsule bottle provides a full month at the standard twice-daily dosing. Third-party tested for purity, non-GMO, and gluten-free. The moderate 500mg dose allows users to easily adjust their intake based on individual needs and tolerance.
- Pros:
- Clean, single-ingredient formula
- Third-party tested, non-GMO, gluten-free
- Flexible dosing with 500mg capsules
- Cons:
- Only 60 capsules per bottle
- No added absorption enhancers
Best for: Purists who want straightforward berberine HCl without extra ingredients
5. Extreme Berberine Plus – Best Multi-Ingredient Formula
- POTENT BLOOD SUGAR SUPPORT: The berberine in this supplement is a powerful compound that can help support healthy blood sugar levels. Additionally, cinnamon, turmeric, and bitter melon are also included in this formula for their ability to support glucose level.
- CARDIO HEALTH: Coenzyme Q10 (CoQ10) is an antioxidant that is naturally produced in the body and plays a crucial role in the production of energy. It has been shown to support healthy blood pressure levels, as well as overall cardiovascular health.
- IMMUNE SYSTEM SUPPORT: Royal jelly, Korean Panax, and other herbs in this formula can help to support a healthy immune system. These ingredients are rich in antioxidants, vitamins, and minerals that can help to strengthen your body's natural defenses.
- SUPPORT FOR HEALTHY DIGESTION: Bitter melon and banaba leaf are both known for their ability to support healthy digestion. Bitter melon can help to stimulate the production of digestive enzymes, while banaba leaf has been shown to help regulate blood sugar levels and support healthy digestion.
- HEALTHY JOINT SUPPORT : Turmeric is a well-known immunity and joint support herb that can be especially beneficial for those with joint pain, as well as for overall health and wellness.
This comprehensive formula stacks berberine with alpha lipoic acid, CoQ10, turmeric, cinnamon, bitter melon, and banaba leaf for broad metabolic support.
Extreme Berberine Plus takes a kitchen-sink approach with clinically relevant support ingredients. Alpha lipoic acid and CoQ10 add antioxidant and mitochondrial support, while bitter melon and banaba leaf provide additional blood sugar management compounds. Cinnamon and turmeric offer anti-inflammatory benefits. This is a solid all-in-one option for users who would otherwise take multiple supplements.
- Pros:
- Comprehensive formula with 7+ active ingredients
- Includes ALA and CoQ10 for additional metabolic support
- Good value for a multi-ingredient supplement
- Cons:
- Individual ingredient doses may be lower in a blend
- More ingredients increase potential for interactions
Best for: Users who want a single supplement covering berberine, antioxidants, and blood sugar support
6. Toplux Berberine 1800mg – Most Potent
- ★Ultra High Purity 97% Berberine HCl - Our Berberine Supplement delivers 1800mg of Berberine HCl 97% purity to ensure optimal results with a potent and concentrated form of Berberine and support your health and overall wellness goals. Higher purity means more of the active compounds which results in berberine powerful benefits. Berberine supplement is made to balance levels and support a healthy diet for better natural body functions.
- ★Maximize the Results - Looking for natural supplement support? Berberine Supplement supports maintaining daily balance naturally. Berberine ultra high purity formula is designed to provide peak effectiveness. The high purity berberine hcl formula provides a concentrated dose that can be added into a healthy diet to support overall health and balance. It delivers pure, potent, and natural berberine hcl in an easy-to-digest vegetable capsule.
- ★Pure and Premium Quality Berberine - With Berberine HCl 97% purity our supplement ensures that every capsule is effective and potent to deliver optimum concentration. Our Berberine supplement provides 600mg of berberine hcl in each easy-to-swallow veggie capsule. Berberine is a trusted compound that has been used traditionally to help support your overall wellness.
- ★GMP Registered Facility - Our products are manufactured and formulated in USA. Our Supplements are manufactured under GMP (Good Manufacturing Practice) badge and we deliver the highest quality supplement to our customers. The formula and solutions have been made and verified base on scientific research to assure you get the best Result
- ★Customer Satisfaction - Since we trust in our quality supplement, it is returnable with no question asked so you can shop with confidence. Customer satisfaction is our top priority so simply contact us if you have any issues or concerns
Toplux delivers one of the highest berberine HCl doses on the market at 1800mg per serving, with 97% tested purity.
At 1800mg per serving, this is among the strongest berberine supplements available. The 97% purity testing ensures you’re getting a high-quality extract. The capsule format provides straightforward dosing, and the higher potency means fewer capsules compared to lower-dose alternatives. Manufactured in the USA with GMP certification.
- Pros:
- Ultra-high 1800mg dose per serving
- 97% tested purity
- USA manufactured, GMP certified
- Cons:
- High dose may cause GI side effects, especially for new users
- Not ideal for those who want to start with a lower dose
Best for: Experienced berberine users who need maximum potency
7. Berberine with Ceylon Cinnamon, Bitter Melon & Gymnema – Best Blood Sugar Blend
- CORE INGREDIENTS & PREMIUM SOURCES - Each serving of Berberine with Ceylon Cinnamon delivers 1500mg of 97% pure Berberine HCl, paired with Ceylon Cinnamon, Bitter Melon, and Gymnema. Berberine Supplement is sourced from 5+ year-old wild Berberis plants, and Ceylon Cinnamon uses inner bark from 8+ year-old trees - natural nutrient content is 40% higher than artificially grown alternatives
- WHO IT’S FOR - Ideal for people focused on daily wellness, those seeking post-meal digestive comfort, and anyone wanting to support metabolism through natural ingredients. Perfect for office workers, fitness enthusiasts, or anyone prioritizing long-term, gentle wellness care
- SYNERGISTIC INGREDIENT BENEFITS - Ceylon Cinnamon enhances Berberine absorption, while Bitter Melon and Gymnema work together to support natural metabolic balance from multiple angles. Friendly for sensitive stomachs.
- HOW & WHEN TO USE - Take 3 capsules daily, either with meals or right after eating—no complicated routines. Fits seamlessly into busy workdays, at-home relaxation time, pre/post-workout schedules, or even travel, making it easy to stick to your wellness goals.
- STRICT QUALITY & TRUSTWORTHY CHOICE - Made under strict quality control standards—100% Non-GMO, sugar-free, gluten-free, wheat-free, and free of artificial flavors. No harsh additives, so it’s safe for long-term use, giving you peace of mind for daily wellness support.
A well-rounded blood sugar support formula combining 1500mg berberine with bitter melon and gymnema sylvestre for multi-pathway glucose management.
This supplement targets blood sugar from multiple angles. Berberine activates AMPK, bitter melon contains compounds that mimic insulin, and gymnema sylvestre has been traditionally used to reduce sugar cravings and support healthy glucose metabolism. The 1500mg berberine dose hits the clinical range used in most research studies. Ceylon cinnamon rounds out the formula for additional metabolic support.
- Pros:
- Clinically relevant 1500mg berberine dose
- Multi-pathway blood sugar support with gymnema and bitter melon
- Ceylon cinnamon (not cassia) included
- Cons:
- Multiple capsules per serving
- Newer brand with less long-term track record
Best for: Users specifically seeking comprehensive blood sugar management support
8. Berberine HCL with Ceylon Cinnamon Liquid Drops – Best Liquid Formula
- 【Berberine HCL Supplement】Berberine liquid drops supplement made with natural ingredients.We extract key elements from natural herb ingredients.We've combined a unique blend of more naturally sourced herbs extracts Berberine HCI, Aloe vera, Bitter Melon, Ceylon Cinnamon, Milk Thistle, Turmeric, Artichoke Leaf, Chromium, Cactus, Turmeric Curcumin Root, Goldenseal Root, Black Pepper, and Vegetable Cellulose.
- 【 Powerful Blend Ingredient】Berberine supplement has been studied for its potential effects to support overall health including enhanced immunity boost, digestive system, wellness support, and sores in mouth care and gut health. Berberine liquid drops help maintain health levels balance. Black pepper a natural absorption-enhancing herb, is added to unlock the full potential of each ingredient.
- 【Friendly Vegan】Berberine liquid drops supplement is a natural organic, gluten-free, non-GMO, plant-based, and vegan product. Berberine supplement helps maintain a healthy body. It also helps to maintain normal body levels already within the normal range.
- 【Convenient to Take】 Total health benefits by taking only 1-2 ml of berberine supplement once a day after food, or add to your drink like water, tea, or juice, daily with a meal for optimal results. You can effortlessly support your support wellness, and keep your gut happy.
- 【Well-being Life Commitment】We make sure you will always get the highest-quality products that help our customers to live happier and healthier lives. The convenient and tasty way to incorporate berberine, Ceylon cinnamon, and milk thistle into your routine; enhances wellness with great taste and vital nutrients. Align your wellness journey with B BEWORTHS, a brand committed to your well-being.
A liquid berberine phytosome formula offering enhanced absorption through liposomal-style delivery with Ceylon cinnamon support.
Liquid drops provide an alternative for users who struggle with capsules or want faster absorption. The phytosome delivery system binds berberine to phospholipids, which may improve bioavailability compared to standard HCl capsules. Ceylon cinnamon extract is included for synergistic metabolic benefits. The dropper format allows precise dose adjustment.
- Pros:
- Liquid format for easy absorption and flexible dosing
- Phytosome delivery may enhance bioavailability
- No capsules to swallow
- Cons:
- Taste may not appeal to everyone
- More expensive per serving than capsules
Best for: Users who prefer liquid supplements or have difficulty swallowing capsules
9. Snap Supplements Cholesterol Health with Berberine – Best for Cholesterol Support
- Healthy Heart & Cholesterol Support: Formulated with two bioactive blends, this antioxidant-rich supplement supports heart health, healthy fat metabolism, and cholesterol levels already within the normal range.
- Milk Thistle Supplement with Garlic Extract: Includes milk thistle with silymarin to support liver and cholesterol wellness, plus garlic extract, a natural prebiotic that promotes digestive and metabolic health by supporting beneficial gut bacteria.
- Plant-Based Lipid Balance Formula with Artichoke: This formula features artichoke leaf extract and plant sterols, including beta-sitosterol, to support healthy fat metabolism and cholesterol balance as part of a plant-based wellness routine.
- Enhance Your Wellness Routine: Formulated for adults looking for a natural, plant-powered way to support digestive and metabolic health - convenient for use at home, the office, or while traveling - simply take 2 capsules daily.
- Quality You Can Trust: Our vitamins and supplements are crafted by health experts and manufactured in the USA with globally sourced ingredients. This supplement is non-GMO, free of major allergens, gluten-free, and manufactured in a GMP-certified facility to ensure purity, potency, and quality. It contains no gelatin, dairy, or other animal-derived substances – making it a great option for vegans & vegetarians.
Snap Supplements pairs berberine with artichoke extract, milk thistle, and garlic for a targeted cholesterol and cardiovascular health formula.
While many berberine supplements focus on blood sugar, this formula zeroes in on lipid management. Artichoke extract and garlic have research supporting their roles in healthy cholesterol levels, while milk thistle provides liver support for optimal lipid metabolism. Berberine ties it together with its well-documented effects on LDL cholesterol and triglycerides. Clean label with no unnecessary fillers.
- Pros:
- Targeted cholesterol support with berberine + artichoke + garlic
- Includes milk thistle for liver health
- Well-rounded cardiovascular formula
- Cons:
- Not a pure berberine supplement
- Garlic may cause digestive discomfort in sensitive users
Best for: Users primarily taking berberine for cholesterol and cardiovascular support
How to Choose the Best Berberine HCl Supplement
The most important factor when choosing a berberine supplement is the dose per serving. Most clinical studies use between 900mg and 1500mg daily, typically split into two or three doses. A supplement providing 500mg per capsule gives flexibility to adjust intake, while higher-dose formulas (1000mg+) reduce the number of pills needed.
Look for berberine HCl specifically, as this is the most commonly studied and bioavailable form. Some formulas use berberine phytosome or pair berberine with absorption enhancers like black pepper extract or phospholipids. These may offer improved bioavailability but often come at a higher price point.
Consider what form works best for your lifestyle. Capsules are the most cost-effective, gummies are easier to take consistently, and liquid drops offer the fastest absorption. If you’re new to berberine, starting with a lower dose (500mg) and gradually increasing helps minimize common GI side effects like bloating and cramping.
Third-party testing and GMP certification are non-negotiable for quality assurance. Look for brands that publish their testing results or use recognized third-party labs. Supplements that combine berberine with complementary ingredients like Ceylon cinnamon, chromium, or alpha lipoic acid can provide additional metabolic benefits.
Frequently Asked Questions
What is berberine HCl and what does it do?
Berberine HCl (hydrochloride) is a bioactive compound extracted from several plants including barberry, goldenseal, and Oregon grape. It activates an enzyme called AMPK, which plays a key role in regulating metabolism, blood sugar levels, and lipid profiles. Research has shown berberine can support healthy blood sugar levels, improve insulin sensitivity, reduce LDL cholesterol, and promote healthy triglyceride levels.
How much berberine HCl should I take daily?
Most clinical studies use 900mg to 1500mg daily, typically divided into two or three doses taken with meals. Starting with 500mg once daily and gradually increasing over one to two weeks helps minimize digestive side effects. Do not exceed 1500mg daily without guidance from a healthcare provider.
When is the best time to take berberine?
Take berberine with meals, ideally splitting the daily dose across two or three meals. Taking it with food improves absorption and reduces the likelihood of stomach upset. Spacing doses throughout the day also helps maintain more consistent blood levels of the compound.
Are there any side effects of berberine?
The most common side effects are gastrointestinal, including bloating, gas, cramping, diarrhea, and constipation. These typically subside within the first week or two as the body adjusts. Starting with a lower dose and increasing gradually helps minimize these effects. Berberine can interact with certain medications, particularly those for diabetes, blood pressure, and blood thinning.
Can I take berberine with other supplements?
Berberine pairs well with Ceylon cinnamon, alpha lipoic acid, chromium, and CoQ10 for enhanced metabolic support. However, it should not be combined with metformin or other blood sugar-lowering medications without medical supervision, as the combined effect could cause hypoglycemia. Berberine may also interact with medications metabolized by the CYP3A4 liver enzyme.
How long does it take for berberine to work?
Most users notice improvements in blood sugar levels within two to four weeks of consistent use. Cholesterol and lipid changes typically take eight to twelve weeks to become apparent. For best results, take berberine consistently with meals and combine it with a healthy diet and regular physical activity.
