Best Beta-Glucan Supplements (2026)

Beta-glucans are naturally occurring polysaccharides found in the cell walls of yeast, oats, mushrooms, and algae. The most immunologically active forms — beta-1,3/1,6-D-glucans — bind to receptors on immune cells like macrophages and neutrophils, priming the immune system for a faster and more effective response to threats. These supplements have become a staple for year-round immune support backed by extensive clinical research.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Transfer Point Beta 1,3D Glucan 100mg	Beta 1,3D Glucan 100mg	Capsules	Best Overall	9.5/10
Better Way Health Beta Glucan 500	Beta 1,3/1,6 Glucan 500mg	Capsules	Best Premium	9.4/10
Immune Health Basics 500mg	Wellmune Beta Glucan 500mg	Capsules	Best Clinically Studied	9.2/10
NOW Foods Beta-Glucans Extra Strength	Beta-Glucans + ImmunEnhancer	Veg Capsules	Best Value	9.0/10
SMNutrition Beta Glucan 1100mg	Beta 1,3D/1,6D Glucan 1100mg	Capsules	Most Potent	8.9/10
Truth Nutrition Beta Glucan	Algae-Based Beta 1,3 Glucan 375mg	Capsules	Best Algae-Based	8.8/10
Nutriana Beta Glucan 1000mg	Beta 1,3/1,6D Glucan 1000mg	Capsules	Best Black Yeast Source	8.7/10

1. Transfer Point Beta 1,3D Glucan 100mg – Best Overall

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Transfer Point is widely considered the gold standard in beta-glucan supplementation, delivering highly purified beta-1,3D glucan from baker’s yeast with no fillers and GRAS safety status.

Transfer Point’s Beta 1,3D Glucan has built a reputation as the purest and most effective beta-glucan supplement available. Each 100mg capsule contains highly purified beta-1,3D glucan sourced from Saccharomyces cerevisiae (baker’s yeast) with no fillers, sweeteners, or artificial flavors. The product holds GRAS (Generally Recognized As Safe) status, and the brand emphasizes that purity level — not just dosage — is what determines a beta-glucan’s effectiveness. The vegetarian capsules can be easily opened for mixing with food, making them versatile enough for pets as well as adults. Transfer Point recommends 1-2 capsules daily on an empty stomach for optimal results.

• Pros:
• Highest purity beta-1,3D glucan with no fillers
• GRAS-rated with extensive safety studies
• Capsules can be opened for versatile use including pets

• Cons:
• 100mg dose may require multiple capsules for larger individuals
• Higher price per milligram than less pure alternatives

Best for: Those who prioritize purity and want the most trusted name in beta-glucan supplementation

2. Better Way Health Beta Glucan 500 – Best Premium

Outperforming over 100 competing brands in double-blind University of Louisville studies, Better Way Health delivers 500mg of highly purified 1,3/1,6 beta-glucan per capsule for maximum immune activation.

Better Way Health’s Beta Glucan 500 has been validated through rigorous university research, demonstrating superior immune cell activation compared to hundreds of competing supplements in controlled studies. Each capsule provides 500mg of highly purified beta 1,3/1,6-D-glucan that enhances production of neutrophils, antibodies, B cells, natural killer cells, and macrophages without overstimulating the immune system. The formula is based on published research from the University of Louisville spanning multiple studies from 2016 to 2020. The recommended protocol is 2 capsules (1,000mg) daily on an empty stomach, taken 30 minutes before eating. The product is made in the USA and contains no artificial additives.

• Pros:
• Clinically tested and published research showing superiority over 100+ brands
• 500mg per capsule for high-dose immune support
• Supports trained immunity — helps the body remember past threats

• Cons:
• Premium pricing reflects the clinical research backing
• Requires taking on an empty stomach for optimal effectiveness

Best for: Those willing to invest in a research-backed, clinically validated beta-glucan with proven superiority

3. Immune Health Basics Ultra Strength 500mg – Best Clinically Studied

The only yeast beta-glucan brand supported by its own human clinical studies, featuring the patented Wellmune ingredient that has been proven to support immune function without overstimulation.

Immune Health Basics uses the Wellmune beta-glucan ingredient — a highly purified beta-1,3/1,6-glucan derived from baker’s yeast through a proprietary process designed for optimal bioavailability. What sets this product apart is its brand-specific clinical research demonstrating immune support benefits in human subjects. Each capsule delivers 500mg of Wellmune beta-glucan, and the product is safe for daily use without risk of immune overstimulation. The formula is non-GMO, gluten-free, lactose-free, vegetarian, vegan, and contains no additives or fillers. This extra-strength version is specifically designed for adults with challenged immune health or those wanting maximum support.

• Pros:
• Patented Wellmune ingredient with brand-specific clinical studies
• 500mg extra-strength dose for adults with challenged immune health
• Safe for daily use with no immune overstimulation risk

• Cons:
• Higher cost than generic beta-glucan supplements
• Only 60 capsules per bottle at 1-per-day dosing

Best for: Those who want a clinically studied beta-glucan with patented ingredient verification and proven safety for daily use

4. NOW Foods Beta-Glucans with ImmunEnhancer – Best Value

NOW Foods combines 250mg of beta-1,3/1,6-D-glucan with ImmunEnhancer (larch arabinogalactan) for dual-pathway immune support at a fraction of premium brand pricing.

This extra-strength formula from NOW Foods pairs beta-glucans with ImmunEnhancer, a high molecular weight polysaccharide extracted from the larch tree that has been studied for its ability to promote a healthy immune response. The dual-ingredient approach provides immune support through two complementary pathways — beta-glucan activates innate immune cells while arabinogalactan supports adaptive immune function. Each bottle contains 60 vegetarian capsules, and the product is manufactured in NOW’s GMP-certified facilities. For those who want effective immune support without the premium pricing of single-ingredient brands, this formula offers excellent value with solid research behind both ingredients.

• Pros:
• Dual-pathway immune support with beta-glucans and larch arabinogalactan
• Significantly more affordable than premium single-ingredient brands
• Trusted NOW Foods brand with GMP-certified manufacturing

• Cons:
• 250mg beta-glucan dose is lower than premium competitors
• Contains additional inactive ingredients (cellulose, silicon dioxide, magnesium stearate)

Best for: Value-conscious consumers who want effective dual-pathway immune support from a trusted brand

5. SMNutrition Beta Glucan 1100mg – Most Potent

Delivering the highest per-serving dose at 1,100mg with 85% concentration and both 1,3D and 1,6D beta-glucan types, this is the most potent formula for those who want maximum immune cell activation.

SMNutrition’s Extra Strength Beta Glucan stands out with an industry-leading 1,100mg per 2-capsule serving at a minimum 85% beta-glucan concentration. Unlike many competitors that only offer type 1,3 beta-glucans, this formula includes the full spectrum of both 1,3D and 1,6D beta-glucans for comprehensive immune receptor activation. The product is Gluten Intolerance Group Certified, Non-GMO, Certified Vegan, and formulated without titanium dioxide, silicon dioxide, or the top 9 allergens. Each batch is third-party tested in a GMP-compliant facility certified to NSF standards. The 60-capsule bottle provides 30 servings at the full-dose protocol.

• Pros:
• Highest dose available at 1,100mg with 85% minimum concentration
• Full spectrum 1,3D and 1,6D beta-glucan types for comprehensive support
• Clean formula — free from titanium dioxide, silicon dioxide, and top 9 allergens

• Cons:
• Requires 2 capsules per serving to reach full 1,100mg dose
• Smaller brand with less research pedigree than Transfer Point or Better Way

Best for: Those who want the highest available dose of beta-glucans with both 1,3D and 1,6D types in a clean formula

6. Truth Nutrition Beta Glucan Immune – Best Algae-Based

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For those who prefer non-yeast sources, Truth Nutrition uses Euglena gracilis algae — which contains the highest natural concentration of beta-1,3 glucan of any organism — in a clinically studied formulation.

Truth Nutrition takes a unique approach by sourcing their beta-glucan from Euglena gracilis algae rather than the traditional baker’s yeast. This algae strain naturally contains a higher concentration of beta-1,3 glucan than any other plant or cell life, and the proprietary BetaVia Complete ingredient is produced through a patented fermentation process. Each capsule provides 375mg of dried whole-cell algae fermentate, and the product works through three distinct pathways to support year-round immune health including respiratory and digestive tract support. The formula is plant-based, non-GMO, vegan, and gluten-free, making it ideal for those with yeast sensitivities.

• Pros:
• Algae-based source — ideal for those with yeast sensitivities or preferences
• Clinically studied BetaVia Complete proprietary ingredient
• Supports immune, respiratory, and digestive health through three pathways

• Cons:
• 375mg per capsule is lower than yeast-based competitors
• Less established research base compared to yeast-derived beta-glucans

Best for: Those with yeast sensitivities who want a plant-based, clinically studied alternative to traditional beta-glucan sources

7. Nutriana Beta Glucan 1000mg – Best Black Yeast Source

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Sourced from black yeast (Aureobasidium pullulans), Nutriana offers a structurally complete 1,3/1,6D beta-glucan at 1,000mg per serving with additional bone and joint support benefits.

Nutriana’s Beta Glucan supplement uses the Polycan ingredient sourced from black yeast (Aureobasidium pullulans), which produces a more structurally complete beta-glucan chain compared to typical baker’s yeast or oat sources. Each 2-capsule serving delivers 1,000mg of purified 1,3/1,6 beta-glucans, and the product is formulated to support not only immune function but also bone structure and joint health — a benefit unique to this particular beta-glucan source. The formula is vegan, non-GMO, gluten-free, and manufactured in a GMP-certified facility in the USA. This is a strong choice for those who want immune support with the added benefit of skeletal system support.

• Pros:
• Black yeast source provides structurally complete beta-glucan chains
• 1,000mg per serving with dual immune and bone/joint benefits
• Vegan, non-GMO, USA-made in GMP-certified facility

• Cons:
• Less clinical research on black yeast-derived beta-glucans compared to baker’s yeast
• Requires 2 capsules per serving

Best for: Those seeking beta-glucan immune support with the added benefit of bone and joint health from a unique yeast source

8. SOLARAY Beta Glucan – Best for Heart & Digestion

SOLARAY delivers 200mg of baker’s yeast beta-glucan fiber with both 1,3 and 1,6 linkages, targeting immune defense, heart health, and digestive regularity in a single supplement.

SOLARAY’s Beta Glucan takes a fiber-forward approach, emphasizing the dual benefits of beta-glucan as both an immune modulator and a prebiotic fiber. The formula provides 200mg of beta-glucan fiber from baker’s yeast cell wall with polybranched 1,3 and 1,6 linkages for immune defense and heart health support. As an insoluble fiber, it also contributes to healthy digestion and regularity. SOLARAY manufactures in their GMP-certified facility and tests products in their own state-of-the-art lab in Utah. The brand uses 100% PCR (post-consumer recycled) bottles and partners with the One Million Trees reforestation initiative. Each bottle contains 30 vegetarian capsules.

• Pros:
• Triple benefit — immune, heart, and digestive support in one supplement
• Lab-tested in SOLARAY’s own facility for verified quality
• Eco-friendly packaging with 100% PCR bottles

• Cons:
• 200mg dose is lower than high-potency competitors
• Only 30 capsules per bottle

Best for: Those who want a versatile beta-glucan supplement supporting immune, heart, and digestive health from an eco-conscious brand

How to Choose the Best Beta-Glucan Supplement

The source and purity of beta-glucan are the most important selection criteria. Baker’s yeast (Saccharomyces cerevisiae) is the most clinically studied source for immune-active beta-1,3/1,6-D-glucans. Oat-derived beta-glucans are better suited for heart health and cholesterol management. Algae-based options like BetaVia Complete from Euglena gracilis offer an alternative for those with yeast sensitivities. The higher the purity percentage, the more immune-active the product will be — look for supplements that specify their concentration level.

Dosage varies significantly across products, from 100mg to over 1,000mg per serving. Research suggests that purity matters more than raw dose — a highly purified 100mg supplement can outperform a less pure 500mg product. For general immune maintenance, 100-500mg daily is typical. For intensive immune support, 500-1,000mg may be more appropriate. Beta-glucan is best taken on an empty stomach, 30 minutes before eating, for optimal immune cell receptor binding.

Look for products that specify the beta-glucan linkage type — 1,3/1,6 is the most immunologically active configuration. Third-party testing, GMP certification, and clinical research behind the specific ingredient (not just beta-glucan in general) provide additional quality assurance. Beta-glucan supplements can be safely combined with other immune support supplements like elderberry, vitamin C, and zinc for comprehensive protection, making them an excellent foundation for a year-round immune support stack.

Frequently Asked Questions

What is beta-glucan and what does it do?

Beta-glucan is a type of soluble fiber found in the cell walls of yeast, mushrooms, oats, and algae. The immunologically active form — beta-1,3/1,6-D-glucan — binds to specific receptors on immune cells (particularly macrophages, neutrophils, and natural killer cells), essentially “priming” them for a faster and more effective response to pathogens. Unlike some immune stimulants, beta-glucan modulates the immune system without overstimulating it, making it safe for daily use.

How much beta-glucan should I take daily?

Most clinical studies use doses between 100-500mg of purified beta-1,3/1,6 glucan daily. Transfer Point recommends 100-500mg based on body weight, while Better Way Health suggests 1,000mg (two 500mg capsules) for optimal results. Purity matters more than raw dose — a highly purified 100mg supplement may be more effective than a less pure 500mg product. Start with the manufacturer’s recommended dose and adjust based on results.

When is the best time to take beta-glucan?

Take beta-glucan on an empty stomach, ideally 30 minutes before eating. This timing allows the beta-glucan molecules to reach the immune cells in the gut lining (Peyer’s patches) without interference from food. Taking it with food significantly reduces its immune-activating effects because food proteins and fats can bind to the beta-glucan molecules before they reach immune receptors.

Are there any side effects of beta-glucan?

Beta-glucan is extremely well-tolerated with minimal reported side effects. Unlike some immune boosters, it modulates rather than overstimulates the immune system, making it safe for daily use. Rare side effects may include mild digestive discomfort when first starting. Those with yeast allergies should choose algae-based alternatives. Immunocompromised individuals or those on immunosuppressive medications should consult their healthcare provider before use.

Can I take beta-glucan with other supplements?

Beta-glucan works well as part of a broader immune support stack. It can be combined with vitamin C, zinc, elderberry, and vitamin D for comprehensive immune defense. Some research suggests these combinations may be synergistic. However, take beta-glucan separately from meals and most other supplements (30 minutes before) for optimal absorption. It is generally compatible with medications, but consult your healthcare provider if you take immunosuppressive drugs.

How long does it take for beta-glucan to work?

Beta-glucan begins priming immune cells within hours of ingestion. However, the full immune-modulating effects build over 1-2 weeks of consistent daily supplementation. Clinical studies showing significant immune improvements typically run for 4-12 weeks. Many users report fewer and shorter illness episodes within the first month of use. For best results, take beta-glucan consistently year-round rather than only when feeling unwell.

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