Best DGL Licorice Supplements (2026)

DGL (deglycyrrhizinated licorice) supplements remove the glycyrrhizin compound from licorice root, delivering the digestive benefits without the blood pressure concerns associated with regular licorice. DGL supports the stomach’s protective mucus lining, soothes the GI tract, and is widely used for acid reflux, heartburn, gastritis, and ulcer support — making it one of the most popular natural digestive remedies available.

Quick Comparison

Product	Strength	Form	Best For	Rating
Zazzee Organic DGL Licorice	7,000 mg (20:1)	Capsules	Best Overall	9.5/10
Nature’s Way DGL Ultra	75 mg GutGard	Capsules	Best Clinically Studied	9.4/10
Natural Factors DGL Chewable	400 mg	Chewable Tablets	Best Chewable	9.3/10
Pure Encapsulations DGL Plus	300 mg DGL + Herbs	Capsules	Best Premium	9.2/10
Designs for Health DGL Synergy	500 mg	Chewable Tablets	Best Practitioner Grade	9.1/10
Nutricost DGL Extract	5,000 mg (10:1)	Capsules	Best Value	9.0/10
Carlyle DGL Licorice	4,000 mg	Capsules	Best Budget Pick	8.8/10

1. Zazzee Organic DGL Licorice – Best Overall

Zazzee delivers the most potent USDA Certified Organic DGL licorice on the market, with a 20:1 extract providing 7,000 mg equivalent strength per capsule.

Each bottle contains 120 vegan capsules for a four-month supply at one capsule per day. The 20:1 concentration means each capsule delivers the equivalent of 7,000 mg of licorice root, making it one of the strongest DGL supplements available. All ingredients — including stabilizers and capsules — are 100% USDA organic, with no sweeteners, artificial flavors, gluten, soy, or GMOs. The product is manufactured in the USA and lab-tested for purity.

• Pros:
• USDA Certified Organic with 100% organic ingredients
• Potent 20:1 extract at 7,000 mg strength per capsule
• Four-month supply per bottle

• Cons:
• Capsule form doesn’t coat the throat like chewables
• Higher price point than non-organic alternatives

Best for: Anyone seeking the most potent organic DGL supplement in a convenient one-capsule-per-day format

2. Nature’s Way DGL Ultra – Best Clinically Studied Formula

Nature’s Way DGL Ultra features GutGard, a clinically researched deglycyrrhizinated licorice root extract standardized for consistent potency and digestive relief.

Each capsule provides 75 mg of GutGard DGL root extract combined with glycine for enhanced absorption. The suggested use is one capsule after food in the morning and one in the evening. The formula is vegan, gluten-free, and free from salt, wheat, corn, soy, dairy, gelatin, and artificial ingredients. Nature’s Way has over 50 years of experience in natural health products.

• Pros:
• Features patented GutGard clinically studied extract
• Vegan capsule format with clean ingredient profile
• Trusted brand with over 50 years of heritage

• Cons:
• Lower milligram dose compared to concentrated extracts
• Requires two capsules daily for full effect

Best for: Those who prioritize clinically researched ingredients and want a standardized DGL extract

3. Natural Factors DGL Chewable – Best Chewable

Natural Factors DGL Chewable is the go-to option for people who prefer to chew their DGL before meals, delivering 400 mg of deglycyrrhizinated licorice per tablet with a pleasant anise flavor.

The 180-count bottle provides a generous supply at one to three tablets per day, chewed 20 minutes before meals. The sugar-free formula includes anise seed powder for flavor and is specially processed to remove glycyrrhizin while retaining beneficial compounds. The tablets are non-GMO, gluten-free, soy-free, and vegan-friendly. Natural Factors is a family-owned B-Corp and Carbon Neutral company with third-party verification.

• Pros:
• Sugar-free chewable format ideal for pre-meal use
• 180-count bottle offers excellent supply
• B-Corp certified company with carbon-neutral operations

• Cons:
• Anise/licorice flavor may not appeal to everyone
• Lower potency per tablet than concentrated extracts

Best for: People who prefer chewable DGL tablets taken before meals for maximum stomach-coating benefit

4. Pure Encapsulations DGL Plus – Best Premium Formula

Pure Encapsulations combines 300 mg of DGL with marshmallow root, aloe vera extract, and slippery elm bark for comprehensive GI tract support in a single capsule.

Each vegetarian capsule delivers DGL licorice root extract alongside 200 mg marshmallow root extract, 100 mg slippery elm bark powder, and 50 mg aloe vera inner fillet extract. This multi-herb approach stimulates mucous production while soothing and protecting the stomach lining from multiple angles. Pure Encapsulations products are free from common allergens, artificial ingredients, and unnecessary fillers. For those also looking at gut lining repair, this formula addresses multiple needs in one capsule.

• Pros:
• Multi-herb formula with four gut-soothing ingredients
• Hypoallergenic — free from all major allergens
• Trusted by healthcare practitioners

• Cons:
• Premium pricing
• Only 60 capsules per bottle (two-month supply)

Best for: Those seeking a practitioner-grade DGL supplement with complementary GI-soothing herbs

5. Designs for Health DGL Synergy – Best Practitioner Grade

Designs for Health DGL Synergy combines standardized DGL with glycine and calcium glycerophosphate in a pleasant-tasting chewable specifically designed for dyspepsia support.

Each two-tablet serving provides 500 mg of deglycyrrhizinated licorice alongside glycine and calcium for synergistic stomach-soothing effects. The formula is sugar-free, non-GMO, gluten-free, and vegetarian-friendly. Designs for Health is the number one practitioner supplement brand recommended by functional medicine professionals, with no-compromise quality standards for raw material selection.

• Pros:
• Synergistic formula with glycine and calcium for enhanced relief
• Number one practitioner-recommended supplement brand
• Sugar-free chewable format

• Cons:
• Higher cost per serving than consumer-grade brands
• 90 tablets per bottle (45 servings)

Best for: Users who want a functional medicine practitioner-grade DGL with synergistic ingredients

6. Nutricost DGL Extract – Best Value

Nutricost delivers a potent 5,000 mg equivalent DGL extract per capsule at an unbeatable price, with 120 servings per bottle and rigorous third-party testing.

Each capsule contains 500 mg of a 10:1 DGL extract, equivalent to 5,000 mg of licorice root. The 120-capsule bottle provides a full four-month supply. Manufactured in an NSF-certified GMP-compliant facility and tested by independent ISO-accredited laboratories, Nutricost prioritizes transparency and quality at accessible prices. The formula is non-GMO and vegan.

• Pros:
• 120 servings per bottle at excellent value
• NSF-certified manufacturing with ISO lab testing
• Potent 10:1 extract delivering 5,000 mg equivalent

• Cons:
• Capsule form rather than chewable
• Not organic

Best for: Value-conscious buyers who want a potent, well-tested DGL extract at a low price

7. Nature’s Way DGL Chewable – Best Classic Chewable

The original Nature’s Way DGL chewable has been a natural health staple for decades, offering straightforward DGL support in a licorice-flavored tablet designed to be chewed before meals.

Each tablet provides DGL extract with a 3:1 concentration, chewed 20 minutes before each meal for optimal stomach-coating benefit. The formula uses fructose, mannitol, and sorbitol as sweeteners with natural licorice flavoring. Nature’s Way sources quality ingredients and maintains non-GMO Project Verification across their product line.

• Pros:
• Time-tested formula with decades of consumer trust
• Licorice-flavored chewable that most users enjoy
• 100-count bottle at an accessible price

• Cons:
• Contains fructose and sorbitol sweeteners
• Lower concentration than newer extract formulas

Best for: Those who prefer a classic, time-tested DGL chewable with traditional licorice flavor

8. Carlyle DGL Licorice – Best Budget Pick

Carlyle packs 200 vegetarian capsules into one bottle at a 4,000 mg licorice equivalent per serving, delivering one of the best price-per-serving ratios in the DGL category.

Each capsule provides DGL extract equivalent to 4,000 mg of licorice root. The 200-count bottle is a generous supply lasting several months. The formula is vegetarian, non-GMO, and gluten-free, backed by Carlyle’s laboratory testing and over 40 years of supplement manufacturing expertise. If you’re also exploring digestive regularity support, DGL pairs well with gentle probiotics.

• Pros:
• 200 capsules per bottle for outstanding supply
• Budget-friendly pricing
• Laboratory tested with trusted ingredient sourcing

• Cons:
• Not organic
• Basic formula without complementary herbs

Best for: Budget shoppers who want a straightforward, well-priced DGL capsule in bulk supply

How to Choose the Best DGL Licorice Supplement

DGL supplements come in two primary forms: chewable tablets and capsules. Chewable DGL is traditionally preferred because it coats the esophagus and stomach lining directly as you chew, providing more immediate soothing contact. Capsules are more convenient and typically offer higher concentrations but bypass the throat-coating benefit.

Look for extract ratios and equivalent dosages when comparing products. A 10:1 extract means 500 mg of extract equals 5,000 mg of raw licorice root. Higher ratios (20:1) deliver more concentrated benefits per capsule. The patented GutGard extract used in Nature’s Way products is one of the few clinically studied DGL forms, making it a strong choice for evidence-based supplementation.

For acid reflux and heartburn, chewable DGL taken 20 minutes before meals is the traditional approach recommended by naturopathic practitioners. For general gut-lining support, capsule forms taken with meals work effectively. USDA organic certification, as found in Zazzee’s product, ensures no pesticide residues in the licorice root — an important consideration since licorice can accumulate contaminants.

Premium formulas from brands like Pure Encapsulations and Designs for Health combine DGL with complementary gut-soothing herbs like marshmallow root and slippery elm, offering a more comprehensive approach to GI support in a single product.

Frequently Asked Questions

What is DGL licorice and what does it do?

DGL (deglycyrrhizinated licorice) is licorice root extract with the glycyrrhizin compound removed. This makes it safer for long-term use, as glycyrrhizin can cause elevated blood pressure and potassium depletion. DGL supports the stomach’s protective mucus lining, soothes the GI tract, and is commonly used for acid reflux, heartburn, gastritis, and stomach ulcer support.

How much DGL licorice should I take daily?

Standard dosing for DGL chewable tablets is 380-500 mg chewed two to three times daily, 20 minutes before meals. For concentrated extracts (10:1 or 20:1), one capsule delivering 3,000-7,000 mg equivalent is typically taken once or twice daily. Follow the specific product’s label directions, as potency varies widely between brands.

When is the best time to take DGL licorice?

For acid reflux and heartburn prevention, chew DGL tablets 15-20 minutes before meals. This allows the extract to coat and protect the stomach lining before food arrives. For general gut-lining support, DGL capsules can be taken with meals. Some practitioners recommend an additional dose before bed for nighttime reflux symptoms.

Are there any side effects of DGL licorice?

DGL is generally considered very safe because the glycyrrhizin — the compound responsible for licorice’s side effects — has been removed. Mild side effects may include headache or digestive discomfort in sensitive individuals. Unlike regular licorice root, DGL does not typically affect blood pressure or potassium levels. Still, pregnant or nursing women should consult a healthcare provider before use.

Can I take DGL licorice with other supplements?

Yes, DGL pairs well with probiotics, digestive enzymes, marshmallow root, slippery elm, and aloe vera for comprehensive GI support. Some practitioners combine DGL with zinc carnosine for enhanced stomach-lining repair. Avoid combining DGL with regular licorice root supplements, as the combined effect could increase glycyrrhizin exposure.

How long does it take for DGL licorice to work?

Many users notice reduced heartburn and stomach discomfort within the first few days of consistent use. For gut-lining repair and longer-term digestive improvement, allow four to eight weeks of daily supplementation. Chewable forms may provide faster symptom relief due to direct contact with the stomach lining.

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