Best DLPA Supplements (2026)
DLPA (DL-phenylalanine) is a unique 50/50 blend of the D and L forms of the essential amino acid phenylalanine. The L-form serves as a precursor to neurotransmitters like dopamine, norepinephrine, and epinephrine that support mood and alertness. The D-form may help extend the life of endorphins and enkephalins — the body’s natural “feel-good” compounds — by inhibiting the enzyme that breaks them down. This dual-action formula makes DLPA popular for mood support, comfort, and mental focus.
Quick Comparison
| Product | Dosage | Form | Best For | Rating |
|---|---|---|---|---|
| Pure Encapsulations DL-Phenylalanine | 500mg | Vegetarian Capsules | Best Overall | 9.5/10 |
| Life Extension D,L-Phenylalanine 500mg | 500mg | Vegetarian Capsules | Best for Mood Support | 9.4/10 |
| Solgar DLPA 500mg | 500mg | Vegetable Capsules | Best Premium | 9.3/10 |
| Source Naturals DLPA 750mg | 750mg | Tablets | Best High Dose | 9.2/10 |
| Carlyle DL-Phenylalanine 1000mg | 1000mg | Quick-Release Capsules | Most Potent | 9.1/10 |
| SOLARAY DL-Phenylalanine 500mg | 500mg | VegCaps | Best for Stress Response | 9.0/10 |
| BulkSupplements DL-Phenylalanine | 500mg | Capsules | Best Value | 8.9/10 |
1. Pure Encapsulations DL-Phenylalanine – Best Overall
- DL-Phenylalanine is a combination of the well-tolerated essential amino acids, d-phenylalanine and l-phenylalanine. Together, these compounds help promote mental functioning and support positive outlook.*
- Memory And Learning Support: l-Phenylalanine is a precursor to l-tyrosine, which converts to the neurotransmitters norepinephrine, epinephrine, dopamine and tyramine. l-Tyrosine and its metabolites may support memory and learning.*
- Muscle/Joint Support: d-Phenylalanine may promote the levels of certain endorphins, thereby calming stressed muscles and joints.*
- Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
- Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.
A hypoallergenic DLPA formula from the gold standard in professional-grade supplementation.
Pure Encapsulations delivers 500mg of DL-phenylalanine per capsule in their signature hypoallergenic format. The formula is free from wheat, eggs, tree nuts, peanuts, gluten, artificial colors, flavors, sweeteners, coatings, GMOs, and unnecessary binders or fillers. With 90 capsules per bottle, this provides a 45-to-90 day supply depending on dosage. Pure Encapsulations is a practitioner-trusted brand that tests every product for potency and purity, and all ingredients are sourced from trusted suppliers.
- Pros:
- Hypoallergenic formula with no unnecessary additives
- Practitioner-grade quality with rigorous testing
- Supports both cognitive function and joint/muscle comfort
- Cons:
- Premium pricing
- 90-count bottle may not last long at higher dosing
Best for: Those who want the cleanest, most trusted DLPA supplement available
2. Life Extension D,L-Phenylalanine 500mg – Best for Mood Support
- Neurotransmitters – Phenylalanine is an amino acid. The liver converts it to L-tyrosine, which your body uses to make the neurotransmitters dopamine, norepinephrine and adrenaline.
- Mood health – Phenylalanine supplementation helps your body synthesize neurotransmitters like dopamine. Studies suggest phenylalanine promotes mood health.
- Brain health – Phenylalanine also supports norepinephrine production. Norepinephrine protects brain cells by promoting a healthy inflammatory response and inhibiting oxidative stress.
- Ingredients matter – We use only the finest raw ingredients with the purity and potency you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
- Live your healthiest life – We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.
A research-backed DLPA from a science-focused brand that prioritizes neurotransmitter health.
Life Extension provides 500mg of D,L-phenylalanine per vegetarian capsule, specifically formulated to support mood health and promote neurotransmitter production. The formula is gluten-free, non-GMO, and vegetarian. With 100 capsules per bottle, this provides a generous supply. Life Extension’s commitment to clinical dosages and ingredient transparency — backed by over 40 years of research — makes this a top choice for mood-focused supplementation. A Certificate of Analysis is available for every product.
- Pros:
- 100-capsule bottle for extended supply
- Formulated specifically for mood and neurotransmitter support
- 40+ years of research-backed supplement expertise
- Cons:
- Contains rice flour as an excipient
- Only 500mg per capsule — higher protocols require multiple capsules
Best for: Those seeking DLPA specifically for mood enhancement and emotional wellbeing. For complementary mood support, see our guide to dopamine supplements.
3. Solgar DLPA 500mg – Best Premium
- What is DLPA; DL-Phenylalanine (DLPA) is a mixture of both the D and L forms of the amino acid phenylalanine.
- Benefits; DLPA may have the unique ability to reduce the activity of the enzyme enkephalinase in the central nervous system, thereby sparing feel good hormones such as endorphins and enkephalins.
- Optimal Absorption; This formulation provides free form DLPA to promote optimal absorption and assimilation.
- Gluten, Wheat & Dairy Free; Solgar DLPA is non-GMO, vegan, kosher, and free of: gluten, wheat, yeast, sugar, salt, artificial flavors, artificial sweeteners, and artificial colors.
- The Gold Standard; For over 75 years Solgar has been committed to quality, health, and well-being. Our mission is to create the finest nutritional supplements in small batches, through tireless research, using only the finest raw materials.
Over 75 years of supplement heritage in a free-form DLPA designed for optimal absorption.
Solgar delivers 500mg of free-form DL-phenylalanine per vegetable capsule. The free-form designation means the amino acid doesn’t require digestion and can be directly absorbed, promoting optimal utilization. DLPA may reduce the activity of the enzyme enkephalinase in the central nervous system, sparing endorphins and enkephalins. The formula is non-GMO, vegan, kosher, and free from gluten, wheat, dairy, soy, yeast, sugar, salt, artificial flavors, sweeteners, and colors. With 100 capsules per bottle, this provides a 50-to-100 day supply.
- Pros:
- Free-form amino acid for direct absorption without digestion
- Vegan, kosher, and free from all major allergens
- 75+ years of premium supplement manufacturing
- Cons:
- Higher price per capsule than generic alternatives
- Some users may prefer higher dosage options
Best for: Those who value free-form amino acid delivery and a premium, heritage brand
4. Source Naturals DLPA 750mg – Best High Dose
- Support An Alert State of Mind. These are proteins that bind to opioid receptor sites in the brain, thereby influencing the perception of discomfort. By obstructing the action of this enzyme, DPA may extend the life of endorphins and enkephalins and their positive influence on comfort levels. L-Phenylalanine is the precursor to two neurotransmitters that help support an alert state.
- Suggested Use. 1 tablet 1 to 3 times daily.
- 750 mg Tablet Option Available: 30, 60
- Trusted For Over 35 Years. Source Naturals was created in 1982 by CEO Ira Goldberg to support each individual's potential to enjoy optimal health.
- Manufactured in the USA. Manufactured in Scotts Valley, CA, under the Good Manufacturing Practices (cGMPs) established by the US Food and Drug Administration (FDA)
A high-dose 750mg tablet backed by Source Naturals’ Bio-Aligned Formula approach to whole-body health.
Source Naturals delivers 750mg of DL-phenylalanine per tablet — 50% more than the standard 500mg dose. Their Bio-Aligned Formulas philosophy evaluates the underlying causes of system imbalances and provides targeted nutrition to interdependent body systems. The formula explains that D-phenylalanine may extend the life of endorphins and enkephalins, while L-phenylalanine is the precursor to neurotransmitters that support an alert state. The suggested use is 1 tablet 1-3 times daily. Manufactured in Scotts Valley, CA under FDA-established GMP standards.
- Pros:
- 750mg per tablet — highest standard single-tablet dose available
- Flexible dosing from 750mg to 2,250mg daily
- Over 40 years of trusted US manufacturing
- Cons:
- Tablet form rather than capsules
- Contains dibasic calcium phosphate and stearic acid
Best for: Those who want a higher per-serving dose to reduce pill count
5. Carlyle DL-Phenylalanine 1000mg – Most Potent
- DLPA: DL-Phenylalanine is an advanced form of phenylalanine, a beneficial amino acid
- INNOVATIVE FORMULA: Delivers 1,000 mg per serving of free-form DLPA in quick-release capsules
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Artificial Flavor, Preservatives & Non-GMO
The highest-potency DLPA option with 1,000mg per two-capsule serving in a massive 180-capsule bottle.
Carlyle delivers 1,000mg of free-form DL-phenylalanine per two-capsule serving in quick-release capsules. With 180 capsules per bottle, this provides a 90-day supply at the full 1,000mg dosage — or even longer at lower doses. The formula is naturally gluten-free and non-GMO, with no artificial flavors, sweeteners, or preservatives. Carlyle has over 40 years of experience in health and wellness across three generations, combining pure ingredient sourcing with advanced manufacturing technologies.
- Pros:
- 1,000mg per serving — the highest potency available
- 180 capsules for a full three-month supply
- Quick-release capsule design for rapid absorption
- Cons:
- Requires two capsules per serving
- Gelatin capsules (not suitable for vegans)
Best for: Those who want maximum-strength DLPA at an excellent value per serving
6. SOLARAY DL-Phenylalanine 500mg – Best for Stress Response
- 50/50 Blend - DL-Phenylalanine combines equal parts of the essential amino acids D-Phenylalanine and L-Phenylalanine to support a healthy stress response and overall well-being*
- Healthy Hormone Support - D-Phenylalanine may help support the body's natural production of healthy hormone levels*
- Wellness from the Inside Out - L-Phenylalanine supports healthy dopamine, norepinephrine, and epinephrine production that may support emotional well-being, energy, and nervous system health*
- Suggested Use - Use only as directed. Take one Veg Cap daily with a glass of water. For optimal results, take on an empty stomach. Store in a cool, dry place. Each bottle contains 60 capsules
- Backed by Decades of Expertise - With over 50 years in supplements, Solaray combines tradition and innovation to deliver high-quality supplements you can trust for your health journey
A trusted 50/50 D and L-phenylalanine blend specifically formulated for nervous system and energy support.
SOLARAY provides 500mg of DL-phenylalanine per VegCap in an equal 50/50 blend of the D and L forms. The formula is designed to support a healthy stress response and overall well-being. D-phenylalanine supports healthy hormone production, while L-phenylalanine promotes healthy dopamine, norepinephrine, and epinephrine production for emotional well-being, energy, and nervous system health. With 60 VegCaps per bottle and a one-capsule daily serving, this provides a two-month supply. SOLARAY has over 50 years of experience in supplements.
- Pros:
- Balanced 50/50 D and L blend for comprehensive support
- VegCap formulation suitable for vegetarians
- 50+ years of trusted supplement expertise
- Cons:
- Only 60 capsules per bottle
- Single daily capsule may be insufficient for some protocols
Best for: Those seeking balanced nervous system and stress response support
7. BulkSupplements DL-Phenylalanine – Best Value
- Elevate Your Daily Routine: DL-Phenylalanine (DLPA) capsules offer a simple way to complement an active lifestyle. This essential amino acid supports everyday balance, making it a thoughtful addition to your supplement plan.
- Tailored for Modern Lifestyles: DL-Phenylalanine (DLPA) capsules are made to fit seamlessly into today’s active routines. Whether you’re beginning a wellness journey or maintaining healthy habits, this supplement complements a balanced lifestyle with ease.
- Compact Nutrition for Busy Lifestyles: Designed for those always on the move, our DL-Phenylalanine capsules, providing 500mg per serving, deliver essential support in a convenient form. Staying consistent with your daily routine has never been simpler.
- Produced in a cGMP-Compliant Facility: Manufactured in a facility that follows current Good Manufacturing Practices (cGMP), ensuring a consistent and reliable product. This reflects our commitment to quality and care in every step of the process.
- Made with Quality and Integrity: All our supplements are produced with a focus on clarity, consistency, and high standards. Every batch is tested to help ensure quality and peace of mind for wellness-focused consumers.
A straightforward 240-capsule supply of pure DLPA with flexible dosing at an accessible price.
BulkSupplements provides 500mg of DL-phenylalanine per two-capsule serving in a 240-capsule bottle. The formula is gluten-free and manufactured in a cGMP-compliant facility. BulkSupplements is known for clean, no-frills formulations that deliver pure ingredients without unnecessary additives. The two-capsule serving design allows for flexible dosing — take one capsule for 250mg or two for the full 500mg. At 240 capsules per bottle, this provides a four-to-eight month supply depending on dosage.
- Pros:
- 240 capsules per bottle for exceptional long-term value
- Flexible dosing with two-capsule serving design
- cGMP manufacturing with quality assurance testing
- Cons:
- Gelatin capsules (not vegetarian)
- Minimal brand marketing — less product information available
Best for: Value-seekers who want a large supply of pure DLPA at the lowest cost per serving
8. Amazing Formulas DLPA 1000mg – Best with Vitamin B6
- - DLP (DL-Phenylalanine) 1000 Mg per Serving Supplement
- - 30 Servings per Bottle, 2 Capsules Per Serving
- - Non-GMO, Gluten Free, Third Party Tested
- - Manufactured in accordance with GMP Standards
- - Proudly made in the USA with Guaranteed Purity & Potency
A potent 1,000mg DLPA formula enhanced with vitamin B6 for improved amino acid metabolism.
Amazing Formulas delivers 1,000mg of DL-phenylalanine per two-capsule serving along with vitamin B6 (as pyridoxine). Vitamin B6 plays a critical role in amino acid metabolism and neurotransmitter synthesis, making it a smart addition to a DLPA formula. The suggested use is two capsules daily, 30 minutes before a meal for optimal absorption. The formula is non-GMO, gluten-free, and made in the USA. With 60 capsules per bottle, this provides a one-month supply at full dosage.
- Pros:
- Added vitamin B6 supports amino acid metabolism and neurotransmitter production
- 1,000mg per serving for potent effects
- Non-GMO, gluten-free, made in the USA
- Cons:
- Only 60 capsules per bottle (one-month supply)
- Gelatin capsules (not suitable for vegans)
Best for: Those who want DLPA enhanced with vitamin B6 for optimized neurotransmitter support. For related amino acid supplementation, check out our guide to L-tyrosine supplements.
9. Best Naturals DLPA 500mg – Best Budget Pick
- 3rd Party Lab Tested for Purity & Quality.
- 500 mg of DLPA per Tablet - 120 Tablets per Bottle.
- Non-GMO & Gluten-Free.
- Proudly Made in USA, GMP Compliant, FDA Registered Facility.
- No Artificial Color, Flavor, or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
An affordable, clean 120-tablet supply of DLPA from a trusted US manufacturer.
Best Naturals provides 500mg of free-form DL-phenylalanine per tablet in a 120-count bottle. The formula is non-GMO, gluten-free, and manufactured in a USA-based, GMP-compliant, FDA-registered facility. It’s free from artificial colors, flavors, sweeteners, preservatives, sugar, milk, corn, soy, egg, lactose, wheat, yeast, and fish. At one tablet daily, this bottle provides a full four-month supply at the lowest cost in the category.
- Pros:
- 120 tablets for a four-month supply at an accessible price
- GMP-compliant, FDA-registered manufacturing
- Free from all major allergens
- Cons:
- Tablet form rather than capsules
- Contains vegetable cellulose and silica as excipients
Best for: Budget-conscious buyers who want a long-lasting supply of quality DLPA
How to Choose the Best DLPA Supplement
The standard effective dose of DLPA ranges from 500-1,500mg per day, typically divided into one to three doses. For mood support, 500-1,000mg daily is commonly used. For comfort support (the D-form’s endorphin-preserving effects), higher doses of 1,000-1,500mg may be more effective. Start at 500mg and adjust based on response.
Free-form DLPA is preferred for optimal absorption because it doesn’t require enzymatic digestion before absorption. Brands like Solgar, Pure Encapsulations, and Carlyle specifically offer free-form DL-phenylalanine. Taking DLPA on an empty stomach, 30 minutes before meals, enhances absorption.
Consider whether you want a standalone DLPA or one enhanced with complementary nutrients. Amazing Formulas adds vitamin B6 to support amino acid metabolism. Some users combine DLPA with L-tyrosine or SAM-e for broader mood and neurotransmitter support.
Quality markers to look for include GMP-certified manufacturing, third-party testing, and established brands with transparent ingredient lists. Those with phenylketonuria (PKU) should avoid DLPA entirely, and it should not be combined with MAO inhibitor or SSRI antidepressants without medical supervision.
Frequently Asked Questions
What is DLPA and what does it do?
DLPA is a 50/50 mixture of D-phenylalanine and L-phenylalanine. The L-form is a precursor to neurotransmitters dopamine, norepinephrine, and epinephrine that support mood and alertness. The D-form may inhibit the enzyme that breaks down endorphins and enkephalins, helping to preserve the body’s natural feel-good compounds and support comfort levels.
How much DLPA should I take daily?
The typical effective dose is 500-1,500mg per day, taken in one to three divided doses. Most supplements provide 500mg per capsule. For mood support, 500-1,000mg daily is common. Take on an empty stomach, 30 minutes before meals, for best absorption. Do not exceed 2,000mg daily without practitioner guidance.
When is the best time to take DLPA?
DLPA is best taken on an empty stomach, 30 minutes before meals. Morning dosing is ideal for those using it for mood and energy support. If taking multiple doses daily, divide them between morning and early afternoon. Avoid taking DLPA late in the evening as the L-form’s neurotransmitter effects may interfere with sleep in some individuals.
Are there any side effects of DLPA?
DLPA is generally well-tolerated at recommended doses. Possible side effects include headache, anxiety, nausea, and heartburn — typically at higher doses. People with phenylketonuria (PKU) must avoid DLPA completely. It should not be taken during pregnancy or breastfeeding, or combined with MAO inhibitor or SSRI antidepressants without medical supervision. Those with chronic high blood pressure should take DLPA after meals.
Can I take DLPA with other supplements?
DLPA combines well with vitamin B6 (which supports amino acid metabolism), L-tyrosine, and mood support supplements. It may also complement SAM-e for broader neurotransmitter support. Avoid combining with other phenylalanine-containing supplements to prevent excessive intake. Do not combine with anticholinergic drugs or MAO/SSRI antidepressants without medical guidance.
How long does it take for DLPA to work?
Many users report noticing mood and focus improvements within 1-2 weeks of consistent use. The D-form’s endorphin-preserving effects may be felt more quickly, sometimes within days. For maximum comfort support benefits, 4-6 weeks of consistent supplementation is typically recommended. Results vary by individual and dosage.
