Best Dry Eye Supplements (2026)

Dry eye syndrome affects millions of people, causing discomfort, irritation, and blurred vision due to insufficient tear production or poor tear quality. While eye drops provide temporary relief, oral supplements targeting tear production and ocular inflammation from the inside out can deliver more lasting results. The most effective dry eye supplements focus on omega-3 fatty acids, GLA, astaxanthin, lutein, and vitamin D to support healthy tear film and reduce inflammation.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
NATURELO Omega-3 Fish Oil	EPA + DHA (1,100mg)	Softgels	Best Overall	9.5/10
NATURELO Vegan DHA	Algae-Based DHA	Softgels	Best Vegan Option	9.3/10
Astaxanthin 10mg	Astaxanthin	Softgels	Best Antioxidant	9.2/10
Blink NutriTears	Lutein + Zeaxanthin + Curcumin	Softgels	Best Clinically Tested	9.1/10
PRN De3 Dry Eye Omega-3	EPA + DHA (2,400mg)	Softgels	Best High-Potency	9.0/10
10-in-1 Astaxanthin 12mg	Astaxanthin + Lutein	Capsules	Best Multi-Nutrient	8.9/10
Easy Absorption Astaxanthin	Astaxanthin 10mg	Softgels	Best Budget Pick	8.7/10

1. NATURELO Omega-3 Fish Oil – Best Overall

This burpless omega-3 fish oil delivers a clinically relevant dose of EPA and DHA in highly absorbable triglyceride form, making it one of the best overall supplements for dry eye relief.

Each serving provides 1,100mg of triglyceride-form omega-3s, including substantial EPA and DHA shown in clinical studies to support healthy tear production and reduce ocular surface inflammation. The formula comes in easy-to-swallow softgels with a lemon coating to prevent fishy aftertaste. NATURELO sources its fish oil from wild-caught fish and tests for heavy metals and contaminants. Research published in the journal Cornea confirms that omega-3 supplementation for at least three months can significantly improve dry eye symptoms by boosting tear film stability.

• Pros:
• Triglyceride form for superior absorption compared to ethyl ester fish oils
• Burpless formula with no fishy aftertaste
• Third-party tested for purity and potency

• Cons:
• Not suitable for vegans or those with fish allergies
• Requires consistent use for 2-3 months to see full results

Best for: Anyone seeking a well-rounded omega-3 supplement specifically proven to support tear production and reduce dry eye inflammation

2. NATURELO Vegan DHA – Best Vegan Option

For plant-based consumers dealing with dry eyes, this algae-derived DHA supplement provides the same essential fatty acids found in fish oil without any animal products.

Each serving delivers a meaningful dose of DHA from sustainably harvested algae, the original source of omega-3s in the marine food chain. The vegan softgels support brain, heart, and eye health simultaneously. Algae-based DHA has been shown to support healthy tear film composition, and this formula avoids the common contaminants associated with fish-sourced supplements. The 120-count bottle provides a full two-month supply. Pair this with a vegan omega-3 supplement that also includes EPA for maximum dry eye benefits.

• Pros:
• 100% plant-based and suitable for vegans
• Free from ocean-borne contaminants like mercury
• Sustainably sourced from algae

• Cons:
• Lower EPA content compared to fish oil alternatives
• Slightly higher price per serving than fish-based options

Best for: Vegans, vegetarians, or anyone with fish allergies who need omega-3 support for dry eyes

3. Astaxanthin Supplement 10mg – Best Antioxidant for Dry Eyes

Astaxanthin is a powerful carotenoid antioxidant that crosses the blood-retinal barrier, providing targeted protection against oxidative stress that contributes to dry eye symptoms.

This supplement delivers 10mg of astaxanthin per softgel, sourced from Haematococcus pluvialis microalgae. Astaxanthin has been shown in clinical research to improve eye accommodation, reduce eye fatigue, and support tear production by protecting the meibomian glands from oxidative damage. The lipid-based softgel format enhances absorption since astaxanthin is fat-soluble. Each bottle provides a multi-month supply at one softgel per day.

• Pros:
• 6,000 times more potent than vitamin C as an antioxidant
• Crosses the blood-retinal barrier for direct eye support
• Supports both dry eye relief and overall eye health

• Cons:
• Works best as part of a comprehensive dry eye protocol rather than standalone
• Results may take 4-8 weeks to become noticeable

Best for: Those experiencing dry eyes alongside digital eye strain and general eye fatigue

4. Blink NutriTears – Best Clinically Tested

Developed by the makers of Blink eye drops, NutriTears is one of the few oral dry eye supplements backed by clinical studies showing improved tear hydration within 28 days.

This formula combines lutein, zeaxanthin, curcumin, and vitamin D in a targeted blend designed to promote healthy tear production from the inside out. Clinical testing demonstrated that users’ eyes stayed hydrated 33% longer after 28 days of supplementation. The 50-count softgel bottle provides nearly a two-month supply. Unlike generic eye vitamins, NutriTears was specifically formulated for dry eye relief rather than general eye health, making it one of the most targeted options available.

• Pros:
• Clinically tested formula with published results
• Targets the root causes of dry eyes, not just symptoms
• From a trusted eye care brand

• Cons:
• Higher price point than generic eye supplements
• Contains only 50 softgels per bottle

Best for: Those wanting a clinically validated dry eye supplement from a recognized eye care brand

5. PRN De3 Dry Eye Omega-3 – Best High-Potency

Recommended by over 4,000 ophthalmologists and optometrists, this high-potency omega-3 delivers 2,400mg of EPA and DHA in re-esterified triglyceride form for maximum dry eye support.

PRN’s De3 formula provides one of the highest omega-3 concentrations available specifically for dry eye management. The re-esterified triglyceride (rTG) form is up to three times more absorbable than common ethyl ester fish oils. Manufactured in an NSF-certified, cGMP-compliant facility in Norway and third-party tested in the USA, this is a pharmaceutical-grade supplement. The recommended dose is three softgels daily, and PRN suggests allowing at least 90 days to experience full results. If you also deal with eye fatigue from screens, see our guide to eye health supplements for additional support.

• Pros:
• Doctor-recommended by thousands of eye care professionals
• Ultra-pure, NSF-certified manufacturing
• Re-esterified TG form for 3x better absorption

• Cons:
• Premium pricing reflects pharmaceutical-grade quality
• Requires three softgels daily

Best for: Those with moderate to severe dry eye symptoms who want the highest-quality, doctor-recommended omega-3

6. 10-in-1 Astaxanthin 12mg with Lutein – Best Multi-Nutrient

This comprehensive eye support formula combines astaxanthin with lutein, zeaxanthin, and seven additional eye-supporting nutrients for a broad-spectrum approach to dry eye relief.

Each serving delivers 12mg of astaxanthin from fresh algal extract alongside 40mg of lutein and zeaxanthin, providing both antioxidant protection and macular support. The 10-in-1 formula includes additional nutrients that work synergistically to support tear film health, reduce inflammation, and protect against blue light damage. A four-month supply per bottle makes this one of the best-value multi-nutrient eye supplements available. The capsule form makes it easy to integrate into a daily supplement routine.

• Pros:
• Comprehensive formula covers multiple angles of dry eye support
• 4-month supply offers excellent value
• High-dose astaxanthin at 12mg per serving

• Cons:
• Multi-ingredient formula makes it harder to isolate which nutrients are helping
• Some may prefer standalone ingredients for targeted dosing

Best for: Those wanting an all-in-one eye supplement that addresses dry eye, blue light protection, and macular health

7. Easy Absorption Astaxanthin 10mg – Best Budget Pick

This affordable astaxanthin supplement delivers a clinical dose of the potent carotenoid in an easy-absorption format, making antioxidant eye support accessible at a lower price point.

Each softgel provides 10mg of astaxanthin from Haematococcus pluvialis, the same high-quality source used in premium supplements. The easy-absorption formula ensures the fat-soluble nutrient is efficiently delivered to the eyes and other tissues. Astaxanthin’s ability to reduce oxidative stress in the tear glands and support healthy meibomian gland function makes it particularly relevant for dry eye sufferers. This is a solid entry point for those new to astaxanthin supplementation.

• Pros:
• Affordable price point for quality astaxanthin
• Easy-absorption formula for enhanced bioavailability
• Clean ingredient profile

• Cons:
• Single-ingredient formula requires pairing with omega-3s for comprehensive dry eye support
• Smaller bottle size than some competitors

Best for: Budget-conscious buyers looking to add astaxanthin to their dry eye supplement routine

8. ScienceBased Health HydroEye – Best Doctor-Formulated

HydroEye is one of the most clinically studied dry eye supplements available, featuring a patented blend of GLA and omega-3s that targets all three layers of the tear film.

This doctor-recommended formula combines GLA (gamma-linolenic acid) from black currant seed oil with EPA and DHA from USP-verified fish oil, plus vitamins A, B6, C, and magnesium to support fatty acid metabolism and tear production. GLA is a unique omega fatty acid not found in standard fish oil or flaxseed oil that has been clinically shown to decrease dry eye symptoms in multiple studies. A peer-reviewed clinical trial published in Cornea confirmed HydroEye promotes eye comfort and maintains corneal smoothness. Each bottle contains 120 softgels for a one-month supply at four per day. For additional vision support, pair with a lutein supplement.

• Pros:
• Patented formula backed by peer-reviewed clinical research
• Contains GLA, a unique fatty acid not found in standard fish oil
• Targets all three layers of the tear film

• Cons:
• Requires four softgels per day
• Higher price point reflects clinical-grade formulation

Best for: Those with persistent dry eye who want the most clinically validated supplement option

How to Choose the Best Dry Eye Supplement

The most important ingredient to look for in a dry eye supplement is omega-3 fatty acids, specifically EPA and DHA. Clinical research consistently shows that omega-3 supplementation for at least three months can significantly improve tear production and tear film stability. Look for triglyceride or re-esterified triglyceride forms, which are up to three times more absorbable than cheaper ethyl ester versions. A combined EPA/DHA dose of at least 1,000mg daily is a reasonable target based on clinical studies.

GLA (gamma-linolenic acid) from black currant seed oil or evening primrose oil is another evidence-backed nutrient specifically shown to reduce dry eye symptoms. Unlike standard omega-3s, GLA promotes the production of anti-inflammatory compounds that directly support tear gland health. Astaxanthin is also worth considering, as this potent antioxidant crosses the blood-retinal barrier to protect the meibomian glands and reduce oxidative stress on the ocular surface.

Capsules and softgels are the preferred delivery method for dry eye supplements since the active ingredients are fat-soluble and absorb best in lipid-based formats. Powders and gummies are generally less effective for omega-3 and astaxanthin delivery. Take dry eye supplements with a meal containing healthy fats for optimal absorption.

Look for third-party testing, NSF certification, or USP verification as indicators of quality and purity. Supplements manufactured in GMP-certified facilities provide additional assurance. Give any dry eye supplement at least 60-90 days of consistent use before evaluating results, as tear film changes happen gradually.

Frequently Asked Questions

What supplements are best for dry eyes?

The most evidence-backed supplements for dry eyes are omega-3 fatty acids (EPA and DHA), GLA (gamma-linolenic acid), astaxanthin, lutein, zeaxanthin, and vitamin D. Omega-3s support healthy tear production and reduce ocular inflammation, while astaxanthin provides targeted antioxidant protection for the tear glands. A combination approach addressing both inflammation and antioxidant protection tends to produce the best results.

How much omega-3 should I take for dry eyes?

Clinical studies on dry eye typically use combined EPA and DHA doses ranging from 1,000mg to 2,400mg per day. Most eye care professionals recommend at least 1,000mg of combined EPA/DHA daily, taken with food for optimal absorption. Higher doses in the 2,000-2,400mg range may be more effective for moderate to severe dry eye symptoms. Allow at least 90 days of consistent supplementation to evaluate results.

How long do dry eye supplements take to work?

Most dry eye supplements require 30 to 90 days of consistent use before noticeable improvement. Some clinically tested formulas like Blink NutriTears report measurable tear production improvements within 28 days. Omega-3 supplements typically take 60-90 days to fully integrate into cell membranes and influence tear film quality. Astaxanthin may begin showing effects within 4-8 weeks.

Can I take dry eye supplements with eye drops?

Yes, oral dry eye supplements work well alongside topical eye drops. The supplements address the root causes of dry eye from within—supporting tear gland health and reducing inflammation—while eye drops provide immediate surface-level relief. Many eye care professionals recommend using both approaches together for comprehensive dry eye management.

Are there side effects of dry eye supplements?

Omega-3 supplements may cause mild gastrointestinal effects like fishy burps or upset stomach, especially at higher doses. Choosing enteric-coated or triglyceride-form fish oil can minimize these issues. Astaxanthin is generally well-tolerated with few reported side effects. Those taking blood-thinning medications should consult a healthcare provider before starting high-dose omega-3 supplements, as they can have mild anticoagulant effects.

Is fish oil or flaxseed oil better for dry eyes?

Fish oil is generally more effective for dry eyes because it provides preformed EPA and DHA, which the body can use directly. Flaxseed oil contains ALA (alpha-linolenic acid), which must be converted to EPA and DHA—a process that is very inefficient, with conversion rates below 10%. For vegans who prefer plant-based options, algae-derived DHA supplements are a more effective alternative to flaxseed oil for dry eye support.

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