Best GLP-1 Support Supplements (2026)
GLP-1 support supplements are designed to naturally enhance the body’s production of glucagon-like peptide-1, a gut hormone that plays a key role in appetite regulation and blood sugar management. Often sought as a natural alternative to prescription Ozempic and Wegovy, these supplements combine probiotics, berberine, and other metabolic ingredients to support the body’s own GLP-1 pathways.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Lunakai PRO GLP-1 Supplement | Probiotics + Resveratrol | Capsules | Best Overall | 9.5/10 |
| Pink Stork Digestive Enzymes | Enzymes + Metabolism Blend | Capsules | Best for Women | 9.2/10 |
| Serene Herbs GLP-1 Supplement | Berberine + Inositol | Capsules | Best Berberine Formula | 9.0/10 |
| Bio.me GLP-1 Support | Probiotic Powder Blend | Powder | Best Powder | 8.8/10 |
| 17-in-1 GLP-1 Gummies | Berberine + Akkermansia | Gummies | Best Gummies | 8.7/10 |
| JSHealth Lean+ with Eriomin | Eriomin + Creatine | Powder | Best for Active Women | 8.5/10 |
| GLP-1 + AMPK Activator Gummies | Akkermansia + Berberine | Gummies | Best Dual-Pathway Formula | 8.4/10 |
1. Lunakai PRO GLP-1 Supplement — Best Overall
- GLP-1 Booster for Healthy Weight Management – Formulated to support healthy weight control, this natural glp-1 supplement helps you feel fuller, longer.
- Vegan GLP 1 Supplement – 60 Capsules per Bottle – Each daily serving provides glp 1 support in an easy-to-swallow vegan capsule. Designed for consistency and simplicity in your wellness regimen.
- GLP1 Support for Cravings and Appetite Control – This glp 1 booster supports appetite regulation and cravings management, making it ideal for those focused on mindful eating habits.
- Supports Gut-Brain Signaling Pathways – Includes plant-based ingredients traditionally used to support gut-brain communication and natural satiety signals in daily health routines.
- No Artificial Ingredients or Fillers – This glp1 booster formula is free from artificial additives, colors, and preservatives, delivering only what you need without unnecessary extras.
Lunakai’s PRO formula stands out as the top GLP-1 support supplement with its probiotic-driven approach enhanced by resveratrol and other natural GLP-1 boosting compounds.
This USA-made supplement pairs targeted probiotics with resveratrol — a polyphenol that research suggests can stimulate GLP-1 secretion from intestinal L-cells. The probiotic component supports the gut microbiome environment where GLP-1 is naturally produced, creating a synergistic formula. Manufactured in a GMP-certified facility, the capsule format allows for clinical-strength doses without added sugars.
- Pros:
- Synergistic probiotic + polyphenol formula
- USA manufactured in GMP-certified facility
- Clean capsule format with no added sugars
- Cons:
- Premium price compared to basic supplements
- Capsules only — no gummy option from this brand
Best for: Those seeking the most comprehensive probiotic-based GLP-1 support available
2. Pink Stork Digestive Enzymes — Best for Women
- Supports Digestion with 13 Plant-Based Enzymes: Not a normal fiber supplement, support debloating for women! Unlike similar products that only contain single-enzymes, Pink Stork Digestive Enzymes include a full-spectrum blend of 13 vegan enzymes that support the natural breakdown of proteins, fats, carbs, dairy, and fiber. Each capsule helps promote comfortable digestion and nutrient absorption — especially during hormonal shifts like PMS, postpartum, or perimenopause. Thoughtfully formulated for women with sensitive stomachs. 30 servings.
- Bloat Bye Bye — Designed for Women: Say “bye bye” to that sluggish, heavy feeling after meals. Our enzymes support your body’s ability to digest food and reduce occasional bloating — so instead of dreading social meals, you can feel light, balanced, and more like yourself. Great for women navigating hormone changes, irregular digestion, or food sensitivities. A must-have for digestive support in every season of womanhood. Just take two capsules with your largest meal. Some women feel lighter after their first meal; take for at least 2 weeks for best results.
- Gut Health for Women with Natural Metabolism Support: Enzymes are key for more than just digestion — they play a role in supporting gut health and your body’s natural metabolism. We added Amla, an antioxidant-rich fruit, to further support digestive function and gut balance. Whether paired with prebiotics, probiotics, or collagen, our formula helps keep your digestive system supported and aligned. Always consult with your healthcare provider to ensure your personal needs are being met.
- Great for women seeking digestive support alongside GLP-1 wellness routines! Made with 100% plant-based enzymes and formulated without gluten, dairy, GMOs, peanuts, tree nuts, animal products/byproducts, or artificial ingredients. Our supplements are clean, gentle, and thoughtfully crafted for women who want support without compromise. Small, easy-to-swallow capsules make them a great choice for those with sensitive digestive systems or dietary preferences. Suitable for men and women. No refrigeration needed.
- Expert Formulated, Women-Owned: Pink Stork products are developed by a team of female experts and rigorously tested for quality and effectiveness. Founded by Integrative Nutrition Health Coach Amy Suzanne, Pink Stork is women-owned and women-run, dedicated to supporting women's wellness through every life stage — from motherhood and mood changes to hormonal balance and daily stress management.
Pink Stork delivers a women-focused formula that supports GLP-1 pathways through improved digestive health, gut optimization, and metabolic support.
This supplement addresses GLP-1 support from the digestion side, combining digestive enzymes with metabolism-supporting ingredients. Since GLP-1 is produced by L-cells in the intestinal lining, optimizing digestive function can naturally support hormone production. Pink Stork is a well-established women’s health brand with a reputation for clean, effective formulations and strong customer satisfaction.
- Pros:
- Addresses digestion, bloating, and metabolism together
- Trusted women’s health brand
- Supports the gut environment where GLP-1 is produced
- Cons:
- Not a standalone GLP-1 formula
- Designed primarily for women
Best for: Women who want digestive support alongside natural GLP-1 enhancement
3. Serene Herbs GLP-1 Supplement — Best Berberine Formula
- APPETITE CONTROL: Support your wellness journey with our all natural non-stimulant GLP-1 supplement designed to help balance cravings, support healthy digestion, and promote steady energy levels throughout your day without jitters or crashes.
- RESEARCH-BACKED INGREDIENTS: Features premium Berberine HCl, InnoSlim, Actiponin, African Mango extract, Apple Cider Vinegar, White Kidney Bean extract, Green Tea Extract, Banaba Leaf, Bitter Melon, and BioPerine for enhanced absorption and metabolic support.
- EASY DAILY ROUTINE: Take 2 capsules with your first meal to kickstart your wellness routine - supports healthy digestive balance in week 1, helps reduce food cravings by weeks 2-3, and promotes balanced metabolic rhythm by months 3-4.
- USA MADE & TESTED: Crafted in FDA-registered cGMP-certified facility using globally sourced premium ingredients, our vegan, non-GMO, stimulant-free formula undergoes rigorous third-party lab testing for purity, potency and quality assurance.
- WELLNESS RESET: We are focused on helping you create sustainable healthy habits and balanced food choices rather than restrictive crash dieting - experience a gentle metabolic reset approach rooted in traditional herbal wellness science and modern research.
Serene Herbs leads with berberine as its primary active ingredient, backed by inositol and additional metabolic support compounds for a targeted GLP-1 support formula.
Berberine is arguably the most studied natural compound for GLP-1 support, with research showing it can increase GLP-1 secretion and improve glucose metabolism. This formula builds on that foundation with inositol — which supports insulin sensitivity — and other complementary ingredients designed for a full metabolic reset. The capsule format ensures optimal doses of each ingredient.
- Pros:
- Berberine-led formula backed by extensive research
- Inositol adds insulin sensitivity support
- Designed for both men and women
- Cons:
- Berberine can cause initial GI discomfort
- Multiple capsules per serving
Best for: Those who want a berberine-centered approach to GLP-1 support
4. Bio.me GLP-1 Support — Best Powder Formula
- SUPPORTS YOUR GLP-1 JOURNEY – If you're taking a GLP-1 medication, you know it can come with side effects like low energy and digestive discomfort. That’s where GLP-1 Support comes in. Designed to work alongside your treatment—not replace it—this supplement helps keep you feeling balanced, energized, and on track with your health goals.
- HELPS DIGESTION & SUSTAINS ENERGY – Bloating, irregular digestion, and energy dips can be challenges when following a GLP-1 lifestyle. Our GLP1 supplement is packed with fiber, digestive enzymes, and collagen peptides to support gut health and help you stay naturally energized throughout the day—without artificial stimulants or crashes.
- CLINICALLY-BACKED INGREDIENTS THAT WORK – We use only the best, research-backed ingredients to support your GLP-1 lifestyle. Fiber for digestion, collagen for muscle support, B vitamins for energy, and enzymes for better nutrient absorption—this appetite suppressant GLP1 formula is made to help you feel your best, every day.
- DELICIOUS, CLEAN, & EASY TO PREPARE – Our GLP 1 supplement support is delicious and blends easily into water, smoothies, or your favorite drink. Plus, it’s gluten-free, dairy-free, non-GMO, and has no artificial ingredients—just clean, high-quality nutrition for your wellness journey.
- QUALITY-TESTED & RESPONSIBLY MANUFACTURED – We take your health seriously. That’s why GLP 1 Support is third-party tested and made in a cGMP- and SQF-certified facility to ensure purity and potency. Plus, we’re Upcycled Certified, meaning we’re committed to sustainability. When you choose Bio.me, you’re choosing a product that’s good for you and the planet.
Bio.me’s powder formula takes a microbiome-first approach to GLP-1 support, delivering targeted probiotics and prebiotics in a mixable format for rapid absorption.
This powder supplement focuses on building the gut microbiome environment that naturally produces GLP-1. The formula includes specific probiotic strains and prebiotic fibers designed to nurture the intestinal L-cells responsible for GLP-1 secretion. The powder format offers faster absorption than capsules and can be mixed into water, smoothies, or morning beverages for easy integration into daily routines.
- Pros:
- Fast-absorbing powder format
- Microbiome-targeted approach to GLP-1 production
- Flexible dosing — easy to adjust serving size
- Cons:
- Requires daily mixing — less portable than capsules
- Flavor preferences vary among users
Best for: Those who prefer powders and want to support GLP-1 through gut microbiome optimization
5. 17-in-1 GLP-1 Gummies — Best Gummies
- Comprehensive GLP-1 Pathway Support : Our GLP-1 supplement features a powerful 5-in-1 blend system with berberine, probiotics (including Akkermansia), and natural fibers. This complete formula support for the body’s GLP-1 hormone through its production, activation, and enhancement, promoting overall metabolic wellness.
- Berberine & Akkermansia Probiotic : The synergy of Berberine and Akkermansia in our GLP-1 supplement—a foundation for healthy digestion, balanced bl**d sugar, and key metabolic pathways (AMPK/GLP-1). From Berberine, the path to smoother, more vibrant skin. Through Akkermansia, nurturance of your gut ecosystem—the cornerstone of metabolic health and a radiant glow. Support your inner health and outer glow in our delicious GLP1 Gummies.
- Enhanced Gut Health : GLP-1 Supplement featuring live anaerobic strains (Akkermansia muciniphila, Clostridium butyricum, and Bifidobacterium infantis), they are specifically designed to reach the lower intestine. Our formula promoting a balanced microbiome for optimal GLP-1 production and gut health.
- Enjoy a healthier lifestyle : Our GLP-1 supplement also contains turmeric, organic resveratrol, cinnamon, green tea, yerba mate, milk thistle, bitter melon, and more. A gentle formulation for stomach comfort, enhanced nutrient absorption, and boosted overall efficacy—all for direct support of metabolic function, the GLP-1 pathway, and your overall health.
- Zero Sugar & Natural Ingredients : Savor the natural, refreshing taste of yuzu in every gummy. Our GLP 1 gummies are completely sugar-free, with monk fruit extract providing sweetness. Perfect for maintaining a low-calorie diet without compromising taste or efficacy, they are 100% vegan, gelatin-free, non-GMO, and gluten-free. Each bottle contains 90 gummies—take 3 daily to support your journey toward a healthier lifestyle.
With 17 active ingredients including berberine and Akkermansia probiotics, these gummies offer one of the most comprehensive chewable GLP-1 support options on the market.
This formula combines the convenience of gummies with a serious ingredient profile. Berberine provides the core GLP-1 signaling support, while Akkermansia muciniphila — a probiotic strain emerging as a key player in metabolic health — supports the gut-hormone connection. The additional 15 ingredients round out metabolic support across multiple pathways, all in a pleasant-tasting chewable format.
- Pros:
- 17 active ingredients in a convenient gummy
- Includes trending Akkermansia probiotic strain
- Easy daily compliance — no pills to swallow
- Cons:
- Individual ingredient doses may be lower in gummy format
- Contains some added sugars for taste
Best for: Those who want a comprehensive gummy option with maximum ingredient diversity
6. JSHealth Lean+ with Eriomin — Best for Active Women
- Creatine for Lean Muscle Support: Provides 5 g of micronized creatine monohydrate per serving to support lean muscle mass, strength, and workout performance.*
- Eriomin for Metabolic Balance: Features a citrus bioflavonoid complex shown to help support healthy GLP-1 levels and promote balanced blood sugar and metabolic function in healthy individuals.*
- Probiotics for Gut Wellness: Includes a clinically studied strain, Bifidobacterium animalis ssp. lactis, to support healthy digestion, gut flora balance, and overall digestive comfort.*
- Three-in-One Wellness Support: Combines muscle strength, metabolic health, and gut balance into one comprehensive daily formula designed to optimize whole-body wellbeing.*
- Clean and Conscious Formula: Vegan, gluten free, and free from artificial colors and flavors, offering a clean formulation suitable for various dietary preferences.*
JSHealth combines Eriomin — a patented citrus flavonoid clinically studied for GLP-1 support — with creatine monohydrate, creating a unique formula for active women focused on both body composition and metabolic health.
This is one of the few GLP-1 support products that also includes 5g of micronized creatine monohydrate, making it a standout for women who exercise regularly. Eriomin is a branded lemon polyphenol extract with clinical data showing it can support GLP-1 activity and metabolic function. The powder format delivers generous doses of both key ingredients and mixes easily into pre- or post-workout beverages.
- Pros:
- Clinically studied Eriomin ingredient for GLP-1 support
- Includes 5g creatine for body composition and performance
- Designed specifically for active women
- Cons:
- Creatine component may not be desired by all users
- Higher price point as a premium dual-purpose formula
Best for: Active women who want GLP-1 support combined with creatine for exercise performance
7. GLP-1 Support Gummies — Best Sugar-Free Option
- [Supports GLP-1 Function Naturally*] These sugar-free gummies are designed to support GLP-1 pathways that influence fullness, digestion, and wellness rhythms using plant-based ingredients backed by emerging science.
- [3-6 Week Ramp Up - Realistic Timeline Expectations] Natural GLP1 production from Plant-based supplements happen gradually - most users begin noticing subtle support within 3 to 6 weeks with consistent daily use as part of their routine. 8-12 weeks is optimal for ramp, and daily use is critical.
- [Berberine-Enhanced Wellness Formula] This GLP-1 support supplement for weight loss includes 95% pure berberine HCL, a powerful botanical traditionally used to support appetite suppression, fat burn, weight loss, and overall wellness as part of a healthy lifestyle.
- [Metabolic Health* & Energy Balance] With turmeric, cinnamon, and garcinia cambogia, this blend helps support a balanced metabolism and steady energy levels without the use of caffeine or synthetic stimulants.
- [Vegan & Gut-Friendly Ingredients] Made with plant-based pectin, not gelatin. These Gluten-free, non-GMO, GLP-1 supplement gummies are formulated with inulin fiber to support digestive comfort and clean daily supplementation.
These sugar-free gummies deliver berberine, cinnamon, and turmeric for appetite and craving control without the added sugars that undermine the purpose of a metabolic support supplement.
Sugar-free formulation is particularly important in the GLP-1 category. These gummies combine berberine for GLP-1 signaling with cinnamon for blood sugar support and turmeric for inflammation management. The trio covers several metabolic pathways in a chewable format that doesn’t spike blood sugar — a critical advantage for those focused on metabolic health.
- Pros:
- Sugar-free formula aligns with metabolic health goals
- Berberine + cinnamon + turmeric synergy
- Targets appetite and craving control specifically
- Cons:
- Simpler ingredient list than some competitors
- Sugar alcohols may cause mild digestive effects
Best for: Those who want a sugar-free gummy option for daily GLP-1 support
8. GLP-1 + AMPK Activator Gummies — Best Dual-Pathway Formula
- COMPREHENSIVE GLP-1 ACTIVATION: Our GLP1 gummies gummies feature a powerful multi-ingredient blend, meticulously crafted to help naturally activate GLP-1 and AMPK pathways. This synergistic formula supports your body's metabolism.
- POTENT COMPLEX: Experience the power of 1000mg Organic Berberine Extract combined with 100M AFU Akkermansia muciniphila and 100B CFU of targeted probiotics . This unique blend is designed to promote superior gut health, optimize digestion, and support the natural production of GLP-1.
- HEALTHY CRAVING SUPPORT: Our GLP-1 gummies gummies are infused with Organic Ginseng, Green Tea, and Yerba Mate to help boost natural energy levels. With added Organic Konjac and Fenugreek, they also support feelings of satiety, helping to manage cravings and portion sizes for a healthier, more balanced lifestyle.
- RICH ANTIOXIDANT BLEND: Our expertly formulated gummies include Organic Curcumin, Resveratrol, Pomegranate, Cinnamon, and Mulberry Leaf extracts. These powerful botanicals work synergistically to provide robust antioxidant support.
- PREMIUM QUALITY, DELICIOUS & CONVENIENT: Enjoy your daily wellness routine with our delicious, sugar-free, and easy-to-take gummies. Crafted with 100% organic, non-GMO, and vegan ingredients, they are free from gluten.
By targeting both GLP-1 and AMPK activation simultaneously, this gummy formula offers a dual-mechanism approach to metabolic support that goes beyond basic GLP-1 supplements.
AMPK is a cellular energy sensor that, when activated, promotes fat burning and glucose uptake — making it a natural complement to GLP-1 support. This formula combines Akkermansia probiotics and berberine to address both pathways in a single supplement. The dual-target approach may provide broader metabolic benefits than products focused solely on GLP-1 signaling.
- Pros:
- Targets two major metabolic pathways (GLP-1 + AMPK)
- Akkermansia probiotic for microbiome support
- Chewable format for easy daily use
- Cons:
- Dual-pathway approach is relatively new and less proven
- May require larger serving size
Best for: Those looking for maximum metabolic support across multiple biological pathways
How to Choose the Best GLP-1 Support Supplement
The most effective GLP-1 support supplements contain ingredients with clinical evidence for influencing GLP-1 production. Berberine tops the list with multiple studies demonstrating its ability to stimulate GLP-1 secretion and improve glucose metabolism. Akkermansia muciniphila is the standout probiotic strain, with emerging research linking it to improved metabolic signaling. Branded ingredients like Eriomin offer the advantage of clinical studies behind their specific formulations.
Consider your primary goal when choosing a formula. If appetite management is the priority, look for berberine-forward products. If gut health is the focus, probiotic-centered formulas may be more effective. For active individuals, combination products that pair GLP-1 support with performance ingredients like creatine offer dual benefits.
Form should match your lifestyle. Capsules deliver the highest doses per serving and avoid added sugars entirely. Powders offer fast absorption and flexible dosing. Gummies provide the easiest daily compliance but typically contain lower active ingredient doses and may include added sugars — opt for sugar-free versions when possible.
Quality markers matter in this rapidly growing category. Look for GMP-certified manufacturing, third-party testing, transparent ingredient labels with specific dosages listed (not proprietary blends), and brands with a track record. Avoid products making claims that sound too close to prescription drug marketing, as these may face regulatory issues.
Frequently Asked Questions
What is GLP-1 and why does it matter for weight management?
GLP-1 (glucagon-like peptide-1) is a hormone produced by L-cells in the small intestine in response to food intake. It signals the brain to reduce appetite, slows stomach emptying to increase satiety, and stimulates insulin release to manage blood sugar. Higher GLP-1 activity is associated with reduced food intake and improved metabolic function, which is why both prescription drugs and supplements targeting this pathway have become popular for weight management support.
Can GLP-1 supplements replace Ozempic or Wegovy?
No. Over-the-counter GLP-1 supplements are not equivalent to prescription GLP-1 receptor agonists. Prescription medications like semaglutide directly mimic GLP-1 at pharmaceutical concentrations, producing significant clinical effects. Supplements aim to modestly support the body’s own GLP-1 production using natural ingredients. They may be appropriate for those seeking mild metabolic support but should not be considered substitutes for prescribed medications.
What is the best natural ingredient for boosting GLP-1?
Berberine has the most research supporting its role in GLP-1 enhancement. Studies show it can stimulate GLP-1 secretion from intestinal L-cells and improve glucose metabolism through multiple mechanisms. Other well-studied options include curcumin, resveratrol, green tea catechins, and specific probiotic strains like Akkermansia muciniphila that influence the gut environment where GLP-1 is produced.
How long do GLP-1 supplements take to show results?
Most users report noticing changes in appetite and cravings within 2-4 weeks of consistent daily use. Broader metabolic effects like improved energy levels and body composition changes typically take 6-12 weeks. Probiotic-based formulas may require a longer adjustment period as the gut microbiome adapts. Individual results vary based on diet, exercise habits, and starting metabolic health.
Should I take GLP-1 supplements with food or on an empty stomach?
Most GLP-1 supplements are best taken 20-30 minutes before meals, as this timing aligns with the natural GLP-1 release cycle that occurs during food intake. Berberine-based supplements specifically are typically recommended before the two largest meals of the day. Probiotic-based formulas are often taken on an empty stomach for optimal bacterial survival. Always check the specific product label for manufacturer-recommended timing.
Are GLP-1 supplements safe to take long term?
The individual ingredients in most GLP-1 supplements — berberine, probiotics, resveratrol, cinnamon — have long histories of safe use and are generally well-tolerated for extended periods. However, the specific combinations and doses in newer GLP-1 formulas lack long-term studies. The most common side effects are mild digestive discomfort that typically resolves within the first few weeks. Those taking medications for diabetes or blood sugar management should consult a healthcare provider before starting any GLP-1 supplement.
