Best Lactoferrin Supplements (2026)
Lactoferrin is a naturally occurring iron-binding glycoprotein found in high concentrations in colostrum and milk. It plays a critical role in immune modulation, iron regulation, gut health, and antioxidant defense. Supplementing with lactoferrin has become increasingly popular for adults seeking to support their immune system, improve iron absorption without the GI side effects of traditional iron supplements, and promote a healthy microbiome.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Natures Craft Lactoferrin & Monolaurin | 250mg Lactoferrin + 1000mg Monolaurin | Capsules | Best Overall | 4.5/5 |
| Double Wood Lactoferrin (Bioferrin) | 250mg Patented Bioferrin | Capsules | Best for Iron Absorption | 4.5/5 |
| Nutricost Lactoferrin 300mg | 300mg Lactoferrin | Capsules | Best Value | 4.4/5 |
| Jarrow Formulas Lactoferrin 250mg | 250mg Freeze-Dried Lactoferrin | Capsules | Best Freeze-Dried | 4.6/5 |
| Life Extension Lactoferrin Caps | 300mg Apolactoferrin | Capsules | Best for Immune & Eye Health | 4.5/5 |
| HUMANX Lactoferrin 500mg | 500mg Lactoferrin | Capsules | Most Potent | 4.4/5 |
| Carlyle Lactoferrin 300mg | 300mg Bovine Lactoferrin | Capsules | Best Budget Pick | 4.3/5 |
1. Natures Craft Lactoferrin & Monolaurin – Best Overall
- Digestive Support Immunity Supplement - Support your immunity from your gut with Monolaurin to help stop the growth of bad gut flora plus lactoferrin supplements to promote healthy microbiome growth
- Promote Iron Absorption - This one of a kind immune system booster for adults works to support gut health for women & men by binding with iron and preventing invaders from using it for their growth
- Clean Formulas - We proudly source our monolaurin from coconuts and our lactoferrin from carefully sourced freeze dried cow's milk and manufacture and test in American GMP and ISO 17025 labs
- Multi Targeted Approach - Reap the rewards of enhanced digestion and immune system support by helping your body maintain a balanced microbiome while encouraging the production of immune defenders
- Natures Craft Quality - We are proud to be a leading name in men and women gut health supplements because we know just how important maintaining optimal digestion is for feeling your best
This dual-action formula combines 250mg of freeze-dried lactoferrin with 1000mg of coconut-derived monolaurin for comprehensive immune and digestive support in a single supplement.
Natures Craft delivers a unique two-in-one approach by pairing lactoferrin’s iron-binding immune benefits with monolaurin’s antimicrobial properties. Each serving provides 30 capsules of vegetarian-friendly support. The formula is manufactured and tested in American GMP and ISO 17025 labs, giving it a strong quality assurance profile. The combination targets both microbiome balance and immune defense simultaneously.
- Pros:
- Dual-ingredient formula covers immune and gut health in one product
- Freeze-dried lactoferrin preserves bioactivity
- Manufactured in GMP and ISO 17025 certified facilities
- Cons:
- Only 30 servings per bottle
- Contains milk-derived ingredients (not suitable for dairy-allergic individuals)
Best for: Anyone seeking a comprehensive immune and gut health supplement that combines two powerful bioactive compounds in one formula.
2. Double Wood Lactoferrin – Best for Iron Absorption
- IRON SUPPLEMENT SUPPORT: Lactoferrin may support iron absorption by binding to free iron particles in the intestines and helping your body utilize them
- WELL-ABSORBED IRON SUPPORT: Clinical research shows that Lactoferrin may offer advantages compared to traditional iron sources such as ferrous sulfate
- PATENTED BIOFERRIN LACTOFERRIN: Bioferrin is a milk derived lactoferrin compound that is partially saturated with Iron for gentle and is formulated to support iron intake
- NOT ALL LACTOFERRIN IS CREATED EQUAL: Bioferrin contains a high concentration of lactoferrin peptides and has been evaluated for its consistency and composition
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
Featuring patented Bioferrin lactoferrin that may be up to 5.8x more bioavailable than ferrous sulfate, this is the go-to option for gentle, effective iron support.
Double Wood uses Bioferrin, a partially iron-saturated lactoferrin derived from milk that has been tested against five other brands and shown to contain the highest concentration of lactoferrin peptides (484 peptides). Each bottle contains 60 capsules at 250mg per serving (2 capsules). The formula is third-party tested, soy-free, gluten-free, and non-GMO. For those looking to support iron levels without the constipation or nausea common with traditional iron supplements, this patented form stands out.
- Pros:
- Patented Bioferrin with superior bioavailability
- Clinically researched for iron absorption superiority
- Third-party tested for purity and potency
- Cons:
- Only 30 servings per bottle (2 capsules per serving)
- Gelatin capsules (not vegetarian)
Best for: Individuals with iron deficiency or those seeking a gentle, highly bioavailable alternative to traditional iron supplements.
3. Nutricost Lactoferrin 300mg – Best Value
- Lactoferrin Supplement: Nutricost Lactoferrin Capsules, a dietary supplement designed to support your daily routine.
- Generous Supply: Each bottle contains 60 capsules, providing a 60-serving supply at 300mg per serving.
- Dietary-Friendly: Suitable for vegetarians, and crafted to be non-GMO and gluten-free.
- Quality Assurance: Manufactured in a facility compliant with established standards and third-party tested for quality and authenticity.
- Easy Integration: Convenient capsules for easy incorporation into your daily routine, promoting your overall wellness.
Delivering a full 300mg dose per capsule with 60 servings per bottle, Nutricost offers one of the best price-to-potency ratios in the lactoferrin market.
Nutricost Lactoferrin provides 300mg per vegetarian capsule with a clean ingredient profile. The product is third-party tested, GMP compliant, non-GMO, and gluten-free. With 60 capsules per bottle at one capsule per day, it offers a two-month supply at a competitive price point. The hypromellose capsule makes it suitable for vegetarians, and the minimal excipient list appeals to those who prefer clean-label supplements.
- Pros:
- High 300mg dose per single capsule
- 60-day supply at an affordable price
- Vegetarian capsules with clean formula
- Cons:
- No patented lactoferrin form
- Less brand recognition than legacy supplement companies
Best for: Budget-conscious consumers who want a potent, clean lactoferrin supplement without paying premium prices.
4. Jarrow Formulas Lactoferrin 250mg – Best Freeze-Dried
- Suggested Use for Lactoferrin: Adults take 1 capsule once a day with food or as directed by your qualified healthcare professional
Jarrow’s freeze-dried apolactoferrin preserves the native structure of lactoferrin for maximum biological activity and immune-modulating potential.
Jarrow Formulas has been a trusted name in supplements for decades, and their lactoferrin product reflects that expertise. Each capsule delivers 250mg of freeze-dried apolactoferrin (iron-free form), which is particularly beneficial for immune modulation without adding extra iron. The freeze-drying process preserves the protein’s tertiary structure, ensuring it remains biologically active. Available in 60-capsule bottles, the product is non-GMO and gluten-free. For those interested in pairing lactoferrin with broader immune support, this pairs well with zinc and vitamin C supplementation.
- Pros:
- Freeze-dried to preserve protein structure and potency
- Trusted legacy brand with decades of experience
- Apolactoferrin form ideal for immune support without added iron
- Cons:
- Bovine gelatin capsule (not vegetarian)
- Contains milk allergen
Best for: Those who prioritize protein integrity and want a well-researched lactoferrin from a legacy supplement brand.
5. Life Extension Lactoferrin Caps – Best for Immune & Eye Health
- Supports a healthy immune response – Found primarily in milk, the compound lactoferrin helps modulate immune function and encourages the immune system’s natural defenses.
- Encourages GI health – Lactoferrin promotes the growth of beneficial digestive bacteria, an important component of supporting the overall health of your GI tract.
- Promotes eye health – Studies have found that lactoferrin can support vision by helping to encourage natural tear production and, with it, ocular lubrication.
- Ingredients matter – We use the finest raw ingredients with the quality and purity you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
- Live your healthiest life – We believe the answers to a healthier life are in reach, and that scientific research is the key to getting there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.
Life Extension’s lactoferrin formula targets immune response, GI tract health, and vision support, making it one of the most versatile options available.
Life Extension delivers 300mg of apolactoferrin per vegetarian capsule with a focus on three key health areas: immune modulation, digestive bacterial balance, and eye health. Clinical studies referenced by Life Extension show lactoferrin can increase tear breakup time by 77%, making this a standout option for individuals concerned about dry eyes alongside immune health. Each bottle contains 60 capsules for a 60-day supply. The formula uses pure, quality ingredients and is manufactured in the US.
- Pros:
- Triple-benefit formula targeting immunity, gut, and eye health
- Vegetarian capsules
- Backed by Life Extension’s rigorous research standards
- Cons:
- Premium price point
- Single-ingredient formula without synergistic additions
Best for: Adults seeking broad-spectrum lactoferrin benefits including immune, digestive, and ocular support.
6. HUMANX Lactoferrin 500mg – Most Potent
- LACTOFERRIN 500 MG: Lactoferrin supports the regulation iron utilization and the body's natural immune response.*
- IMMUNE RESPONSE: Lactoferrin is protein naturally found in the fluids of the human body and supports the body's immune function.*
- IRON UTILIZATION: Lactoferrin caps support the iron utilization in the intestine.*
- Evidence Based Ingredients - Our ingredients are extensively studied with many of the world's leading scientists publishing their peer reviewed findings in scientific publications.
- USA: Made in a USA GMP certified facility with global ingredients under strict regulatory standards.
At 500mg per capsule, HUMANX delivers the highest per-serving lactoferrin dose on this list, ideal for those who want maximum potency in fewer capsules.
HUMANX Lactoferrin stands out with its high-potency 500mg dose per capsule, nearly double what most competitors offer. The product is made in the USA in a GMP-certified facility with evidence-based ingredients. It is gluten-free, non-GMO, and soy-free. The formula supports immune function and iron utilization without unnecessary fillers. For those following protocols that call for higher lactoferrin doses, this eliminates the need to take multiple capsules.
- Pros:
- Highest dose per capsule at 500mg
- USA-made with GMP certification
- Evidence-based ingredient sourcing
- Cons:
- Higher price per bottle
- Fewer customer reviews compared to established brands
Best for: Individuals on higher-dose lactoferrin protocols who want maximum potency per capsule.
7. Carlyle Lactoferrin 300mg – Best Budget Pick
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Carlyle delivers a solid 300mg bovine lactoferrin dose at one of the lowest price points in the category, backed by over 40 years of supplement manufacturing experience.
Carlyle’s Lactoferrin formula provides 300mg per serving from bovine sources in quick-release capsules. The product is non-GMO and gluten-free, manufactured by a family-owned company with three generations of health and wellness experience. Each bottle contains 60 capsules, providing a generous supply at an entry-level price. While it lacks patented forms or freeze-dried processing, it delivers straightforward lactoferrin supplementation at exceptional value.
- Pros:
- One of the most affordable lactoferrin options available
- Trusted family-owned brand with 40+ years in the industry
- Quick-release capsule format
- Cons:
- No patented or freeze-dried lactoferrin form
- Three capsules per serving
Best for: First-time lactoferrin users or budget-minded consumers who want reliable quality at an accessible price.
8. Best Naturals Lactoferrin 250mg – Best Clean Label
- 3rd Party Lab Tested for Purity & Quality.
- 250 mg of Lactoferrin per Vegetarian Capsule - 60 Capsules per Bottle.
- Non-GMO & Gluten-Free.
- Proudly Made in USA, GMP Compliant, FDA Registered Facility.
- No Artificial Color, Flavor, or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
Best Naturals offers a straightforward 250mg lactoferrin capsule free from sugar, soy, egg, lactose, gluten, wheat, yeast, and fish — one of the cleanest formulas available.
Best Naturals focuses on purity with an impressively long list of excluded allergens and additives. Each veggie capsule delivers 250mg of lactoferrin, produced in a GMP-compliant, FDA-registered facility in the USA. The product is sodium-free with no artificial colors, flavors, sweeteners, or preservatives. With 60 capsules per bottle, it provides a two-month supply at one capsule per day.
- Pros:
- Extensive allergen-free certifications
- Vegetarian capsules with no artificial additives
- Made in FDA-registered, GMP-compliant facility
- Cons:
- Lower 250mg dose compared to some competitors
- Small brand with less market visibility
Best for: Individuals with multiple food sensitivities or allergies who need a clean, allergen-free lactoferrin supplement.
9. Symbiotics Colostrum Plus with Lactoferrin – Best Colostrum Combo
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Symbiotics combines lactoferrin with bovine colostrum delivering 233mg of immunoglobulins and 28mg of PRPs for a synergistic immune formula that mirrors nature’s first defense.
This formula takes a whole-food approach by combining lactoferrin with full-spectrum bovine colostrum, including immunoglobulins (IgG), proline-rich polypeptides (PRPs), and other immune factors. The unique BIO-lipid coating protects the colostrum from stomach acid degradation, ensuring better bioavailability than uncoated colostrum products. Each bottle contains 120 vegetarian capsules. For those interested in the broader benefits of colostrum supplementation, this product delivers lactoferrin in its natural biological context.
- Pros:
- Full-spectrum colostrum with lactoferrin, immunoglobulins, and PRPs
- BIO-lipid coating for acid-resistant delivery
- 120 capsules per bottle for extended supply
- Cons:
- Lactoferrin dose not standardized on label
- Contains dairy-derived ingredients
Best for: Those who prefer a whole-food approach to lactoferrin supplementation with the added benefits of colostrum’s full immune factor profile.
How to Choose the Best Lactoferrin Supplement
When selecting a lactoferrin supplement, dosage is the first consideration. Most research supports doses between 200-600mg per day for general immune and gut health support, with higher doses sometimes used for iron-related concerns. Look for supplements that clearly state the lactoferrin content per serving rather than hiding it in proprietary blends.
The form of lactoferrin matters significantly. Freeze-dried lactoferrin (like Jarrow’s) preserves the protein’s native structure better than heat-processed versions. Patented forms like Bioferrin (used by Double Wood) have been clinically evaluated for potency and consistency. Apolactoferrin (iron-free) is preferred for immune modulation, while partially iron-saturated forms are better for iron absorption support.
Capsule type is worth noting for dietary restrictions. Vegetarian capsules are available from brands like Nutricost and Life Extension, while others use bovine gelatin. Since lactoferrin is derived from milk, those with severe dairy allergies should consult a healthcare provider before supplementing, though lactoferrin itself is a protein rather than a dairy sugar like lactose.
Third-party testing and GMP certification should be non-negotiable. Reputable brands will list their testing credentials on the label or website. Look for ISO 17025 lab testing, NSF certification, or USP verification for the highest quality assurance.
Frequently Asked Questions
What is lactoferrin and what does it do?
Lactoferrin is an iron-binding glycoprotein found naturally in milk (especially colostrum), saliva, tears, and other bodily secretions. It supports immune function by modulating the immune response, promotes healthy gut bacteria, acts as an antioxidant, and helps regulate iron absorption and utilization in the body.
How much lactoferrin should I take daily?
Most studies and supplement manufacturers recommend 200-300mg per day for general immune and gut health support. For iron absorption support, doses of 250-500mg daily are common. Some protocols use up to 600-1000mg per day, though it is advisable to start at lower doses and increase gradually.
When is the best time to take lactoferrin?
Lactoferrin is typically taken with food to support absorption and reduce any potential for mild digestive discomfort. Taking it with a meal also helps when using lactoferrin for iron absorption purposes, as it can bind and transport dietary iron more effectively.
Are there any side effects of lactoferrin?
Lactoferrin is recognized as Generally Recognized As Safe (GRAS) by the FDA and is well-tolerated by most adults. Some people may experience mild digestive discomfort, particularly when starting supplementation. Those with milk allergies should exercise caution, as lactoferrin is derived from bovine milk.
Can I take lactoferrin with other supplements?
Lactoferrin pairs well with many supplements including probiotics, vitamin C, zinc, and colostrum. It may enhance the absorption of iron supplements due to its iron-binding properties. There are no widely reported negative interactions, but individuals on medication should consult their healthcare provider.
How long does it take for lactoferrin to work?
Many users report noticing improvements in digestive comfort and general well-being within 2-4 weeks of consistent daily use. For iron-related benefits, blood markers may show improvement within 4-8 weeks. Immune support effects are cumulative and build over time with continued supplementation.
