Best Liposomal Glutathione Supplements (2026)
Liposomal glutathione supplements use advanced lipid encapsulation technology to protect glutathione molecules through the digestive tract, dramatically improving absorption compared to standard glutathione capsules. Often called the body’s “master antioxidant,” glutathione supports detoxification, immune function, skin health, and cellular protection from oxidative stress — and the liposomal delivery format ensures more of it actually reaches your cells.
Quick Comparison
| Product | Glutathione Dose | Form | Best For | Rating |
|---|---|---|---|---|
| Luma Nutrition Premium Glutathione | 500mg | Capsules | Best Overall | 9.2/10 |
| Codeage Liposomal Glutathione | 500mg Setria | Capsules | Best Setria Formula | 9.1/10 |
| Core Med Science Liposomal Glutathione | 500mg Setria | Softgels | Best Softgel | 9.0/10 |
| Pure Encapsulations Liposomal Glutathione | 375mg Setria | Softgels | Best Premium | 8.9/10 |
| Nutricost Liposomal Glutathione | 720mg | Capsules | Best Value | 8.8/10 |
| Zeylamum Liposomal Glutathione | 2400mg | Softgels | Most Potent | 8.7/10 |
| Double Wood Liposomal Glutathione | 500mg | Capsules | Best Budget Pick | 8.6/10 |
1. Luma Nutrition Premium Glutathione — Best Overall
- Powerful Health Benefits: Unlock natural antioxidant support with our reduced Glutathione supplement shown to neutralize free radicals, promote cellular health, reduce oxidative stress, and combat the signs of aging. Glutathione 500mg is all you need.
- Liver Support and Skin Supplement Pills: Luma's s-acetyl l-glutathione supplement capsules aid liver support health, promote even skin tone, reduces hyperpigmentation, and boosts natural collagen production leading to radiant skin complexion.
- 30 Day Supply: Each bottle lasts for a month to maintain optimal freshness and provide strong immune support. Acheive brighter skin with our pure glutathione supplements on a monthly subscription for both men and women. Stay in stock and save money at the same time!
- Convenient Daily Dose: Our vegan and gluten-free Glutathione supplement provides powerful antioxidant support with just 2 capsules daily. Enhance liver health and immune function effortlessly, ensuring optimal wellness with a simple once-per-day routine.
- Made in the USA by Veteran-Owned Small Business: Trust in Luma Nutrition's GMP certified, USA-manufactured supplements that are 3rd party verified. As a veteran-owned brand, we prioritize quality and expert craftsmanship to assist with your entire health journey.
Luma Nutrition delivers a well-rounded liposomal glutathione formula that balances potency, absorption, and value in a single daily capsule.
Each serving provides 500mg of L-glutathione in a liposomal delivery system designed for enhanced bioavailability. The formula is manufactured in a GMP-certified facility in the USA and undergoes third-party testing for purity and potency. The capsules are easy to swallow and free from common allergens including gluten, soy, and dairy.
- Pros:
- Solid 500mg dose with liposomal delivery for enhanced absorption
- Third-party tested and manufactured in GMP-certified USA facility
- Clean formula free from major allergens
- Cons:
- Some users report a mild sulfur smell when opening the bottle
- Only available in capsule form
Best for: Anyone looking for a reliable, well-tested daily liposomal glutathione supplement at a reasonable price point
2. Codeage Liposomal Glutathione — Best Setria Formula
- High-Potency Setria L-Glutathione: Codeage Liposomal Glutathione supplement delivers 500 mg of patented Setria L-Glutathione per serving, providing a substantial dose in each capsule.
- Advanced Liposomal Delivery: This L-Glutathione formula features a liposomal delivery with a 350 mg phospholipid complex from non-GMO sunflower for added purity.
- Premium Quality Ingredients: This glutathione formula utilizes clinically studied Setria L-Glutathione, known for its purity and quality.
- Convenient Capsule Format: Offers a practical alternative to liquid glutathione, glutathione tablet, injectable glutathione, or glutathione IV, making it easy to incorporate into your daily routine.
- Manufactured in the USA: Codeage Liposomal L-Glutathione pills supplement is vegan, non-GMO, dairy-free, soy-free, and gluten-free. This glutathione formula is manufactured in the USA with global ingredients in a cGMP-certified facility for quality and purity. Each bottle provides 30 servings for a one-month supply.
Codeage uses patented Setria L-Glutathione — a clinically studied, highly stable form of reduced glutathione — paired with a 350mg phospholipid complex from non-GMO sunflower.
Each serving delivers 500mg of Setria L-Glutathione with liposomal encapsulation for maximum bioavailability. The phospholipid complex is derived from non-GMO sunflower lecithin rather than soy, making it suitable for those with soy sensitivities. The supplement is vegan, non-GMO, dairy-free, and manufactured in a cGMP-certified facility in the USA.
- Pros:
- Uses patented Setria glutathione backed by clinical research
- Soy-free phospholipid complex from sunflower lecithin
- Vegan-friendly capsule format
- Cons:
- Higher price point than non-Setria alternatives
- Only 60 capsules per bottle (30-day supply at 2 per day)
Best for: Users who want a clinically studied, branded form of glutathione with premium ingredient sourcing
3. Core Med Science Liposomal Glutathione — Best Softgel
No products found.
Core Med Science combines Setria reduced glutathione with sunflower-derived phospholipids in an easy-to-absorb softgel format that protects the active ingredient from digestive degradation.
Each softgel provides 500mg of Setria glutathione encapsulated in a phospholipid complex for enhanced delivery directly into the bloodstream. The softgel format offers superior protection compared to standard capsules, as the liquid interior ensures the liposomal structure remains intact. The product is made in the USA and free from GMOs, gluten, and soy.
- Pros:
- Softgel format preserves liposomal integrity better than powdered capsules
- Uses premium Setria glutathione with phospholipid complex
- Widely recommended by integrative health practitioners
- Cons:
- Softgels are slightly larger than standard capsules
- Premium pricing compared to powder-based alternatives
Best for: Those who prefer softgels and want maximum liposomal protection for their glutathione supplement
4. Pure Encapsulations Liposomal Glutathione — Best Premium
- Setria Glutathione Supplement: Each antioxidant softgel has 375 mg of Setria glutathione, providing enhanced liver support and aiding liver detoxification*
- Liposomal Delivery: Our liposomal glutathione supports absorption through a phospholipid complex, maximizing benefits by protecting from degradation during digestion*
- Antioxidant Protection: Supports cellular health with antioxidants and supports liver detox*
- Suggested Use: As a dietary supplement, take 1 liposomal glutathione supplement capsule, 1-2 times daily, with meals, or as directed by a health professional
- Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs
Pure Encapsulations brings pharmaceutical-grade quality to liposomal glutathione with a hypoallergenic formula trusted by healthcare practitioners worldwide.
Each softgel contains 375mg of Setria glutathione in a phospholipid complex designed for enhanced absorption and liver support. Pure Encapsulations is known for rigorous quality control, and this product is free from all common allergens including gluten, dairy, soy, eggs, nuts, and artificial additives. The company is a trusted name among integrative medicine practitioners and frequently recommended in clinical settings.
- Pros:
- Pharmaceutical-grade quality with hypoallergenic formulation
- Trusted by healthcare professionals and widely recommended clinically
- Free from virtually all common allergens and artificial ingredients
- Cons:
- Lower dose (375mg) compared to competitors at 500mg+
- Highest price per serving in this category
Best for: Health-conscious consumers who want a practitioner-grade supplement with the strictest purity standards
5. Nutricost Liposomal Glutathione — Best Value
No products found.
Nutricost delivers one of the highest-dose liposomal glutathione options at a remarkably affordable price, making it ideal for long-term daily use.
Each two-capsule serving provides 720mg of liposomal glutathione — substantially more than many competitors. The product is manufactured in a GMP-compliant facility, third-party tested for quality, and carries the Amazon’s Choice designation. The vegan capsules are clean and straightforward with no unnecessary fillers or additives.
- Pros:
- High 720mg dose per serving — among the strongest available
- Excellent price-to-potency ratio for budget-conscious users
- Third-party tested and GMP manufactured
- Cons:
- Does not use branded Setria glutathione
- Capsule form rather than softgel
Best for: Budget-conscious users who want a high-dose liposomal glutathione without paying premium prices
6. Zeylamum Liposomal Glutathione — Most Potent
No products found.
Zeylamum packs an industry-leading 2400mg of liposomal glutathione per serving along with a proprietary antioxidant blend including hyaluronic acid, resveratrol, and alpha-lipoic acid.
This softgel formula combines high-dose reduced glutathione with complementary antioxidants for comprehensive cellular protection. The advanced liposomal encapsulation technology enhances absorption efficiency, while added ingredients like vitamin C and milk thistle extract provide synergistic support for detoxification and skin health. Each bottle contains 60 softgels for a 30-day supply.
- Pros:
- Highest glutathione dose available at 2400mg per serving
- Includes complementary antioxidants like resveratrol and hyaluronic acid
- Softgel format with advanced liposomal technology
- Cons:
- Softgels are large and may be difficult to swallow
- Higher cost per bottle due to premium dosing
Best for: Users seeking maximum glutathione potency with added antioxidant support in a single supplement
7. Double Wood Liposomal Glutathione — Best Budget Pick
No products found.
Double Wood offers a clean, straightforward 500mg liposomal glutathione formula at one of the lowest prices in the category, backed by third-party testing and USA manufacturing.
Each serving provides 500mg of reduced glutathione with sunflower lecithin for liposomal delivery. Double Wood is known for transparent labeling and rigorous third-party testing for purity and potency. The vegan capsules contain no GMOs, gluten, or soy, and the company manufactures all products in the USA. At 60 capsules per bottle, this offers a solid month’s supply.
- Pros:
- One of the most affordable liposomal glutathione options available
- Third-party tested with transparent lab results
- Vegan, non-GMO, and manufactured in the USA
- Cons:
- Standard 500mg dose without additional synergistic ingredients
- Capsules rather than softgels
Best for: First-time glutathione users or those on a budget who want a reliable liposomal formula without breaking the bank
8. Liposomal Glutathione Liquid Supplement — Best Liquid Option
- [Antioxidant Supplement for Natural Detoxification] Glutathione, as a master antioxidant in the body, helps to eliminate harmful free radicals and aid in detoxification. It can convert harmful stuff in the body into harmless substances and excrete them from the body.
- [Immunity Enhance] Glutathione supplement can enhance the body's immunity and improve resistance. It can regulate the function of the immune system and enhance the activity of immune cells. Suitable for immunocompromised and susceptible populations.
- [Pure Glutathione] Vervidora liquid liposome glutathione is manufactured in a cGMP-compliant facility, distributed by a U.S. company, and has third-party certification. It is GMO-free, gluten-free, dairy-free, and vegan-friendly. The ingredients are pure and all extracted from plants. You can take it with confidence. Compared to other liquid glutathione, our product is primarily a grape-flavored liquid. After special treatment to remove the distinctive sulfur smell, it is not strange in terms of smell and taste. Pure glutathione 500mg per serving(4 milliliters).
- [Skin Health] This liquid glutathione can promote skin health by promoting metabolism through antioxidant activity. It can also promote cell renewal, slow down cell aging, and help delay the aging process. Suitable for people who want to improve their skin condition.
- [High Bioavailability for Better Absorption] Compared to solid state, liposomal glutathione liquid are more suitable for human absorption. It can be absorbed without the need for stomach acid breakdown, making it more gastrointestinal friendly. Vervidora glutathione liposomal supplement comes with a measuring cup that cover the cap, making it easy to accurately see the amount of liquid when taking it with no less or more intake, which is convenient for daily use.
This liquid liposomal glutathione formula offers an alternative delivery method for those who prefer drops over capsules, with fast sublingual absorption potential.
The liquid format allows for flexible dosing and may offer faster absorption when held under the tongue before swallowing. The liposomal encapsulation protects glutathione molecules in the liquid medium, supporting natural detoxification processes, immune function, and skin health. The dropper bottle makes it easy to adjust your dose as needed.
- Pros:
- Liquid format allows flexible dosing and potentially faster absorption
- Easy to add to beverages or take sublingually
- Good option for those who cannot swallow capsules or softgels
- Cons:
- Taste may be unpleasant for some users
- Requires refrigeration after opening for optimal potency
Best for: Those who prefer liquid supplements or have difficulty swallowing pills
How to Choose the Best Liposomal Glutathione Supplement
The most important factor when choosing a liposomal glutathione supplement is the delivery technology itself. True liposomal encapsulation uses phospholipids (typically from sunflower lecithin) to wrap glutathione molecules in protective lipid bubbles that survive digestion. Look for products that specifically mention a phospholipid complex rather than simply adding the word “liposomal” to the label. Softgel formats tend to preserve the liposomal structure better than powdered capsules.
Dosage varies widely in this category, from 375mg to 2400mg per serving. For general antioxidant support, 250–500mg of liposomal glutathione daily is a common starting point. Higher doses in the 500–1000mg range may be more appropriate for targeted liver support or detoxification protocols. Because liposomal delivery enhances absorption, you may not need as high a dose compared to standard glutathione capsules.
The form of glutathione matters as well. Reduced glutathione (also labeled as L-glutathione or GSH) is the active form your body can use immediately. Setria is a patented, clinically studied form of reduced glutathione that offers verified purity and stability. Products using Setria glutathione typically come at a premium but provide an extra layer of quality assurance.
Third-party testing, GMP certification, and clean ingredient lists round out the evaluation. Avoid products with unnecessary fillers, artificial colors, or common allergens. Many high-quality liposomal glutathione supplements are now available in vegan, non-GMO formulations manufactured in USA facilities.
Frequently Asked Questions
What is liposomal glutathione and how is it different from regular glutathione?
Liposomal glutathione is encapsulated in tiny lipid spheres called liposomes, which protect the glutathione molecule from being broken down by stomach acid and digestive enzymes. This allows significantly more glutathione to reach your bloodstream intact compared to standard glutathione capsules, which have notoriously poor oral bioavailability. Studies suggest liposomal delivery can increase glutathione absorption by several times over conventional supplements.
How much liposomal glutathione should I take daily?
Most clinical studies and product formulations suggest 250–500mg of liposomal glutathione per day for general health support. Because the liposomal delivery system enhances absorption, lower doses can be effective compared to standard glutathione. Some individuals may benefit from higher doses of 500–1000mg for targeted detoxification or immune support, but it’s best to start at the lower end and adjust based on individual response.
When is the best time to take liposomal glutathione?
Liposomal glutathione is generally best taken on an empty stomach, either 30 minutes before a meal or 2 hours after eating. The empty stomach allows the liposomes to pass through the digestive system without interference from food. However, some people experience mild stomach discomfort on an empty stomach and may prefer to take it with a light meal — absorption will still be superior to non-liposomal forms.
Are there any side effects of liposomal glutathione?
Liposomal glutathione is generally considered safe and well-tolerated. The most commonly reported side effects are mild and temporary, including digestive discomfort, bloating, or a sulfur-like taste or smell (which is normal for glutathione as it contains sulfur-containing amino acids). Some users report transient headaches when first starting supplementation, likely due to enhanced detoxification activity. Allergic reactions are rare but possible.
Can I take liposomal glutathione with other supplements?
Liposomal glutathione pairs well with several complementary supplements. Vitamin C helps regenerate oxidized glutathione back to its active reduced form, making them excellent partners. NAC (N-acetylcysteine) provides the amino acid precursor cysteine, which supports the body’s own glutathione production. Alpha-lipoic acid is another synergistic antioxidant that works alongside glutathione in the body’s detoxification pathways. Milk thistle supports liver health and may complement glutathione’s detox benefits.
How long does it take for liposomal glutathione to work?
Most users begin noticing benefits within 2–4 weeks of consistent daily use. Early improvements often include increased energy levels and mental clarity, while benefits like improved skin tone and stronger immune resilience may take 4–8 weeks to become apparent. Blood glutathione levels can increase within days of starting supplementation, but the downstream health effects take longer to manifest. Consistency is key — glutathione works best as a daily supplement rather than taken sporadically.
