Best Longevity Supplements (2026)

Longevity supplements target the fundamental biological pathways that drive aging — declining NAD+ levels, mitochondrial dysfunction, cellular senescence, and oxidative damage. Research from institutions like Harvard, the Buck Institute for Research on Aging, and the Mayo Clinic has identified specific compounds that can meaningfully influence these processes. NMN, resveratrol, urolithin A, and nicotinamide riboside lead the field with the strongest human evidence. The longevity supplement market has matured significantly in recent years, moving from speculative ingredients to clinically tested compounds with published trial data. The best longevity supplements provide clinically relevant doses of these evidence-backed ingredients in formats designed for optimal absorption.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Lunakai PRO NAD+ Formula	NR + Resveratrol	Capsules	Best Overall	9.6/10
Effective Nutra Resveratrol Gummies	Resveratrol 1,500 mg	Gummies	Best Resveratrol	9.5/10
Timeline Mitopure Softgels	Urolithin A 500 mg	Softgels	Best for Mitochondria	9.4/10
Renue By Science NMN Powder	NMN 500 mg	Powder	Best NMN	9.3/10
Vital Nutrients Resveratrol	Trans-Resveratrol	Capsules	Best Premium	9.2/10
Timeline Mitopure Gummies	Urolithin A	Gummies	Best Gummies	9.1/10
Renue By Science Liposomal NMN	NMN 250 mg	Capsules	Best Absorption	9.0/10
Renue By Science NMN SLC Capsules	NMN 250 mg	Enteric Capsules	Best Value NMN	8.9/10

1. Lunakai PRO Dual-Pathway NAD+ Formula – Best Overall

Lunakai’s PRO NAD+ formula pairs nicotinamide riboside with resveratrol to attack declining NAD+ levels from two angles — making it the most comprehensive single-product longevity supplement available.

NAD+ decline is considered one of the primary drivers of aging, affecting everything from DNA repair to mitochondrial function to immune response. This USA-made formula uses nicotinamide riboside (NR) as a direct NAD+ precursor while resveratrol activates the sirtuin proteins that consume NAD+ to perform their longevity-promoting functions. The dual-pathway approach means both the supply and utilization of NAD+ are optimized in a single supplement.

• Pros:
• Addresses both NAD+ production and sirtuin activation simultaneously
• USA manufactured with stringent quality controls
• Simplifies longevity supplementation into one product

• Cons:
• Premium pricing reflects the advanced dual-ingredient formula
• Individual NR and resveratrol doses may be lower than dedicated single-ingredient products

Best for: Anyone building a longevity-focused supplement regimen who wants a comprehensive NAD+ solution in one product

2. Effective Nutra Resveratrol Gummies – Best Resveratrol

At 1,500 mg per serving in a sugar-free gummy, Effective Nutra delivers one of the highest resveratrol doses available in the most enjoyable format for daily longevity supplementation.

Resveratrol is one of the most extensively studied longevity compounds, with research demonstrating its ability to activate SIRT1 — the “longevity gene” — and provide potent antioxidant protection against cellular aging. Dr. David Sinclair of Harvard Medical School has identified resveratrol as a key sirtuin activator in his aging research. These sugar-free gummies eliminate the added sugars that can counteract anti-aging benefits while maintaining a flavor that supports daily compliance.

• Pros:
• High-potency 1,500 mg resveratrol per serving
• Sugar-free formula supports metabolic health alongside longevity goals
• Excellent taste drives consistent daily use

• Cons:
• Gummy format contains more inactive ingredients than pure capsules
• Resveratrol has variable bioavailability depending on the individual

Best for: Those who want a high-dose resveratrol supplement they will consistently take every day for long-term longevity benefits

3. Timeline Mitopure Urolithin A Softgels – Best for Mitochondrial Health

Timeline’s Mitopure is the first clinically proven urolithin A supplement, targeting mitophagy — the process by which cells clear out damaged mitochondria and replace them with healthy ones.

Urolithin A is one of the most exciting longevity compounds to emerge in recent years. Produced naturally from pomegranate by gut bacteria (though most people lack the right microbiome to produce adequate amounts), supplemental urolithin A triggers mitophagy at a cellular level. Timeline’s Mitopure has been validated in multiple peer-reviewed clinical trials showing improvements in mitochondrial function and muscle endurance. Each softgel delivers a clinically studied dose of 500 mg pure urolithin A.

• Pros:
• Clinically proven urolithin A with published human trial data
• Targets mitophagy — a unique mechanism not addressed by other supplements
• Softgel format for improved absorption of this fat-soluble compound

• Cons:
• Among the most expensive longevity supplements per serving
• Newer compound with less long-term safety data than resveratrol or CoQ10

Best for: Longevity enthusiasts who want to add mitophagy support to their supplement stack with a clinically validated product

4. Renue By Science NMN Powder – Best NMN Supplement

Renue By Science’s 100g fast-dissolve NMN powder provides approximately 200 servings of 500 mg NMN — one of the most direct and well-researched NAD+ precursors for longevity.

NMN (nicotinamide mononucleotide) has been a centerpiece of longevity research since Dr. David Sinclair’s lab demonstrated its ability to raise NAD+ levels and reverse certain age-related markers in animal studies. Human trials have since confirmed NMN supplementation increases blood NAD+ levels. Renue By Science’s powder format enables sublingual delivery for enhanced absorption, bypassing first-pass metabolism in the liver. The 100g tub provides exceptional value compared to capsule alternatives.

• Pros:
• 500 mg NMN per serving from a dedicated NAD+ research brand
• Fast-dissolve powder enables sublingual absorption
• Outstanding value at approximately 200 servings per container

• Cons:
• Powder requires measuring — less convenient than capsules
• Taste is unappealing to many users

Best for: Committed longevity enthusiasts who want high-value NMN with flexible dosing and enhanced sublingual absorption

5. Vital Nutrients Resveratrol – Best Premium

Vital Nutrients offers ultra-high potency trans-resveratrol in a practitioner-grade formula that exceeds industry testing standards — the choice for those who demand pharmaceutical-level quality.

Trans-resveratrol is the most bioactive form of this polyphenol, and Vital Nutrients delivers it in a clean capsule formulation with minimal excipients. Every batch undergoes extensive testing for identity, potency, purity, and contaminants including heavy metals, pesticides, and microbes. This level of quality control is what makes Vital Nutrients a favorite among integrative medicine practitioners and longevity-focused physicians.

• Pros:
• Ultra-potent trans-resveratrol with superior bioactivity
• Practitioner-grade testing exceeds standard industry protocols
• Minimal, clean excipient profile

• Cons:
• Significantly higher cost than consumer brands
• Available mainly through practitioners and specialty retailers

Best for: Those who prioritize practitioner-grade quality and are willing to invest in premium resveratrol for long-term longevity

6. Timeline Mitopure Urolithin A Gummies – Best Longevity Gummies

Timeline brings their clinically proven urolithin A formula into a convenient gummy format, making daily mitophagy support as easy as eating a piece of candy.

This gummy version delivers the same Mitopure urolithin A that demonstrated mitochondrial health benefits in clinical trials, now in a chewable format. For longevity enthusiasts who already take multiple capsules daily, adding a gummy version of one of their key supplements can reduce pill fatigue. Timeline maintains the same clinical standards across their product line, with every batch tested for purity and potency.

• Pros:
• Same clinically proven Mitopure formula in an enjoyable gummy
• Reduces pill fatigue for those with complex supplement stacks
• No water needed — take anywhere, anytime

• Cons:
• May contain more inactive ingredients than softgel version
• Premium pricing for the gummy format

Best for: Longevity supplement users who prefer gummies over capsules and want clinically proven mitophagy support

7. Renue By Science Liposomal NMN – Best Absorption

Liposomal encapsulation wraps each 250 mg NMN dose in phospholipid layers that protect the compound through digestion and enhance cellular delivery for superior bioavailability.

Standard NMN can be partially degraded in the digestive tract before reaching cells. Renue By Science’s liposomal technology addresses this by encasing NMN molecules in lipid bilayers that mimic cell membranes, allowing for enhanced absorption directly into cells. Each bottle contains 90 capsules, and the liposomal delivery system means that a 250 mg dose may be as effective as higher doses of standard NMN.

• Pros:
• Liposomal delivery for significantly improved NMN absorption
• 90 capsules per bottle for a solid supply
• Produced by a brand specializing in NAD+ precursor research

• Cons:
• Higher cost per milligram than standard NMN capsules or powder
• 250 mg per capsule requires 2 capsules for 500 mg dosing

Best for: Users who prioritize absorption efficiency and want the highest bioavailability from their NMN supplement

8. Renue By Science NMN SLC Enteric Capsules – Best Value NMN Capsules

Renue’s SLC (Slow-Release Capsules) use enteric coating to protect NMN through stomach acid and deliver it intact to the small intestine, offering a cost-effective alternative to liposomal delivery.

Each bottle contains 200 enteric-coated capsules at 250 mg NMN per capsule, providing outstanding value for long-term supplementation. The enteric coating prevents stomach acid from degrading NMN before it reaches the small intestine, where absorption is most efficient. This approach provides better bioavailability than standard capsules at a lower cost than liposomal alternatives, making it the best value proposition for committed NMN users.

• Pros:
• 200-count bottle provides exceptional long-term value
• Enteric coating protects NMN through stomach acid
• More affordable than liposomal NMN with improved absorption over standard capsules

• Cons:
• Enteric capsules should not be opened or crushed
• Absorption may not match liposomal delivery

Best for: Long-term NMN users who want solid bioavailability at the best price per serving

How to Choose the Best Longevity Supplement

Building an effective longevity supplement stack starts with understanding the major aging pathways. NAD+ decline affects cellular energy, DNA repair, and immune function — NAD+ precursors like NMN and NR directly address this. Sirtuin activation through compounds like resveratrol enhances DNA repair, inflammation control, and metabolic health. Mitochondrial dysfunction is targeted by urolithin A (which triggers mitophagy) and CoQ10 (which supports energy production). The most comprehensive approach covers multiple pathways.

Clinical evidence should guide your choices. Look for supplements with human trial data, not just animal or in-vitro studies. Timeline’s Mitopure has published clinical trials. NMN has multiple human studies confirming NAD+ elevation. Resveratrol has decades of research backing its sirtuin-activating effects. Prioritize compounds with the strongest evidence base for your specific goals.

Delivery technology affects whether you actually receive the active compound at the cellular level. Liposomal delivery, sublingual powders, and enteric-coated capsules all improve upon standard capsule absorption. For fat-soluble compounds, softgels with lipid matrices enhance uptake. The cheapest supplement per milligram may not be the most cost-effective if poor absorption means most of the active ingredient is wasted.

Longevity supplementation is a long-term commitment, so cost per month and convenience matter. Calculate the true monthly cost based on recommended doses, not just bottle price. Choose formats you will actually take consistently — the most scientifically advanced supplement does nothing sitting unopened in a cabinet.

Frequently Asked Questions

What are the most evidence-backed longevity supplements?

The compounds with the strongest current evidence include NMN and nicotinamide riboside (NAD+ precursors with human trial data), resveratrol (decades of sirtuin activation research), urolithin A (clinical trials showing improved mitochondrial function), and CoQ10 (extensive cardiovascular and mitochondrial research). Emerging compounds like fisetin and spermidine show promise in early research but have less human data.

How much NMN should I take for longevity?

Most human studies use 250-500 mg of NMN daily. Some longevity researchers and biohackers take 500-1,000 mg per day, though the optimal dose is still being established. Starting at 250 mg and assessing your response before increasing is a reasonable approach. The delivery method (sublingual, liposomal, enteric) affects how much is actually absorbed, so a lower dose in a better delivery system may match a higher dose in standard capsules.

Can longevity supplements extend lifespan?

Animal studies show lifespan extension with several compounds including NMN, resveratrol, and rapamycin. Human lifespan studies are impractical due to their required length, but human trials demonstrate measurable improvements in biomarkers associated with aging — NAD+ levels, mitochondrial function, muscle endurance, and inflammatory markers. These improvements in biological age markers are encouraging, but definitive proof of human lifespan extension from supplements does not yet exist.

What age should I start taking longevity supplements?

NAD+ levels begin declining in the 30s, and most aging biomarkers show measurable deterioration by the 40s. Resveratrol and antioxidant supplements can provide preventive benefits starting in the 30s. NAD+ precursors become particularly relevant in the 40s when decline accelerates. Urolithin A supports mitochondrial health at any age but becomes more important as mitochondrial function declines. Earlier is generally better for prevention, but the 35-45 range is when most longevity researchers recommend starting a dedicated regimen.

Are longevity supplements safe for long-term use?

NMN, resveratrol, and CoQ10 all have strong safety profiles in clinical studies lasting 6-12 months. NR (nicotinamide riboside) has FDA GRAS (Generally Recognized as Safe) status. Urolithin A has demonstrated safety in published human trials. Long-term data beyond a few years is limited for newer compounds, but the mechanisms of action and safety profiles are well-understood. As with any supplement, periodic blood work to monitor health markers is prudent.

What is the best longevity supplement stack?

A commonly recommended evidence-based stack includes an NAD+ precursor (NMN or NR) for cellular energy and DNA repair, resveratrol for sirtuin activation, and urolithin A or CoQ10 for mitochondrial support. Some researchers also include omega-3s for inflammation management and vitamin D for immune function. The goal is covering the major aging pathways without redundancy. Start with one or two core supplements and add others as you assess results.