Best Methylene Blue Supplements (2026)
Methylene blue has rapidly emerged as one of the most talked-about supplements in the biohacking community. Originally used in medical settings, this synthetic compound is now valued for its potential to support mitochondrial function, cognitive performance, and cellular energy production. With growing demand comes a flood of products — and quality varies dramatically. The supplements below have been selected for purity, proper dosing, and transparent manufacturing practices.
Quick Comparison
| Product | Key Feature | Form | Best For | Rating |
|---|---|---|---|---|
| Lunakai PRO Methylene Blue | 99.99% Pure USP Grade 1% | Liquid Drops | Best Overall | 9.5/10 |
| 2% Methylene Blue Pharmaceutical Grade | 2% Concentration, USP Grade | Liquid Drops | Higher Concentration | 9.2/10 |
| Methylene Blue USP Grade 2% | 60 ml, USA Made | Liquid Drops | Best Value | 9.0/10 |
| PureGood Methylene Blue 1% | Third-Party Tested, Alcohol-Free | Liquid Drops | Clean Formula | 9.0/10 |
| Zazzee Organic Blueberry Extract | 5,000 mg Blueberry 10:1 Extract | Capsules | Antioxidant Stack | 8.8/10 |
1. Lunakai PRO Methylene Blue Pharmaceutical Grade – Best Overall
- Cognitive & Mental Clarity Support – Designed for focus, memory, and clear thinking. Ideal for professionals, students, and anyone seeking sustained mental performance with methylene blue for humans.
- 1% Methylene Blue Liquid – USA made with global ingredients with 99.99% pure USP grade methylene blue pharmaceutical grade. Supports cognitive function, mental clarity, focus, and overall brain wellness in a 1.69 fl oz dropper bottle.
- Convenient Liquid Dropper – Easy-to-measure blue methylene drops allow precise serving size control, offering flexibility for individual needs and preferences.
- Daily Wellness & Nootropic Benefits – Methylene blue USP grade is known for supporting cellular energy and antioxidant activity, making it a valuable brain supplement and nootropic.
- Simple, Clean Ingredients – Contains purified water, glycerin, and methylene blue USP grade 1%. Free from GMOs, gluten, soy, and common allergens.
Lunakai PRO delivers pharmaceutical-grade methylene blue at 99.99% purity, making it one of the cleanest options available for cognitive and mitochondrial support.
This 1% USP-grade methylene blue solution is manufactured in the USA under strict GMP standards. The liquid dropper format allows for precise, customizable dosing — critical with a compound where accuracy matters. Each bottle comes in a glass container to preserve potency and prevent degradation from light exposure. The formula is formaldehyde-free and independently tested for heavy metals and contaminants.
- Pros:
- 99.99% purity — pharmaceutical/USP grade
- Precise dropper for accurate microdosing
- Glass bottle preserves potency
- Cons:
- Liquid format can stain teeth and tongue temporarily
- Taste is bitter without mixing into a beverage
Best for: Biohackers and nootropic users who want the highest-purity methylene blue in a flexible liquid format.
2. 2% Methylene Blue Pharmaceutical Grade – Best Higher Concentration
- USP GRADE METHYLENE BLUE: Methylene Blue for clinical applications is the purest grade available.
- Combat Aging: Harness the power of antioxidants in our top-tier pharmaceutical grade ethylene blue (Equivalent to 8oz of 1% Methylene Blue) to combat cellular aging
- EXACT CONCENTRATION AND ASSURED QUALITY: Boasting 99.9% purity, each of blue methylene drops delivers a precise 0.5mg dose, ensuring consistent strength for accurate application in therapeutic settings
- Exceptional Purity: Trust in the exceptional purity and strength of our methylen blue usp consumption, rigorously tested and free from formaldehyde, adhering to USP standards
- REACH US: If you find any issue with the product please don't hesitate to reach us through Amazon for a replacement.
For users who prefer a stronger concentration per drop, this 2% pharmaceutical-grade formula delivers double the standard potency.
Made in the USA with USP-grade methylene blue, this 2% solution provides more milligrams per drop than typical 1% formulas, which means fewer drops are needed per serving. The product comes in a glass dropper bottle and is formaldehyde-free. It’s a solid choice for experienced users who have already dialed in their preferred dosage and want a more concentrated option. Third-party testing verifies purity and the absence of heavy metals.
- Pros:
- 2% concentration — fewer drops needed per dose
- USP pharmaceutical grade, made in USA
- Glass bottle with dropper for precise dosing
- Cons:
- Higher concentration requires more careful dosing
- Not ideal for first-time users who should start low
Best for: Experienced methylene blue users who want a higher-concentration formula for convenience.
3. Methylene Blue USP Grade 2% (60 ml) – Best Value
- MADE IN USA: Produced in a certified facility following strict industry guidelines.
- 2% USP Grade Quality – Formulated with high-purity methylene blue (USP grade) to meet strict quality standards.
- Enhanced Liquid Solution – Designed for improved absorption and flexible usage.
- Clean Formula – Free from gluten and unnecessary additives, ideal for clean-label routines.
This 60 ml bottle of 2% USP-grade methylene blue provides excellent value with a generous supply at a competitive price point.
Proudly made in the USA, this methylene blue supplement delivers 2% concentration in a 2 fl oz (60 ml) glass bottle. The larger volume means it lasts significantly longer than standard 30 ml or 50 ml bottles, making it a cost-effective choice for daily users. The formula is pharmaceutical grade and follows USP standards for purity. The dropper allows for controlled, measured dosing.
- Pros:
- Larger 60 ml bottle — great value per dose
- USP-grade purity at 2% concentration
- Made in the USA
- Cons:
- Less brand recognition than some competitors
- Blue staining is common with all liquid MB products
Best for: Budget-conscious users who want a high-quality, long-lasting supply of pharmaceutical-grade methylene blue.
4. PureGood Pharmaceutical Grade Methylene Blue 1% – Best Clean Formula
- Peace of Mind: Our pharmaceutical grade Methylene Blue is proudly USP grade. By adhering to these qualifications, our Methylene Blue conforms to the rigorous standards established by the USP for identity, purity, strength, and performance.
- High Purity: Our Methylene Blue undergoes rigorous testing by third-party labs to ensure it is free from heavy metals, microorganisms, and other impurities. Our commitment allows you to have complete confidence in the quality of our Methylene Blue.
- Sharp Minds: Methylene Blue for humans is a powerful antioxidant that may offer a range of health benefits. It may support an increase in bloodflow and oxygen to the brain, improve memory, and even contribute to increased energy levels.
- Quality Packaging: Our Methylene Blue is packaged in a pharmaceutical-grade, light-resistant, dark amber glass bottle with dropper, minimizing light exposure and allowing your Methylene Blue to maintain its efficacy throughout its shelf life.
- In the Bottle: Our methylene blue comes in a 30 mL bottle with dropper. Our solution is alcohol-free, GMO-Free, gluten free, formaldehyde-free, preservative-free, and contains no artificial color so you can enjoy without compromising on quality.
PureGood stands out with a fully alcohol-free, third-party tested formula that prioritizes clean ingredients and transparent quality control.
This 1% methylene blue solution comes in an amber dropper bottle designed to protect the compound from UV degradation. PureGood’s formula is alcohol-free — a differentiator since many liquid methylene blue products use alcohol as a solvent. Every batch undergoes independent third-party testing for purity, potency, and contaminant screening. The 60 ml bottle provides approximately 60 servings depending on dosage, and the clean-label approach appeals to health-conscious users who scrutinize ingredient lists.
- Pros:
- Alcohol-free formula — cleaner than most competitors
- Third-party tested with transparent lab results
- Amber glass bottle protects from light degradation
- Cons:
- Premium pricing compared to basic formulas
- 1% concentration means more drops per dose vs. 2% options
Best for: Users who prioritize clean, alcohol-free formulations with verified third-party testing.
5. Zazzee USDA Organic Blueberry 10:1 Extract – Best Antioxidant Stack Companion
- OUTSTANDING VALUE: Our Organic Wild Blueberry Extract contains 5000 mg strength per capsule, is Certified Organic AND 120 capsules per bottle – an amazing value! A single bottle contains a 4 month supply. Compare this to other leading brands that require 2 capsules per serving, are not organic, are not concentrated extracts, and are made with gelatin. Our Blueberry Extract is a bargain not be found elsewhere!
- USDA CERTIFIED ORGANIC: Any Blueberry that is not CERTIFIED organic can be highly contaminated and even harmful. With Zazzee Naturals Certified Organic Wild Blueberry, you can be sure your Blueberry is organic, all-natural, vegan, and non-GMO. More, while other competing products use various chemicals as fillers, binders, and excipients, our Organic Blueberry instead uses a unique Organic Stabilizer Blend.
- 5000 MG STRENGTH / 10:1 EXTRACT / MAXIMUM STRENGTH DOSAGE: Our Organic Wild Blueberry Extract is the strongest dosage available! Each capsule contains 5000 mg strength of Blueberry Extract made from a potent, powerful 10:1 extract.
- NATURAL, VEGAN AND NON-GMO: All ingredients, including the capsule, are 100% organic, vegan and Non-GMO. Our Certified Organic Blueberry Extract does not contain any sweeteners, artificial flavors, wheat, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Enjoy the amazing antioxidant and health benefits of blueberries without worrying about what else might be hiding in each capsule!
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our Organic Blueberry Extract is manufactured in the USA, in a fully compliant facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
While not methylene blue itself, Zazzee’s blueberry extract is a popular stacking partner that delivers concentrated anthocyanins for complementary brain and mitochondrial support.
Each capsule delivers the equivalent of 5,000 mg of blueberry through a potent 10:1 extract ratio. The formula is USDA Organic certified, vegan, and provides 120 capsules per bottle (a 4-month supply). Blueberry extract is rich in anthocyanins and other polyphenols that research has linked to cognitive function and neuroprotection. Many methylene blue users stack it with high-potency antioxidants like blueberry extract to support overall brain health from multiple angles.
- Pros:
- USDA Organic certified with 10:1 concentration
- 120 vegan capsules — 4-month supply
- Pairs well with methylene blue for comprehensive brain support
- Cons:
- Not a methylene blue product — complementary supplement
- Effects are more gradual than direct nootropics
Best for: Users who want to stack a high-potency antioxidant alongside their methylene blue protocol.
6. HumanN SuperBeets Brain Chews – Best for Cognitive Energy
- BRAIN HEALTH SUPPORT: Polyphenol-powered SuperBeets chews to support memory, focus, and mental alertness. Each delightful memory supplement for brain health may support your brain health the smart way.
- SUPPORT MENTAL FOCUS: Ingredients backed by clinical research. The decaffeinated Coffee Fruit Extract in each Memory and Focus supplement is clinically studied to support BDNF levels, a key neuroprotein associated with learning and memory.
- SUPPORT ALERTNESS: Each SuperBeets chew is uniquely formulated to deliver 150mg of clinically studied fermented Resveratrol, a nootropic, plus 100mg of patented Coffee Fruit Extract and 300mg of USA-grown Beet Root Powder without caffeine.
- EASY & CONVENIENT: Simply eat one delicious, pomegranate berry flavored brain supplement for memory and focus every day for the best results. Any time of day is OK! They’re decaffeinated and contain no artificial sweeteners or synthetic colors.
- RECOMMENDED BEET BRAND: #1 Cardiologist, Doctor, and Pharmacist Recommended Beet Brand for Heart Health Support. These super beets chews are non-GMO, gluten-free, and made with plant-based ingredients.
HumanN SuperBeets Brain Chews combine clinically studied ingredients for memory, focus, and mental alertness in a convenient chewable format.
These chews are designed to support cognitive performance through a blend that targets brain circulation and mental energy. The chewable format makes them easy to take without water, and they’re a practical option for users who prefer not to deal with liquid supplements. While not a pure methylene blue product, they occupy the same nootropic category and appeal to users looking for brain-boosting support with a more approachable delivery system. The brand is well-established in the nitric oxide and cardiovascular supplement space.
- Pros:
- Convenient chewable format — no water needed
- Clinically studied brain support ingredients
- Established, trusted brand in the supplement industry
- Cons:
- Not a pure methylene blue product
- Lower potency than dedicated nootropic capsules
Best for: Users who want convenient, chewable brain support from a well-known brand.
7. Organic Blue Spirulina Chlorella Gummies – Best for Beginners
- Spirulina Gummies: Organic Spirulina Gummies from Spirulina Powder Organic (Arthrospira Platensis), 2500mg Per Serving. Green Algae Super Food, Vegan Friendly, Filler Free, Easy to Swallow
- Healthy Aging: Superfood Greens Blend loaded with Chlorophyll, Spirulina, Sea Moss, GLA, Immune Vitamins(Vitamin A, Vitamin B6, Vitamin B12, Vitamin C, Vitamin K), Minerals (Zinc, Sodium, Iron). Powerfully Supports Energy, Digestive Function, Immune System*
- Clean Sources: Our spirulina comes from our scientifically farmed grounds, each of our spirulina strains has had full access to sunlight.Our GMO-certified facility ensures that every production process is safe, transparent, and clean
- Benefits Abound: Spirulina has a low content of fatty acids, of which unsaturated fatty acids, which are very beneficial to the human body, account for a large proportion. Spirulina is rich in a variety of biologically active ingredients, such as β-carotene, phycobiliprotein, γ-linolenic acid and endogenous enzymes, etc., which are very beneficial to human health
- Serving Advice: Due to its special effect on the stomach, we highly recommend that you take it within half an hour before a meal, as this will not only help you to relieve discomfort, but also help you to absorb the ingredients inside
This 13-in-1 superfoods gummy offers a gentle entry into brain and energy support with blue spirulina, chlorella, and other supergreens.
For users who are curious about the biohacking space but not ready to commit to pure methylene blue supplementation, these organic gummies provide a more approachable option. The formula combines blue spirulina with chlorella and additional superfoods in a palatable gummy format. While the mechanism of action differs from methylene blue, the antioxidant and nutrient density supports cellular energy and overall vitality. The gummies are easy to take and don’t come with the staining issues associated with liquid methylene blue.
- Pros:
- 13-in-1 superfoods blend in a tasty gummy
- No staining or bitter taste issues
- Organic ingredients with broad antioxidant support
- Cons:
- Not pure methylene blue — different mechanism of action
- Lower potency for targeted cognitive support
Best for: Beginners or casual users who want gentle brain and energy support in a gummy format.
How to Choose the Best Methylene Blue Supplement
Purity is the single most important factor when shopping for methylene blue. Look for products labeled “USP grade” or “pharmaceutical grade” with a purity of at least 99%. Industrial-grade methylene blue — the kind used in aquariums or labs — can contain heavy metals and contaminants that are unsafe for human consumption. Always verify that the product is specifically marketed as a dietary supplement for humans.
Concentration matters as well. Most methylene blue supplements come in either 1% or 2% solutions. A 1% solution is ideal for beginners and those who want precise microdosing control, while a 2% solution works well for experienced users who have established their optimal dosage. Typical supplemental doses range from 0.5 mg to 4 mg per kg of body weight, though most biohackers use doses on the lower end.
Liquid drops in glass bottles are the gold standard for methylene blue delivery. Glass packaging prevents the compound from interacting with plastic, and dropper bottles allow for measured, repeatable dosing. Amber or cobalt glass is preferred because it blocks UV light that can degrade the compound over time.
Third-party testing and a Certificate of Analysis (CoA) are strong indicators of a trustworthy product. Reputable brands will test for purity, potency, heavy metals, and the absence of formaldehyde — a common contaminant in lower-quality methylene blue products.
Frequently Asked Questions
What is methylene blue and what does it do?
Methylene blue is a synthetic compound originally developed as a textile dye and later adopted for medical use. As a supplement, it is primarily used for its potential to support mitochondrial function — the energy-producing process in cells. Users report improvements in mental clarity, focus, and sustained energy. It works as an electron carrier in mitochondria, which may help optimize cellular energy production.
How much methylene blue should I take daily?
Most supplement users take between 0.5 mg and 2 mg per kg of body weight. For a 1% liquid solution, this typically translates to a few drops per day. It’s important to start with the lowest effective dose and increase gradually. Higher doses do not necessarily produce better results and can cause side effects.
Will methylene blue turn my mouth or urine blue?
Yes, temporary blue discoloration of the mouth, tongue, and urine is normal and expected. This is harmless and resolves once supplementation is paused. Mixing drops into a beverage can minimize mouth staining, and capsule forms avoid the issue entirely.
Are there any side effects of methylene blue?
At typical supplemental doses, most users tolerate methylene blue well. Possible side effects include mild nausea, headache, or gastrointestinal discomfort. Taking it with food usually reduces stomach-related issues. Methylene blue can interact with serotonergic medications (SSRIs, MAOIs), so anyone on antidepressants should consult a healthcare provider before use.
Can I take methylene blue with other supplements?
Methylene blue pairs well with antioxidants like vitamin C, blueberry extract, and CoQ10. Many nootropic stacks include it alongside lion’s mane, creatine, or alpha-GPC for comprehensive cognitive support. Avoid combining it with serotonergic compounds due to the risk of serotonin syndrome.
How long does it take for methylene blue to work?
Many users report feeling subtle improvements in focus and energy within the first few days. However, the full cognitive and mitochondrial benefits may take 2-4 weeks of consistent use to become noticeable. Effects can vary based on individual metabolism, dosage, and overall health status.
