Best Mood Support Supplements (2026)
Stress, anxiety, and low mood affect millions of people, and the right supplements can provide meaningful support alongside a healthy lifestyle. Ingredients like ashwagandha (KSM-66), GABA, L-theanine, saffron extract, and magnesium glycinate have strong clinical evidence for promoting calm, balanced mood, and emotional resilience. Here are the best mood support supplements worth trying this year.
Quick Comparison
| Product | Key Ingredient | Form | Best For |
|---|---|---|---|
| PYM Mood Chews (Citrus) | GABA + L-Theanine | Chews | Best Overall |
| Effective Nutra Ashwagandha Gummies | Ashwagandha 1500mg | Gummies | Best Ashwagandha |
| Lunakai Calm & Stress Relief Gummies | GABA + L-Theanine | Gummies | Best for Stress Relief |
| Lunakai KSM-66 Ashwagandha Gummies | KSM-66 Ashwagandha | Gummies | Best Clinically Studied Form |
| Effective Nutra Saffron Gummies | Saffron + Vitamin D2 | Gummies | Best Saffron Supplement |
| PYM Omega-3 for Mood | Omega-3 (DHA/EPA) | Softgels | Best Omega-3 for Mood |
| Natures Craft Calming Gummies | Ashwagandha + Magnesium | Gummies | Best Budget Pick |
| Genius Joy Nootropic | SAM-e + Rhodiola + 5-HTP | Capsules | Best Nootropic Mood Booster |
1. PYM Citrus Mood Chews — Best Overall
- Prepare Your Mind: PYM Mood Chews are formulated with all-natural vegan ingredients that intuitively optimize your body’s ability to absorb mood-boosting nutrients. Think your favorite fruit chew, built to support your stress, worry and overwhelm.
- Mindful Blend Of Ingredients: Our gluten-free gummies are made with 90mg of L-Theanine to help support relaxation and focus, as well as 130mg of GABA to help ease stress and support better sleep.
- Clean & Flavorful Boost: This balance of sweet and sour is perfect for a citrusly refreshing mood boost. Proudly manufactured in the USA, our chews are non-GMO and keto-friendly, with no added sugars.
- Everyday Solution To Everyday Stress: Designed by neuroscientists and nutritionional psychiatrists, our blend of amino acids target the neurotransmitters that help your body manage stress, allowing you to naturally relax and focus with a calm state of mind.
- A Mindful Mission: PYM’s mission is to provide natural and effective mental hygiene products to promote self-care and mental well-being. PYM prepares your mind to produce the naturally occurring neurotransmitters that help you feel like yourself again.
PYM Mood Chews deliver a targeted blend of GABA (130mg) and L-Theanine (90mg) in a convenient, great-tasting citrus chew that provides fast-acting calm without drowsiness.
Each serving provides clinically relevant doses of GABA and L-theanine — two amino acids studied for their ability to reduce stress and promote relaxation without sedation. The chewable format allows for faster absorption compared to traditional capsules. PYM was founded with mental wellness at its core, and the formula is free from artificial colors, flavors, and common allergens. Take 2 chews as needed for situational stress or daily mood support. 60 count per bag.
- Pros:
- Fast-acting chewable format with pleasant citrus flavor
- Clinically studied GABA + L-Theanine combination
- Non-drowsy — can be taken anytime without sedation
- Cons:
- Contains sugar (not sugar-free)
- 30-serving supply at recommended dose goes quickly
Best for: Anyone seeking fast-acting, on-the-go mood and stress support without drowsiness
2. Effective Nutra Ashwagandha Gummies — Best Ashwagandha
- GET ALL THE BENEFITS: Our Ashwa Gummies are packed in a potent blend that may promote Improved Sleep, Reduced Stress, Balanced Immune System, Sports Performance, Healthy Mood and Cognitive Health.*
- HELPS REDUCE STRESS: Ashwagandha is an adaptogen, a type of herb used to help promote relaxation, stress relief and mental clarity. A couple of gummies a day may help keep the stress away!*
- HEALTHY & DELICIOUS: Yes, we did it! At Effective Nutra we want to provide a healthy and enjoyable experience. Our Ashwa gummies are naturally strawberry flavored. With no artificial colors or flavors, you can be sure you’re getting the most nourishing health gummies out there!*
- EFFECTIVE NUTRA’S SEAL OF EXCELLENCE: QUALITY YOU CAN TRUST: Our Ashwagandha Gummy supplements are Vegan, Gluten-Free, Non-GMO, Third Party Tested, GMP Certified and proudly Made in USA with Globally Sourced Ingredients. Ashwa you can trust! That’s the Effective Nutra seal of excellence!
Effective Nutra packs 1500mg of ashwagandha per serving into a sugar-free gummy that supports stress relief, calm mood, and sustained energy.
This high-potency ashwagandha supplement delivers 1500mg per serving in a natural, sugar-free gummy format. Ashwagandha is one of the most clinically studied adaptogens for reducing cortisol levels and improving stress resilience. The formula also supports immune function and natural energy production. Vegan-friendly, non-GMO, and made without artificial sweeteners or colors.
- Pros:
- High-potency 1500mg ashwagandha per serving
- Sugar-free gummy format with natural flavoring
- Supports mood, stress, energy, and immune function
- Cons:
- Does not specify KSM-66 or Sensoril ashwagandha extract
- Gummy texture may not appeal to all users
Best for: Those who want a high-dose ashwagandha gummy for daily mood and stress support
3. Lunakai Calm & Stress Relief Gummies — Best for Stress Relief
- Natural Stress Relief Gummies – Formulated with GABA, L-Theanine and Lemon Balm these delicious chewables help support natural stress relief and a calm mindset for adults and kids without causing drowsiness.
- Fast-Acting Calm Gummies – Designed to work quickly, these calming gummies for adults and kids support relaxation, focus, and balance when you need it throughout the day.
- Vegan & Allergy-Friendly Formula – Made with natural ingredients and free from gluten, dairy, soy, nuts, shellfish, and animal products—ideal for those with food sensitivities or dietary restrictions.
- Flexible Daily or As-Needed Use – Take 1–2 calming gummies daily or when occasional stress arises. This anti stress support option fits effortlessly into your wellness routine.
- No Artificial Additives or Sweeteners – These stress less gummies are crafted without artificial sweeteners, dyes, or preservatives, offering a clean way to support a relaxed state of mind.
Lunakai’s Calm & Stress Relief Gummies combine GABA and L-Theanine in a delicious gummy format designed specifically for daily anxiety and stress management.
These USA-made gummies pair GABA with L-theanine — two calming amino acids that work synergistically to reduce stress without causing drowsiness. The formula is designed for adults who want a non-sedating daily supplement to promote calm focus and emotional balance throughout the day. Non-GMO, vegan, and manufactured in a GMP-certified facility.
- Pros:
- GABA + L-Theanine synergy for calm without sedation
- USA manufactured in GMP-certified facility
- Great-tasting gummy format for easy daily compliance
- Cons:
- Contains added sugars typical of gummy supplements
- Lower potency per gummy compared to capsule alternatives
Best for: Daily stress and anxiety management in a convenient gummy format
4. Lunakai KSM-66 Ashwagandha Gummies — Best Clinically Studied Form
- Formulated with KSM-66 - These ashwagandha gummies support your body’s natural response to everyday tension, making them effective stress gummies for adults seeking a calming routine.
- Mood Support for Women and Men - Designed for emotional balance support, these ashwagandha gummies for women and men offer gentle mood support to help you feel more centered throughout the day.
- Supports Restful Sleep - These ashwagandha sleep gummies are a convenient way to support relaxation in the evening, helping to ease into a more restful night’s sleep.
- Made with KSM-66 Ashwagandha Root Extract - Each gummy delivers 1000mg of KSM-66, a high-concentration root extract used in ashwagandha supplements for women and men to support overall well-being.
- Vegan, Gelatin-Free, and Non-GMO Formula - Our ashwa gandha gummies are made with pectin, not gelatin, and contain no animal-derived ingredients—perfect for vegan and vegetarian lifestyles.
Lunakai uses KSM-66 — the most clinically studied ashwagandha extract — in a vegan gummy that targets stress, mood, and cognitive performance.
KSM-66 is the gold standard of ashwagandha extracts, backed by over 24 clinical studies demonstrating reductions in cortisol, improvements in stress resilience, and enhanced cognitive function. This USA-manufactured supplement delivers KSM-66 in a daily vegan gummy format. The full-spectrum root extract ensures the complete profile of ashwagandha’s bioactive compounds (withanolides) are preserved.
- Pros:
- Uses KSM-66 — the most clinically validated ashwagandha extract
- Full-spectrum root extract for complete bioactive profile
- Vegan, non-GMO, USA manufactured
- Cons:
- Ashwagandha takes 4-8 weeks for full effects
- Not recommended for pregnant or nursing women
Best for: Those who want the most clinically backed ashwagandha extract for mood and stress
5. Effective Nutra Saffron Gummies — Best Saffron Supplement
- #1 ULTIMATE SAFFRON GUMMY: Not a fan of swallowing large capsules? Our sugar free saffron gummies taste good & go down easy. 90 Gummies in a bottle for the best value out there!*
- GET ALL THE BENEFITS: Our saffron supplement is packed with a 5-in-1 blend that may promote positive mood and attitude, digestion, physical fitness, increase in energy and focus, stress relief, heart health and brain function.*
- SUPPORTS HEALTHY MOOD: Saffron extract has a long history of traditional use for supporting a healthy mood and promoting emotional balance. A great way to maintain a positive attitude and mood all day long!*
- HEALTHY & DELICIOUS: Yes, we did it! At Effective Nutra we want to provide a healthy and enjoyable experience. Our saffron gummies are naturally berry flavored. With no artificial colors or flavors, you can be sure you’re getting the most nourishing health gummies out there!*
- EFFECTIVE NUTRA’S SEAL OF EXCELLENCE: QUALITY YOU CAN TRUST: Our supplements are Vegan, Gluten-Free, Non-GMO, Third Party Tested, GMP Certified and proudly Made in USA with Globally Sourced Ingredients. That’s the Effective Nutra seal of excellence!*
Effective Nutra combines saffron extract with vitamin D2 and passion flower in a sugar-free gummy targeting mood, emotional balance, and seasonal well-being.
Saffron extract (Crocus sativus) has been shown in multiple clinical trials to support positive mood and emotional balance, with some studies showing effects comparable to certain conventional treatments. This formula pairs saffron with vitamin D2 (important for mood regulation, especially in winter) and passion flower for added calming support. Sugar-free, vegan, and free from artificial ingredients.
- Pros:
- Combines three evidence-based mood ingredients
- Sugar-free gummy with natural flavoring
- Saffron clinically shown to support positive mood
- Cons:
- Does not list specific saffron extract standardization (e.g., affron)
- Vitamin D2 is less bioavailable than D3
Best for: Those seeking saffron-based mood support with added vitamin D and calming botanicals
6. PYM Omega-3 for Mood and Emotional Support — Best Omega-3 for Mood
- Prepare Your Mind: PYM Mood Omegas are formulated by neuroscientists and nutritional psychiatrists to support feelings of brain fog, nerves and overall mood.
- Mindful Blend Of Ingredients: These non-GMO capsules are made with DHA, to support feelings of brain fog, as well as EPA to support lower inflammation.
- Sustainably Sourced: Our gluten-free omegas are sustainably sourced from deep sea, cold water sardines and mackerel in Chile. With an added touch of citrus, you'll experience no aftertaste. Made in the USA.
- Everyday Solution To Everyday Stress: Fatty acids can be taken at any time of day, but some research shows additional benefits if you take them with a full meal and before bed.
- A Mindful Mission: PYM’s mission is to provide natural and effective mental hygiene products to promote self-care and mental well-being. PYM prepares your mind to produce the naturally occurring neurotransmitters that help you feel like yourself again.
PYM’s Omega-3 delivers DHA and EPA fatty acids specifically formulated for mood and emotional support rather than general health.
Research consistently links omega-3 fatty acid intake to improved mood and reduced symptoms of anxiety and depression. PYM’s formula provides therapeutic doses of both DHA and EPA — the two omega-3s most associated with brain health and emotional regulation. The softgels are designed to complement PYM’s other mood products for a comprehensive mental wellness routine. 60-count bottle for a 30-day supply.
- Pros:
- Targeted omega-3 formula designed specifically for mood
- Contains both DHA and EPA at therapeutic doses
- Pairs well with other mood support supplements
- Cons:
- Fish-derived — not suitable for vegans
- Softgels may cause fishy aftertaste for some users
Best for: Those who want omega-3 supplementation focused on emotional well-being
7. Natures Craft Calming Gummies — Best Budget Pick
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Natures Craft combines ashwagandha with magnesium in an affordable calming gummy designed for daily relaxation and stress support.
These stress-relief gummies pair ashwagandha with magnesium — two ingredients that work together to reduce cortisol and promote muscular and mental relaxation. The formula is designed for adults who want affordable, daily mood support without the complexity of multi-ingredient stacks. Great-tasting gummy format makes daily compliance easy, and the price point makes it one of the most accessible options on this list.
- Pros:
- Affordable price for daily mood and stress support
- Ashwagandha + magnesium is a well-studied combination
- Pleasant-tasting gummy format
- Cons:
- Lower individual ingredient doses than standalone products
- Contains added sugars
Best for: Budget-conscious shoppers wanting a simple ashwagandha and magnesium mood supplement
8. Genius Joy Nootropic Mood Enhancer — Best Nootropic Mood Booster
- Amp Up the Joy in Your Life*: Genius Joy by the Genius Brand is a natural mood-boosting supplement formulated with high-quality ingredients including SAMe, Panax Ginseng, and L-Theanine. Genius Joy is non-GMO, organic, gluten free, and made in the USA. Serving size 4 vegetarian capsules, 25 servings per container.
- Enhance Mood & Neural Function*: Genius Joy’s hand-picked blend of nootropics, adaptogens, and natural energy boosters promote a natural sense of well-being. SAMe has been shown to support and enhance mood and neural function, and 5-HTP increases serotonin levels
- Support Cognitive Health: L-Theanine, N-Acetyl-L-Tyrosine, and Rhodiola support calm, alertness, and mental focus. Red Panax Ginseng may support focus, concentration, memory, and energy.*
Genius Joy combines SAM-e, rhodiola rosea, and 5-HTP in a capsule formula that targets serotonin and dopamine pathways for a nootropic approach to mood support.
This multi-pathway formula stands out by targeting multiple neurotransmitter systems simultaneously. SAM-e supports serotonin and dopamine production, rhodiola rosea is an adaptogen that combats stress-related fatigue, and 5-HTP is a direct precursor to serotonin. The combination creates a comprehensive mood-enhancing effect that also supports cognitive focus and mental energy. 90 vegetarian capsules per bottle.
- Pros:
- Targets multiple neurotransmitter pathways (serotonin, dopamine)
- Includes SAM-e, a well-studied mood support ingredient
- Added cognitive and energy benefits from rhodiola
- Cons:
- Should not be combined with SSRIs or MAOIs without medical guidance
- Capsule format (not gummies) — requires swallowing pills
Best for: Those who want a neuroscience-based, multi-ingredient nootropic for mood and cognitive performance
How to Choose the Best Mood Support Supplement
The best mood supplement for you depends on what you’re targeting. For daily stress and anxiety, look for GABA, L-theanine, or ashwagandha (preferably the KSM-66 extract). For low mood and emotional balance, saffron extract, SAM-e, and omega-3 fatty acids have the strongest clinical evidence. For a combination approach, multi-ingredient formulas that pair an adaptogen with a calming amino acid can be highly effective.
Form matters for compliance. Gummies and chews are easier to take daily and absorb faster than capsules, but they often contain added sugars and may deliver lower doses. Capsules typically provide higher potencies and cleaner formulations. Choose the format you’ll actually take consistently — the best supplement is the one you use every day.
Look for specific extract forms when possible. KSM-66 ashwagandha has more clinical data than generic ashwagandha powder. Standardized saffron extracts (like affron) provide consistent doses of active compounds. SAM-e should be in its S,S form (the biologically active version) for optimal absorption.
Third-party testing and GMP certification ensure the product contains what the label claims. Avoid products with proprietary blends that hide individual ingredient doses. Mood supplements typically take 2-8 weeks of consistent use before full effects are noticed, so give any new supplement adequate time before evaluating results.
Frequently Asked Questions
What supplements are best for mood support?
The most evidence-based mood support ingredients include ashwagandha (KSM-66), GABA, L-theanine, saffron extract, SAM-e, omega-3 fatty acids (DHA/EPA), magnesium glycinate, and rhodiola rosea. Each works through different mechanisms — adaptogens like ashwagandha lower cortisol, while amino acids like GABA and L-theanine promote relaxation by modulating neurotransmitter activity.
How much ashwagandha should I take for mood?
Clinical studies typically use 300-600mg of KSM-66 ashwagandha extract per day, split into one or two doses. Some gummy formulas use higher amounts of root powder (up to 1500mg) to achieve similar effects. Start at the lower end and increase if needed. Most people notice effects within 4-8 weeks of consistent daily use.
When is the best time to take mood supplements?
It depends on the ingredient. Ashwagandha and adaptogens are best taken in the morning or early afternoon to support daytime stress resilience. GABA and L-theanine can be taken anytime — morning for calm focus or evening for relaxation. SAM-e is best taken on an empty stomach in the morning. Omega-3s can be taken with any meal containing fat for better absorption.
Are there side effects from mood support supplements?
Most mood supplements are well-tolerated at recommended doses. Ashwagandha may cause mild drowsiness or digestive upset in some people. SAM-e can cause nausea or insomnia if taken late in the day. 5-HTP should not be combined with SSRIs or other serotonergic medications without medical supervision due to the risk of serotonin syndrome. Start with lower doses and increase gradually.
Can I take mood supplements with prescription medications?
Some mood supplements can interact with prescription medications, particularly antidepressants (SSRIs, SNRIs, MAOIs). SAM-e, 5-HTP, and St. John’s Wort have the highest interaction potential. GABA, L-theanine, and omega-3s are generally considered safe to combine with most medications. Always consult your healthcare provider before combining supplements with prescription mood or anxiety medications.
How long do mood supplements take to work?
Fast-acting ingredients like GABA and L-theanine can produce noticeable calm within 30-60 minutes of taking them. Adaptogens like ashwagandha and rhodiola take 2-4 weeks for initial effects and 6-8 weeks for full benefits. SAM-e typically shows effects within 1-2 weeks. Omega-3s require 4-8 weeks of consistent supplementation to influence mood through changes in brain cell membrane composition.
