Best NAC for Liver Support (2026)

N-acetyl cysteine (NAC) is one of the most effective supplements for liver health, serving as a direct precursor to glutathione — the body’s master antioxidant and primary liver detoxification compound. NAC is so effective at supporting liver function that it’s used medically to treat acetaminophen overdose. For daily liver support, these are the best NAC supplements available.

Quick Comparison

Product	NAC Dose	Form	Best For	Rating
Lunakai Liver Cleanse Detox & Repair	NAC + Multi-Herb Blend	Capsules	Best Overall	4.5/5
Natures Craft Liver Support NAC	NAC + Milk Thistle	Capsules	Best Combo Formula	4.4/5
Pure Encapsulations NAC 600mg	600mg	Capsules	Best Pure NAC	4.6/5
Evlution Nutrition NAC 600mg	600mg	Capsules	Best Value	4.3/5
Truevantage NAC 1000mg	1000mg	Capsules	Best High Dose	4.4/5
1MD LiverMD	NAC + Siliphos Milk Thistle	Capsules	Best Premium	4.5/5
10 in 1 NAC Gummies 600mg	600mg	Gummies	Best Gummies	4.2/5

1. Lunakai Liver Cleanse Detox & Repair – Best Overall

A comprehensive liver support formula that pairs NAC with milk thistle, artichoke extract, and other liver-protective herbs for complete daily liver care.

Lunakai’s formula takes a synergistic approach to liver support by combining NAC with complementary ingredients that enhance its effectiveness. NAC boosts glutathione production for detoxification, while milk thistle protects liver cells from oxidative damage and artichoke extract supports bile production and fat metabolism. This USA-manufactured supplement uses a multi-pathway strategy that makes it more effective than NAC alone for people seeking comprehensive liver support. The capsule form provides precise dosing and the formula is designed for daily long-term use rather than short-term cleanses.

• Pros:
• NAC combined with proven liver-support herbs
• Multi-pathway approach to liver health
• USA manufactured with quality controls
• Designed for daily long-term use

• Cons:
• NAC dose may be lower than standalone NAC products
• Higher price than single-ingredient NAC supplements

Best for: People who want NAC as part of a complete liver support formula rather than a standalone supplement.

2. Natures Craft Liver Support NAC Supplement – Best Combo Formula

Pairs N-acetyl cysteine with milk thistle, turmeric, choline, dandelion root, and L-glutathione for a formula specifically designed around NAC’s liver-protective mechanisms.

This formula puts NAC at the center of its liver support strategy and surrounds it with ingredients that amplify its benefits. The included L-glutathione provides direct antioxidant support alongside NAC’s role as a glutathione precursor, creating a two-pronged approach to boosting the liver’s antioxidant defenses. Choline supports fat transport out of the liver, turmeric reduces inflammation, and dandelion root promotes bile flow. The 60-capsule bottle provides a 30-day supply at two capsules per day, delivering a meaningful dose of each ingredient.

• Pros:
• NAC + direct glutathione for enhanced antioxidant support
• Includes choline for liver fat metabolism
• Turmeric and dandelion for inflammation and bile support
• Well-balanced ingredient profile

• Cons:
• 30-day supply per bottle
• Two capsules required per serving

Best for: Those who want a NAC-forward liver supplement that also includes complementary ingredients for comprehensive liver support.

3. Pure Encapsulations NAC 600mg – Best Pure NAC

A practitioner-grade, single-ingredient NAC supplement delivering 600mg of free-form N-acetyl-L-cysteine per capsule with no fillers or common allergens.

Pure Encapsulations is one of the most trusted names in professional-grade supplements, and their NAC formula reflects that standard. Each capsule delivers 600mg of free-form NAC — the most bioavailable form of the amino acid. The formula is free from gluten, wheat, dairy, soy, eggs, nuts, and GMOs, making it accessible to people with dietary sensitivities. Free-form NAC is absorbed more efficiently than bound forms, which means more of the active compound reaches the liver where it can support glutathione production. The 90-capsule bottle allows for flexible dosing between 600-1800mg daily depending on individual needs.

• Pros:
• Practitioner-grade purity and quality
• Free-form NAC for superior absorption
• Free from all major allergens
• Flexible dosing (1-3 capsules daily)

• Cons:
• Premium price point
• NAC only — no additional liver-support ingredients

Best for: Health-conscious consumers who want the purest, highest-quality standalone NAC supplement for liver support.

4. Evlution Nutrition NAC 600mg – Best Value

No products found.

A straightforward 600mg NAC supplement from a trusted sports nutrition brand, offering reliable liver and antioxidant support at a competitive price.

Evlution Nutrition (EVL) brings their sports supplement expertise to this clean NAC formula. Each serving delivers 600mg of N-acetyl L-cysteine — the standard clinically studied dose — in an easy-to-swallow capsule. The formula focuses on purity without unnecessary additives, keeping the price accessible for daily long-term use. EVL’s quality controls and brand reputation in the sports nutrition space translate to consistent potency and reliable manufacturing standards. For people who want a no-frills NAC supplement for liver support without paying premium prices, this is a strong choice.

• Pros:
• 600mg clinical dose per serving
• Affordable price for daily use
• Clean formula without unnecessary fillers
• Trusted brand with quality manufacturing

• Cons:
• Single ingredient — no added liver herbs
• Sports brand may not appeal to general health consumers

Best for: Budget-conscious buyers who want a reliable, properly-dosed NAC supplement for everyday liver support.

5. Truevantage NAC Supplement 1000mg – Best High Dose

Delivers a potent 1000mg of NAC per serving for those who need higher-dose liver support, with third-party testing and vegetarian capsules.

Truevantage steps up the dosage to 1000mg of N-acetyl cysteine per serving — nearly double the standard 600mg found in most competing products. This higher dose may benefit people with greater liver support needs or those who prefer fewer capsules to reach their target intake. The supplement is third-party tested for purity, potency, and safety, and manufactured in the USA in a GMP-certified facility. The vegetarian capsules are free from GMOs and common allergens. The 120-capsule count provides a 60-day supply at the recommended dose, making the per-serving cost reasonable despite the higher potency.

• Pros:
• 1000mg per serving for maximum liver support
• Third-party tested for purity and potency
• 120 vegetarian capsules (60-day supply)
• USA manufactured, GMP certified

• Cons:
• Higher dose may cause digestive discomfort in sensitive individuals
• Two capsules per serving

Best for: People who want a higher-dose NAC supplement for more intensive liver support or those who prefer reaching 1000mg+ daily with a single product.

6. 1MD Nutrition LiverMD – Best Premium

A clinically formulated liver supplement featuring NAC alongside Siliphos — a patented milk thistle extract that’s 10x more bioavailable than standard silymarin.

1MD LiverMD distinguishes itself through its use of patented, clinically studied ingredients. The Siliphos silybin is a breakthrough in milk thistle delivery that achieves dramatically higher absorption than standard extracts, meaning more of the liver-protective compound actually reaches the liver. Combined with NAC for glutathione support and EVNolMax (a potent form of vitamin E derived from red palm fruit), this formula addresses liver health through multiple evidence-based pathways. The six-ingredient formula uses clinically studied amounts of each component — not just label-decoration doses. The 60-capsule bottle provides a full 30-day supply.

• Pros:
• Patented Siliphos milk thistle (10x more absorbable)
• Clinically studied ingredient doses
• NAC + enhanced vitamin E for comprehensive antioxidant support
• Exclusive 6-ingredient formula

• Cons:
• Premium price reflects patented ingredients
• 30-day supply per bottle

Best for: Those willing to invest in a premium liver supplement with patented, high-bioavailability ingredients and clinical backing.

7. Cycle Defender Organ Superfood – Best for Athletes

No products found.

A liver, kidney, and heart support formula with NAC and milk thistle designed for athletes and fitness enthusiasts who put extra demand on their organs.

Cycle Defender takes a whole-body organ support approach with NAC as a key ingredient alongside milk thistle and other protective compounds. While designed for athletes and active individuals who need robust organ support, the formula works equally well for general liver health. The combination of NAC for glutathione production, milk thistle for liver cell protection, and additional nutrients for kidney and heart health makes this a comprehensive organ support supplement. The formula recognizes that liver health doesn’t exist in isolation — supporting connected organ systems improves overall detoxification and metabolic function.

• Pros:
• Multi-organ support (liver, kidney, heart)
• NAC + milk thistle for liver-specific benefits
• Designed for people with higher metabolic demands
• Comprehensive formula beyond liver-only support

• Cons:
• Not exclusively liver-focused
• May include ingredients some users don’t need

Best for: Athletes, fitness enthusiasts, and active individuals who want NAC-based liver support as part of a broader organ health formula.

8. 10 in 1 NAC Gummies 600mg – Best Gummies

A gummy NAC supplement delivering 600mg per serving with nine additional supporting ingredients, suitable for both adults and older children.

For people who can’t or won’t swallow capsules, these NAC gummies provide 600mg of N-acetyl cysteine in a chewable format with added liver and immune support ingredients. The 10-in-1 formula includes complementary compounds that enhance NAC’s effectiveness, including ingredients that support antioxidant activity and immune function. The gummy format eliminates the sulfur smell that some users find off-putting in NAC capsules — a common complaint with the amino acid. While gummies generally have slightly lower bioavailability than capsules, the convenience factor means better compliance for people who might otherwise skip their liver support supplement.

• Pros:
• 600mg NAC in gummy form
• No sulfur taste or smell
• 10 supporting ingredients included
• Suitable for adults and kids

• Cons:
• Contains sugar (unlike capsule alternatives)
• Gummies may have lower bioavailability than capsules

Best for: Anyone who dislikes swallowing pills or wants a more pleasant way to get their daily NAC for liver support.

How to Choose the Best NAC for Liver Support

The most important factor when choosing a NAC supplement for liver support is the dosage per serving. Clinical studies on NAC for liver health typically use 600-1200mg per day, with 600mg being the most common starting dose. Look for supplements that clearly state the NAC dosage per serving rather than burying it in a proprietary blend. Free-form N-acetyl-L-cysteine is the preferred form for maximum bioavailability.

Decide whether you want a standalone NAC supplement or a combination formula. Pure NAC supplements give you control over dosing and allow you to combine it with other supplements of your choice. Combination formulas that include milk thistle, glutathione, or turmeric can simplify your regimen by addressing multiple liver-support pathways in a single product. Both approaches are effective — the choice depends on whether you prefer simplicity or customization.

Quality markers matter significantly with NAC supplements. Look for third-party testing, GMP-certified manufacturing, and products made in the USA or other countries with strict manufacturing standards. NAC is a sulfur-containing amino acid, so some brands include special packaging to minimize the characteristic smell. Vegetarian capsules, allergen-free formulations, and non-GMO sourcing are additional quality indicators worth checking.

Consider the cost per serving rather than the bottle price. A 120-capsule bottle at 600mg per capsule may actually cost less per effective dose than a 60-capsule bottle at 1000mg per serving. For liver support, consistency matters more than taking the highest possible dose — choose a product and dosage you can maintain daily over the long term.

Frequently Asked Questions

What is NAC and how does it support liver health?

N-acetyl cysteine (NAC) is a supplemental form of the amino acid cysteine. It’s a direct precursor to glutathione, the body’s most powerful antioxidant and a critical compound for liver detoxification. By boosting glutathione levels, NAC helps the liver neutralize and eliminate toxins, protects liver cells from oxidative damage, and supports the organ’s natural regeneration processes. NAC is so effective at liver protection that it’s the standard medical treatment for acetaminophen (Tylenol) overdose.

How much NAC should I take daily for liver support?

The standard dose for liver support is 600mg taken once or twice daily, totaling 600-1200mg per day. Most clinical studies use 600mg as the effective dose. Some people benefit from higher doses up to 1800mg per day, but it’s best to start at 600mg and increase gradually if needed. Taking NAC between meals on an empty stomach may improve absorption, though taking it with food can reduce potential stomach discomfort.

When is the best time to take NAC?

NAC is generally best absorbed when taken on an empty stomach, ideally 30 minutes before a meal or two hours after eating. However, if NAC causes stomach upset, taking it with food is perfectly acceptable and won’t significantly reduce its effectiveness. For liver support, consistency matters more than timing — pick a time that fits your routine and take it at the same time each day. If taking multiple doses, splitting them between morning and evening is ideal.

Are there any side effects of NAC supplements?

NAC is generally well-tolerated at standard doses. The most common side effects include mild nausea, diarrhea, or stomach discomfort, which can usually be minimized by taking NAC with food or reducing the dose. Some people notice the sulfur-like smell of NAC capsules, though this doesn’t affect efficacy. At very high doses (above 2400mg daily), NAC may cause headaches or dizziness in some individuals. NAC can interact with nitroglycerin and certain blood pressure medications, so consult a healthcare provider if you take prescription medications.

Can I take NAC with milk thistle?

Yes, NAC and milk thistle are one of the most effective combinations for liver support. They work through complementary mechanisms: NAC boosts glutathione production for detoxification while milk thistle (silymarin) protects liver cells from oxidative damage and supports cell regeneration. Many liver support supplements combine these two ingredients for this reason. Taking them together does not cause interactions and may provide better liver support than either ingredient alone.

How long does it take for NAC to improve liver health?

Most people notice improvements in energy and general well-being within 2-4 weeks of consistent NAC supplementation. Changes in liver enzyme levels (ALT, AST) typically become measurable after 8-12 weeks of daily use. For significant liver health improvements, plan on at least 3 months of consistent supplementation. NAC works best as a long-term daily supplement rather than a short-term intervention, and its benefits are enhanced when combined with a liver-friendly diet and regular exercise.