Best NR (Nicotinamide Riboside) Supplements (2026)
Nicotinamide riboside (NR) is a form of vitamin B3 that serves as a direct precursor to NAD+, a coenzyme essential for cellular energy production, DNA repair, and healthy aging. NAD+ levels naturally decline with age, making NR supplementation one of the most researched strategies for supporting cellular vitality and longevity. The best NR supplements use patented, clinically studied forms for proven efficacy.
Quick Comparison
| Product | Key Ingredient | Form | Best For | Rating |
|---|---|---|---|---|
| Tru Niagen 300mg | Niagen NR 300mg | Capsules | Best Overall | 9.6/10 |
| Luma Nutrition NAD+ 1000mg | NAD+ with NR 1,000mg | Capsules | Best High-Dose | 9.2/10 |
| Thorne NiaCel 400 | NR Hydrogen Malate 415mg | Capsules | Best for Athletes | 9.4/10 |
| Tru Niagen Pro 1,000mg | Niagen NR 1,000mg | Capsules | Best Premium | 9.5/10 |
| Liposomal NAD+ NR 1,500mg | NR + Resveratrol 1,500mg | Capsules | Best Combo Formula | 9.0/10 |
| Thorne ResveraCel | NR + Resveratrol + Quercetin | Capsules | Best Longevity Stack | 9.3/10 |
1. Tru Niagen 300mg – Best Overall
- A COMPLETE ANTI AGING SUPPLEMENT - Support whole body wellness and boost cellular energy with Tru Niagen, a patented NAD+ supplement that supports the 37.2 trillion cells in your body Tru Niagen helps the production of nicotinamide adenine dinucleotide to promote healthy cell activity and can help reduce aging-related health concerns. Tru Niagen is clinically proven to be one of the safest and most efficient boosters of NAD+ levels, shown to increase NAD+ over 50% in just 2 weeks with daily use.
- VITAL FOR CELLULAR ENERGY - Tru Niagen supports your ability to stay healthy by boosting NAD+ levels, which naturally decline as you age. NAD+ is vital for cells to function and repair. It supports brain health, muscle health and recovery, heart health, cellular energy and repair, and lifestyle stress management. Patented Tru Niagen is more efficient at raising NAD+ than other NAD+ precursors such as NMN, niacinamide, or niacin.
- TRU STORY: WITHOUT NAD, CELLS DIE - Our bodies naturally decrease in NAD+, with up to a 65% decline between ages 30-70. Effects of metabolic stress and time on your cells can accelerate aging, which leads to many health concerns. Everyone’s body, stressors, and goals are different. Most clinical studies have used 1000mg daily. NAD+ decline begins in your 30s, it's recommended to start with 300mg daily. As you age and are exposed to more metabolic stressors, such as environmental factors or immune challenges, you can move to 1000mg daily. Always check with your healthcare provider for the best dose for you.
- TESTED FOR SAFETY, POTENCY, AND PURITY - Tru Niagen is one of the most well-studied, patented, supplements. Our patented ingredient Niagen has achieved regulatory acceptance by the US FDA for use in supplements: twice as an NDI (New Dietary Ingredient), and once as GRAS (Generally Recognized As Safe). Every batch is made in the United States with globally sourced ingredients and third-party tested by ISO/IEC accredited labs for potency, safety, and purity. Tru Niagen NAD+ capsules are vegetarian, gluten free, nut free, caffeine free, and have no artificial flavors or colors.
- SUPPORTED BY DECADES OF RESEARCH - Tru Niagen is one of the most well-researched patented supplements and is backed by a Nobel Prize winner, 50 owned and licensed patents, 500+ published scientific studies, 300+ global research collaborations, and 40+ clinical trials. Supported by decades of science and research, Tru Niagen is truly one-of-a-kind.
Tru Niagen is the gold standard in nicotinamide riboside supplementation, backed by more clinical research than any other NR product on the market.
Each capsule delivers 300mg of patented Niagen — the most clinically validated form of nicotinamide riboside. Tru Niagen is clinically proven to increase NAD+ levels by over 50% in just two weeks of daily use. The product is supported by 50+ patents, 500+ published scientific studies, 300+ global research collaborations, and 40+ clinical trials. It has achieved FDA regulatory acceptance twice as a New Dietary Ingredient and once as Generally Recognized As Safe (GRAS). The capsules are vegetarian, gluten-free, nut-free, and caffeine-free.
- Pros:
- Most clinically validated NR supplement available
- Patented Niagen ingredient with FDA-reviewed safety profile
- Clinically proven to boost NAD+ by 50%+ in 2 weeks
- Cons:
- Premium price compared to generic NR supplements
- Single-ingredient formula — no synergistic additions
Best for: Anyone seeking the most research-backed, clinically proven NR supplement for healthy aging and cellular energy.
2. Luma Nutrition NAD+ 1,000mg – Best High-Dose
- High-Potency NAD+ Supplement: Each serving delivers a potent NAD+ dosage to support advanced cellular energy, metabolism, and overall wellness. More convenient and stable than liquid NAD Plus supplements.
- Supports Energy, Metabolism & Cellular Health: NAD+ plays a key role in cellular regeneration and energy production, making it one of the best NAD+ supplements for men and women looking to maintain vitality with a resveratrol supplement alternative.
- Clean, High-Quality Formula: Our pure NAD capsules are made with premium NAD+ supplement ingredients for maximum effectiveness and consistency.
- Designed for Men & Women: Perfect as a daily NAD+ supplements women or NAD+ supplements for men, helping support healthy aging, energy levels, and overall cellular function.
- Made in USA + GMP-Certified Quality: All of Luma Nutrition’s supplements are proudly made in the USA in a GMP-certified facility. Every batch is tested for purity and potency, giving you trusted quality in every capsule.
Luma Nutrition delivers a robust 1,000mg NAD+ formula with 500mg per capsule for those seeking aggressive NAD+ support.
This high-dose supplement is designed for individuals who want maximum cellular energy and aging support. Luma Nutrition is a CC brand offering a 10% commission rate. The formula targets energy metabolism, cellular repair, and healthy aging pathways. Each bottle provides a full month’s supply at the recommended two-capsule daily serving. The product is manufactured under GMP guidelines and third-party tested for quality assurance.
- Pros:
- High 1,000mg daily dose for maximum NAD+ support
- Competitive pricing for the dosage
- Supports energy, metabolism, and aging pathways
- Cons:
- Does not use the patented Niagen form of NR
- Less clinical research backing compared to Tru Niagen
Best for: Those who want a high-potency NAD+ booster at an accessible price point.
3. Thorne NiaCel 400 – Best for Athletes
- Cellular Energy: Helps your body optimize daily vitality at every age by supporting cellular repair, healthy metabolism, and a normal sleep-wake cycle*
- Healthy Aging: Provides nicotinamide riboside to promote ideal levels of NAD+, an important coenzyme found in every cell and supports cellular repair and energy production*
- Athletic Peformance: Supports exercise efficiency to help meet your fitness goals; NSF Certified for Sport*
- NSF Certified for Sport: Tested for compliance with label claims and to ensure the absence of nearly 300 substances banned by many major athletic organizations
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)
Thorne’s NiaCel 400 is the only NR supplement with NSF Certified for Sport status, making it the top choice for competitive athletes and those who require banned-substance testing.
Each capsule provides 415mg of nicotinamide riboside hydrogen malate — Thorne’s exclusive NR form bound to hydrogen malate, an important Krebs cycle organic acid that further supports cellular energy production. The product undergoes four rounds of testing including raw material, in-process, finished product, and stability testing. NSF Certified for Sport means every batch is verified for the absence of nearly 300 banned substances. Thorne is trusted by 100+ professional sports teams and is the #1 recommended clinical brand by healthcare practitioners.
- Pros:
- NSF Certified for Sport — ideal for tested athletes
- Unique NR hydrogen malate form supports Krebs cycle
- Four rounds of testing exceed industry standards
- Cons:
- Higher price reflects premium brand and certification
- 60 capsules per bottle at 1-2 daily usage
Best for: Athletes, professionals, and anyone requiring NSF Certified for Sport supplementation.
4. Tru Niagen Pro 1,000mg – Best Premium
- A COMPLETE ANTI AGING SUPPLEMENT - Support whole body wellness and boost cellular energy with Tru Niagen, a patented NAD+ supplement that supports the 37.2 trillion cells in your body Tru Niagen helps the production of nicotinamide adenine dinucleotide to promote healthy cell activity and can help reduce aging-related health concerns. Tru Niagen is clinically proven to be one of the safest and most efficient boosters of NAD+ levels, shown to increase NAD+ over 50% in just 2 weeks with daily use.
- VITAL FOR CELLULAR ENERGY - Tru Niagen supports your ability to stay healthy by boosting NAD+ levels, which naturally decline as you age. NAD+ is vital for cells to function and repair. It supports brain health, muscle health and recovery, heart health, cellular energy and repair, and lifestyle stress management. Patented Tru Niagen is more efficient at raising NAD+ than other NAD+ precursors such as NMN, niacinamide, or niacin.
- TRU STORY: WITHOUT NAD, CELLS DIE - Our bodies naturally decrease in NAD+, with up to a 65% decline between ages 30-70. Effects of metabolic stress and time on your cells can accelerate aging, which leads to many health concerns. Everyone’s body, stressors, and goals are different. Most clinical studies have used 1000mg daily. NAD+ decline begins in your 30s, it's recommended to start with 300mg daily. As you age and are exposed to more metabolic stressors, such as environmental factors or immune challenges, you can move to 1000mg daily. Always check with your healthcare provider for the best dose for you.
- TESTED FOR SAFETY, POTENCY, AND PURITY - Tru Niagen is one of the most well-studied, patented, supplements. Our patented ingredient Niagen has achieved regulatory acceptance by the US FDA for use in supplements: twice as an NDI (New Dietary Ingredient), and once as GRAS (Generally Recognized As Safe). Every batch is made in the United States with globally sourced ingredients and third-party tested by ISO/IEC accredited labs for potency, safety, and purity. Tru Niagen NAD+ capsules are vegetarian, gluten free, nut free, caffeine free, and have no artificial flavors or colors.
- SUPPORTED BY DECADES OF RESEARCH - Tru Niagen is one of the most well-researched patented supplements and is backed by a Nobel Prize winner, 50 owned and licensed patents, 500+ published scientific studies, 300+ global research collaborations, and 40+ clinical trials. Supported by decades of science and research, Tru Niagen is truly one-of-a-kind.
Tru Niagen Pro delivers 1,000mg of patented Niagen per daily serving — the highest dose from the most clinically validated NR brand.
Originally developed for professional athletes and physicians, Tru Niagen Pro provides a more pronounced NAD+ boost for those with higher cellular demands. The 1,000mg daily dose (two 500mg capsules) has been shown in studies to produce a more significant increase in NAD+ levels compared to the standard 300mg dose. Tru Niagen is safe to consume up to 2,000mg per day based on clinical data. The formula maintains all the quality standards of the original, including third-party ISO/IEC accredited lab testing.
- Pros:
- Maximum 1,000mg dose of patented Niagen
- Originally formulated for pro athletes and physicians
- Backed by the same extensive clinical research portfolio
- Cons:
- Highest price point in the NR category
- Requires two capsules daily
Best for: High-performance individuals, athletes, and those who want the maximum clinically supported NR dose.
5. Liposomal NAD+ with NR and Resveratrol 1,500mg – Best Combo Formula
- Boosts NAD+ Levels Naturally - UNcena Liposomal NAD Supplement - Support cellular vitality and health with 1500mg NAD per serving. Advanced nad+ formula supports mitochondrial function, enhances energy at the cellular level, promote healthy aging and Helps maintain natural vitality. Get a full 60-day supply with 120 high-potency capsules in every bottle
- Healthy Aging Starts with NAD - NAD is a vital coenzyme for DNA repair, energy production, and metabolism. As we age, NAD+ levels decline, leading to fatigue and reduced vitality. Our NAD+ resveratrol supplement is specially formulated for both men and women, helping to restore NAD+ levels. Formulated with ingredients shown in research to outperform NMN or Niacin in supporting NAD+ levels, it helps you age with strength and combat fatigue, help with healthy aging, supports optimal cellular function
- 10X Liposomal NAD+ Power – Unlock energy, vitality, and wellness with the power of NAD+. Our advanced 10X liposomal delivery ensures superior absorption, maximizing the bioavailability of Nicotinamide Riboside (NR) and Resveratrol. This cutting-edge technology helps your body fully harness these potent ingredients, delivering 10X stronger cellular support for healthy aging and lasting vitality
- Amazing Benefits - Each nad capsule serving combines resveratrol with nicotinamide riboside (NR) for a powerful antioxidant and NAD+ boosting effect. This synergistic formula support cellular health and renewal, promote DNA repair, and support healthy aging—supporting skin health, memory, helping you feel revitalized from within
- Trusted Quality – Enjoy daily support with peace of mind — Formulated with transparency using clean-label, tested ingredients, just pure wellness. Our NAD+ capsules are made in a GMP-certified facility using non-GMO, high-quality ingredients. Every batch is carefully tested for purity, safety, and potency, ensuring you get a supplement that truly supports your energy, cellular health, and overall well-being.
This comprehensive formula combines nicotinamide riboside with resveratrol and NAD+ precursors in a liposomal delivery system for enhanced absorption.
The 1,500mg total formula pairs NR with trans-resveratrol — a polyphenol that activates sirtuin enzymes, the same longevity pathways that NAD+ supports. The liposomal encapsulation protects ingredients from stomach acid degradation, improving bioavailability significantly compared to standard capsules. This makes it an efficient option for those who want a multi-compound approach to cellular aging without taking multiple separate supplements.
- Pros:
- Liposomal delivery for superior absorption
- NR + resveratrol combination for synergistic aging support
- High total formula dose of 1,500mg
- Cons:
- Individual NR dose may be lower in combined formula
- Does not use patented Niagen form
Best for: Those who want a convenient all-in-one NR and resveratrol supplement with enhanced absorption.
6. Thorne ResveraCel – Best Longevity Stack
- Healthy Aging: Supports cellular repair, up-regulates sirtuin proteins for detoxification benefits, boosts NAD+ production, and enhances cellular energy production in the mitochondria to support the aging process*
- Unique Ingredients: Formulated with a unique form of nicotinamide riboside (NR) to protect against DNA damage, resveratrol for stress resistance, and quercetin to help reduce cellular senescence*
- NAD+ Support: Stimulates the production of NAD+, an important coenzyme that declines significantly with age but plays an integral role in every cell throughout the body, including for cellular repair and normal circadian rhythm function*
- Third-Party Certified: This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)
ResveraCel combines Thorne’s proprietary NR with quercetin phytosome, trans-resveratrol, and betaine in a premium multi-target longevity formula.
This formula addresses multiple aging pathways simultaneously: NR boosts NAD+ for cellular energy, resveratrol activates sirtuins for stress resistance, and quercetin helps reduce cellular senescence. Each serving delivers 415mg NR hydrogen malate, 250mg quercetin phytosome, 150mg trans-resveratrol, and 85mg betaine. Thorne’s third-party certification verifies label accuracy and purity. The product targets DNA protection, NAD+ support, and methylation support.
- Pros:
- Multi-target longevity formula addressing 4 aging pathways
- Quercetin phytosome for enhanced absorption
- Premium Thorne quality with third-party certification
- Cons:
- Requires two capsules per serving
- Higher price than single-ingredient NR supplements
Best for: Those seeking a comprehensive longevity supplement combining NR with complementary anti-aging compounds.
7. Airboy Liposomal NR 900mg – Best Budget Liposomal
- VITALITY & COMBAT AGING: When we are young, NAD+ levels are high. However, as we age, these levels decline, leading to a decrease in energy, cognitive function and overall vitality. These NAD+ supplement capsules are designed to help increase nad+ levels, increase cellular energy, slow cellular aging, improve cognitive performance and regulate metabolic function
- BOOSTS NAD+ LEVEL: NAD+ is vital to cells’ normal function and resilience. Unlike 500 mg of nicotinamide riboside, our 900 mg high potency nicotinamide riboside acts as a direct precursor of NAD+ and is more readily absorbed than other NAD+ precursors
- BENEFITS OF LIPOSOMAL NAD PLUS - NAD+ is arguably one of the most restorative and anti-aging treatments available today. A powerful dose can greatly improve your energy levels, protect your cells and DNA from damage, promote mitochondrial integrity (energy-producing capacity of our cells), and even improve your sleep and mood
- RESVERATROL & QUERCETIN: Each NAD+ supplement capsule contains 3 natural ingredients, in addition to nicotinamide riboside, there are also trans-resveratrol and quercetin, two antioxidants that inhibit oxidative reactions in the body and help slow down the aging process
- GET BACK TO YOUR BEST: Our NAD supplements 900mg come in a capsule form that is easy to swallow. All natural, non-GMO, gluten-free and third-party tested by ISO/IEC accredited labs for potency, safety, and purity. Take 2 capsules a day to get back to your best
Airboy combines 900mg of liposomal nicotinamide riboside with resveratrol and quercetin at a price point that undercuts most premium NR brands.
The liposomal delivery system enhances absorption, while the addition of resveratrol and quercetin provides complementary sirtuin activation and senolytic support. This is a strong option for those who want the benefits of liposomal NR without the premium pricing of brand-name products. The formula is designed for cellular energy, healthy aging, and antioxidant defense in a convenient capsule format.
- Pros:
- Liposomal delivery at an affordable price
- Triple-action formula with NR, resveratrol, and quercetin
- High 900mg serving size
- Cons:
- Less brand recognition than Tru Niagen or Thorne
- Exact NR content within blend not always specified
Best for: Budget-conscious buyers who want liposomal NR delivery with complementary longevity ingredients.
8. Vitalitown 5-in-1 NAD+ – Best Multi-Pathway Formula
- Support NAD+ Levels*: NAD+ is a vital molecule found in every cell of your body, essential for cellular energy, brain function, and skin health.* NAD+ levels may naturally decline with age. This supplement provides a 1100 mg blend of 5 nutrients per serving designed to help support healthy NAD+ levels and overall cellular vitality.*
- NR + Niacinamide + L-Tryptophan: This comprehensive formula includes 3 nutrients that participate in NAD+ production.* Each serving delivers 500 mg of NR, a highly efficient NAD+ precursor especially beneficial for women, the middle-aged & elderly.* Niacinamide offers additional support through a complementary pathway, while L-tryptophan contributes to overall processes involved in NAD+ production.*
- With Trans-Resveratrol + Quercetin: Bioactive trans-resveratrol helps support NAD+ activity and amplifies NAD+ benefits.* Highly absorbable quercetin dihydrate provides additional antioxidant support and works synergistically with resveratrol to support healthy cellular function.*
- Made in the USA: All Vitalitown products are manufactured and packaged in the USA. The products are tested for purity and potency to ensure that each and every bottle of Vitalitown products represents the highest standards.
- PURITY & QUALITY: Vitalitown NAD+ supplement is intended for both men and women free of artificial flavors and preservatives. All products are non-GMO, and contain no gluten, dairy, soy, eggs, fish, shellfish, tree nuts, or peanuts.
Vitalitown combines nicotinamide riboside with four additional NAD+ precursors and longevity compounds for a comprehensive 5-in-1 approach.
This formula goes beyond single-ingredient NR by combining multiple pathways for NAD+ boosting and cellular support. The 5-in-1 approach includes NR alongside trans-resveratrol and additional NAD+ supportive compounds. Each ingredient targets a different aspect of cellular health, creating a broader foundation for longevity support than single-compound products. The formula is designed as an NMN supplement alternative that leverages multiple NAD+ precursor pathways.
- Pros:
- Five complementary ingredients for multi-pathway NAD+ support
- Comprehensive approach to cellular aging
- Good value for a multi-ingredient formula
- Cons:
- Individual ingredient doses may be modest
- Less research behind the specific combination
Best for: Those who want a broad-spectrum NAD+ supplement hitting multiple cellular pathways.
How to Choose the Best NR Supplement
The most critical factor is the form of nicotinamide riboside used. Patented Niagen (from ChromaDex) is the most clinically studied form with extensive safety and efficacy data. Thorne’s NR hydrogen malate offers an alternative with added Krebs cycle support. Generic NR can be effective but typically lacks the clinical validation of branded forms. For those interested in broader longevity supplementation, NR pairs well with resveratrol and quercetin.
Dosage ranges from 250-1,000mg daily. Clinical studies show meaningful NAD+ increases at 300mg daily, with more pronounced effects at higher doses. For most adults, 300mg is a solid starting point. Athletes, older adults, or those under significant metabolic stress may benefit from 500-1,000mg daily. NR is safe to consume at doses up to 2,000mg per day based on available research.
Liposomal delivery systems can enhance absorption but add cost. For budget-conscious buyers, standard capsules with clinically validated NR forms still deliver proven results. NSF Certified for Sport status matters for competitive athletes. Third-party testing, GMP certification, and transparent labeling are baseline requirements for any quality NR supplement.
NR supplements support similar goals as NMN supplements and can be complemented with CoQ10 for energy for a comprehensive cellular energy stack. Consider your specific goals — pure NAD+ boosting versus broader longevity support — when choosing between single-ingredient and combination formulas.
Frequently Asked Questions
What is nicotinamide riboside and what does it do?
Nicotinamide riboside (NR) is a form of vitamin B3 that serves as a precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in every cell of the body. NAD+ is essential for converting food into cellular energy, repairing damaged DNA, supporting immune function, and regulating circadian rhythms. NR is considered one of the most efficient ways to boost NAD+ levels, which naturally decline 50% or more between ages 40-60.
How much NR should I take daily?
Clinical studies have used 250-1,000mg daily with positive results. A daily dose of 300mg has been shown to increase NAD+ levels by over 50% within two weeks. Higher doses of 500-1,000mg may provide more pronounced benefits, particularly for older adults or those with high metabolic demands. NR has been shown to be safe at doses up to 2,000mg per day.
When is the best time to take NR?
NR can be taken with or without food at any time of day. Morning dosing is most common since NR supports cellular energy production. Some users prefer splitting higher doses between morning and afternoon. NR does not contain caffeine and should not interfere with sleep, though its energy-supporting effects make morning use practical for most people.
Are there any side effects of NR?
NR is generally well tolerated with an excellent safety profile across multiple clinical trials. Some users report mild nausea, headache, or digestive discomfort when first starting, which typically resolves within a few days. NR does not cause the flushing associated with niacin (another form of vitamin B3). The patented Niagen form has achieved FDA GRAS status.
Can I take NR with other supplements?
NR pairs well with resveratrol, quercetin, and pterostilbene for enhanced longevity support. Combining NR with CoQ10 provides complementary energy production through different cellular pathways. NR can also be stacked with vitamin D, omega-3s, and other foundational supplements. There are no well-documented negative interactions with common supplements.
How long does it take for NR to work?
Clinical studies show measurable NAD+ increases within 2 weeks of daily use at 300mg. Many users report improvements in energy and overall vitality within 2-4 weeks. Benefits related to healthy aging and cellular repair are cumulative and become more apparent over months of consistent use. Some users notice quicker results at higher doses.
