Best Sublingual B12 Supplements (2026)
Sublingual B12 supplements dissolve under the tongue and absorb directly into the bloodstream, bypassing the digestive system entirely. This makes them an ideal choice for people with absorption issues, older adults, vegans, and anyone who wants faster, more efficient B12 delivery compared to standard capsules or tablets.
Quick Comparison
| Product | B12 Form | Dosage | Best For | Rating |
|---|---|---|---|---|
| Vitamin B12 Liquid Drops 5000 mcg | Methylcobalamin | 5,000 mcg | Best Overall | 4.5/5 |
| EZ Melts Dissolvable B12 2,500 mcg | Methylcobalamin | 2,500 mcg | Best Dissolvable Tablet | 4.5/5 |
| Luma Nutrition Vitamin B12 1000 mcg | Methylcobalamin | 1,000 mcg | Best Budget Pick | 4.4/5 |
| L-Methyl Folate 15mg + Methyl B12 | Methylcobalamin | 1,000 mcg + Folate | Best B12 + Folate Combo | 4.5/5 |
| Vitamin B12 Sublingual Spray 5000 mcg | Methylcobalamin | 5,000 mcg | Best Spray | 4.4/5 |
| BioActive Vitamin B12 5000 mcg | Triple B12 Forms | 5,000 mcg | Best Multi-Form B12 | 4.6/5 |
| Safrel Vitamin B12 1000 mcg Fast Dissolve | Methylcobalamin | 1,000 mcg | Best Value (200 Count) | 4.3/5 |
1. Vitamin B12 Liquid Drops 5000 mcg – Best Overall
- Fast-Absorbing - Our fast-acting, sublingual liquid B12 is more soluble than capsules, allowing you to get the most nutrients with methylcobalamin b12 out of every serving of our vegan B12 liquid vitamin drops.
- Fuel Your Body and Mind - Our Vitamin B12 liquid supplement contains pure vitamins with 1.7mg of Vitamin B2, 20mgNE of Vitamin B3, 3mg of Vitamin B6, and 5000 mcg of Vitamin B12 to support energy, brain health, and metabolism.
- Be More, Do More - Vitamin B12 sublingual plays a key role in converting carbohydrates into glucose for energy production. Stay alert and energized with sufficient Vitamin B12, including vitamin B12 5000 mcg, alongside other B vitamins in our liquid vitamin B12 drops.
- Speed Up Metabolism - Maximize your gains and get the most out of your diet with a Vitamin B complex that works. Our B12 methylcobalamin with b12 sublingual complex vitamin supplements and b12 liquid support the proper metabolism of macronutrients to help convert food into energy.
- Vegan B Vitamin Drops You Can Trust - All of our liquid Vitamin B Complex supplements are proudly made and bottled in Salt Lake City, Utah in an approved facility that follows strict GMP guidelines. Our sublingual B12 products are Third Party Tested to ensure the highest quality possible and the purity of each batch.
These vegan liquid B12 drops deliver 5,000 mcg of methylcobalamin per serving in a fast-acting sublingual format designed for maximum absorption.
The liquid drop format allows the B12 to absorb directly through the mucous membranes under the tongue, making it one of the most bioavailable options on the market. Each bottle provides approximately a 60-day supply, and the dropper makes dosing easy and adjustable. The formula is vegan-friendly and free from common allergens.
- Pros:
- High-potency 5,000 mcg methylcobalamin per serving
- Liquid sublingual format for rapid absorption
- Vegan and allergen-free formula
- Cons:
- Taste may not appeal to everyone
- Requires refrigeration after opening for best freshness
Best for: Anyone seeking a high-potency sublingual B12 with fast absorption and vegan-friendly ingredients
2. EZ Melts Dissolvable B12 2,500 mcg – Best Dissolvable Tablet
- Vitamin B12 Supplement: EZ Melts B12 are dissolvable tablets that deliver 2,500 mcg of vitamin B12 per serving for easy metabolic energy support*
- Energy Support Supplement: Supports healthy energy levels, cellular health, and natural energy production to support overall wellness*
- Brain Health Supplement: Methylcobalamin B12 is essential to help maintain focus and cognitive function, so you can stay alert when it matters most*
- Mood Support Supplement: Supports nervous system function, which helps maintain clarity*
- Non-GMO & Vegan Supplement: EZ Melts makes it easier to take superior quality vitamins—free from artificial flavors, gluten, dairy, soy, and sugar
EZ Melts delivers 2,500 mcg of methylcobalamin in a sugar-free, fast-dissolving sublingual tablet with a pleasant cherry flavor.
These tablets dissolve in seconds under the tongue without water, making them one of the most convenient sublingual B12 options available. Each bottle contains 90 tablets for a 3-month supply. The formula is non-GMO, vegan, and free from gluten, dairy, soy, and sugar—sweetened with monk fruit extract instead. For broader B-vitamin support, check out our guide to methyl B12 supplements.
- Pros:
- Dissolves in seconds with no water needed
- Sugar-free with monk fruit sweetener
- 90-count bottle provides excellent value
- Cons:
- 2,500 mcg may be more than some people need
- Cherry flavor may not suit all preferences
Best for: People who want a convenient, great-tasting sublingual B12 tablet they can take anywhere
3. Luma Nutrition Vitamin B12 Methylcobalamin 1000 mcg – Best Budget Pick
- High Potency Vitamin B12 1000 mcg: Energy & Metabolism Support: Each serving provides a powerful 1000 mcg of Vitamin B12 (B-12) in easy-to-swallow capsules to help convert food into fuel, support metabolism, and promote all-day energy.
- Supports Nervous System & Brain Health: Vitamin B12 (also known as B 12, B12 vitamin, and Vit B12) plays an essential role in maintaining a healthy nervous system, supporting memory, focus, and overall cognitive function.
- Pure and Effective B12 Support: Unlike many vitamin B12 supplements or B12 complex formulas, Luma Nutrition provides a high-quality B-12 vitamin designed for maximum absorption and reliable support for energy, metabolism, and overall wellness.
- Trusted B12 Vitamin for Daily Wellness: Whether you’re looking for Vitamin B-12, B12 vitamins for energy, or a simple B12 supplement alternative to sublingual B12 or Vitamin B12 gummies, Luma Nutrition delivers premium nutrition you can rely on.
- Made in USA + GMP-Certified Quality: All of Luma Nutrition’s supplements are proudly made in the USA in a GMP-certified facility. Every batch of this B-12 1000 mcg formula is tested for purity and potency, giving you trusted quality in every capsule.
Luma Nutrition offers a straightforward 1,000 mcg methylcobalamin B12 at an affordable price point with high-potency vegan capsules.
This formula uses the bioactive methylcobalamin form of B12, which requires no conversion by the body. Each bottle provides a generous supply, and the capsules are designed for easy swallowing. The formula is vegan, non-GMO, and manufactured in a GMP-certified facility in the USA.
- Pros:
- Affordable price per serving
- Active methylcobalamin form
- Made in GMP-certified USA facility
- Cons:
- Capsule form rather than true sublingual dissolve
- Lower potency than liquid drops
Best for: Budget-conscious shoppers who want reliable methylcobalamin B12 from a trusted brand
4. L-Methyl Folate 15mg + Methyl B12 – Best B12 + Folate Combo
- HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
- VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
- ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
- SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
- SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.
This sublingual liquid combines 15 mg of L-methylfolate with methyl B12 in an organic berry-flavored formula for comprehensive methylation support.
The combination of methylfolate and methylcobalamin is particularly beneficial for individuals with MTHFR gene variants who have difficulty processing standard folic acid and cyanocobalamin. The liquid sublingual delivery ensures both nutrients absorb quickly and efficiently. The organic berry flavor makes daily dosing pleasant.
- Pros:
- Combines two critical methylated nutrients in one formula
- High-potency 15 mg L-methylfolate dosage
- Organic berry flavor with sublingual delivery
- Cons:
- Premium price point compared to B12-only supplements
- May not be necessary for those without methylation concerns
Best for: Individuals with MTHFR variants or anyone wanting combined B12 and folate methylation support
5. Vitamin B12 Sublingual Spray 5000 mcg – Best Spray
- Fast Absorption - Our Vitamin B12 Sublingual Fast-Acting Complex will not only be absorbed into your body faster, but it is also more soluble than capsules so that you will get more of the vitamin into your system as well.
- Suitable for Vegans and Vegetarians - Our Vitamin B12 is Vegan, Non-GMO, Gluten Free and does NOT contain any Yeast, Wheat, Milk or Milk Derivatives, Lactose, Sugar, Soy, Artificial Colors and Flavors. Each easy to open bottle contains 2 fluid ounces which is a full 60-day supply.
- Energy Boost - If you’ve been dragging a lot lately, it could be that you’re not getting enough Vitamin B12. Along with the other B Vitamins, B12 is known for its ability to convert carbohydrates into glucose which leads to energy production. The boost in energy levels will help keep you alert and feeling energized throughout the day.
- Speed Up Metabolism - Vitamin B-12 assists the digestive system to function properly and you will notice that if you don't get enough of it you are more prone to constipation and a sluggish digestive system.
- Satisfaction Guaranteed - All of our supplements are proudly made and bottled in Salt Lake City, Utah in an approved facility which follows strict GMP guidelines. Our products are Third Party Tested to ensure the highest quality possible and the purity of each batch. If you have any inquiries, our amazing customer service team is always available to take care of your needs.
This vegan methylcobalamin spray delivers 5,000 mcg of B12 directly under the tongue for rapid absorption without pills or drops.
The spray format is arguably the most convenient sublingual delivery method—just a quick spray under the tongue and you’re done. Each bottle provides approximately a 30-day supply, and the fine mist ensures even distribution across the sublingual membrane for efficient absorption. The formula is vegan-friendly and designed for those who want maximum convenience with their B12 supplementation.
- Pros:
- Spray format is the most convenient sublingual option
- High-potency 5,000 mcg per serving
- Vegan and easy to use on the go
- Cons:
- Smaller supply per bottle than tablets
- Spray mechanism can occasionally malfunction
Best for: People who want the fastest, most convenient sublingual B12 delivery method
6. BioActive Vitamin B12 5000 mcg – Best Multi-Form B12
- Full-Spectrum Vitamin B12 - Plus Methyl Folate Cofactor: Methylcobalamin, Adenosylcobalamin & Hydroxocobalamin are the 3 most beneficial forms of Vitamin B12, with each having different functions in the body. They are naturally occurring, biologically active, coenzyme forms of vitamin B12, the forms the body needs for cellular utilization. The formula also provides a full serving of L-Methylfolate, an essential cofactor of B12.
- Maximum Strength (5000 mcg of B12): Each serving contains a maximum strength dose of 5000 mcg of B12. It also delivers 1000 mcg of Methylfolate per serving.
- Methylcobalamin B12 - The Essential Form: Methyl B12 is the form needed to raise overall b12 status levels across the body. It is the most prevalent form within the bloodstream and is needed for carrying out the essential functions of vitamin B12.
- Adenosylcobalamin B12: The "Cellular Energy" Form: This is the form especially needed by the energy factories of the cells, the mitochondria. Adenosylcobalamin helps mitochondria burn food more efficiently for better energy production and metabolism.
- Hydroxocobalamin B12: The "Storage" Form: Shown to be stored and stays in the bloodstream longer and is universally distributed through the body to ensure long-lasting B12 levels. It also plays a role in detoxification processes within the body.
This formula combines three bioactive forms of B12—methylcobalamin, adenosylcobalamin, and hydroxocobalamin—plus methylfolate for comprehensive coverage.
Rather than relying on a single form of B12, this supplement provides all three bioactive forms, each serving different metabolic pathways in the body. Methylcobalamin supports nerve function and methylation, adenosylcobalamin is the mitochondrial form for cellular energy, and hydroxocobalamin acts as a long-lasting storage form. The addition of methylfolate enhances overall B-vitamin synergy. Those looking for additional B12 for energy should consider pairing with CoQ10 for enhanced cellular energy production.
- Pros:
- Three bioactive B12 forms for comprehensive coverage
- Includes methylfolate cofactor
- 5,000 mcg total B12 per serving
- Cons:
- Higher price than single-form B12 supplements
- Multi-form approach may be unnecessary for basic supplementation
Best for: Those who want the most comprehensive B12 supplement covering all metabolic pathways
7. Safrel Vitamin B12 Methylcobalamin 1000 mcg Fast Dissolve – Best Value
- ✅ Energy metabolism support: Vitamin B12 methylcobalamin helps support cellular energy production and healthy metabolism as part of an everyday wellness routine.
- ✅ Nervous system support: B12 plays an important role in nerve health, making this a simple option for consistent daily support when you want a straightforward formula.
- ✅ Fast dissolve convenience: Designed for easy taking, these sublingual tablets dissolve quickly and feature a pleasant cherry flavor, no large pills to swallow.
- ✅ 200 count value supply: One bottle includes 200 fast dissolve tablets, labeled as a 200 day supply for simple stocking and routine consistency.
- ✅ Simple, easy to take: Clear strength and format for everyday use, with a focus on convenience and taste, Made in USA.
Safrel packs 200 fast-dissolve sublingual tablets into one bottle, delivering 1,000 mcg of methylcobalamin per tablet at an exceptional price per serving.
With 200 tablets per bottle, this is one of the best-value sublingual B12 options available. Each tablet dissolves quickly under the tongue and provides a moderate 1,000 mcg dose that’s suitable for daily maintenance. The formula is straightforward and free from unnecessary fillers.
- Pros:
- 200-count bottle offers outstanding value
- Fast-dissolve sublingual tablets
- Moderate 1,000 mcg dose suitable for daily use
- Cons:
- Lower potency than 5,000 mcg options
- Less well-known brand compared to established names
Best for: Value-seekers who want a large supply of sublingual B12 at a low cost per serving
8. Vitamin B12 and B6 Liquid Drops – Best B12 + B6 Combo
- B12 Drops Formulated for Maximum Potency - Our Liquid Vitamin B12 Drops contain Vit B12 5000mcg, B6, B1, Niacin, and Folic Acid, supporting overall body functions with 100% or more Daily Value.
- Tons of Benefits - Experience the synergy of digestive balance, energy metabolism, heart wellness, and immune support in each drop of our Vitamin B complex liquid sublingual formula.
- Rapid Sublingual Absorption - Our Liquid B12 Drops are designed for efficient sublingual absorption. Just place the drops under your tongue for 30secs and swallow the remaining liquid. Quick and easy!
- Carefully Curated Organic Vitamin B12 Liquid - Our Vitamin B12 Methylcobalamin B6 B1 Drops contain No Fillers, are Vegan, Non-GMO, Gluten-Free, and proudly USA-made with Global Ingredients.
- Ultimate 5-in-1 Vitamin B12 Complex - Not all liquid supplements are made equal. Our B-12 Vitamin drops are packed with nutritional benefits. If you’re unhappy with your purchase, do reach out to us.
This 2-pack of sublingual liquid drops combines vitamin B12 with B6 for enhanced energy metabolism and nervous system support.
The addition of B6 to the B12 formula creates a synergistic combination that supports energy production, homocysteine metabolism, and nervous system health more effectively than B12 alone. The sublingual liquid format ensures rapid absorption, and the 2-pack provides excellent long-term value. B6 is particularly beneficial for mood regulation and immune function. For a broader approach to energy support, see our guide to natural energy supplements without caffeine.
- Pros:
- B12 + B6 combination for enhanced benefits
- 2-pack provides extended supply
- Sublingual liquid for fast absorption
- Cons:
- B6 addition unnecessary for those getting adequate B6 from diet
- Liquid requires careful storage
Best for: Those seeking a B-vitamin combo for energy and nervous system support in sublingual form
How to Choose the Best Sublingual B12 Supplement
The most important factor is the form of B12 used. Methylcobalamin is the active, bioavailable form that requires no conversion by the body, making it the preferred choice for sublingual supplements. Cyanocobalamin is synthetic and less efficient, though it’s more shelf-stable. Some premium formulas include adenosylcobalamin and hydroxocobalamin for broader metabolic coverage.
Dosage ranges widely from 500 mcg to 5,000 mcg per serving. For general maintenance, 1,000 mcg is typically sufficient. Higher doses of 2,500–5,000 mcg are better suited for people with confirmed deficiencies, absorption issues, or those following vegan diets who may need more aggressive supplementation.
The delivery format matters for sublingual supplements specifically. True sublingual options include fast-dissolve tablets, liquid drops, and sprays. All three work by absorbing through the mucous membranes under the tongue. Liquid drops and sprays tend to absorb slightly faster, while dissolve tablets are more portable and convenient for travel.
Look for products that are third-party tested, free from unnecessary fillers, and manufactured in GMP-certified facilities. Vegan formulations are widely available since most sublingual B12 supplements don’t require animal-derived ingredients.
Frequently Asked Questions
What is sublingual B12 and how does it work?
Sublingual B12 is placed under the tongue where it dissolves and absorbs directly into the bloodstream through the mucous membranes. This bypasses the digestive system entirely, which is particularly beneficial for people with absorption issues, low stomach acid, or gastrointestinal conditions that interfere with nutrient uptake.
How much sublingual B12 should I take daily?
For general maintenance, 1,000 mcg of sublingual B12 daily is sufficient for most adults. People with confirmed deficiency, absorption disorders, or those on vegan diets may benefit from 2,500–5,000 mcg daily. The body excretes excess B12 through urine, so higher doses are generally well-tolerated.
Is sublingual B12 better than regular B12 pills?
Sublingual B12 can be more effective for people with digestive issues, low intrinsic factor, or conditions like pernicious anemia, Crohn’s disease, or celiac disease. For healthy individuals with normal absorption, both forms can be equally effective, though sublingual delivery offers faster uptake.
When is the best time to take sublingual B12?
Morning is the ideal time to take sublingual B12, as it supports energy metabolism throughout the day. Taking B12 later in the evening may disrupt sleep for some individuals. Hold the tablet, liquid, or spray under the tongue for 30–60 seconds before swallowing for maximum absorption.
Can I take sublingual B12 with other supplements?
Yes, sublingual B12 pairs well with most supplements. It works synergistically with folate for methylation support and with iron for red blood cell production. Avoid taking high-dose vitamin C at the same time, as it may slightly reduce B12 absorption. Spacing them 30 minutes apart resolves this.
How long does it take for sublingual B12 to work?
Many people notice improvements in energy levels within 1–2 weeks of consistent sublingual B12 supplementation. However, correcting a true deficiency can take 2–3 months of daily use. Blood levels of B12 typically normalize within 4–8 weeks when using adequate sublingual doses.
