Best Supplements for Eczema (2026)

Eczema (atopic dermatitis) affects up to 10% of the U.S. population, causing chronic itching, redness, and skin barrier dysfunction. While topical treatments remain the first line of defense, research increasingly supports certain supplements for managing eczema from the inside out. Omega-3 fatty acids, vitamin D, probiotics, and zinc have the strongest clinical evidence for reducing inflammation and supporting skin health in people with eczema.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
DERMOIA Eczema Supplements	Multi-Nutrient Eczema Formula	Capsules	Best Overall	4.8
Icelandic Cod Liver Oil	Omega-3 + Vitamin D & A	Softgels	Best Fish Oil	4.7
Maju Black Seed Oil	Cold-Pressed Nigella Sativa	Softgels	Best Anti-Inflammatory Oil	4.6
Greenford Eczema Support	Zinc, Niacinamide, Probiotics	Capsules	Best Targeted Formula	4.5
DaVinci Labs Omega 3 HP-D	High-Potency EPA/DHA + Vitamin D	Softgels	Best Premium Omega-3	4.7
Pink Stork Magnesium Glycinate + D	Magnesium Glycinate + Vitamin D	Capsules	Best for Immune & Skin Support	4.6
Genius Mushrooms	Lion’s Mane, Reishi, Cordyceps	Capsules	Best Immune Modulator	4.5

1. DERMOIA Eczema Supplements – Best Overall

A comprehensive eczema-specific formula combining the key vitamins, minerals, and anti-inflammatory compounds research has linked to reduced eczema severity.

DERMOIA packs vitamins C, D3, E, B5, biotin, zinc, and copper alongside targeted skin ingredients like evening primrose oil, omega-3 powder, quercetin, turmeric extract, tart cherry, grape seed extract, glutathione, and probiotics. Each bottle provides 60 capsules (a 30-day supply at the recommended two capsules daily). The formula is manufactured in an FDA-registered, GMP-certified facility and is non-GMO and cruelty-free.

• Pros:
• All-in-one eczema formula covers multiple research-backed pathways
• Includes both omega-3s and evening primrose oil (GLA) for anti-inflammatory support
• Contains probiotics and antioxidants like glutathione and quercetin

• Cons:
• Two capsules daily may be inconvenient for some
• Higher price point than individual supplements

Best for: Anyone wanting a single comprehensive supplement targeting eczema from multiple angles

2. Icelandic Wild Caught Cod Liver Oil – Best Fish Oil for Eczema

A triple-benefit softgel delivering omega-3 EPA/DHA, vitamin D, and vitamin A — three nutrients with the strongest evidence for eczema symptom reduction.

This cod liver oil provides a potent dose of omega-3 fatty acids along with naturally occurring vitamins D and A in easy-to-swallow softgels. Omega-3s help reduce leukotriene B4, a key inflammatory compound involved in eczema flares, while vitamin D supports immune regulation and skin barrier function. The wild-caught Icelandic sourcing ensures high purity and potency. For those who prefer liquid fish oil, the brand also offers a liquid formulation.

• Pros:
• Combines three research-backed eczema nutrients in one softgel
• Wild-caught from pristine Icelandic waters for purity
• Natural vitamin D3 and A included — no synthetic additions needed

• Cons:
• Not suitable for vegetarians or vegans
• Fishy aftertaste possible for some users

Best for: Eczema sufferers who want a multi-nutrient fish oil targeting inflammation and skin barrier support

3. Maju Black Seed Oil – Best Anti-Inflammatory Oil

Cold-pressed Nigella sativa oil with potent thymoquinone content, traditionally used for inflammatory skin conditions and gaining modern research support for eczema management.

Black seed oil contains thymoquinone, a compound with demonstrated anti-inflammatory and antihistamine properties. Each softgel delivers cold-pressed, non-GMO black seed oil in an easy-to-absorb format. Studies suggest black seed oil may help modulate the immune response and reduce the oxidative stress associated with eczema flares. The 120-count bottle provides a two-month supply at the standard dosage.

• Pros:
• Cold-pressed to preserve active thymoquinone content
• Natural antihistamine and anti-inflammatory properties
• Non-GMO, vegan-friendly softgel capsules

• Cons:
• Strong taste if capsules are opened
• Research on black seed oil for eczema is still emerging

Best for: Those looking for a natural anti-inflammatory supplement with traditional and emerging evidence for skin conditions

4. Greenford Eczema Support – Best Targeted Formula

Formulated by healthcare professionals specifically for eczema, psoriasis, and rosacea with clinical-dose zinc, niacinamide, and probiotics for skin clearing.

Greenford combines biotin, vitamin A, niacinamide (vitamin B3), zinc, and selenium in potent dosages alongside probiotic strains selected for skin health. Zinc and niacinamide are particularly well-studied for their roles in reducing skin inflammation and promoting barrier repair. The 60-capsule bottle provides a 30-day supply. All capsules are vegan, non-GMO, and manufactured in a certified U.S. facility.

• Pros:
• Formulated specifically for inflammatory skin conditions
• Clinical-strength zinc and niacinamide dosages
• Includes probiotics for gut-skin axis support

• Cons:
• Smaller brand with fewer customer reviews
• Does not include omega-3s or vitamin D

Best for: Eczema sufferers wanting a targeted skin supplement with zinc, niacinamide, and probiotics

5. DaVinci Labs Omega 3 HP-D – Best Premium Omega-3

A high-potency omega-3 formula combining concentrated EPA/DHA with vitamin D3 from a trusted professional-grade supplement brand.

DaVinci Labs delivers a premium fish oil with high EPA and DHA concentrations alongside 1,000 IU of vitamin D3. The concentrated formula means fewer softgels per day to reach therapeutic omega-3 levels. Clinical research suggests 1.8 grams of EPA daily may improve eczema symptoms after 12 weeks, and this product makes reaching that threshold straightforward. DaVinci Labs is a practitioner-trusted brand known for rigorous third-party testing and quality standards. Those interested in further immune support strategies may benefit from combining omega-3s with additional nutrients.

• Pros:
• Professional-grade quality with third-party testing
• High EPA concentration for anti-inflammatory support
• Added vitamin D3 addresses common deficiency in eczema patients

• Cons:
• Premium pricing compared to standard fish oils
• Large softgels may be difficult for some to swallow

Best for: Those willing to invest in a practitioner-grade omega-3 + D3 combination for maximum eczema support

6. Pink Stork Magnesium Glycinate with Vitamin D – Best for Immune & Skin Support

A well-absorbed magnesium glycinate paired with vitamin D to support immune regulation, reduce inflammation, and address two common nutrient deficiencies in eczema sufferers.

Pink Stork combines highly bioavailable magnesium glycinate with vitamin D3 in a formula designed for optimal absorption. Magnesium plays a role in immune function and inflammatory pathways, while vitamin D deficiency has been strongly linked to increased eczema severity in both children and adults. Clinical trials have demonstrated that vitamin D supplementation can significantly reduce eczema symptoms, particularly during winter months when sun exposure is limited.

• Pros:
• Highly absorbable magnesium glycinate form — gentle on the stomach
• Vitamin D3 directly addresses a common deficiency linked to eczema flares
• Clean formula from a trusted women’s health brand

• Cons:
• Does not include omega-3s or probiotics
• Marketed primarily toward women, though suitable for anyone

Best for: Those with vitamin D deficiency or seasonal eczema flares who also want magnesium support

7. Codex Labs BIA Eczema Probiotic – Best Probiotic for Eczema

No products found.

A clinically tested synbiotic (probiotic + prebiotic) specifically developed for eczema-prone skin, featuring strains studied for their impact on the gut-skin axis.

Codex Labs BIA combines clinically proven probiotic strains with a prebiotic blueberry extract to support the gut-skin connection. Research suggests probiotics containing Lactobacillus rhamnosus and Bifidobacterium lactis strains may help reduce eczema severity, particularly when taken consistently for 8+ weeks. Each capsule delivers targeted bacterial strains selected for their immune-modulating properties rather than general digestive health.

• Pros:
• Synbiotic formula (probiotic + prebiotic) for enhanced efficacy
• Clinically tested strains specifically for eczema-prone skin
• Dermatologist-developed with science-backed strain selection

• Cons:
• Premium price for a probiotic supplement
• Results may take 8+ weeks of consistent use

Best for: Eczema sufferers interested in the gut-skin axis who want a probiotic designed specifically for skin conditions

8. Power Grain Eczema Gummies – Best Gummy Option

No products found.

A sugar-free gummy formula combining 50+ vitamins and probiotics targeted at eczema relief, making daily supplementation easy and enjoyable.

Power Grain offers a comprehensive eczema support formula in a convenient gummy format with over 50 active ingredients including vitamins, minerals, probiotics, and botanical extracts. The gummies are sugar-free and USA-made, designed to soothe itching, calm redness, and boost overall skin health. Each bottle provides 60 gummies for a 30-day supply at two gummies daily.

• Pros:
• Easy-to-take gummy format ideal for those who dislike swallowing capsules
• Sugar-free formulation suitable for those watching sugar intake
• Comprehensive multi-ingredient approach to eczema support

• Cons:
• Individual ingredient doses may be lower than standalone supplements
• Newer product with fewer long-term user reviews

Best for: Those who prefer a gummy supplement and want an all-in-one eczema support formula

9. Phytoceramides 350mg – Best for Skin Barrier Repair

No products found.

Plant-derived ceramides that help rebuild the skin’s lipid barrier from within — directly addressing the compromised skin barrier that defines eczema.

Phytoceramides are plant-based lipids identical to the ceramides naturally found in healthy skin. In eczema, the skin barrier is compromised with lower ceramide levels, leading to increased water loss and susceptibility to irritants. Each softgel provides 350mg of plant-derived ceramides to support barrier repair from the inside. The formula contains no fillers or synthetic vitamins and is non-GMO. Research on skin health supplements consistently highlights ceramides as a key component for maintaining skin integrity.

• Pros:
• Directly targets the ceramide deficiency associated with eczema
• Plant-derived with no synthetic additives or fillers
• Simple one-capsule-per-day dosing

• Cons:
• Single-ingredient supplement — needs to be combined with other nutrients
• Results take 4-8 weeks of consistent use

Best for: Those focused specifically on rebuilding skin barrier function from the inside

How to Choose the Best Supplement for Eczema

When selecting an eczema supplement, look for ingredients with the strongest clinical evidence. Vitamin D3 has the most robust research showing reduced eczema severity, particularly in those with low baseline levels. A simple blood test from a healthcare provider can determine if supplementation is needed, with most studies using 1,000-5,000 IU daily. Omega-3 fatty acids (specifically EPA at doses of 1-2 grams daily) have demonstrated anti-inflammatory effects that may reduce eczema flares after 8-12 weeks of consistent use.

Probiotics are gaining attention for eczema, but strain selection matters. Look for products containing Lactobacillus rhamnosus, Bifidobacterium lactis, or Lactobacillus acidophilus — the strains with the most clinical support for skin conditions. Multi-strain synbiotics (probiotics combined with prebiotics) may offer enhanced benefits. Probiotics typically require 8+ weeks of daily use before noticeable improvements.

Zinc, vitamin E, and quercetin each offer additional support through different mechanisms — zinc for immune function and skin repair, vitamin E for antioxidant protection (400 IU daily showed benefits in clinical trials), and quercetin for natural antihistamine effects. If choosing between individual supplements and an all-in-one formula, consider that comprehensive products offer convenience but may have lower doses of each ingredient compared to standalone options.

Third-party testing (NSF, USP, or independent lab verification) and GMP certification provide important quality assurance. Eczema supplements work best as part of a broader management plan that includes proper skin care, trigger avoidance, and appropriate medical treatment.

Frequently Asked Questions

What supplements have the most evidence for helping eczema?

Vitamin D has the strongest clinical evidence, with multiple trials showing reduced eczema severity when deficient levels are corrected. Omega-3 fatty acids (fish oil) rank second, with studies showing improvements after 12 weeks at therapeutic doses. Probiotics have mixed but promising results, particularly multi-strain formulas used for 8+ weeks. Zinc and vitamin E have supporting evidence, especially in those with documented deficiencies.

How long do eczema supplements take to work?

Most eczema supplements require consistent daily use for 4-12 weeks before noticeable improvements. Vitamin D may show effects within 4-6 weeks, fish oil typically takes 8-12 weeks, and probiotics generally need at least 8 weeks. Phytoceramides may begin improving skin hydration within 4 weeks. Consistency is key — intermittent use significantly reduces effectiveness.

Can probiotics help with eczema?

Research is mixed but promising. Specific strains like Lactobacillus rhamnosus and Bifidobacterium lactis have shown the most potential for reducing eczema severity. Probiotics appear most effective for prevention (particularly in high-risk infants) rather than treating established eczema, though some adults do report symptom improvement. Choose products with strains studied specifically for skin conditions rather than general digestive health.

Is vitamin D deficiency linked to eczema?

Yes. Multiple studies have found that people with eczema often have lower vitamin D levels than those without the condition. Research shows eczema prevalence is higher in regions with less sun exposure, and supplementation has improved symptoms in roughly two-thirds of clinical studies. A blood test can determine if supplementation is appropriate, with most adults benefiting from 1,000-5,000 IU daily during winter months.

Can I take multiple eczema supplements together?

Yes, most eczema supplements can be safely combined. A common effective stack includes fish oil (for omega-3s), vitamin D3, and a probiotic — each targeting eczema through different mechanisms. When combining vitamin D with vitamin E, one study found a 64% reduction in eczema severity. Always check with a healthcare provider before starting multiple supplements, especially if you take prescription medications, as fish oil and some herbs may interact with blood thinners.

Are there any supplements to avoid with eczema?

High-dose vitamin A supplements should be used cautiously, as excessive intake can be toxic. Evening primrose oil and borage oil, while popular, have shown results no better than placebo in recent meta-analyses. Some people with eczema may also react to supplements containing common allergens like soy, dairy, or gluten. Start with one supplement at a time to identify any reactions, and choose products free from unnecessary fillers and artificial additives.

What is the gut-skin axis and why does it matter for eczema?

The gut-skin axis refers to the bidirectional communication between the gut microbiome and skin health. Research shows that people with eczema often have altered gut bacteria compared to those without the condition, with less microbial diversity and imbalances in key bacterial populations. This gut dysbiosis can trigger systemic inflammation that manifests as skin flares. Probiotics and prebiotics aim to restore healthy gut flora, which may in turn reduce the immune dysregulation driving eczema symptoms. Studies on infants show that probiotic supplementation during pregnancy and early infancy can reduce eczema risk by up to 50% in high-risk children, underscoring the importance of this gut-skin connection.

Should I take individual supplements or a combination formula for eczema?

Both approaches have merit. Individual supplements allow precise dosing of specific nutrients — for example, taking a standalone high-dose vitamin D3 alongside a separate concentrated fish oil. This approach is ideal when addressing a confirmed deficiency. Combination formulas offer convenience and may be more cost-effective, covering multiple pathways in a single product. However, multi-ingredient products often contain lower doses of each individual component. A practical approach is to use a combination formula as a baseline and add standalone supplements for any nutrients where higher doses are desired based on blood work or healthcare provider recommendations.

Related Articles

• Best Skin Supplements
• Best Vegan Omega-3 Supplements
• Best Probiotics for Women