Best Supplements for Endometriosis (2026)

Endometriosis affects roughly 10-15% of reproductive-age women, causing chronic pelvic pain, heavy periods, and inflammation. While supplements won’t replace medical treatment, research supports several nutrients — including curcumin, omega-3s, NAC, DIM, and magnesium — for reducing inflammation, managing pain, and supporting hormone balance. These are the best supplements for endometriosis available right now.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Effective Nutra DIM 300mg	DIM 300mg + BioPerine	Capsules	Best Overall	9.5/10
Pink Stork Magnesium Glycinate	Magnesium + Vitamin D	Capsules	Best for Cramps	9.3/10
Turmeric Curcumin 1500mg	Curcumin + Black Pepper	Capsules	Best for Inflammation	9.2/10
DIM 200mg Estrogen Balance	DIM 200mg	Capsules	Best Budget DIM	9.0/10
Lunakai Pure Moringa Capsules	Moringa Leaf Extract	Capsules	Best Antioxidant Support	8.9/10
NOW NAC 600mg	N-Acetylcysteine 600mg	Capsules	Best for Cyst Reduction	8.8/10
Nordic Naturals Ultimate Omega	EPA/DHA 1280mg	Softgels	Best Omega-3	8.7/10

1. Effective Nutra DIM Supplement 300mg – Best Overall

Effective Nutra’s DIM 300mg with BioPerine is an excellent first-line supplement for endometriosis, supporting healthy estrogen metabolism and hormone balance — two key factors in managing the condition.

DIM (diindolylmethane) is a compound derived from cruciferous vegetables that helps the body metabolize estrogen more efficiently. Since endometriosis is an estrogen-dependent condition, supporting healthy estrogen clearance can help slow tissue proliferation and reduce symptoms. This formula delivers 300mg of DIM per capsule with BioPerine black pepper extract for enhanced absorption — a higher dose than most competitors. It’s non-GMO, gluten-free, and manufactured in a GMP-certified facility.

• Pros:
• 300mg DIM — among the highest potency available
• BioPerine enhances absorption significantly
• Supports estrogen metabolism, a root factor in endometriosis

• Cons:
• Some users report mild headaches during the first week
• May affect hormonal birth control — consult your doctor

Best for: Women looking to support healthy estrogen metabolism as part of their endometriosis management plan

2. Pink Stork Magnesium Glycinate with Vitamin D – Best for Cramps

This magnesium glycinate formula from Pink Stork combines a highly absorbable form of magnesium with vitamin D to target the muscle cramping and pelvic pain that endometriosis sufferers experience.

Magnesium glycinate is essential for relaxing smooth muscle tissue — critical for reducing the severe cramping associated with endometriosis. Research shows magnesium deficiency is common in women with endometriosis and can worsen pain symptoms. Vitamin D has also been studied for its anti-inflammatory and immune-modulating effects on endometrial tissue. Pink Stork formulates specifically for women’s health, and the glycinate form means minimal GI side effects compared to cheaper magnesium oxide. For more options, see our guide to magnesium for cramps.

• Pros:
• Highly absorbable glycinate form reduces cramping effectively
• Added vitamin D for anti-inflammatory support
• Gentle on the stomach — no laxative effect

• Cons:
• Magnesium alone won’t address all endometriosis symptoms
• May need to be paired with other targeted supplements

Best for: Women with endometriosis who experience significant cramping and pelvic pain

3. Turmeric Curcumin with Black Pepper Extract 1500mg – Best for Inflammation

Curcumin is one of the most researched natural anti-inflammatories for endometriosis, with studies showing it can reduce estradiol production and suppress endometrial tissue migration.

This high-potency formula delivers 1500mg of turmeric curcumin per serving with black pepper extract (BioPerine) to boost absorption by up to 2000%. Research in the Iranian Journal of Reproductive Medicine found curcumin inhibits endometriosis endometrial cells by reducing estrogen production, while additional studies have demonstrated its anti-proliferative and anti-angiogenic properties — meaning it may help slow the growth and blood supply to endometrial implants. The capsules are non-GMO, gluten-free, and manufactured in the USA.

• Pros:
• 1500mg high-potency dose with absorption enhancer
• Strong clinical research supporting use for endometriosis
• Addresses inflammation at the molecular level

• Cons:
• May interact with blood thinning medications
• Takes 4-6 weeks for noticeable anti-inflammatory effects

Best for: Women seeking a research-backed anti-inflammatory to reduce endometriosis-driven inflammation

4. DIM Supplement 200mg – Best Budget DIM

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A more accessible entry point into DIM supplementation for estrogen balance, this 200mg formula delivers effective hormone support at a lower price point than premium options.

At 200mg per capsule, this DIM supplement provides a clinically relevant dose for supporting healthy estrogen metabolism without the premium price tag. DIM works by promoting the conversion of estrogen into less potent metabolites, which can help reduce the estrogen dominance that drives endometriosis progression. This formula is suitable for women who want to test DIM’s effects before committing to a higher dose. It’s third-party tested, non-GMO, and made in a GMP-certified facility. For broader hormone management, explore our guide to hormone balance supplements.

• Pros:
• Affordable entry-level DIM at a clinically studied dose
• Supports healthy estrogen metabolism
• Third-party tested for purity

• Cons:
• Lower dose than Effective Nutra’s 300mg option
• No absorption enhancer included

Best for: Women new to DIM supplementation who want an affordable starting point for estrogen balance

5. Lunakai Pure Moringa Capsules – Best Antioxidant Support

Moringa is a nutrient-dense plant with potent anti-inflammatory and antioxidant properties, providing broad-spectrum support for endometriosis through oxidative stress reduction.

Moringa leaf extract delivers over 90 nutrients including vitamins A, C, and E, plus quercetin and chlorogenic acid — powerful antioxidants that combat the oxidative stress associated with endometriosis. Research shows that oxidative stress plays a significant role in the progression of endometrial implants, making antioxidant support a valuable complement to other targeted supplements. Lunakai’s formula uses a concentrated moringa leaf extract for maximum potency, and the capsules are vegan, non-GMO, and manufactured in the USA.

• Pros:
• 90+ nutrients with powerful antioxidant compounds
• Addresses oxidative stress — a key driver of endometriosis
• Concentrated extract for higher potency

• Cons:
• Less specific to endometriosis than DIM or curcumin
• May cause mild digestive upset initially

Best for: Women who want broad-spectrum antioxidant protection alongside more targeted endometriosis supplements

6. NOW NAC 600mg – Best for Cyst Reduction

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N-acetylcysteine (NAC) has been shown in clinical research to reduce endometriotic cyst volume and improve pain symptoms, making it one of the most promising supplements for endometriosis management.

A landmark study found that NAC supplementation was effective at reducing ovarian endometrioma size and improving symptoms in women with ovarian endometriosis. NAC works as a precursor to glutathione — the body’s master antioxidant — helping to reduce oxidative stress, modulate inflammation, and potentially influence cell proliferation in endometrial tissue. NOW’s 600mg formula provides a therapeutic dose in a trusted, GMP-certified product. Research from 2025 further confirms NAC’s ability to stimulate organelle dysfunction in endometriotic cells, potentially slowing disease progression.

• Pros:
• Clinical evidence for reducing endometrioma size
• Precursor to glutathione — the body’s most powerful antioxidant
• Trusted brand with GMP-certified manufacturing

• Cons:
• Best results seen at doses of 1200-1800mg/day (requires multiple capsules)
• Mild sulfur taste or smell

Best for: Women with ovarian endometriomas who want clinical-grade support for cyst reduction

7. Nordic Naturals Ultimate Omega – Best Omega-3

High-dose omega-3 fatty acids are among the most studied supplements for endometriosis pain, with research showing EPA and DHA can significantly reduce inflammation and endometriosis-associated pain.

Nordic Naturals Ultimate Omega delivers 1280mg of EPA/DHA per serving in triglyceride form for superior absorption. A 2020 clinical trial found that fish oil supplementation was superior to vitamin D at reducing endometriosis-related pain in adolescents, and broader research shows women with higher EPA levels are less likely to develop endometriosis. Nordic Naturals is an industry leader in purity — every batch is third-party tested for heavy metals, PCBs, and oxidation. The lemon flavoring eliminates fishy burps, and the product is manufactured in Norway under pharmaceutical-grade standards.

• Pros:
• 1280mg EPA/DHA — clinically meaningful dose
• Triglyceride form for 70% better absorption than ethyl ester
• Third-party tested and pharmaceutical-grade purity

• Cons:
• Premium price for high-quality fish oil
• Not suitable for vegans — algae-based alternatives exist

Best for: Women looking for research-backed anti-inflammatory omega-3 support for endometriosis pain

8. NEVISS Methylated Multivitamin for Women – Best Multi for Endo

A comprehensive 52-in-1 women’s multivitamin featuring methylated B vitamins, omega-3, and iron — providing foundational nutritional support that complements targeted endometriosis supplements.

Endometriosis management works best with a strong nutritional foundation. This NEVISS multivitamin delivers methylated folate and B12 for better bioavailability, omega-3 for anti-inflammatory support, plus iron to address the anemia that can result from heavy menstrual bleeding. The 52-ingredient formula covers a broad spectrum of vitamins and minerals in gummy form, making it an easy daily habit. While not specifically formulated for endometriosis, it provides the nutritional baseline that supports overall hormonal health and immune function.

• Pros:
• Comprehensive formula with methylated B vitamins
• Includes omega-3 and iron — both critical for endo sufferers
• Easy gummy format

• Cons:
• Not specifically targeted for endometriosis
• Individual nutrient amounts are lower than standalone supplements

Best for: Women with endometriosis who want a foundational daily multivitamin to pair with targeted supplements

How to Choose the Best Supplements for Endometriosis

The most effective approach to supplementing for endometriosis targets multiple mechanisms: estrogen metabolism (DIM), inflammation (curcumin, omega-3s), oxidative stress (NAC, vitamin E), and muscle tension (magnesium). Most women with endometriosis benefit from combining 2-3 targeted supplements rather than relying on a single product. Start with one supplement at a time and add others gradually to identify what provides the most benefit for your specific symptoms.

Dosage matters significantly. Clinical research on curcumin for endometriosis uses doses of 1000-1500mg daily, NAC studies show benefits at 1200-1800mg daily, and omega-3 research typically uses 1000-2000mg EPA/DHA combined. DIM is generally effective at 200-300mg daily. Underdosing is one of the most common mistakes — check that your supplement provides a clinically studied amount.

Look for absorption-enhancing ingredients. Curcumin has notoriously poor bioavailability unless paired with piperine (black pepper extract) or in a liposomal form. Similarly, DIM absorbs better with BioPerine, and omega-3s in triglyceride form absorb 70% better than ethyl ester forms. These details can make the difference between a supplement that works and one that doesn’t.

Quality testing is essential. Choose supplements that are third-party tested, manufactured in GMP-certified facilities, and free from heavy metals and contaminants. This is especially important for supplements taken long-term, as endometriosis management is typically ongoing.

Frequently Asked Questions

What supplements are most effective for endometriosis?

Research supports several supplements for endometriosis management. Curcumin has strong evidence for reducing inflammation and estrogen production in endometrial tissue. NAC (N-acetylcysteine) has been shown to reduce endometrioma size. DIM supports healthy estrogen metabolism. Omega-3 fatty acids reduce inflammation and pain. Magnesium helps with cramping and muscle tension. Combining multiple supplements typically produces better results than any single one.

How long do endometriosis supplements take to work?

Most endometriosis supplements require 2-3 menstrual cycles (6-12 weeks) to show meaningful results. Anti-inflammatory supplements like curcumin and omega-3s may provide some relief within 4-6 weeks, while hormone-modulating supplements like DIM typically need at least 2-3 months to demonstrate their full effects on estrogen metabolism and symptom reduction.

Can supplements cure endometriosis?

No. Supplements cannot cure endometriosis, which is a chronic condition that currently has no known cure. However, research shows that targeted supplementation can reduce symptom severity, manage inflammation, support hormone balance, and improve quality of life when used alongside conventional medical treatment. Think of supplements as complementary tools, not replacements for medical care.

Should I take DIM for endometriosis?

DIM is one of the most relevant supplements for endometriosis because the condition is estrogen-dependent. DIM promotes healthier estrogen metabolism by shifting the balance toward less potent estrogen metabolites. Studies suggest doses of 200-300mg daily can meaningfully impact estrogen balance. However, DIM can interact with hormonal medications, so consulting your doctor before starting is important.

Is turmeric good for endometriosis?

Turmeric’s active compound, curcumin, has substantial research supporting its use for endometriosis. Studies show curcumin can reduce estradiol production, inhibit endometrial tissue growth, and suppress the inflammatory pathways that drive endometriosis symptoms. For best results, use a curcumin supplement with black pepper extract (piperine) for enhanced absorption, as standard turmeric has very low bioavailability.

Can omega-3 help with endometriosis pain?

Yes. Clinical trials have shown omega-3 fatty acids, particularly EPA, can significantly reduce endometriosis-related pain. A 2020 randomized trial found fish oil was superior to vitamin D supplementation for reducing pain in adolescents with endometriosis. Research also indicates women with higher EPA levels have a lower risk of developing endometriosis. Aim for at least 1000mg combined EPA/DHA daily from a high-quality source.

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