Best Supplements for Fatty Liver (2026)

Fatty liver disease affects millions of people and occurs when excess fat builds up in liver cells. Whether caused by diet, alcohol, or metabolic factors, the right supplements can support liver function, reduce fat accumulation, and promote healthy detoxification. The most effective options include milk thistle (silymarin), NAC, TMG (betaine), and omega-3 fatty acids — all backed by research for liver health support.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Effective Nutra Milk Thistle Gummies	Milk Thistle 1000mg	Gummies	Best Overall	4.5/5
PurePremium Milk Thistle Supplement	Silymarin 80%	Capsules	Best Potency	4.5/5
Lunakai Liver Cleanse Detox & Repair	Multi-Herb Blend	Capsules	Best Multi-Ingredient	4.4/5
Snap Supplements Liver Health & Detox	Milk Thistle Complex	Capsules	Best Brand Reputation	4.4/5
TMG Supplements 1000mg Liquid Drops	Trimethylglycine	Liquid Drops	Best for Fat Metabolism	4.3/5
Natures Craft Liver Cleanse Detox & Repair	Milk Thistle + NAC	Capsules	Best Value	4.4/5
Liver Support NAC Supplement	NAC + Milk Thistle	Capsules	Best NAC Combo	4.3/5

1. Effective Nutra Milk Thistle Gummies – Best Overall

A sugar-free gummy that delivers 1000mg of milk thistle extract per serving, making liver support easy and enjoyable for anyone who dislikes swallowing capsules.

Effective Nutra uses a concentrated milk thistle extract standardized for silymarin content — the active compound most studied for fatty liver support. Each serving provides a clinically relevant dose in a chewable gummy format. The sugar-free formula makes it suitable for those watching their caloric and sugar intake, which is especially important for people managing fatty liver. GMP-certified manufacturing ensures quality and consistency across batches.

• Pros:
• 1000mg milk thistle per serving
• Sugar-free gummy format
• Easy to take daily without water
• GMP-certified facility

• Cons:
• Gummies may not suit those who prefer capsules
• Fewer additional liver-support ingredients compared to complex formulas

Best for: Anyone who wants a straightforward, high-dose milk thistle supplement in an easy-to-take gummy form.

2. PurePremium Milk Thistle Supplement – Best Potency

Standardized to 80% silymarin, this capsule-based milk thistle supplement delivers one of the highest concentrations of the active liver-protective compound available.

PurePremium’s formula focuses on silymarin purity, standardizing their milk thistle extract to 80% — well above the industry average. Silymarin has been extensively studied for its ability to protect liver cells from oxidative damage and support regeneration, making it a go-to ingredient for fatty liver. The capsule format allows for precise dosing and rapid absorption. Each bottle provides a full supply for consistent daily use.

• Pros:
• 80% silymarin standardization for maximum potency
• Clean capsule formula
• Strong research backing for liver cell protection
• Good value per serving

• Cons:
• Single-ingredient formula (milk thistle only)
• Capsules may be large for some users

Best for: Those who want the highest-potency milk thistle supplement specifically targeting fatty liver protection.

3. Lunakai Liver Cleanse Detox & Repair – Best Multi-Ingredient Formula

A comprehensive liver support formula that combines multiple research-backed ingredients including milk thistle, artichoke extract, and dandelion root for broad-spectrum fatty liver support.

Lunakai takes a multi-angle approach to fatty liver support by combining several herbal extracts that target different aspects of liver health. Milk thistle provides antioxidant protection, artichoke extract supports bile production and fat metabolism, and dandelion root promotes healthy detoxification pathways. This USA-manufactured supplement is designed as a daily liver health formula rather than a short-term cleanse. The combination of ingredients works synergistically to address inflammation, fat accumulation, and oxidative stress in the liver.

• Pros:
• Multi-ingredient formula targeting multiple liver pathways
• USA manufactured with quality controls
• Includes artichoke extract for bile and fat metabolism support
• Designed for daily long-term use

• Cons:
• Individual ingredient doses may be lower than standalone supplements
• Higher price point than single-ingredient options

Best for: People looking for an all-in-one liver support formula that addresses fatty liver from multiple angles.

4. Snap Supplements Liver Health & Detox – Best Brand Reputation

From a well-known supplement brand, this milk thistle-based liver formula combines trusted ingredients with consistent manufacturing standards.

Snap Supplements has built a reputation for quality across their product line, and their Liver Health & Detox formula continues that tradition. The milk thistle complex serves as the foundation, supported by additional ingredients that promote healthy liver enzyme levels and support the body’s natural detoxification processes. Each capsule delivers a potent dose of liver-supportive compounds in an easy-to-swallow vegetarian capsule. The formula is designed for people dealing with fatty liver concerns who want a supplement from a brand they can trust.

• Pros:
• Established brand with strong quality reputation
• Milk thistle complex with supporting ingredients
• Vegetarian capsules
• Consistent third-party quality testing

• Cons:
• Premium price compared to generic alternatives
• May require two capsules per serving

Best for: Buyers who value brand trust and want a well-rounded liver support supplement from a reputable manufacturer.

5. TMG Supplements 1000mg Liquid Drops – Best for Fat Metabolism

Trimethylglycine (betaine) in liquid drop form targets one of the key mechanisms behind fatty liver — impaired fat metabolism in liver cells.

TMG (trimethylglycine), also known as betaine, plays a direct role in liver fat metabolism by acting as a methyl donor. Research has shown that betaine supplementation can help reduce fat accumulation in the liver and support healthy homocysteine levels. This liquid drop format offers 1000mg per serving with high absorption compared to capsules. The dropper allows for flexible dosing, and the liquid form bypasses the need for capsule digestion, making it a strong choice for people with digestive sensitivities. TMG is one of the most underrated supplements for fatty liver and is specifically studied for non-alcoholic fatty liver disease (NAFLD).

• Pros:
• 1000mg TMG per serving for clinically relevant dosing
• Liquid drops for fast absorption
• Directly targets liver fat metabolism
• Flexible dosing with dropper

• Cons:
• Taste may not appeal to everyone
• Less convenient to travel with than capsules

Best for: People specifically targeting fat metabolism in the liver, especially those with NAFLD looking for a research-backed approach beyond milk thistle.

6. Natures Craft Liver Cleanse Detox & Repair – Best Value

A 120-capsule bottle that delivers a comprehensive herbal liver support blend at one of the most affordable price points in the category.

Natures Craft packs milk thistle, dandelion root, choline, beetroot, and artichoke extract into a single formula at a price that undercuts most competitors. The 120-capsule count provides a full two-month supply for most users, bringing the per-day cost well below premium brands. Choline is a notable inclusion — it plays a critical role in fat transport out of the liver and is recognized by researchers as essential for preventing fatty liver. The combination of traditional liver herbs with choline makes this formula particularly well-suited for fatty liver support on a budget.

• Pros:
• 120 capsules for extended supply
• Includes choline for fat transport support
• Multiple liver-supportive herbs in one formula
• Excellent price-to-value ratio

• Cons:
• Individual ingredient doses not always disclosed on label
• Capsule size may be larger than average

Best for: Budget-conscious buyers who want a comprehensive liver support formula without paying premium prices.

7. Liver Support NAC Supplement with Milk Thistle – Best NAC Combo

Combines N-acetyl cysteine (NAC) with milk thistle, turmeric, and glutathione for a formula that targets fatty liver through antioxidant and detoxification pathways.

NAC is a precursor to glutathione — the body’s master antioxidant and a critical compound for liver detoxification. This formula pairs NAC with milk thistle for cell protection, turmeric for anti-inflammatory support, choline for fat metabolism, and dandelion for bile flow. The inclusion of L-glutathione provides direct antioxidant support alongside the NAC-driven glutathione production. At 60 capsules per bottle, this is designed as a 30-day supply with a two-capsule daily serving. The combination approach makes it one of the more complete fatty liver formulas available.

• Pros:
• NAC + glutathione for powerful antioxidant support
• Milk thistle and turmeric for inflammation and cell protection
• Includes choline and dandelion root
• Well-rounded formula for fatty liver

• Cons:
• Only 30-day supply per bottle
• Two capsules per serving required

Best for: Those who want a NAC-centered liver formula that also includes milk thistle and other proven liver-support ingredients.

8. Icelandic Wild Caught Cod Liver Oil Softgels – Best Omega-3 Option

Wild-caught cod liver oil provides omega-3 fatty acids (EPA and DHA) along with vitamins A and D — all shown to support liver health and reduce liver inflammation.

Omega-3 fatty acids are among the most studied nutrients for fatty liver disease. Research shows that EPA and DHA can help reduce liver fat, lower triglycerides, and decrease inflammation in the liver. This Icelandic wild-caught cod liver oil delivers omega-3s in their natural triglyceride form for better absorption, plus naturally occurring vitamins A and D that further support liver function and immune health. The softgel format makes daily dosing simple and eliminates the fishy taste associated with liquid fish oils. For people with fatty liver, adding omega-3s alongside other liver-support supplements can provide complementary benefits.

• Pros:
• Wild-caught Icelandic source for purity
• Natural omega-3s with vitamins A and D
• Research-backed for reducing liver fat and triglycerides
• Easy-to-swallow softgel format

• Cons:
• Not suitable for vegetarians or vegans
• Does not contain herbal liver-support ingredients

Best for: People who want to add omega-3 fatty acids to their fatty liver protocol for reducing inflammation and liver fat accumulation.

9. Zazzee USDA Organic Milk Thistle 50:1 Extract – Best Organic Option

A USDA-certified organic milk thistle with a potent 50:1 extract ratio, delivering the equivalent of 20,000mg of milk thistle per capsule.

Zazzee stands out with its USDA organic certification and an impressive 50:1 concentration ratio, meaning each capsule delivers the active compounds equivalent to 20,000mg of raw milk thistle seed. The 200-capsule bottle provides an extended supply that can last over six months depending on dosage. Organic certification ensures the milk thistle is grown without synthetic pesticides or herbicides, which matters when you’re taking a supplement specifically to support liver detoxification. The vegan capsules make this accessible to plant-based consumers.

• Pros:
• USDA organic certified
• 50:1 extract ratio (20,000mg strength)
• 200 vegan capsules per bottle
• Exceptional value for long-term use

• Cons:
• Single ingredient — no additional liver herbs
• High concentration may not be necessary for all users

Best for: Organic-minded consumers who want a high-potency, clean milk thistle supplement with a long-lasting supply.

10. Vital Nutrients Detox Formula – Best Premium Option

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A practitioner-grade liver detox formula with a curated blend of antioxidants and detoxification-support compounds designed for comprehensive liver protection.

Vital Nutrients is a brand frequently recommended by healthcare practitioners, and their Detox Formula reflects that clinical pedigree. The vegan formula includes a targeted combination of antioxidants that promote both Phase I and Phase II liver detoxification pathways — the two-step process the liver uses to neutralize and eliminate toxins. This dual-phase approach is especially relevant for fatty liver, where impaired detoxification can worsen fat accumulation and inflammation. The supplement is manufactured under strict quality controls and undergoes third-party testing for potency and purity.

• Pros:
• Practitioner-grade quality and formulation
• Supports both Phase I and Phase II liver detox
• Vegan formula
• Third-party tested for purity

• Cons:
• Higher price point than mass-market options
• May require multiple capsules per serving

Best for: Health-conscious consumers who want a premium, practitioner-recommended liver formula for serious fatty liver support.

How to Choose the Best Supplement for Fatty Liver

The most important factor when choosing a fatty liver supplement is the active ingredient and its dosage. Milk thistle (standardized to at least 70-80% silymarin) is the most researched liver-protective herb and should be a starting point for most people. NAC is equally important for its role in boosting glutathione production, which directly supports liver detoxification. TMG (betaine) is worth considering if fat metabolism is a primary concern, as it specifically helps the liver process and export fats.

Look for supplements that disclose their ingredient amounts per serving rather than hiding behind proprietary blends. Clinically studied doses for milk thistle range from 200-600mg of silymarin daily, while NAC is typically effective at 600-1200mg per day. TMG doses in studies range from 500-2000mg daily. Products that fall well below these ranges may not deliver meaningful results.

Form matters as well. Capsules and softgels generally offer better absorption and more precise dosing than gummies, though high-quality gummies can be effective for people who struggle with pills. Liquid formulas like TMG drops offer fast absorption and flexible dosing. Choose a form you’ll actually take consistently, since liver support supplements work best with daily, long-term use.

Third-party testing, GMP certification, and transparent labeling are non-negotiable quality markers. Avoid supplements with excessive fillers, artificial colors, or proprietary blends that mask individual ingredient amounts. If you’re managing diagnosed fatty liver disease, consider practitioner-grade brands that undergo more rigorous testing and quality controls.

Frequently Asked Questions

What supplements are best for fatty liver disease?

The most research-backed supplements for fatty liver include milk thistle (silymarin), N-acetyl cysteine (NAC), omega-3 fatty acids, vitamin E, TMG (betaine), and choline. Milk thistle protects liver cells from oxidative damage, NAC boosts glutathione for detoxification, omega-3s reduce liver inflammation and fat, and TMG supports fat metabolism in the liver. Many people benefit from combining two or three of these for a comprehensive approach.

How much milk thistle should I take for fatty liver?

Most clinical studies use 200-600mg of silymarin (the active compound in milk thistle) per day, typically divided into two or three doses. Look for supplements standardized to at least 70-80% silymarin to ensure you’re getting a clinically meaningful amount. Higher-concentration extracts (like 50:1 ratios) can deliver effective doses in a single capsule.

How long does it take for liver supplements to work?

Most people begin noticing improvements in energy and digestion within 2-4 weeks of consistent supplementation. However, meaningful changes in liver enzyme levels and fat reduction typically take 8-12 weeks of daily use. Liver supplements work best as part of a long-term protocol rather than a short-term fix, and results are enhanced when combined with dietary changes and regular exercise.

Can I take multiple liver supplements together?

Yes, many liver supplements work well together since they target different pathways. For example, combining milk thistle (cell protection) with NAC (glutathione production) and omega-3s (inflammation reduction) covers multiple aspects of fatty liver. However, avoid doubling up on the same ingredient from different products, and consult a healthcare provider if you’re on medications, as some liver herbs can affect drug metabolism.

Are liver supplements safe to take daily?

Most liver supplements, including milk thistle, NAC, and omega-3s, have strong safety profiles for daily use in healthy adults. Milk thistle has been used for centuries with minimal reported side effects. NAC can occasionally cause digestive discomfort at higher doses. TMG is generally well-tolerated. The most important safety consideration is potential interactions with medications — particularly blood thinners, diabetes drugs, and cholesterol medications.

What lifestyle changes help alongside liver supplements?

Reducing sugar and refined carbohydrate intake is the single most impactful dietary change for fatty liver. Regular exercise (at least 150 minutes per week) helps reduce liver fat even without weight loss. Limiting alcohol consumption, staying hydrated, and maintaining a healthy weight all support liver function. Supplements work best as one component of a comprehensive approach that includes diet and lifestyle modifications.