Best Supplements for Inflammation (2026)

Chronic inflammation is linked to a wide range of health issues, from joint pain and fatigue to heart disease and cognitive decline. While diet and lifestyle changes are the foundation, targeted supplements with clinically studied anti-inflammatory compounds can help reduce inflammatory markers like C-reactive protein (CRP) and interleukin-6 (IL-6). These are the best inflammation supplements available right now.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Solaray Turmeric Curcumin with BioPerine	Curcumin (95% Curcuminoids)	Capsules	Best Overall	4.8
Turmeric Quercetin with Bromelain	Curcumin + Quercetin + Bromelain	Capsules	Best Multi-Pathway Formula	4.7
Nordic Naturals Ultimate Omega	Omega-3 (EPA/DHA)	Softgels	Best Omega-3	4.8
Vimerson Health Turmeric Curcumin with Boswellia	Curcumin + Boswellia + Ginger	Capsules	Best Joint Inflammation	4.6
HEAL-N-SOOTHE Proteolytic Enzyme Formula	Bromelain + Papain + Boswellia	Capsules	Best Enzyme-Based	4.5
NOW Supplements Curcumin Phytosome	Meriva Curcumin	Capsules	Best Bioavailability	4.7
MaryRuth’s Organic Turmeric Liquid Drops	Curcumin + Black Pepper	Liquid Drops	Best Liquid	4.6

1. Solaray Turmeric Curcumin with BioPerine – Best Overall

A potent, high-absorption turmeric formula that delivers clinical-strength curcuminoids for broad-spectrum inflammation support.

This supplement provides 1,500mg of turmeric curcumin extract standardized to 95% curcuminoids per serving, enhanced with BioPerine black pepper extract for up to 2,000% better absorption. Each bottle contains 90 capsules (a 30-day supply at the recommended three-capsule serving). The formula is non-GMO, manufactured in a GMP-certified facility, and uses vegetarian capsules with no artificial fillers or binders.

• Pros:
• High-potency 95% curcuminoid standardization
• BioPerine enhances absorption significantly
• Clean formula with no artificial additives

• Cons:
• Requires three capsules per serving
• May stain clothing if capsule is opened

Best for: Anyone looking for a reliable, high-dose curcumin supplement for daily inflammation management

2. Turmeric Quercetin with Bromelain – Best Multi-Pathway Formula

A triple-action formula combining three clinically studied anti-inflammatory compounds that target inflammation through different biological pathways.

This supplement combines turmeric curcumin with quercetin (a powerful flavonoid antioxidant) and bromelain (a proteolytic enzyme from pineapple). Together, these ingredients address inflammation through multiple mechanisms — curcumin blocks COX-2 and NF-kB pathways, quercetin inhibits inflammatory cytokines, and bromelain reduces swelling by breaking down fibrin. The capsules are vegan-friendly and manufactured in a GMP-compliant facility. For those also interested in supporting joint health, this multi-pathway approach offers broader coverage than single-ingredient formulas.

• Pros:
• Three distinct anti-inflammatory mechanisms in one supplement
• Quercetin also provides antioxidant and immune support
• Bromelain enhances absorption of other compounds

• Cons:
• Lower individual doses than standalone supplements
• Not ideal for those who want maximum curcumin potency

Best for: People who want a comprehensive, multi-ingredient anti-inflammatory supplement

3. Nordic Naturals Ultimate Omega – Best Omega-3 for Inflammation

A premium fish oil delivering high-potency EPA and DHA — two omega-3 fatty acids with extensive clinical evidence for reducing inflammatory markers.

Nordic Naturals Ultimate Omega provides 1,280mg of omega-3s per two-softgel serving, including 650mg EPA and 450mg DHA in highly absorbable triglyceride form. Research consistently shows omega-3 supplementation can reduce CRP, IL-6, and TNF-alpha levels. This product is third-party tested for purity by IFOS (International Fish Oil Standards), Friend of the Sea certified, and free from heavy metals and environmental toxins. The lemon-flavored softgels minimize fishy aftertaste.

• Pros:
• Triglyceride form for superior absorption over ethyl ester fish oils
• IFOS 5-star certified for purity and potency
• Extensive clinical research backing omega-3s for inflammation

• Cons:
• Premium price point
• Two softgels per serving

Best for: Those wanting the most research-backed anti-inflammatory supplement with cardiovascular benefits

4. Vimerson Health Turmeric Curcumin with Boswellia – Best for Joint Inflammation

A synergistic blend of turmeric, boswellia, and ginger designed specifically for joint-related inflammation and mobility support.

This formula combines 800mg organic turmeric with 100mg turmeric extract (95% curcuminoids), 600mg boswellia serrata extract (standardized to 65% boswellic acids), 100mg ginger root, and 10mg BioPerine. Boswellia is particularly effective for joint inflammation, as boswellic acids — especially AKBA — block 5-lipoxygenase (5-LOX), an enzyme that produces inflammatory leukotrienes. Each bottle provides 60 capsules for a 30-day supply. The formula is vegan, non-GMO, and manufactured in an NSF-certified facility.

• Pros:
• Boswellia targets a different inflammatory pathway than curcumin
• Ginger adds complementary anti-inflammatory support
• Clean formula — no gluten, dairy, sugar, or soy

• Cons:
• Curcumin dose is on the lower side at 100mg extract
• Boswellia requires fat for optimal absorption

Best for: People dealing with joint stiffness and inflammation from exercise, aging, or arthritis. For targeted joint support, also check out our guide to boswellia supplements for joints.

5. HEAL-N-SOOTHE Proteolytic Enzyme Formula – Best Enzyme-Based

A unique enzyme-first approach to inflammation that uses proteolytic enzymes like bromelain and papain to break down inflammatory proteins and reduce swelling.

HEAL-N-SOOTHE takes a different approach than standard curcumin supplements by leading with proteolytic enzymes — bromelain, papain, and other protein-digesting enzymes that directly break down fibrin and inflammatory compounds. The formula also includes boswellia extract, turmeric, ginger, and devil’s claw for complementary anti-inflammatory action. This enzyme-based approach is particularly effective for post-exercise inflammation and recovery. The capsules are designed to be taken on an empty stomach for maximum systemic enzyme activity.

• Pros:
• Proteolytic enzymes offer a unique mechanism for reducing swelling
• Multi-ingredient formula covers multiple inflammatory pathways
• Includes devil’s claw, a traditional anti-inflammatory herb

• Cons:
• Must be taken on an empty stomach for best results
• Higher price than basic curcumin supplements

Best for: Active individuals dealing with exercise-induced inflammation, post-surgical swelling, or chronic pain

6. NOW Supplements Curcumin Phytosome – Best Bioavailability

Uses Meriva phytosome technology to dramatically increase curcumin absorption — up to 29 times more bioavailable than standard curcumin extracts.

NOW’s Curcumin Phytosome uses Meriva technology, which binds curcumin to phosphatidylcholine to create a lipid-friendly complex that passes through the intestinal wall far more efficiently than standard curcumin. Clinical studies on Meriva have shown significant reductions in inflammatory markers and joint discomfort at relatively modest 500mg doses. Each vegetarian capsule delivers 500mg of the Curcumin Phytosome complex. The product is GMP-certified, non-GMO, and third-party tested for identity and purity.

• Pros:
• Meriva technology provides dramatically superior absorption
• Clinically studied delivery format
• Only one capsule per serving needed

• Cons:
• Lower total curcumin content per capsule than standard extracts
• Premium price compared to basic turmeric supplements

Best for: Those who have tried standard curcumin supplements without results and want better absorption

7. MaryRuth’s Organic Turmeric Liquid Drops – Best Liquid

USDA Organic liquid turmeric drops with black pepper for those who prefer a capsule-free option with faster absorption.

MaryRuth’s delivers 1,000mg of turmeric curcumin per serving in USDA Organic liquid drop form, enhanced with black pepper extract for improved bioavailability. Liquid supplements bypass the dissolution step required by capsules, allowing for potentially faster uptake. The dropper bottle provides approximately 30 servings per container. The formula is vegan, non-GMO, gluten-free, and free from major allergens. It can be taken directly under the tongue or mixed into beverages.

• Pros:
• USDA Organic certified
• Liquid form allows flexible dosing
• No pills to swallow — great for those with difficulty swallowing capsules

• Cons:
• Strong turmeric taste that not everyone enjoys
• Fewer servings per bottle than capsule alternatives

Best for: People who dislike swallowing pills or want a versatile liquid supplement they can add to smoothies and drinks

8. Designs for Health Inflammatone – Best Premium Formula

No products found.

A practitioner-grade anti-inflammatory formula combining curcumin, boswellia, quercetin, resveratrol, and proteolytic enzymes in one comprehensive supplement.

Inflammatone is a professional-grade formula that packs curcumin, boswellia, quercetin, resveratrol, ginger, and proteolytic enzymes into a single supplement. This broad-spectrum approach targets multiple inflammatory cascades simultaneously. Designed for use under practitioner guidance, it delivers clinical doses of each ingredient. The formula is manufactured in a GMP-certified facility, is gluten-free and soy-free, and uses vegetarian capsules. For those also looking to support their heart health, the resveratrol component adds cardiovascular anti-inflammatory benefits.

• Pros:
• Practitioner-grade with clinical dosing
• Six distinct anti-inflammatory ingredients
• Resveratrol adds antioxidant and cardiovascular support

• Cons:
• Premium price point
• Three capsules per serving

Best for: Those willing to invest in a comprehensive, professional-quality anti-inflammatory supplement

9. Sports Research Triple Strength Omega-3 Fish Oil – Best Value Omega-3

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A triple-strength fish oil offering 1,040mg EPA and 390mg DHA per single softgel — one of the highest potencies per capsule on the market.

Sports Research delivers an impressive 1,040mg EPA and 390mg DHA in a single softgel using AlaskOmega fish oil sourced from wild-caught Alaska pollock. The triglyceride form ensures high bioavailability, and each batch is IFOS 5-star certified for purity, potency, and freshness. The high EPA content is particularly relevant for inflammation, as research shows EPA is more effective than DHA at reducing pro-inflammatory cytokines. One softgel per day is all that’s needed, making it more convenient than competing products requiring two or more capsules.

• Pros:
• Only one softgel per day needed
• High EPA content specifically beneficial for inflammation
• IFOS 5-star certified and sourced from wild-caught fish

• Cons:
• Large softgel size may be difficult for some to swallow
• Only available in unflavored version

Best for: Those wanting maximum anti-inflammatory omega-3 potency in a single daily softgel

10. Life Extension Super Bio-Curcumin – Best for Chronic Inflammation

No products found.

A highly bioavailable curcumin supplement using BCM-95 technology, clinically shown to maintain elevated blood curcumin levels for up to 8 hours.

Life Extension uses BCM-95 curcumin, a patented extract that combines curcuminoids with turmeric essential oils to achieve up to 7 times greater bioavailability than standard curcumin. Unlike formulas that require black pepper, BCM-95’s unique composition naturally enhances absorption. Each capsule provides 400mg of BCM-95 Bio-Curcumin. Research on this specific extract has demonstrated sustained blood levels of curcumin, making it particularly effective for managing chronic, low-grade inflammation. The product is non-GMO, gluten-free, and vegetarian.

• Pros:
• BCM-95 technology provides sustained curcumin blood levels
• No black pepper needed — ideal for those with GI sensitivity
• One capsule per day dosing

• Cons:
• Lower total curcumin per capsule than standard high-dose options
• Premium pricing

Best for: Individuals managing chronic inflammation who want sustained curcumin levels throughout the day

How to Choose the Best Supplement for Inflammation

The most effective anti-inflammatory supplements target specific biological pathways. Curcumin blocks NF-kB and COX-2 enzymes, omega-3 fatty acids reduce prostaglandin production, boswellia inhibits 5-lipoxygenase, and bromelain breaks down inflammatory fibrin proteins. Choosing a supplement with the right mechanism for your specific type of inflammation makes a significant difference in results.

Bioavailability is arguably the most important factor for curcumin supplements. Standard curcumin is poorly absorbed on its own, so look for enhanced formulations using BioPerine (black pepper extract), Meriva (phospholipid complex), BCM-95 (turmeric essential oil complex), or Theracurmin (nano-particle technology). For omega-3 supplements, triglyceride form absorbs significantly better than ethyl ester form.

Dosage matters considerably. Effective curcumin doses in clinical studies typically range from 500mg to 1,500mg of curcuminoids daily (depending on the delivery technology). For omega-3s, anti-inflammatory benefits are seen at 2,000mg or more of combined EPA and DHA per day, with higher EPA ratios being more effective for inflammation specifically.

Third-party testing is essential for purity and potency. Look for products certified by NSF, USP, IFOS (for fish oils), or other independent testing organizations. GMP-certified manufacturing is the minimum standard, and reputable brands will prominently display their testing certifications.

Frequently Asked Questions

What are the most effective supplements for reducing inflammation?

Curcumin (from turmeric) and omega-3 fatty acids (from fish oil) have the strongest clinical evidence for reducing inflammatory biomarkers like CRP and IL-6. Boswellia, ginger, quercetin, and bromelain also have solid research supporting their anti-inflammatory properties, particularly for joint-related inflammation.

How long does it take for anti-inflammatory supplements to work?

Most people notice improvement within 2 to 4 weeks of consistent use. Omega-3 fatty acids may take 6 to 8 weeks to reach full anti-inflammatory effect, as they need time to incorporate into cell membranes. Enhanced curcumin formulations may show faster results due to superior absorption, with some users reporting benefits within the first week.

Can I take multiple anti-inflammatory supplements together?

Yes, combining supplements that work through different pathways can be more effective than taking a single ingredient. For example, pairing omega-3s (which reduce prostaglandins) with curcumin (which blocks COX-2 and NF-kB) addresses inflammation through complementary mechanisms. However, be cautious about blood-thinning effects if stacking multiple anti-inflammatory supplements, especially before surgery.

What is the best form of curcumin for absorption?

Standard curcumin has very low bioavailability (as low as 1-2% absorption). Enhanced forms significantly improve this: Meriva (curcumin phytosome) is about 29 times more bioavailable, BCM-95 is about 7 times more bioavailable, and Theracurmin (nano-particle) is about 27 times more bioavailable. Adding BioPerine (piperine from black pepper) to standard curcumin increases absorption by approximately 2,000%.

Are there side effects from anti-inflammatory supplements?

Most anti-inflammatory supplements are well-tolerated at recommended doses. Curcumin may cause mild GI discomfort in some people, especially at high doses. Fish oil can cause fishy burps, and high doses may have a mild blood-thinning effect. Bromelain may interact with blood-thinning medications. Starting with a lower dose and increasing gradually is a good strategy to minimize side effects.

Should I take anti-inflammatory supplements with food?

Curcumin and boswellia are fat-soluble and should be taken with a meal containing some fat for optimal absorption. Fish oil supplements are also best taken with food to reduce GI side effects and improve absorption. Proteolytic enzyme supplements like bromelain are the exception — they are most effective for systemic inflammation when taken on an empty stomach, so the enzymes can enter the bloodstream rather than being used for digestion.

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