Best Supplements for Panic Attacks (2026)

Panic attacks can strike without warning, bringing intense waves of fear, racing heartbeat, shortness of breath, and overwhelming dread. While professional treatment remains essential for panic disorder, certain supplements target the neurotransmitter imbalances and stress responses that contribute to panic episodes. The products below feature ingredients like GABA, L-theanine, magnesium, and adaptogenic herbs that research has linked to reduced anxiety and calmer nervous system function.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Lunakai Calm & Stress Relief Gummies	GABA + L-Theanine	Gummies	Best Overall	9.5/10
PYM Berry Mood Chews (120ct)	GABA + L-Theanine	Chews	Best for Acute Episodes	9.3/10
Lithium Orotate 13-in-1 Complex	Lithium Orotate + Ashwagandha	Capsules	Best Multi-Pathway	9.1/10
Vitamatic Kava Kava Complex	Kava + Magnesium + GABA	Capsules	Best Fast-Acting	9.0/10
Pink Stork Magnesium Glycinate	Magnesium + L-Theanine + Lemon Balm	Capsules	Best Magnesium-Based	8.9/10
Natures Craft Calming Gummies	Ashwagandha + Magnesium	Gummies	Best Value	8.8/10
LifeSeasons Anxie-T	Ashwagandha + Kava + GABA	Capsules	Best Premium	8.7/10

1. Lunakai Calm & Stress Relief Gummies – Best Overall

These GABA and L-Theanine gummies provide fast-acting calm that addresses the neurotransmitter imbalances underlying panic attacks, making them an excellent daily prevention tool.

GABA is the brain’s primary inhibitory neurotransmitter — it slows down overactive neural firing that contributes to the “fight-or-flight” cascade during panic episodes. L-Theanine complements this by boosting alpha brain wave activity, promoting a state of relaxed alertness rather than the hyper-arousal associated with panic. Each serving delivers clinical doses of both ingredients in a pleasant gummy format. They’re vegan, non-GMO, and manufactured in the USA under GMP standards.

• Pros:
• Targets GABA deficiency directly linked to panic response
• L-Theanine promotes calm without drowsiness or cognitive impairment
• Easy gummy format encourages consistent daily use

• Cons:
• Oral GABA may have limited blood-brain barrier penetration
• Contains added sugars typical of gummy supplements

Best for: Daily panic prevention with a focus on GABA and L-Theanine supplementation

2. PYM Berry Mood Chews (120ct) – Best for Acute Episodes

PYM’s convenient, portable chews deliver 130mg GABA and 90mg L-Theanine per serving for fast-acting calm that can help interrupt the early stages of a panic episode.

What makes PYM particularly useful for panic attacks is the portability factor. Knowing you have a calming supplement within reach can itself reduce the anticipatory anxiety that often triggers panic episodes. Each chew provides precisely dosed GABA and L-Theanine, and the berry flavor is pleasant enough to take anytime. The 120-count bag provides excellent value for daily users and ensures a generous supply. Many users report feeling calmer within 20-30 minutes.

• Pros:
• Portable format reduces anticipatory anxiety about panic attacks
• 120-count bag provides strong value for daily use
• Fast-acting — many users notice effects within 20-30 minutes

• Cons:
• Sugar content may not suit low-sugar diets
• GABA and L-Theanine doses are moderate per chew

Best for: Keeping on hand for early intervention during the onset of panic symptoms

3. 13-in-1 Lithium Orotate Complex – Best Multi-Pathway

This comprehensive formula pairs low-dose lithium orotate with ashwagandha, L-theanine, and ten other calming ingredients for broad-spectrum nervous system support.

Lithium orotate at low doses (10mg) has gained attention for its potential mood-stabilizing and neuroprotective properties. Unlike prescription lithium carbonate, low-dose lithium orotate is available as a supplement and may help regulate the overactive neural patterns associated with panic. The formula also includes 300mg ashwagandha and 100mg L-theanine alongside supporting ingredients for a multi-pathway approach to calming an overactive nervous system.

• Pros:
• Unique lithium orotate formula for mood stabilization
• Includes ashwagandha and L-theanine at meaningful doses
• 13-ingredient formula covers multiple calming pathways

• Cons:
• Lithium orotate is less studied than other anxiety ingredients
• Should not be combined with prescription lithium

Best for: People seeking a comprehensive, multi-ingredient approach to panic and mood support

4. Vitamatic Kava Kava Complex – Best Fast-Acting

Kava is one of the most potent natural anxiolytics available, and this formula combines 1000mg kava with magnesium, ashwagandha, GABA, theobromine, and L-theanine for rapid calming.

Research consistently shows kava kava reduces anxiety symptoms significantly, with effects often felt within 30-45 minutes. For panic attack sufferers, this rapid onset is crucial. The addition of magnesium supports muscle relaxation and nervous system function, while ashwagandha, GABA, and L-theanine provide complementary calming through different mechanisms. Theobromine from cacao adds gentle mood elevation without the jitters of caffeine.

• Pros:
• Kava provides among the fastest natural anxiety relief available
• Six-ingredient formula for comprehensive calming
• Magnesium supports the muscle tension that accompanies panic

• Cons:
• Kava may affect liver function with prolonged high-dose use
• Not recommended for daily long-term use at full dose

Best for: Situational use when fast-acting panic relief is the priority. For deeper calming support, consider adding a magnesium supplement for anxiety.

5. Pink Stork Magnesium Glycinate – Best Magnesium-Based

This magnesium glycinate formula with L-theanine and lemon balm targets the mineral deficiency that may amplify panic responses while promoting nervous system calm.

Magnesium glycinate is considered the premier form of magnesium for anxiety and panic because the glycine component itself has calming properties. Research suggests that up to 50% of adults are magnesium deficient, and low levels directly correlate with increased anxiety and heightened stress responses. Pink Stork’s formula adds L-theanine for alpha brain wave support and lemon balm, a gentle nervine herb traditionally used to reduce nervous tension. This melatonin-free formula supports relaxation without inducing sleepiness.

• Pros:
• Magnesium glycinate is the best-absorbed form for anxiety
• Glycine itself has independent calming properties
• Melatonin-free so it can be taken any time of day

• Cons:
• Marketed primarily toward women, though suitable for anyone
• Multiple capsules per serving

Best for: People who suspect magnesium deficiency may be contributing to their panic episodes

6. Natures Craft Calming Gummies – Best Value

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An affordable daily option combining ashwagandha and magnesium — two research-backed ingredients for reducing the chronic stress that primes the body for panic attacks.

Panic attacks often occur against a backdrop of chronic stress and elevated cortisol. Ashwagandha directly addresses this by lowering cortisol levels over time, while magnesium restores the mineral balance needed for proper nervous system function. Natures Craft packages both ingredients in a pleasant gummy format at a price point that makes daily supplementation sustainable. Consistent use over several weeks helps build baseline resilience against panic triggers.

• Pros:
• Very affordable for a dual-ingredient calming formula
• Addresses chronic stress patterns that trigger panic
• Pleasant-tasting gummies for easy daily compliance

• Cons:
• Not designed for acute panic relief
• Lower potency per ingredient compared to dedicated formulas

Best for: Budget-friendly daily support to reduce the chronic stress that leads to panic episodes

7. LifeSeasons Anxie-T – Best Premium

Doctor-formulated with ashwagandha, kava kava, L-theanine, GABA, and theobromine, Anxie-T delivers both immediate and long-term panic support.

LifeSeasons designed Anxie-T with transparent dosing and clinically informed ingredient selection. The kava kava and L-theanine provide faster-acting calm for acute moments, while ashwagandha builds cortisol resilience over time. GABA directly supports the inhibitory neurotransmitter system, and theobromine from cacao provides gentle mood elevation. Most users report noticeable calming on the first day of use, with progressive improvements over weeks of consistent supplementation.

• Pros:
• Doctor-formulated with transparent ingredient labeling
• Combines fast-acting (kava, L-theanine) and long-term (ashwagandha) ingredients
• Can be taken morning and evening for around-the-clock support

• Cons:
• Higher price than most anxiety supplements
• Kava component requires awareness of liver health

Best for: Those seeking a premium, clinically formulated supplement for comprehensive panic attack management

8. OLLY Goodbye Stress Softgels – Best Mainstream Option

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OLLY’s ultra-strength formula brings GABA, ashwagandha, L-theanine, and lemon balm together in easy-to-swallow softgels from one of the most trusted names in mainstream supplements.

For people new to supplementation for panic support, OLLY provides a low-barrier entry point with a trusted brand name. The softgel format absorbs efficiently, and the four-ingredient combination covers the most important bases — GABA for neural calming, ashwagandha for cortisol reduction, L-theanine for relaxed alertness, and lemon balm for gentle nervous system support. OLLY products are widely available at retail and online, making restocking convenient.

• Pros:
• Widely trusted mainstream brand with strong quality reputation
• Four research-backed calming ingredients in one softgel
• Easy to find at most retailers and online

• Cons:
• Moderate ingredient doses compared to specialty brands
• Premium pricing for the mainstream category

Best for: Supplement newcomers who want a familiar, widely available brand for panic support. Those interested in standalone L-theanine options can explore dedicated products for higher doses.

9. Nature Made Calm Mind & Body Gummies – Best for Beginners

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Nature Made offers a gentle introduction to calming supplementation with magnesium citrate, ashwagandha, and GABA in a familiar, trusted gummy format.

Nature Made is one of the most pharmacist-recommended supplement brands in the United States, and their Wellblends Calm Mind & Body gummies provide a straightforward calming formula. Magnesium citrate supports nervous system function, ashwagandha (125mg via Sensoril extract) helps modulate cortisol, and GABA (100mg) supports the brain’s calming pathways. The doses are conservative, making this an excellent starting point for people new to anxiety supplementation who want to gauge their response before trying more potent options.

• Pros:
• Pharmacist-recommended brand with USP verification available
• Conservative doses ideal for supplement beginners
• Pleasant gummy format that’s easy to incorporate daily

• Cons:
• Lower doses may be insufficient for severe panic symptoms
• Limited to three active ingredients

Best for: People new to calming supplements who want a gentle, trusted starting point

10. WellPath Zen – Best Herbal Blend

WellPath Zen combines ashwagandha, rhodiola rosea, L-theanine, and lemon balm for an adaptogenic approach to reducing the chronic stress that primes panic attacks.

Rather than targeting acute panic symptoms, WellPath Zen focuses on building long-term stress resilience through adaptogens. Ashwagandha lowers cortisol, rhodiola helps the body adapt to mental and physical stress, L-theanine promotes relaxed focus, and lemon balm calms nervous tension. This makes it ideal as a daily foundational supplement for people whose panic attacks are driven by accumulated stress and burnout. The clean capsule formula contains no artificial fillers or unnecessary additives.

• Pros:
• Strong adaptogenic profile builds long-term stress resilience
• Rhodiola supports energy alongside calm — no sedation
• Clean formula free of artificial fillers

• Cons:
• Not designed for immediate panic episode relief
• Takes weeks of consistent use to build full effects

Best for: Daily foundational support to reduce the chronic stress accumulation that triggers panic attacks

How to Choose the Best Supplement for Panic Attacks

When selecting a supplement for panic attacks, it helps to understand the difference between acute relief and preventive support. Fast-acting ingredients like kava, L-theanine, and GABA can provide calming effects within 30-60 minutes, making them useful for early intervention during panic onset. Long-term adaptogens like ashwagandha and rhodiola reduce the baseline cortisol and stress accumulation that make panic attacks more likely over time. The most comprehensive approach uses both types.

Magnesium deserves special attention for panic attack sufferers. Deficiency in this mineral is remarkably common and directly linked to heightened anxiety, muscle tension, and nervous system excitability — all of which contribute to panic symptoms. Magnesium glycinate is the preferred form because it’s well-absorbed and the glycine component has independent calming properties. A dose of 200-400mg daily is generally well-tolerated.

Pay attention to ingredient transparency. Supplements with clearly listed individual ingredient doses are preferable to proprietary blends that hide amounts behind a single total weight. This allows you to verify that each ingredient is present at a clinically meaningful dose rather than being included at trace amounts purely for label appeal.

Start with one supplement at a time so you can accurately assess its effects. Adding multiple new supplements simultaneously makes it impossible to determine which one is helping or causing any side effects. Give each supplement 2-4 weeks before adding another to your regimen.

Frequently Asked Questions

What supplements help prevent panic attacks?

The most evidence-backed supplements for panic prevention include magnesium glycinate (restores mineral balance critical for nervous system calm), L-theanine (promotes alpha brain waves and GABA activity), ashwagandha (reduces cortisol and chronic stress), GABA (the brain’s primary inhibitory neurotransmitter), and kava kava (one of the most potent natural anxiolytics). Daily use of adaptogens like ashwagandha helps lower the baseline stress that makes panic attacks more likely, while fast-acting options like L-theanine can be used situationally.

Can you take supplements during a panic attack?

Fast-acting supplements like L-theanine chews or kava can provide some calming support during the early stages of a panic attack, though they typically take 20-30 minutes to take effect. Having a portable calming supplement on hand can also reduce anticipatory anxiety — simply knowing you have a tool available can interrupt the escalation cycle. However, supplements work best as preventive tools rather than acute treatments, and grounding techniques and breathing exercises remain the most effective in-the-moment interventions.

Is magnesium good for panic attacks?

Yes, magnesium is one of the most important minerals for panic attack management. Magnesium helps regulate GABA activity, relaxes muscles, and calms the nervous system. Research shows that magnesium deficiency — which affects an estimated 50% of adults — is associated with increased anxiety, heightened stress responses, and nervous system excitability. Magnesium glycinate is the preferred form for panic support because it’s highly absorbable and the glycine provides additional calming benefits. Typical doses range from 200-400mg daily.

How long do calming supplements take to work?

It varies significantly by ingredient type. L-theanine and GABA can produce noticeable calming effects within 30-60 minutes of ingestion. Kava kava typically works within 30-45 minutes. Magnesium glycinate may provide subtle calming within days, with full benefits appearing after 1-2 weeks of consistent use. Ashwagandha requires 2-8 weeks of daily use for its cortisol-lowering and anxiety-reducing effects to fully develop. For comprehensive panic support, many people combine a fast-acting ingredient with a daily adaptogen.

Are there any supplements panic sufferers should avoid?

People prone to panic attacks should generally avoid caffeine-containing supplements, as caffeine can trigger or worsen panic symptoms by increasing heart rate and stimulating the stress response. High-dose stimulant ingredients like yohimbine, ephedra, and synephrine should also be avoided. St. John’s wort can interact with numerous medications and may cause increased anxiety in some individuals. Even B vitamins at very high doses can be stimulating for sensitive individuals. Always introduce new supplements one at a time to monitor for any anxiety-increasing effects.

Can I take panic attack supplements with anti-anxiety medication?

Some supplements can interact with prescription anti-anxiety medications. Kava kava and valerian should be used cautiously with benzodiazepines due to additive sedation risk. GABA supplements may enhance the effects of GABAergic medications. Ashwagandha may interact with thyroid medications and immunosuppressants. L-theanine and magnesium are generally considered safe alongside most medications. However, always consult your prescribing physician before adding any supplement to an existing medication regimen, as interactions vary by individual and specific drug combinations.

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