Best Supplements for Psoriasis (2026)

Psoriasis is an autoimmune condition causing rapid skin cell turnover that leads to scaly, inflamed plaques. While prescription treatments remain the cornerstone of management, research supports several supplements for reducing inflammation, modulating immune response, and improving skin health. Vitamin D, omega-3 fatty acids, turmeric curcumin, and probiotics have the most clinical evidence for complementing psoriasis treatment plans.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
FlareFree Psoriasis Support	Herbal Psoriasis Formula	Capsules	Best Overall	4.7
DaVinci Labs Omega 3 HP-D	High-Potency EPA/DHA + Vitamin D3	Softgels	Best Omega-3 + D3 Combo	4.7
DERMOIA Eczema & Psoriasis	Multi-Nutrient Skin Formula	Capsules	Best Multi-Nutrient	4.8
Icelandic Cod Liver Oil	Omega-3 + Vitamin D & A	Softgels	Best Fish Oil	4.7
10-in-1 Turmeric Softgels	95% Curcuminoids	Softgels	Best Anti-Inflammatory	4.6
Pink Stork Magnesium + Vitamin D	Magnesium Glycinate + D3	Capsules	Best Vitamin D Combo	4.6
Maju Black Seed Oil	Cold-Pressed Nigella Sativa	Softgels	Best Herbal Anti-Inflammatory	4.6

1. FlareFree Psoriasis Support Supplement – Best Overall

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A purpose-built herbal formula designed specifically for psoriasis management, combining natural anti-inflammatory and immune-modulating ingredients to soothe flare-ups.

FlareFree uses a blend of natural herbal ingredients formulated to help manage psoriasis symptoms including itching, redness, scaling, and discomfort. The formula supports healthy skin balance and aids in maintaining clear skin through a combination of anti-inflammatory botanicals. It contains no preservatives, fillers, parabens, artificial sweeteners, dyes, or flavors, and is both gluten-free and lactose-free. The product is easy to incorporate into a daily routine.

• Pros:
• Specifically formulated for psoriasis rather than general skin health
• 100% natural and herbal with no artificial additives
• Gluten-free and lactose-free for sensitive individuals

• Cons:
• Smaller brand with limited independent clinical studies
• Results vary — may take several weeks of consistent use

Best for: Those wanting a dedicated psoriasis supplement with a clean, herbal formulation

2. DaVinci Labs Omega 3 HP-D – Best Omega-3 + D3 Combination

A professional-grade omega-3 fish oil with added vitamin D3, addressing two of the most clinically supported nutrients for psoriasis management in a single supplement.

DaVinci Labs provides concentrated EPA and DHA alongside 1,000 IU of vitamin D3. Omega-3 fatty acids help reduce the chronic inflammation driving psoriasis plaques, while vitamin D plays a critical role in immune regulation — psoriasis is strongly associated with low vitamin D levels. Prescription psoriasis creams often contain vitamin D analogs, reinforcing the nutrient’s importance for this condition. DaVinci Labs maintains rigorous third-party testing standards. Combining this with a quality turmeric supplement may provide synergistic anti-inflammatory benefits.

• Pros:
• Practitioner-grade quality with third-party verification
• High EPA concentration to target psoriasis-driven inflammation
• Added vitamin D3 addresses the most common nutrient deficiency in psoriasis

• Cons:
• Premium pricing compared to standard fish oils
• Large softgels may be challenging for some

Best for: Those seeking a high-quality omega-3 + vitamin D combination with clinical-grade potency

3. DERMOIA Skin Support – Best Multi-Nutrient Formula

A comprehensive skin health formula combining vitamins, minerals, omega-3s, turmeric, quercetin, and probiotics — covering multiple anti-inflammatory pathways relevant to psoriasis.

DERMOIA delivers vitamins C, D3, E, B5, biotin, zinc, and copper alongside turmeric extract, grape seed extract, evening primrose oil, omega-3 powder, quercetin, glutathione, and probiotics in a two-capsule daily dose. This multi-pathway approach addresses inflammation (turmeric, omega-3s, quercetin), oxidative stress (vitamins C and E, glutathione, grape seed), immune modulation (vitamin D, zinc, probiotics), and skin cell health (biotin, B5, copper). The formula is manufactured in a GMP-certified, FDA-registered facility.

• Pros:
• Targets psoriasis through multiple mechanisms of action
• Includes antioxidants to combat the oxidative stress linked to psoriasis
• Probiotics support the gut-immune connection relevant to autoimmune conditions

• Cons:
• Individual ingredient doses may be lower than standalone supplements
• Two capsules daily required

Best for: Those wanting comprehensive multi-nutrient support for psoriasis in a single product

4. Icelandic Wild Caught Cod Liver Oil – Best Fish Oil

Wild-caught Icelandic cod liver oil delivering omega-3 EPA/DHA with naturally occurring vitamins D and A — three nutrients central to managing psoriasis inflammation and immune dysregulation.

Cod liver oil has a unique advantage over standard fish oil for psoriasis: it naturally contains both vitamin D and vitamin A alongside omega-3 fatty acids. Vitamin A supports healthy skin cell turnover (people with psoriasis often have lower skin vitamin A levels), while vitamin D modulates the overactive immune response driving plaque formation. The omega-3 component helps reduce systemic inflammation and may support cardiovascular health — important since psoriasis increases cardiovascular risk.

• Pros:
• Three key psoriasis nutrients in one natural product
• Wild-caught from pristine Icelandic waters
• Vitamin A supports healthy skin cell turnover — critical for psoriasis

• Cons:
• Not suitable for vegetarians or those with fish allergies
• Vitamin A content requires monitoring total daily intake

Best for: Those wanting a natural, multi-nutrient fish oil addressing psoriasis-specific nutritional needs

5. 10-in-1 Turmeric Supplement Softgels – Best Anti-Inflammatory

A high-potency turmeric curcumin formula with 95% curcuminoids in MCT oil-based softgels for enhanced absorption, providing powerful anti-inflammatory support for psoriasis.

This 10-in-1 formula delivers 1,000mg of turmeric with 95% curcuminoids in an MCT oil base for improved bioavailability. Curcumin has demonstrated significant anti-inflammatory activity by inhibiting NF-κB, a key inflammatory pathway activated in psoriasis. Multiple studies have shown curcumin supplements can reduce psoriasis severity scores when used alongside standard treatments. The softgel format with MCT oil enhances the notoriously poor absorption of curcumin.

• Pros:
• 95% curcuminoid concentration for maximum potency
• MCT oil base enhances curcumin absorption significantly
• 60-day supply per bottle for good value

• Cons:
• May interact with blood thinners and some medications
• Can cause stomach upset in sensitive individuals

Best for: Those seeking potent anti-inflammatory support specifically targeting the inflammatory pathways in psoriasis

6. Pink Stork Magnesium Glycinate with Vitamin D – Best Vitamin D Combo

Highly absorbable magnesium glycinate paired with vitamin D3 to address the vitamin D deficiency strongly linked to psoriasis severity and immune dysregulation.

Psoriasis is closely associated with low vitamin D levels, and prescription psoriasis creams frequently contain vitamin D analogs for good reason — the nutrient helps regulate the abnormally accelerated skin cell growth characteristic of the condition. Pink Stork pairs D3 with magnesium glycinate, which supports immune function, reduces stress-related inflammation, and improves sleep quality. Since stress is a known psoriasis trigger, the combined calming and immune-regulating effects of this formula address multiple aspects of psoriasis management. For additional support for autoimmune conditions, consider pairing with an omega-3 supplement.

• Pros:
• Addresses vitamin D deficiency — the most common nutritional link to psoriasis
• Magnesium glycinate is gentle on digestion and supports stress reduction
• Clean ingredients from a trusted brand

• Cons:
• Does not include omega-3s or curcumin
• Marketed toward women but appropriate for all adults

Best for: Those with confirmed or suspected vitamin D deficiency looking for an absorbable D3 + magnesium combination

7. Maju Black Seed Oil – Best Herbal Anti-Inflammatory

Cold-pressed Nigella sativa oil containing thymoquinone, a compound with demonstrated anti-inflammatory and immune-modulating properties relevant to autoimmune skin conditions.

Black seed oil has been used for centuries in traditional medicine for inflammatory skin conditions, and modern research is beginning to validate these applications. Thymoquinone, the primary bioactive compound, has shown anti-inflammatory, antioxidant, and immunomodulatory effects in studies. For psoriasis specifically, thymoquinone may help modulate the Th1/Th17 immune response involved in plaque formation. Each softgel provides cold-pressed, non-GMO oil in an easy-to-absorb format, with 120 capsules per bottle.

• Pros:
• Cold-pressed to preserve the active thymoquinone content
• Traditional and emerging evidence for autoimmune skin conditions
• Non-GMO, vegan-friendly, convenient softgel format

• Cons:
• Clinical trials specific to psoriasis are still limited
• Strong taste if softgels are broken

Best for: Those interested in a traditional herbal supplement with growing modern evidence for autoimmune skin support

8. Naturevite Eczema & Psoriasis Gummies – Best Gummy Option

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A sugar-free gummy formula with 20+ vitamins specifically formulated for inflammatory skin conditions including psoriasis, eczema, and dermatitis.

Naturevite combines over 20 vitamins and botanical ingredients in a tasty gummy format designed to support skin health, soothe itching, calm redness, and promote clearer skin. The sugar-free formulation is USA-made and provides a convenient alternative for those who dislike swallowing capsules or softgels. Each bottle contains 60 gummies for a 30-day supply.

• Pros:
• Convenient gummy format with pleasant taste
• Sugar-free formulation
• Multi-vitamin approach targeting skin health from multiple angles

• Cons:
• Individual ingredient doses may be lower than capsule alternatives
• Newer product with limited long-term reviews

Best for: Those who prefer gummy supplements and want a skin-targeted multi-vitamin formula

9. Codex Labs ANTÜ Skin Barrier Repair – Best Clinically Proven

No products found.

A dermatologist-tested, clinically proven oral supplement for eczema, rosacea, and psoriasis — available as flavored sachets for easy daily use.

Codex Labs ANTÜ is a vegan, clinically proven skin barrier repair supplement specifically tested on people with inflammatory skin conditions. The strawberry lemonade-flavored sachets dissolve in water for convenient daily supplementation. Unlike most skin supplements, ANTÜ has undergone clinical testing specifically for psoriasis, eczema, and rosacea, making it one of the few products with condition-specific evidence. This supplement pairs well with a comprehensive skin health routine.

• Pros:
• Clinically proven and dermatologist-tested for psoriasis
• Pleasant strawberry lemonade flavor — easy to take daily
• Vegan formulation with clean ingredients

• Cons:
• Premium pricing for a 30-day supply
• Available in one flavor only

Best for: Those wanting a clinically tested supplement with specific evidence for psoriasis and inflammatory skin conditions

How to Choose the Best Supplement for Psoriasis

Vitamin D should be the first supplement to consider for psoriasis. Studies consistently show people with psoriasis have lower vitamin D levels, and supplementation — particularly when combined with standard topical treatments — can improve outcomes. Have your levels tested and work with a healthcare provider to determine appropriate dosing, as therapeutic doses for psoriasis may be higher than the general recommended daily allowance.

Omega-3 fatty acids from fish oil represent the second most evidence-backed option. EPA is the primary anti-inflammatory component, so look for concentrated formulas with high EPA content (1-3 grams daily). Fish oil may also help address the increased cardiovascular risk associated with psoriasis. Those who don’t consume fish can consider algae-based omega-3 supplements as an alternative.

Turmeric curcumin supplements should contain at least 500mg of curcuminoids with enhanced absorption technology (BioPerine/piperine, MCT oil, or liposomal delivery). Standard curcumin has extremely poor bioavailability, so absorption-enhanced formulas are essential. Curcumin works best as an adjunct to — not a replacement for — prescribed psoriasis treatments.

Quality certifications matter significantly for psoriasis supplements. Look for third-party testing (NSF, USP, or independent lab), GMP certification, and transparency about ingredient sourcing. Avoid products with excessive fillers, artificial colors, or common allergens that could trigger skin reactions in sensitive individuals.

Frequently Asked Questions

What is the best vitamin for psoriasis?

Vitamin D has the strongest evidence for psoriasis management. Studies show psoriasis is associated with vitamin D deficiency, and supplementation can improve symptoms. This is consistent with the fact that many prescription psoriasis treatments contain vitamin D analogs. Omega-3 fatty acids (via fish oil) rank as the second most-supported supplement, with anti-inflammatory effects that may reduce plaque severity.

Can supplements cure psoriasis?

No supplement can cure psoriasis, which is a chronic autoimmune condition. However, certain supplements may help manage symptoms, reduce flare frequency, and complement prescribed treatments. Vitamin D, omega-3s, and curcumin have the most evidence for reducing psoriasis severity scores when used consistently alongside medical treatment.

How much vitamin D should I take for psoriasis?

Standard supplementation ranges from 1,000-5,000 IU of vitamin D3 daily, but therapeutic doses for psoriasis should be determined by blood testing and medical guidance. Some studies have used higher doses under medical supervision. Have your 25-hydroxy vitamin D levels tested to establish a baseline, and aim for blood levels in the 40-60 ng/mL range, which some research associates with improved psoriasis outcomes.

Does fish oil help psoriasis?

Clinical evidence is promising but mixed. Fish oil’s omega-3 fatty acids (particularly EPA) have anti-inflammatory properties that may reduce the systemic inflammation driving psoriasis. Some studies show improvements in plaque severity and itching with 2-4 grams of EPA/DHA daily over 8-12 weeks. Fish oil may also benefit the cardiovascular health risks commonly associated with psoriasis.

Can turmeric help with psoriasis?

Curcumin (the active compound in turmeric) has shown anti-inflammatory effects that may benefit psoriasis by inhibiting NF-κB, TNF-alpha, and other inflammatory pathways involved in plaque formation. Several studies report reduced psoriasis severity with curcumin supplementation. Use formulations with enhanced absorption (BioPerine, MCT oil, or liposomal) since standard curcumin has very low bioavailability.

Are there supplements that make psoriasis worse?

Some supplements may potentially trigger or worsen psoriasis in certain individuals. High-dose vitamin A (retinol) should be used cautiously. Echinacea and other immune-stimulating supplements could theoretically worsen autoimmune conditions. Some people report psoriasis flares with spirulina, wheatgrass, or other immune-boosting supplements. Introduce one supplement at a time and monitor for any changes in symptoms over 2-4 weeks.

How does stress affect psoriasis and can supplements help?

Stress is one of the most common triggers for psoriasis flares. Psychological stress activates the HPA axis and increases pro-inflammatory cytokines that worsen skin inflammation. Supplements like magnesium glycinate, ashwagandha, and L-theanine may help manage stress and indirectly reduce flare frequency. Magnesium deficiency in particular is associated with increased stress reactivity, and correcting it through supplementation may help break the stress-flare cycle. Omega-3 fatty acids also have mild anxiolytic effects that could provide secondary stress-management benefits.

Should I get my vitamin levels tested before supplementing for psoriasis?

Yes, blood testing is highly recommended before starting a psoriasis supplement regimen. Vitamin D testing (25-hydroxy vitamin D) is especially important since psoriasis is strongly associated with deficiency, and appropriate dosing depends on baseline levels. Testing for zinc, selenium, and omega-3 index can also guide supplementation decisions. Working with a healthcare provider to establish baseline levels allows for targeted supplementation rather than guesswork, and follow-up testing can confirm whether supplements are achieving desired levels.

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