Best Supplements for Sjogren’s Syndrome (2026)

Sjogren’s syndrome is a systemic autoimmune disorder where the immune system attacks moisture-producing glands, resulting in chronic dry eyes, dry mouth, fatigue, and joint pain. Beyond surface-level dryness, Sjogren’s can affect the lungs, gut, sinuses, and nervous system. While conventional treatment focuses on symptom management, targeted supplements can support immune regulation, reduce inflammation, and address the nutritional deficiencies commonly found in Sjogren’s patients to improve overall quality of life.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
NATURELO Omega-3 Fish Oil	EPA + DHA Omega-3	Softgels	Best Overall	9.5/10
NATURELO Vitamin D3 5000 IU	Vitamin D3 Plant-Based	Capsules	Best for Immune Regulation	9.4/10
Lunakai Turmeric Gummies	Turmeric, Ginger, BioPerine	Gummies	Best Anti-Inflammatory	9.2/10
OmniBiotics Evening Primrose Oil	Evening Primrose Oil 1500mg	Capsules	Best for Dry Eyes & Mouth	9.1/10
Effective Nutra Ashwagandha Gummies	Ashwagandha 1500mg	Gummies	Best for Fatigue & Stress	9.0/10
Pink Stork Magnesium Glycinate	Magnesium Glycinate, Vitamin D	Capsules	Best for Joint Pain & Fatigue	8.9/10
Natures Craft Vitamin D3 + K2	Vitamin D3 2000 IU, K2 MK-7	Tablets	Best Budget Vitamin D	8.8/10

1. NATURELO Omega-3 Fish Oil – Best Overall

Omega-3 fatty acids are the most widely recommended supplement for Sjogren’s syndrome, with research showing improvements in dry eye symptoms, inflammation reduction, and immune modulation.

NATURELO delivers 1,100mg of triglyceride-form omega-3s per serving with balanced EPA and DHA. Johns Hopkins Sjogren’s Center recommends omega-3 supplementation at 1,000-3,000mg daily for potential dry eye benefits. Studies show fish oil can improve dry eye and dry mouth symptoms in Sjogren’s patients, reduce systemic inflammation, and support regulatory T cells (Tregs) that help calm the overactive immune response driving the disease. The triglyceride form offers superior absorption, and the burpless coating is important for Sjogren’s patients who may have acid reflux — a common comorbidity.

• Pros:
• Recommended by Johns Hopkins Sjogren’s Center
• Clinical evidence for improving dry eye symptoms
• Supports regulatory T cells to modulate autoimmune response

• Cons:
• Some Sjogren’s studies show mixed results on saliva flow
• Higher doses (2-4g) may be needed for optimal benefit

Best for: Sjogren’s patients seeking a foundational supplement with the broadest evidence base for autoimmune and dryness symptom support

2. NATURELO Vitamin D3 5000 IU – Best for Immune Regulation

Vitamin D deficiency increases autoimmune disease risk by 22%, and Johns Hopkins specifically recommends 1,000-2,000 IU daily supplementation for Sjogren’s patients, particularly those with limited sun exposure.

NATURELO provides 5,000 IU of plant-based Vitamin D3 derived from lichen, making it suitable for vegans and those with sensitivities to animal-sourced D3. Research shows low Vitamin D levels are associated with worse Sjogren’s symptoms including neuropathy and increased lymphoma risk. Vitamin D regulates immune function, reduces inflammation, and supports the body’s ability to distinguish self from non-self — the fundamental dysfunction in Sjogren’s. This higher-dose option allows patients to achieve optimal serum levels under provider guidance.

• Pros:
• Plant-based D3 from lichen — suitable for vegans
• Johns Hopkins recommends D supplementation specifically for Sjogren’s
• Studies link low D levels to worse Sjogren’s outcomes

• Cons:
• 5,000 IU may be excessive for some — blood testing recommended
• Should be taken with fat for proper absorption

Best for: Sjogren’s patients with documented or suspected Vitamin D deficiency seeking immune regulation support

3. Lunakai Turmeric Gummies – Best Anti-Inflammatory

Curcumin, turmeric’s active compound, has demonstrated the ability to support salivary gland function and may improve saliva production — directly addressing one of Sjogren’s most debilitating symptoms.

Lunakai’s Turmeric Gummies combine high-absorption turmeric with ginger and BioPerine for enhanced bioavailability. Beyond general anti-inflammatory benefits, curcumin research specifically suggests it may support salivary gland function and protect against the oxidative stress implicated in autoimmune disease progression. Turmeric’s antioxidant properties help protect cells and glands from free radical damage, which is particularly relevant in Sjogren’s where oxidative stress contributes to glandular destruction. BioPerine increases curcumin absorption by up to 2,000%.

• Pros:
• Research suggests curcumin may support salivary gland function
• BioPerine dramatically enhances absorption
• Ginger provides additional anti-inflammatory and digestive support

• Cons:
• Gummy form contains added sugars
• More research needed on curcumin specifically for Sjogren’s

Best for: Sjogren’s patients seeking potent anti-inflammatory support with emerging evidence for salivary gland protection

4. OmniBiotics Evening Primrose Oil – Best for Dry Eyes & Mouth

Evening primrose oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid with anti-inflammatory properties specifically studied for its potential to ease dry eye and dry mouth symptoms in Sjogren’s patients.

OmniBiotics provides a clinical-strength 1,500mg dose of organic evening primrose oil per capsule. GLA helps regulate inflammation in the moisture-producing glands that Sjogren’s attacks, and multiple natural medicine databases list evening primrose oil as a primary natural treatment for Sjogren’s syndrome. EPO is believed to promote healthy function of the lacrimal glands (tears) and salivary glands, potentially improving moisture production over time. The organic, cold-pressed formulation preserves the integrity of essential fatty acids.

• Pros:
• GLA specifically targets inflammation in moisture-producing glands
• Listed as a primary natural treatment for Sjogren’s
• High-potency 1,500mg organic dose

• Cons:
• Direct clinical evidence in Sjogren’s is limited
• Takes 6-8 weeks for noticeable effects

Best for: Sjogren’s patients with prominent dry eye and dry mouth symptoms looking for targeted fatty acid support

5. Effective Nutra Ashwagandha Gummies – Best for Fatigue & Stress

Fatigue is one of the most debilitating and undertreated symptoms of Sjogren’s syndrome, and ashwagandha is a clinically studied adaptogen that supports energy, stress resilience, and immune modulation.

Effective Nutra delivers 1,500mg of ashwagandha per serving in a convenient gummy format. Sjogren’s-related fatigue significantly impacts quality of life, and conventional treatment often fails to address it adequately. Ashwagandha has demonstrated the ability to reduce cortisol levels, improve energy, and support immune system balance. As an adaptogen, it helps the body manage the physical and emotional stress of living with a chronic autoimmune condition. The formula supports calm mood and energy without stimulants, making it suitable for daily use.

• Pros:
• Addresses fatigue — one of Sjogren’s most disabling symptoms
• Adaptogenic properties support stress management
• Immune-modulating effects may benefit autoimmune conditions

• Cons:
• Not specifically studied in Sjogren’s patients
• Ashwagandha may not be appropriate for those on thyroid medications

Best for: Sjogren’s patients struggling with chronic fatigue and stress who need energy support without stimulants

6. Pink Stork Magnesium Glycinate – Best for Joint Pain & Fatigue

Magnesium supports multiple Sjogren’s concerns including joint pain, muscle aches, fatigue, and sleep quality — all common symptoms that significantly impact daily function.

Pink Stork’s magnesium glycinate formula combines a highly bioavailable form of magnesium with Vitamin D for synergistic immune and musculoskeletal support. Many Sjogren’s patients experience joint pain, muscle aches, and disrupted sleep — all of which magnesium helps address. The glycinate form is gentle on the stomach, which is important since Sjogren’s can affect the GI tract. Combined with Vitamin D, this formula provides dual support for bone health, immune regulation, and mood.

• Pros:
• Addresses joint pain, muscle aches, fatigue, and sleep disruption
• Glycinate form is gentle on the GI tract
• Combined Vitamin D supports immune regulation

• Cons:
• Not specifically formulated for Sjogren’s
• Higher magnesium doses may cause loose stools

Best for: Sjogren’s patients with joint pain, muscle tension, and sleep difficulties seeking a well-tolerated mineral supplement

7. Natures Craft Vitamin D3 + K2 – Best Budget Vitamin D

This affordable Vitamin D3 and K2 combination provides essential immune regulation at a fraction of the cost of premium brands, with K2 ensuring proper calcium utilization for bone health.

Natures Craft combines Vitamin D3 at 2,000 IU with K2 (MK-7) for balanced immune and bone health support. The D3 dose aligns with Johns Hopkins’ recommendation for Sjogren’s patients. Adding K2 directs calcium to bones rather than soft tissues — an important consideration for Sjogren’s patients who may be at higher risk for osteoporosis due to chronic inflammation and potential corticosteroid use. The tablet format is easy to take and the formula provides excellent value for daily autoimmune support.

• Pros:
• Affordable daily Vitamin D within recommended Sjogren’s range
• K2 addition supports proper calcium metabolism and bone health
• Compact tablet format for easy daily use

• Cons:
• 2,000 IU may be insufficient for patients with severe deficiency
• Tablets may be harder to swallow for patients with severe dry mouth

Best for: Budget-conscious Sjogren’s patients seeking essential Vitamin D supplementation with added bone health support

8. Snap Supplements Organic Spirulina & Chlorella – Best Antioxidant Support

Spirulina and chlorella provide concentrated antioxidants, vitamins, and minerals that combat the oxidative stress driving glandular damage in Sjogren’s syndrome while supporting overall immune function.

Snap Supplements delivers USDA-certified organic spirulina and chlorella in a convenient daily dose. Oxidative stress — the imbalance between free radicals and antioxidants — plays a significant role in Sjogren’s disease progression and glandular destruction. These nutrient-dense superfoods provide chlorophyll, beta-carotene, iron, and B-vitamins that support energy production, detoxification, and cellular protection. For Sjogren’s patients who struggle with nutrient absorption due to GI involvement, spirulina and chlorella offer a concentrated source of bioavailable nutrients.

• Pros:
• Concentrated antioxidant support against glandular oxidative damage
• USDA organic certification ensures purity
• Rich in B-vitamins, iron, and chlorophyll for energy support

• Cons:
• Not specifically studied for Sjogren’s
• Green taste may be unappealing to some

Best for: Sjogren’s patients seeking broad antioxidant and nutritional support to combat oxidative stress and glandular damage

9. NATURELO Vegan DHA – Best Vegan Omega-3 Option

For Sjogren’s patients who avoid fish products, this algae-derived DHA supplement provides the anti-inflammatory omega-3 benefits recommended by Johns Hopkins without any animal-sourced ingredients.

NATURELO’s Vegan DHA provides omega-3 fatty acids derived from microalgae — the same original source that fish obtain their omega-3s from. Each serving delivers DHA for brain, heart, and eye health support. This is particularly relevant for Sjogren’s patients following anti-inflammatory diets that may exclude certain animal products. The vegan formulation is also free from the heavy metals sometimes found in fish oil supplements. Algae-sourced omega-3s are sustainable and allergen-friendly.

• Pros:
• Plant-based omega-3 for vegan or fish-sensitive patients
• Supports brain, eye, and heart health simultaneously
• Free from heavy metals and ocean contaminants

• Cons:
• DHA-focused — lower in EPA than fish oil alternatives
• Higher cost per serving than conventional fish oil

Best for: Vegan or vegetarian Sjogren’s patients who need omega-3 support but cannot take fish oil

How to Choose the Best Supplement for Sjogren’s Syndrome

A strategic supplement approach for Sjogren’s should target four key areas: inflammation reduction (omega-3s, turmeric), moisture support (evening primrose oil, omega-3s), immune regulation (Vitamin D, ashwagandha), and nutritional deficiency correction (B12, magnesium, Vitamin D). Start with omega-3 fish oil and Vitamin D as the foundation — these have the strongest evidence base and are recommended by major Sjogren’s centers including Johns Hopkins.

Sjogren’s patients often have unique supplement considerations. Dry mouth can make swallowing large capsules difficult — look for smaller capsules, softgels, gummies, or liquid formulations. Gastrointestinal involvement is common, so choose gentle forms like magnesium glycinate over magnesium oxide, and opt for triglyceride-form fish oil over ethyl ester to reduce digestive discomfort.

Monitor for B12 deficiency if you have a related autoimmune condition (pernicious anemia), which impairs B12 absorption. Johns Hopkins notes this is a common Sjogren’s comorbidity. However, routine B12 supplementation is not necessary unless you have documented deficiency or follow a strict vegan diet. Vitamin C and E provide antioxidant support against the oxidative stress driving glandular damage, but choose buffered or gentle forms of Vitamin C to avoid stomach irritation.

Always inform your rheumatologist about supplements, especially if taking immunosuppressive medications. Some supplements like ashwagandha may theoretically affect immune function, and antioxidants may interact with certain treatments. Quality matters — choose supplements with third-party testing, GMP certification, and minimal fillers.

Frequently Asked Questions

What is Sjogren’s syndrome and how do supplements help?

Sjogren’s syndrome is an autoimmune disorder where the immune system attacks moisture-producing glands, primarily causing dry eyes and dry mouth, but also potentially affecting joints, lungs, skin, and nerves. Supplements help by reducing the chronic inflammation driving glandular damage (omega-3s, turmeric), supporting immune system regulation (Vitamin D), addressing nutritional deficiencies common in Sjogren’s (B12, magnesium), and providing building blocks for moisture production (evening primrose oil, omega-3s).

What is the most important supplement for Sjogren’s?

Omega-3 fish oil and Vitamin D are considered the most important supplements for Sjogren’s based on available evidence and expert recommendations. Johns Hopkins Sjogren’s Center specifically recommends both. Omega-3s address dry eye symptoms and systemic inflammation, while Vitamin D supports immune regulation — with research showing deficiency increases autoimmune disease risk by 22% and is associated with worse Sjogren’s outcomes.

Can supplements help with Sjogren’s dry eyes?

Yes. Omega-3 fatty acids have the most evidence for improving dry eye symptoms in Sjogren’s, with studies showing improvements in tear production and eye comfort. Evening primrose oil (GLA) may also support lacrimal gland function. Vitamin D supplementation has been linked to improved dry eye in some studies. For dry eyes specifically, there are also targeted eye supplements containing omega-3s formulated for ocular health. Combining oral omega-3 supplements with artificial tears provides both internal and external support.

How long do Sjogren’s supplements take to show results?

Omega-3 fish oil typically requires 6-12 weeks of consistent use at adequate doses (1,000-3,000mg daily) for noticeable dry eye improvement. Vitamin D levels take 8-12 weeks to normalize with supplementation. Turmeric’s anti-inflammatory effects may become noticeable within 4-8 weeks. Evening primrose oil generally requires 6-8 weeks. Ashwagandha for fatigue may show initial benefits within 2-4 weeks but continues improving over several months. Patience and consistency are essential.

Are there supplements Sjogren’s patients should avoid?

Sjogren’s patients should be cautious with echinacea and other immune-stimulating supplements, as they may theoretically worsen autoimmune activity. High-dose Vitamin C may cause stomach upset in patients with GI involvement. Some patients report sensitivities to certain B-vitamins. Supplements with caffeine may worsen dry mouth. Always start one supplement at a time and monitor for any changes in symptoms. Patients on immunosuppressive medications should discuss all supplements with their rheumatologist.

Should I take a probiotic for Sjogren’s syndrome?

Emerging research suggests probiotics may benefit Sjogren’s patients, as gut microbiome imbalances have been identified in people with the condition. Probiotic lozenges specifically may help by replenishing healthy oral bacteria, potentially improving dry mouth symptoms. However, the evidence is still developing. If you try probiotics, start with a low dose and choose strains that have been studied for autoimmune conditions. Soil-based and spore-based probiotics tend to be better tolerated by those with sensitive digestive systems.

Related Articles

• Best Supplements for Autoimmune Disease
• Best Dry Eye Supplements
• Best Anti-Inflammatory Supplements