Best Telomere Support Supplements (2026)

Telomeres are the protective caps at the ends of chromosomes that shorten with each cell division, serving as a biological clock for cellular aging. Telomere support supplements aim to slow this shortening process through ingredients like cycloastragenol, astragalus root extract, and antioxidants that activate the telomerase enzyme and protect DNA from oxidative damage. These supplements have become increasingly popular among those interested in longevity and cellular health.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Healthycell Telomere Length	AC-11, Astragalus, Resveratrol	Capsules	Best Overall	9.5/10
CAW Cycloastragenol 10mg	Cycloastragenol 98%	Capsules	Best Cycloastragenol	9.3/10
CAW Cycloastragenol 25mg	Cycloastragenol 98%	Capsules	Most Potent	9.2/10
Enzymedica Telomere Plus	Astragalus, Rhodiola, Broccoli Seed	Capsules	Best Multi-Pathway	9.0/10
CAW Telomere Support 25mg	Cycloastragenol, Enteric-Coated	Capsules	Best Absorption	8.9/10
Better Way Health Beta Glucan 500	Beta 1,3D Glucan 500mg	Capsules	Best Immune + Cellular	8.8/10
Effective Nutra Resveratrol Gummies	Resveratrol 1500mg	Gummies	Best Gummies	8.7/10

1. Healthycell Telomere Length – Best Overall

Formulated by Nobel Prize nominee Dr. Vincent Giampapa, this is the most comprehensive telomere supplement on the market with clinically studied AC-11 extract proven to support telomere lengthening.

Healthycell Telomere Length delivers a multi-pathway approach to telomere health, combining AC-11 (a clinically proven rainforest extract for DNA repair), astragalus root extract, Korean ginseng, milk thistle seed extract, resveratrol, and L-citrulline. The formula targets all five key processes that impact telomere length: telomerase activation, DNA repair, nitric oxide production, homocysteine reduction, and antioxidant protection. It also includes coenzymated B vitamins (5-MTHF and methylcobalamin) for optimal homocysteine management. Each bottle contains 30 capsules for a one-month supply, and the product is non-GMO, gluten-free, and soy-free with no artificial additives or fillers.

• Pros:
• Clinically studied AC-11 ingredient with published telomere research
• Multi-pathway formula addressing five mechanisms of telomere health
• Formulated by a leading stem cell researcher and Nobel Prize nominee

• Cons:
• Premium price point compared to single-ingredient alternatives
• Only 30 capsules per bottle

Best for: Anyone seeking a scientifically-backed, comprehensive telomere support supplement with clinically studied ingredients

2. CAW Hypersorption Cycloastragenol 10mg – Best Cycloastragenol

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CAW delivers pharmaceutical-grade 98% pure cycloastragenol with their proprietary Hypersorption technology for enhanced bioavailability at an accessible entry-level dose.

This supplement focuses on cycloastragenol, the most studied telomerase-activating compound derived from astragalus root. Each capsule provides 10mg of 98% pure cycloastragenol, making it an ideal starting dose for those new to telomere supplementation. The Hypersorption delivery system is designed to increase absorption beyond standard capsule formulations. The product contains 30 capsules per bottle and is manufactured under strict quality standards. Cycloastragenol works by activating the telomerase enzyme, which is responsible for maintaining and rebuilding telomere length at the cellular level.

• Pros:
• 98% purity cycloastragenol – among the highest available
• Hypersorption technology enhances bioavailability
• Good entry-level 10mg dose for beginners

• Cons:
• Single-ingredient formula lacks supporting antioxidants
• 30-capsule supply may require frequent reordering

Best for: Those specifically seeking pure cycloastragenol at a moderate starting dose with enhanced absorption

3. CAW Hypersorption Cycloastragenol 25mg – Most Potent

The higher-dose option from CAW delivers 25mg of 98% pure cycloastragenol per capsule for experienced users seeking maximum telomerase activation.

This is the same pharmaceutical-grade 98% purity cycloastragenol found in CAW’s 10mg version, but at a 2.5x higher concentration per capsule. The 25mg dose is suited for those who have already used cycloastragenol and want to increase their intake for more robust telomere support. The Hypersorption technology remains consistent across the product line, ensuring optimal absorption regardless of dose. Each bottle contains 30 capsules, and the product targets advanced anti-aging support at the cellular level through direct telomerase enzyme activation.

• Pros:
• Highest cycloastragenol dose available in a single capsule
• Same 98% purity and Hypersorption delivery as the 10mg version
• Ideal for experienced users ready for a stronger dose

• Cons:
• Higher price per bottle compared to 10mg option
• May be too potent for first-time users

Best for: Experienced biohackers and longevity enthusiasts seeking maximum-strength cycloastragenol supplementation

4. Enzymedica Telomere Plus – Best Multi-Pathway

Enzymedica combines time-tested botanicals with vitamin D3 in a unique Telomerin blend designed to promote telomerase activation through multiple complementary pathways.

Telomere Plus features a proprietary Telomerin blend that includes astragalus root, SGS broccoli seed extract, and rhodiola extract alongside vitamin D3. This multi-botanical approach targets telomerase enzyme activation while providing adaptogenic stress support through rhodiola, which may help protect telomeres from stress-related shortening. The broccoli seed extract delivers sulforaphane glucosinolate (SGS), a compound with potent antioxidant and cellular protective properties. Each bottle contains 30 capsules in vegetarian capsule form, making it suitable for plant-based lifestyles.

• Pros:
• Multi-botanical formula with complementary mechanisms
• Includes rhodiola for stress-related telomere protection
• Vegetarian capsules from a trusted enzyme supplement brand

• Cons:
• Proprietary blend doesn’t disclose individual ingredient amounts
• Lower brand recognition in the telomere supplement space

Best for: Those who prefer a plant-based, multi-ingredient approach to telomere support with added stress-management benefits

5. CAW Telomere Support 25mg Enteric-Coated – Best Absorption

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This enteric-coated version of CAW’s cycloastragenol bypasses stomach acid degradation, delivering the compound directly to the small intestine for superior absorption.

While containing the same 25mg of 98% pure cycloastragenol as the standard version, this formula uses enteric-coated capsules that resist breakdown in stomach acid and instead dissolve in the alkaline environment of the small intestine. This delivery method can significantly improve the bioavailability of cycloastragenol, ensuring more of the active compound reaches the bloodstream. The product contains 30 capsules per bottle and is ideal for those who have experienced digestive sensitivity with standard capsules or who want to maximize the efficiency of their telomere supplementation.

• Pros:
• Enteric coating protects cycloastragenol from stomach acid degradation
• Potentially higher bioavailability than standard capsule delivery
• Same 98% purity as other CAW products

• Cons:
• Premium pricing for the enteric-coated technology
• Enteric capsules should not be opened or crushed

Best for: Users who want maximum absorption efficiency or experience digestive issues with standard cycloastragenol capsules

6. Codeage Ultra Life Telomeres – Best Methylated Formula

Codeage offers a unique telomere formula built around methylated B vitamins, vitamin D3, and a comprehensive blend of herbal and fruit extracts designed to support DNA integrity from multiple angles.

This supplement combines L-methylfolate 5-MTHF, methylcobalamin B12, and vitamin D3 with an extensive blend of herbal extracts including ashwagandha, astragalus, holy basil, rhodiola, blueberry fruit powder, L-theanine, genistein, and fo-ti extract. The methylated B vitamins are included to support healthy homocysteine metabolism, a key factor in telomere maintenance. The 90-capsule bottle provides a 3-month supply, offering strong value compared to competitors. The formula’s emphasis on methylated vitamins makes it particularly suitable for individuals with MTHFR gene variations who may not efficiently process standard B vitamins.

• Pros:
• 3-month supply per bottle for excellent long-term value
• Methylated B vitamins support those with MTHFR variations
• Broad spectrum of herbal adaptogens and antioxidants

• Cons:
• Does not contain cycloastragenol or AC-11
• Large number of ingredients at potentially lower individual doses

Best for: Those seeking a comprehensive, multi-nutrient telomere formula with methylated vitamins and a broad antioxidant profile

7. Effective Nutra Resveratrol Gummies – Best Gummies

For those who prefer a chewable format, these sugar-free resveratrol gummies deliver 1500mg of trans-resveratrol per serving — a potent antioxidant linked to telomere protection and cellular longevity.

Resveratrol has been extensively studied for its role in activating sirtuins, supporting nitric oxide production, and protecting telomeres from oxidative stress-related shortening. Effective Nutra delivers a generous 1500mg dose in a sugar-free gummy format that makes daily supplementation easy and enjoyable. The formula provides antioxidant support for immunity and overall cellular health. While not a targeted telomere supplement in the same way as cycloastragenol-based products, resveratrol represents one of the most well-researched compounds for anti-aging and cellular longevity support.

• Pros:
• Sugar-free gummy format for easy daily compliance
• High 1500mg resveratrol dose per serving
• Well-researched ingredient for longevity and antioxidant support

• Cons:
• Not a dedicated telomere formula — works through antioxidant pathways
• Gummies may contain additional inactive ingredients

Best for: Those who want a tasty, chewable option for antioxidant-driven telomere protection and general longevity support

8. Green Valley Naturals Genesis Telomere Length – Best Value

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An affordable entry point into telomere supplementation, this CAW Hypersorption formula delivers 10mg of cycloastragenol with the same 98% purity standard at a competitive price.

This variant of the CAW cycloastragenol line provides the same Hypersorption delivery technology and 98% pure cycloastragenol at 10mg per capsule. It offers an accessible option for those looking to begin telomere support supplementation without committing to the higher-dose 25mg versions. The product contains 30 capsules per bottle and follows the same manufacturing standards as the rest of the CAW product line. Cycloastragenol is extracted from the astragalus membranaceus root and has been studied for its ability to activate the telomerase enzyme, supporting natural DNA repair and telomere maintenance.

• Pros:
• Competitive pricing for 98% pure cycloastragenol
• Same Hypersorption technology as premium CAW products
• Good starter option for those exploring telomere support

• Cons:
• Lower dose may require longer supplementation periods for noticeable effects
• Single-ingredient focus without additional antioxidant support

Best for: Budget-conscious consumers who want to try cycloastragenol supplementation at a reasonable starting dose

How to Choose the Best Telomere Support Supplement

When selecting a telomere support supplement, the most important factor is the active ingredient and its mechanism of action. Cycloastragenol and astragaloside IV are the most directly studied compounds for telomerase activation, while resveratrol, astragalus extract, and antioxidant blends work through complementary pathways like DNA repair and oxidative stress reduction. Look for products that specify purity levels — 98% cycloastragenol is the gold standard for that particular compound.

Dosage matters significantly in this category. Cycloastragenol is typically dosed between 5-25mg daily, while resveratrol ranges from 250-1500mg. Multi-ingredient formulas should list individual ingredient amounts rather than hiding behind proprietary blends. Enhanced delivery systems like Hypersorption technology or enteric coating can improve bioavailability, which is especially important for fat-soluble compounds like cycloastragenol.

Capsules remain the most common and effective form for telomere support supplements, as many active compounds are best absorbed in the intestinal tract. Gummies offer convenience but may sacrifice potency. Look for products manufactured in GMP-certified facilities with third-party testing. Consider whether you prefer a single-ingredient approach targeting one specific pathway or a comprehensive formula addressing multiple mechanisms of telomere maintenance, including supplements that support NAD+ pathways for broader longevity benefits.

Frequently Asked Questions

What are telomeres and why do they matter for aging?

Telomeres are protective caps at the ends of chromosomes, often compared to the plastic tips on shoelaces. They prevent DNA strands from fraying or fusing during cell division. Each time a cell divides, telomeres naturally shorten slightly. When they become critically short, cells can no longer divide properly and either become dysfunctional or die. Shorter telomere length has been associated with accelerated biological aging, reduced immune function, and increased risk of age-related health concerns.

How much cycloastragenol should I take daily?

Most supplements provide between 5-25mg of cycloastragenol per serving. Beginners typically start at 5-10mg daily and may increase to 25mg after assessing tolerance. The compound should be taken consistently for several months to see potential effects, as telomere changes occur gradually. It’s best taken with a meal containing some fat to enhance absorption of this fat-soluble compound.

When is the best time to take telomere support supplements?

Most telomere support supplements can be taken at any time of day with food. Cycloastragenol-based supplements benefit from being taken with a fat-containing meal for improved absorption. Multi-ingredient formulas that include B vitamins or energizing adaptogens like rhodiola may be best taken in the morning to avoid potential sleep disruption.

Are there any side effects of telomere supplements?

Telomere support supplements are generally well-tolerated. Cycloastragenol has been used in human studies without significant adverse effects. Some users report mild digestive changes when starting supplementation. Astragalus-based products should be avoided by individuals taking immunosuppressive medications, as astragalus can stimulate immune activity. As with any supplement, start with the lowest recommended dose and increase gradually.

Can I take telomere supplements with other supplements?

Telomere support supplements are generally compatible with most other supplements. In fact, combining them with omega-3 fatty acids, vitamin D, and antioxidants like vitamin C may provide complementary telomere-protective benefits. However, those taking blood thinners should exercise caution with resveratrol-containing formulas, and anyone on immunosuppressive therapy should consult their healthcare provider before using astragalus-based products.

How long does it take for telomere supplements to work?

Telomere changes are gradual biological processes, so patience is essential. Clinical studies on telomere-supporting compounds like AC-11 measured effects over 6-12 months. Most experts recommend committing to at least 3-6 months of consistent supplementation before evaluating results. The effects are cellular in nature and may not produce immediately noticeable physical changes, though some users report improvements in energy and overall vitality within the first few weeks.

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