Best TUDCA Supplements (2026)

TUDCA (tauroursodeoxycholic acid) is a water-soluble bile acid that has gained significant attention for its liver-protective properties. Originally used in traditional Chinese medicine, TUDCA supports bile flow, protects liver cells from toxin damage, and may improve hepatic insulin sensitivity. It’s become a go-to supplement for liver health, gallbladder support, and increasingly for neuroprotective benefits.

Quick Comparison

Product	TUDCA Per Serving	Form	Best For	Rating
Double Wood TUDCA	500mg	Capsules	Best Overall	4.6/5
Nutricost TUDCA 500mg	500mg	Capsules	Best Value	4.5/5
Dr. Berg TUDCA	250mg	Capsules	Best Trusted Brand	4.5/5
Honeylitte TUDCA 1200mg	1200mg	Capsules	Most Potent	4.4/5
Best Naturals TUDCA	250mg	Capsules	Best Budget Pick	4.4/5
BulkSupplements TUDCA	500mg	Powder	Best Powder	4.3/5
LimerenxLush TUDCA Drops	1500mg	Liquid Drops	Best Liquid	4.3/5

1. Double Wood TUDCA – Best Overall

Double Wood’s TUDCA is the gold standard in this category, trusted by thousands of users for reliable liver and gallbladder support.

Each serving delivers 500mg of TUDCA across two capsules (250mg each), providing a clinically relevant dose for bile flow optimization and liver protection. The formula uses genuine bile acid TUDCA with a characteristic bitter taste that confirms authenticity. Manufactured and third-party tested in the USA, this supplement contains no unnecessary fillers. A 60-capsule bottle provides a full 30-day supply at the recommended dose. For those also interested in comprehensive liver cleanse supplements, TUDCA pairs well with milk thistle.

• Pros:
• 500mg per serving at a competitive price point
• Third-party tested in the USA for purity and heavy metals
• Genuine bile acid with authentic bitter taste verification

• Cons:
• Requires two capsules per serving
• Bitter taste may be noticeable if capsule is opened

Best for: Anyone seeking a well-established, trusted TUDCA supplement for daily liver and gallbladder support

2. Nutricost TUDCA 500mg – Best Value

Nutricost delivers a full 500mg of TUDCA per capsule at one of the most affordable prices in the category.

This single-capsule formula simplifies dosing while delivering the same potency as competitors requiring two capsules. Nutricost manufactures in an NSF-certified, GMP-compliant, FDA-registered facility and conducts third-party testing on every batch. The TUDCA is not derived from bear bile, using a synthetic process instead. Each bottle contains 30 capsules for a one-month supply. The straightforward, no-frills formula contains TUDCA with minimal inactive ingredients.

• Pros:
• Full 500mg dose in a single capsule
• NSF-certified facility with third-party testing
• One of the lowest cost-per-serving options

• Cons:
• Only 30 servings per bottle
• Contains gelatin capsule (not vegan)

Best for: Budget-conscious buyers who want a high-potency, single-capsule TUDCA supplement

3. Dr. Berg TUDCA – Best Trusted Brand

Dr. Berg’s TUDCA provides a moderate 250mg dose in a formula designed for targeted liver health, bile flow, and gallbladder support.

Each capsule delivers 250mg of TUDCA per serving, which is a solid maintenance dose for daily liver protection. The formula is recommended by Dr. Berg, a well-known health educator, and is designed for maximum effectiveness in a single capsule format. The 30-capsule bottle provides a full month supply. This is a strong option for those who prefer a moderate dose or want to ease into TUDCA supplementation.

• Pros:
• Backed by a recognized health brand
• One capsule per serving for easy dosing
• Moderate dose suitable for daily maintenance

• Cons:
• Lower dose (250mg) compared to competitors
• Higher cost per milligram than bulk options

Best for: Those who prefer a trusted brand name and moderate TUDCA dosing for daily maintenance

4. Honeylitte TUDCA 1200mg – Most Potent

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Honeylitte delivers the highest per-serving dose on this list at 1200mg of pure TUDCA for aggressive liver support.

This ultra-strength formula provides 1200mg of pharmaceutical-grade TUDCA per serving across two vegan capsules. The clean-label formula contains no fillers, GMOs, gluten, or gelatin, making it suitable for a wide range of dietary preferences. Produced in a cGMP-certified facility with rigorous third-party testing for identity, purity, and potency. The 90-capsule bottle provides a 45-day supply at the recommended two-capsule daily dose.

• Pros:
• Highest potency at 1200mg per serving
• 100% vegan capsules with zero fillers
• 90 capsules for extended 45-day supply

• Cons:
• High dose may be unnecessary for maintenance use
• Newer brand with limited track record

Best for: Those seeking the highest-potency TUDCA supplement for intensive liver support

5. Best Naturals TUDCA – Best Budget Pick

Best Naturals offers a straightforward 250mg TUDCA at an entry-level price point, ideal for those new to the supplement.

Each capsule delivers 250mg of TUDCA in a non-GMO, gluten-free formula. The product is manufactured in a GMP-compliant, FDA-registered facility in the USA. The 60-capsule bottle provides a full two-month supply at one capsule daily, or one month at two capsules daily for a 500mg dose. The clean formula avoids common allergens including milk, corn, soy, egg, lactose, wheat, and yeast.

• Pros:
• Excellent price for 60 capsules
• Free from major allergens
• Flexible dosing at 250mg per capsule

• Cons:
• 250mg may require doubling up for therapeutic doses
• Less brand recognition than premium options

Best for: First-time TUDCA users or anyone seeking affordable daily liver support

6. Nutricost TUDCA 250mg – Best for Flexible Dosing

Nutricost’s lower-dose TUDCA option provides 250mg per capsule, allowing precise dose customization for different health goals.

This 60-capsule bottle at the 250mg strength allows users to take one capsule for maintenance support or two for a full 500mg therapeutic dose. Like its higher-dose sibling, it’s manufactured in an NSF-certified, GMP-compliant facility with independent third-party testing. The TUDCA is synthetically produced rather than derived from animal bile, appealing to those concerned about sourcing. If you’re also supporting liver health with NAC supplements, TUDCA makes an excellent complementary addition.

• Pros:
• Flexible dosing from 250mg to 500mg daily
• 60-capsule bottle stretches up to two months
• Same quality standards as premium Nutricost products

• Cons:
• Requires two capsules for standard 500mg dose
• Contains gelatin capsule

Best for: Those who want flexible dose control to dial in the right TUDCA amount for their needs

7. BulkSupplements TUDCA Powder – Best Powder

BulkSupplements offers TUDCA in pure powder form for maximum dosing flexibility and cost efficiency.

The 50g pouch provides approximately 100 servings at the recommended 500mg per dose, making it one of the most cost-effective TUDCA options available. Produced in a cGMP-compliant facility, the powder is lab-tested for quality and purity. The powder form allows for precise customization of dose amounts and can be mixed into liquids or encapsulated at home. Note that a milligram scale is recommended for accurate dosing.

• Pros:
• Lowest cost per serving in the TUDCA market
• Complete dosing flexibility
• Approximately 100 servings per pouch

• Cons:
• Requires a milligram scale for accurate dosing
• Strong bitter taste in powder form

Best for: Experienced supplement users who want bulk TUDCA at the lowest possible cost

8. LimerenxLush TUDCA Drops 1800mg – Best Liquid

LimerenxLush delivers TUDCA in a fast-absorbing liquid drop format with synergistic liver support ingredients including NAC, Schisandra, and Dandelion Root.

Each serving provides 1500mg of TUDCA in a sugar-free, alcohol-free liquid formula that absorbs faster than traditional capsules. The HepatoDefense Complex adds N-Acetyl Cysteine (NAC), Schisandra Berry Extract, and Dandelion Root Extract for comprehensive liver protection. The 2 fl oz bottle is diet-friendly—vegan, soy-free, gluten-free, and dairy-free. This is an ideal choice for those who have difficulty swallowing pills or want faster absorption. For additional detox support, consider pairing with a full liver cleanse protocol.

• Pros:
• Liquid format for faster absorption
• Multi-ingredient formula with NAC and herbal extracts
• No pills to swallow

• Cons:
• Shorter supply compared to capsule bottles
• More expensive per serving than capsule options

Best for: Those who prefer liquid supplements or want a comprehensive liver support formula beyond TUDCA alone

How to Choose the Best TUDCA Supplement

When selecting a TUDCA supplement, dosage is the most important factor. Clinical studies have used doses ranging from 250mg to 1,750mg daily, with 500mg being the most common dose for general liver support. Start at 250mg daily and increase as needed based on your health goals and practitioner guidance.

Look for third-party tested products manufactured in cGMP-certified facilities. TUDCA should be synthetically produced rather than derived from bear bile, which is both an ethical and quality concern. Genuine TUDCA has a characteristic bitter taste—if a product claims to be TUDCA but has no bitterness, it may be low-quality or underdosed.

Capsules are the most popular delivery form, though powder offers the best cost-per-serving and liquids provide faster absorption. Choose the form that best fits your routine and comfort level. Most users take TUDCA with meals, as it supports bile production that aids fat digestion.

For maximum liver support, TUDCA stacks well with other liver-protective compounds like NAC, milk thistle, and artichoke extract. Check for clean labels free from unnecessary fillers, artificial ingredients, and common allergens.

Frequently Asked Questions

What is TUDCA and what does it do?

TUDCA (tauroursodeoxycholic acid) is a water-soluble bile acid naturally produced in small amounts by the body. It supports liver cell health by reducing endoplasmic reticulum stress, promotes healthy bile flow, protects against liver cell death, and may improve insulin sensitivity. It has been used in clinical settings for liver and gallbladder conditions and is now widely available as a dietary supplement.

How much TUDCA should I take daily?

Most supplements provide 250-500mg per serving, with 500mg daily being the most commonly studied dose for general liver support. Clinical studies have used doses up to 1,750mg daily for specific conditions. Start with a lower dose (250mg) and increase gradually. Always follow the manufacturer’s recommendations and consult a healthcare provider for personalized dosing.

When is the best time to take TUDCA?

TUDCA is best taken with meals, particularly meals containing fat, as it supports bile production needed for fat digestion. Taking it with food also reduces the chance of stomach discomfort. Some users split their dose between morning and evening meals for sustained support throughout the day.

Are there any side effects of TUDCA?

TUDCA is generally well tolerated at recommended doses. Some users report mild digestive discomfort, diarrhea, or nausea when first starting. These effects typically diminish within a few days. TUDCA is a bile acid, so those with bile duct obstruction or certain gallbladder conditions should consult a physician before use.

Can I take TUDCA with other supplements?

TUDCA stacks well with other liver support supplements including NAC, milk thistle, artichoke extract, and dandelion root. It’s commonly used alongside vitamin D and omega-3 fatty acids. Those taking prescription medications should consult a healthcare provider, as TUDCA may affect the absorption of certain drugs through its effects on bile acid metabolism.

How long does it take for TUDCA to work?

Many users report noticing improved digestion and reduced bloating within 1-2 weeks of consistent use. Liver enzyme improvements may be measurable through blood work within 4-8 weeks. For neuroprotective or more systemic benefits, longer-term use of 2-3 months is typically recommended before assessing results.

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