Best Urolithin A Supplements (2026)

Urolithin A is a postbiotic compound produced when gut bacteria metabolize ellagitannins found in pomegranates, walnuts, and berries. It has become one of the most researched longevity molecules due to its ability to activate mitophagy — the process of recycling damaged mitochondria and replacing them with healthy ones. Clinical studies have demonstrated improvements in muscle strength, endurance, and cellular energy with consistent supplementation.

Quick Comparison

Product	Key Ingredient	Form	Best For	Rating
Timeline Mitopure Softgels	Mitopure® 500mg Urolithin A	Softgels	Best Overall	9.6/10
Timeline Mitopure Gummies	Mitopure® Urolithin A	Gummies	Best Gummies	9.4/10
MITIVA Urolithin A with NAD+	Urolithin A + NAD+ + CoQ10 + PQQ	Softgels	Best Longevity Stack	9.2/10
Urolithin A 1800mg with NAD	Liposomal Urolithin A 1800mg	Capsules	Most Potent	9.0/10
Timeline Mitopure Powder	Mitopure® 500mg Urolithin A	Powder	Best Powder	9.0/10
Nutragenis Urolithin A Pro	Urolithin A 500mg	Softgels	Best for Athletes	8.9/10
Codeage Liposomal Urolithin A	Liposomal Urolithin A 500mg	Capsules	Best Absorption Technology	8.8/10

1. Timeline Mitopure Urolithin A Softgels – Best Overall

Timeline’s Mitopure is the gold standard in urolithin A supplementation — a proprietary, clinically validated form backed by 15+ years of longevity research, 50+ global patents, and five gold-standard clinical trials published in journals like JAMA and Cell Reports Medicine.

Each two-softgel serving delivers 500mg of Mitopure, a patented and highly pure form of urolithin A that delivers six times more urolithin A than a glass of pure pomegranate juice. Clinical trials demonstrated that sedentary middle-aged adults increased hamstring muscle strength by up to 12% after 16 weeks and muscle endurance by up to 15% after 8 weeks compared to placebo. The product is formulated in Switzerland and manufactured in the USA, with carbon-neutral certification. Timeline is the most researched brand in the urolithin A space by a significant margin.

• Pros:
• Most clinically studied urolithin A with 5+ gold-standard trials
• Patented Mitopure form with 50+ global patents
• Proven 12% muscle strength improvement in clinical trials

• Cons:
• Premium price point reflects clinical research investment
• Some users report softgel quality inconsistency in shipping

Best for: Anyone who wants the most scientifically validated urolithin A supplement available

2. Timeline Mitopure Gummies – Best Gummies

Timeline extends their clinically proven Mitopure formula into a convenient, strawberry-flavored gummy format for users who prefer a tastier alternative to swallowing softgels or capsules.

These gummies deliver the same patented Mitopure urolithin A found in Timeline’s softgels, backed by the identical clinical research and manufacturing standards. The sugar-free formula makes them suitable for those watching sugar intake. With a 4.7-star rating from over 850 reviews, these are among the highest-rated urolithin A products available. The gummy format improves compliance for users who find daily capsule routines difficult to maintain.

• Pros:
• Same clinically validated Mitopure as the softgel form
• Sugar-free strawberry flavor
• Excellent for users who dislike swallowing pills

• Cons:
• Highest price point in the Timeline lineup
• Gummies require more ingredients than simple softgels

Best for: Users who want clinically proven urolithin A in a convenient, great-tasting gummy

3. MITIVA Urolithin A with NAD+, CoQ10 & PQQ – Best Longevity Stack

MITIVA combines urolithin A with three other powerhouse longevity compounds — NAD+, CoQ10, and PQQ — creating a comprehensive mitochondrial support and anti-aging formula in a single supplement.

This 5-in-1 longevity complex targets cellular energy from multiple angles. Urolithin A activates mitophagy to recycle damaged mitochondria, NAD+ supports cellular energy production and DNA repair, CoQ10 fuels the electron transport chain in mitochondria, and PQQ promotes the growth of new mitochondria (mitochondrial biogenesis). The combination addresses both the recycling of old mitochondria and the creation of new ones, providing a more complete approach to cellular health than urolithin A alone. Each bottle provides 120 softgels for a two-month supply.

• Pros:
• Four complementary longevity compounds in one formula
• Addresses both mitophagy and mitochondrial biogenesis
• 120 softgels for a 2-month supply

• Cons:
• Individual compound doses may be lower than standalone products
• Does not use patented Mitopure form of urolithin A

Best for: Longevity-focused users who want a comprehensive mitochondrial support stack

4. Urolithin A 1800mg with NAD – Most Potent

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At 1,800mg of liposomal urolithin A per serving combined with 200mg of NAD, this is one of the highest-potency urolithin A supplements on the market for users who want maximum dosing.

The liposomal delivery system enhances absorption by encapsulating the urolithin A in lipid spheres that protect the compound through the digestive system and improve cellular uptake. The addition of NAD provides complementary cellular energy support. This ultra-high potency makes it suitable for users who have already established a baseline with lower-dose products and want to explore the effects of more aggressive supplementation. The capsule format is convenient for daily use.

• Pros:
• Ultra-high 1,800mg urolithin A per serving
• Liposomal delivery for enhanced absorption
• NAD included for additional cellular energy support

• Cons:
• Significantly higher dose than clinically studied amounts
• Premium pricing for the high potency

Best for: Experienced users who want the highest available urolithin A dosage

5. Timeline Mitopure Powder – Best Powder

Timeline’s powder format delivers 500mg of clinically proven Mitopure per serving in a mixable form that can be added to smoothies, yogurt, or water for those who prefer not to take pills.

This offers the same patented, clinically validated Mitopure urolithin A as Timeline’s softgels and gummies but in a versatile powder format. The powder mixes easily into beverages and foods, providing flexibility in how you incorporate urolithin A into your daily routine. It maintains the same clinical backing showing improvements in cellular energy, muscle strength, and mitochondrial health after consistent use. The powder form also allows for easier dose adjustments compared to fixed-dose softgels.

• Pros:
• Same clinically proven Mitopure in a mixable powder
• Versatile — add to smoothies, yogurt, or beverages
• Easy dose adjustment compared to pills

• Cons:
• Less convenient than grab-and-go softgels for travel
• Requires mixing rather than simply swallowing

Best for: Users who prefer powder supplements or want to mix urolithin A into foods and beverages

6. Nutragenis Urolithin A Pro Softgels – Best for Athletes

Nutragenis delivers 500mg of ultra-micronized urolithin A per softgel, specifically targeting athletic performance by enhancing mitochondrial biogenesis and muscle cell energy production.

The micronized formulation improves absorption compared to standard urolithin A capsules, ensuring the compound reaches muscle cells more efficiently. The formula is developed with over 15 years of research focus on cellular renewal and muscle performance. Each bottle contains 60 softgels for a 60-day supply at the recommended one-softgel daily dose. Nutragenis manufactures in a GMP and FDA-registered facility in the USA with third-party lab testing for every batch. The premium quality, globally sourced ingredients are designed to support muscle strength, endurance, and post-exercise recovery.

• Pros:
• Ultra-micronized for improved absorption
• Targeted at muscle performance and athletic recovery
• GMP and FDA-registered US manufacturing with 3rd-party testing

• Cons:
• 60-count bottle at one-per-day dosing is only a 2-month supply
• Higher cost per softgel than some alternatives

Best for: Athletes and active adults focused on muscle performance and recovery

7. Codeage Liposomal Urolithin A – Best Absorption Technology

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Codeage uses advanced liposomal delivery technology to wrap urolithin A in phospholipid layers derived from non-GMO sunflower oil, dramatically improving bioavailability compared to standard capsule formulations.

Each serving delivers 500mg of liposomal urolithin A alongside trans-resveratrol (150mg), betaine (102.5mg), CoQ10 (60mg), and ellagitannins — creating a synergistic anti-aging formula. The liposomal encapsulation protects the active ingredients through the harsh digestive environment and facilitates direct cellular uptake. Codeage emphasizes transparency with third-party testing certifications. Each bottle contains 60 capsules for a one-month supply. The formula is non-GMO, vegan-friendly, and free of common allergens.

• Pros:
• Liposomal technology from non-GMO sunflower oil for superior absorption
• Includes resveratrol, betaine, and CoQ10 for synergistic benefits
• Third-party tested with transparent certifications

• Cons:
• 60 capsules at 2-per-serving means only a 30-day supply
• Complex multi-ingredient formula at premium pricing

Best for: Users who prioritize maximum bioavailability through advanced delivery technology

8. Tesseract Urolithin A – Best for Gut Health

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Tesseract’s formula uses an advanced absorption system designed to enhance urolithin A uptake while also supporting gut health and immune function alongside cellular and mitochondrial health.

This unique formulation goes beyond standard urolithin A by incorporating gut-supportive elements that complement the compound’s postbiotic nature. Since urolithin A is naturally produced by gut bacteria, supporting gut health may enhance the body’s own ability to produce urolithin A from dietary sources alongside the supplemental dose. Each bottle provides 90 capsules, and the formula is gluten-free. Tesseract is known for its innovative absorption technologies across multiple supplement categories.

• Pros:
• Advanced absorption formula technology
• Supports gut health alongside mitochondrial function
• 90-capsule bottle for extended supply

• Cons:
• Newer brand in the urolithin A space
• Less clinical data than Timeline’s Mitopure

Best for: Users who want urolithin A combined with gut health support

How to Choose the Best Urolithin A Supplement

The most important consideration is the form and purity of urolithin A used. Timeline’s Mitopure is the only patented form with extensive clinical validation through gold-standard trials published in peer-reviewed medical journals. Other products use generic urolithin A derived from pomegranate extract, which can still be effective but lacks the same depth of clinical evidence. If clinical proof matters to you, Mitopure-based products are the clear choice.

Clinically studied dosing is 500mg per day, which is the amount shown to improve muscle strength by up to 12% and endurance by up to 15% in published trials. Some products offer higher doses (1,000–1,800mg), but these megadoses haven’t been validated in the same rigorous clinical settings. Starting at 500mg daily is recommended, with potential to increase based on individual response and goals.

Delivery technology significantly impacts urolithin A effectiveness. Liposomal formulations and micronized particles improve absorption compared to standard capsules. Softgels with MCT oil or other lipid carriers also enhance absorption since urolithin A is fat-soluble. Powder forms offer versatility but may have slightly different absorption profiles depending on what they’re mixed with.

Consider whether you want standalone urolithin A or a combination formula with other longevity compounds like NAD+, CoQ10, PQQ, or resveratrol. Standalone products provide precise dosing control, while combination formulas offer broader anti-aging support at the trade-off of potentially lower individual compound doses.

Frequently Asked Questions

What is urolithin A and what does it do?

Urolithin A is a postbiotic metabolite naturally produced when gut bacteria break down ellagitannins found in pomegranates, walnuts, and berries. Its primary mechanism is activating mitophagy — the cellular process that identifies and recycles damaged mitochondria, replacing them with healthy new ones. This mitochondrial renewal supports cellular energy production, muscle strength and endurance, healthy aging, and overall vitality. Not everyone’s gut microbiome efficiently produces urolithin A, which is why supplementation ensures a consistent, clinically effective dose.

How much urolithin A should I take daily?

The clinically validated dose is 500mg per day, based on multiple published trials showing improvements in muscle strength and mitochondrial health at this amount. Some products offer doses up to 1,000–1,800mg, but these higher amounts lack the same level of clinical evidence. Start with 500mg daily and maintain consistent use for at least four months to experience the full benefits shown in clinical research.

When is the best time to take urolithin A?

Urolithin A can be taken at any time of day, with or without food. Since it is fat-soluble, taking it with a meal that contains some dietary fat may improve absorption. Many users take it in the morning as part of their daily supplement routine. Consistency is more important than timing — the clinical benefits build over weeks and months of daily use regardless of when during the day you take it.

Are there any side effects of urolithin A?

Urolithin A is generally very well tolerated. Clinical trials have shown it to be safe at 500mg daily over extended periods, and the FDA has granted GRAS (Generally Recognized as Safe) status to Mitopure. Some users report mild digestive effects like nausea or stomach upset, particularly at higher doses. These effects are typically transient and resolve with continued use. People with pomegranate allergies should check ingredient sources before supplementing.

Can I take urolithin A with other supplements?

Urolithin A pairs well with other longevity and cellular health supplements, including NAD+ precursors (NMN, NR), CoQ10, PQQ, and resveratrol. Many combination products already stack these compounds together. Urolithin A can also be taken alongside standard supplements like multivitamins, omega-3s, and vitamin D without known interactions. As always, consult a healthcare provider if you take prescription medications, particularly those metabolized by the liver.

How long does it take for urolithin A to work?

Clinical research shows improvements in cellular energy biomarkers within the first few weeks of daily use. Measurable improvements in muscle strength typically become apparent after four months of consistent supplementation, with endurance benefits showing after approximately eight weeks. Some users report subjective improvements in energy and exercise recovery within two to four weeks. The mitochondrial renewal process is gradual, so longer-term use provides the most significant benefits.